Interactions for 4R9W (chain B)
Structure details
- PDB ID: 4R9W open_in_new
- Protein: CXCL4_HUMAN
- Organism: Homo sapiens
- UniProt ID: P02776 open_in_new
- Method: X-ray
- Resolution: 2.5 Å
- Date: Dec. 16, 2015
- Reference: 10.1038/NCOMMS9277 open_in_new
- State: dimer
Chemokine diagram
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Interactions found in structure
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| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Arg 122 | 81 | N-loop | UNL 1 | fondaparinux (None) | Anionic |
| Arg 122 | 81 | N-loop | UNL 1 | fondaparinux (None) | VdWContact |
| Thr 125 | 84 | B1 | LYS 31 | Platelet factor 4 (A) | Hydrophobic |
| Thr 125 | 84 | B1 | LYS 31 | Platelet factor 4 (A) | HBAcceptor |
| Thr 125 | 84 | B1 | LYS 31 | Platelet factor 4 (A) | VdWContact |
| Ser 126 | 85 | B1 | VAL 29 | Platelet factor 4 (A) | VdWContact |
| Ser 126 | 85 | B1 | GLU 28 | Platelet factor 4 (A) | VdWContact |
| Leu 127 | 86 | B1 | GLU 28 | Platelet factor 4 (A) | VdWContact |
| Leu 127 | 86 | B1 | VAL 29 | Platelet factor 4 (A) | HBAcceptor |
| Leu 127 | 86 | B1 | VAL 29 | Platelet factor 4 (A) | HBDonor |
| Leu 127 | 86 | B1 | VAL 29 | Platelet factor 4 (A) | VdWContact |
| Glu 128 | 87 | B1 | GLU 28 | Platelet factor 4 (A) | Hydrophobic |
| Glu 128 | 87 | B1 | GLU 28 | Platelet factor 4 (A) | VdWContact |
| Val 129 | 88 | B1 | LEU 68 | Platelet factor 4 (A) | Hydrophobic |
| Val 129 | 88 | B1 | ILE 64 | Platelet factor 4 (A) | Hydrophobic |
| Val 129 | 88 | B1 | LEU 67 | Platelet factor 4 (A) | Hydrophobic |
| Val 129 | 88 | B1 | LEU 27 | Platelet factor 4 (A) | HBAcceptor |
| Val 129 | 88 | B1 | LEU 27 | Platelet factor 4 (A) | HBDonor |
| Val 129 | 88 | B1 | LEU 27 | Platelet factor 4 (A) | VdWContact |
| Val 129 | 88 | B1 | SER 26 | Platelet factor 4 (A) | VdWContact |
| Lys 131 | 90 | 30s-loop | THR 25 | Platelet factor 4 (A) | HBDonor |
| Lys 131 | 90 | 30s-loop | THR 25 | Platelet factor 4 (A) | VdWContact |
| Lys 131 | 90 | 30s-loop | LEU 67 | Platelet factor 4 (A) | Hydrophobic |
| Lys 131 | 90 | 30s-loop | LEU 67 | Platelet factor 4 (A) | VdWContact |
| Ala 139 | 99 | 30s-loop | LEU 68 | Platelet factor 4 (A) | Hydrophobic |
| Lys 146 | 106 | 40s-loop | UNL 1 | fondaparinux (None) | HBAcceptor |
| Lys 146 | 106 | 40s-loop | UNL 1 | fondaparinux (None) | Anionic |
| Lys 146 | 106 | 40s-loop | UNL 1 | fondaparinux (None) | VdWContact |
| Tyr 160 | 125 | Helix | LEU 68 | Platelet factor 4 (A) | Hydrophobic |
| Tyr 160 | 125 | Helix | LEU 68 | Platelet factor 4 (A) | VdWContact |
| Ile 164 | 129 | Helix | VAL 29 | Platelet factor 4 (A) | Hydrophobic |
| Ile 164 | 129 | Helix | ILE 64 | Platelet factor 4 (A) | Hydrophobic |
| Ile 164 | 129 | Helix | ILE 64 | Platelet factor 4 (A) | VdWContact |
| Leu 167 | 132 | Helix | ALA 39 | Platelet factor 4 (A) | VdWContact |
| Leu 167 | 132 | Helix | VAL 29 | Platelet factor 4 (A) | Hydrophobic |
| Leu 167 | 132 | Helix | LYS 31 | Platelet factor 4 (A) | Hydrophobic |
| Leu 167 | 132 | Helix | LYS 31 | Platelet factor 4 (A) | VdWContact |
| Leu 168 | 133 | Helix | ALA 39 | Platelet factor 4 (A) | VdWContact |
| Leu 168 | 133 | Helix | LEU 55 | Platelet factor 4 (A) | Hydrophobic |
| Leu 168 | 133 | Helix | TYR 60 | Platelet factor 4 (A) | Hydrophobic |
| Leu 168 | 133 | Helix | TYR 60 | Platelet factor 4 (A) | VdWContact |
| Leu 168 | 133 | Helix | LEU 41 | Platelet factor 4 (A) | Hydrophobic |
| Leu 168 | 133 | Helix | VAL 29 | Platelet factor 4 (A) | Hydrophobic |
| Ser 170 | 135 | Helix | ALA 32 | Platelet factor 4 (A) | HBAcceptor |
| Ser 170 | 135 | Helix | ALA 32 | Platelet factor 4 (A) | VdWContact |
Ligand interaction network
ZDO_C_1_IDS_C_2_SUS_C_3_BDP_C_4_SGN_C_5
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