Interactions for 4R9Y (chain A)
Structure details
- PDB ID: 4R9Y open_in_new
- Protein: CXCL4_HUMAN
- Organism: Homo sapiens
- UniProt ID: P02776 open_in_new
- Method: X-ray
- Resolution: 4.11 Å
- Date: Dec. 16, 2015
- Reference: 10.1038/NCOMMS9277 open_in_new
- State: tetramer
Chemokine diagram
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Interactions found in structure
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| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Asp 7 | 60 | N-term | VAL 13 | Platelet factor 4 (C) | VdWContact |
| Leu 8 | 61 | N-term | LEU 11 | Platelet factor 4 (C) | VdWContact |
| Leu 8 | 61 | N-term | CYS 12 | Platelet factor 4 (C) | Hydrophobic |
| Leu 8 | 61 | N-term | CYS 12 | Platelet factor 4 (C) | VdWContact |
| Leu 8 | 61 | N-term | LYS 50 | Platelet factor 4 (C) | VdWContact |
| Gln 9 | 62 | N-term | LEU 11 | Platelet factor 4 (C) | HBDonor |
| Gln 9 | 62 | N-term | LEU 11 | Platelet factor 4 (C) | VdWContact |
| Gln 9 | 62 | N-term | TYR 26 | Platelet factor 4 antibody KKO heavy chain (N) | VdWContact |
| Gln 9 | 62 | N-term | GLN 9 | Platelet factor 4 (C) | VdWContact |
| Cys 10 | 63 | CX | GLN 9 | Platelet factor 4 (C) | HBAcceptor |
| Leu 11 | 66 | CX | LEU 11 | Platelet factor 4 (C) | Hydrophobic |
| Leu 11 | 66 | CX | LEU 11 | Platelet factor 4 (C) | VdWContact |
| Leu 11 | 66 | CX | LEU 8 | Platelet factor 4 (C) | VdWContact |
| Leu 11 | 66 | CX | GLN 9 | Platelet factor 4 (C) | VdWContact |
| Cys 12 | 67 | CX | TYR 100 | Platelet factor 4 antibody KKO heavy chain (N) | Hydrophobic |
| Cys 12 | 67 | CX | TYR 100 | Platelet factor 4 antibody KKO heavy chain (N) | VdWContact |
| Val 13 | 68 | N-loop | ASP 7 | Platelet factor 4 (C) | Hydrophobic |
| Val 13 | 68 | N-loop | ASP 7 | Platelet factor 4 (C) | VdWContact |
| Val 13 | 68 | N-loop | GLN 9 | Platelet factor 4 (C) | Hydrophobic |
| Val 13 | 68 | N-loop | GLN 9 | Platelet factor 4 (C) | VdWContact |
| Val 13 | 68 | N-loop | ASN 30 | Platelet factor 4 antibody KKO heavy chain (N) | Hydrophobic |
| Lys 14 | 69 | N-loop | ASP 7 | Platelet factor 4 (C) | Hydrophobic |
| Lys 14 | 69 | N-loop | ASP 7 | Platelet factor 4 (C) | VdWContact |
| Ile 24 | 83 | B1 | LYS 31 | Platelet factor 4 (B) | VdWContact |
| Thr 25 | 84 | B1 | LYS 31 | Platelet factor 4 (B) | Hydrophobic |
| Thr 25 | 84 | B1 | LYS 31 | Platelet factor 4 (B) | VdWContact |
| Ser 26 | 85 | B1 | VAL 29 | Platelet factor 4 (B) | VdWContact |
| Ser 26 | 85 | B1 | ILE 30 | Platelet factor 4 (B) | VdWContact |
| Leu 27 | 86 | B1 | LEU 27 | Platelet factor 4 (B) | VdWContact |
| Glu 28 | 87 | B1 | GLU 28 | Platelet factor 4 (B) | Hydrophobic |
| Val 29 | 88 | B1 | LEU 68 | Platelet factor 4 (B) | Hydrophobic |
| Val 29 | 88 | B1 | THR 25 | Platelet factor 4 (B) | VdWContact |
| Val 29 | 88 | B1 | SER 26 | Platelet factor 4 (B) | VdWContact |
| Lys 31 | 90 | 30s-loop | LEU 67 | Platelet factor 4 (B) | Hydrophobic |
| Lys 31 | 90 | 30s-loop | THR 25 | Platelet factor 4 (B) | Hydrophobic |
| Lys 31 | 90 | 30s-loop | THR 25 | Platelet factor 4 (B) | HBDonor |
| Lys 31 | 90 | 30s-loop | THR 25 | Platelet factor 4 (B) | VdWContact |
| Lys 31 | 90 | 30s-loop | ILE 24 | Platelet factor 4 (B) | VdWContact |
| Lys 31 | 90 | 30s-loop | SER 70 | Platelet factor 4 (B) | HBDonor |
| Lys 31 | 90 | 30s-loop | SER 70 | Platelet factor 4 (B) | VdWContact |
| Ala 32 | 91 | 30s-loop | SER 81 | Platelet factor 4 antibody KKO light chain (M) | VdWContact |
| Gly 33 | 92 | 30s-loop | SER 81 | Platelet factor 4 antibody KKO light chain (M) | HBAcceptor |
| Gly 33 | 92 | 30s-loop | SER 81 | Platelet factor 4 antibody KKO light chain (M) | VdWContact |
| Pro 37 | 96 | 30s-loop | SER 81 | Platelet factor 4 antibody KKO light chain (M) | HBAcceptor |
| Pro 37 | 96 | 30s-loop | SER 81 | Platelet factor 4 antibody KKO light chain (M) | VdWContact |
| Pro 37 | 96 | 30s-loop | PRO 99 | Platelet factor 4 antibody KKO heavy chain (N) | Hydrophobic |
| Thr 38 | 97 | 30s-loop | TYR 74 | Platelet factor 4 antibody KKO light chain (M) | VdWContact |
| Thr 38 | 97 | 30s-loop | PRO 99 | Platelet factor 4 antibody KKO heavy chain (N) | Hydrophobic |
| Thr 38 | 97 | 30s-loop | TYR 100 | Platelet factor 4 antibody KKO heavy chain (N) | Hydrophobic |
| Ala 39 | 99 | 30s-loop | LEU 68 | Platelet factor 4 (B) | Hydrophobic |
| Asn 47 | 112 | 40s-loop | ASN 47 | Platelet factor 4 (D) | VdWContact |
| Lys 50 | 115 | B3 | LEU 8 | Platelet factor 4 (C) | Hydrophobic |
| Lys 50 | 115 | B3 | LEU 8 | Platelet factor 4 (C) | VdWContact |
| Asp 54 | 119 | 50s-loop | TYR 104 | Platelet factor 4 antibody KKO heavy chain (N) | VdWContact |
| Leu 55 | 120 | 50s-loop | TYR 104 | Platelet factor 4 antibody KKO heavy chain (N) | Hydrophobic |
| Leu 55 | 120 | 50s-loop | TYR 104 | Platelet factor 4 antibody KKO heavy chain (N) | HBDonor |
| Leu 55 | 120 | 50s-loop | TYR 104 | Platelet factor 4 antibody KKO heavy chain (N) | VdWContact |
| Leu 55 | 120 | 50s-loop | TYR 74 | Platelet factor 4 antibody KKO light chain (M) | Hydrophobic |
| Leu 55 | 120 | 50s-loop | TYR 74 | Platelet factor 4 antibody KKO light chain (M) | VdWContact |
| Leu 55 | 120 | 50s-loop | TYR 100 | Platelet factor 4 antibody KKO heavy chain (N) | Hydrophobic |
| Leu 55 | 120 | 50s-loop | TYR 100 | Platelet factor 4 antibody KKO heavy chain (N) | VdWContact |
| Gln 56 | 121 | 50s-loop | TYR 104 | Platelet factor 4 antibody KKO heavy chain (N) | Hydrophobic |
| Gln 56 | 121 | 50s-loop | THR 56 | Platelet factor 4 antibody KKO light chain (M) | Hydrophobic |
| Gln 56 | 121 | 50s-loop | ASN 57 | Platelet factor 4 antibody KKO light chain (M) | HBDonor |
| Gln 56 | 121 | 50s-loop | ASN 57 | Platelet factor 4 antibody KKO light chain (M) | VdWContact |
| Gln 56 | 121 | 50s-loop | SER 75 | Platelet factor 4 antibody KKO light chain (M) | HBAcceptor |
| Gln 56 | 121 | 50s-loop | SER 75 | Platelet factor 4 antibody KKO light chain (M) | VdWContact |
| Gln 56 | 121 | 50s-loop | TYR 78 | Platelet factor 4 antibody KKO light chain (M) | Hydrophobic |
| Tyr 60 | 125 | Helix | ILE 64 | Platelet factor 4 (B) | Hydrophobic |
| Tyr 60 | 125 | Helix | ILE 64 | Platelet factor 4 (B) | VdWContact |
| Tyr 60 | 125 | Helix | LEU 68 | Platelet factor 4 (B) | Hydrophobic |
| Ile 64 | 129 | Helix | TYR 60 | Platelet factor 4 (B) | Hydrophobic |
| Ile 64 | 129 | Helix | TYR 60 | Platelet factor 4 (B) | VdWContact |
| Leu 67 | 132 | Helix | LYS 31 | Platelet factor 4 (B) | Hydrophobic |
| Leu 68 | 133 | Helix | TYR 60 | Platelet factor 4 (B) | Hydrophobic |
| Leu 68 | 133 | Helix | VAL 29 | Platelet factor 4 (B) | Hydrophobic |
| Leu 68 | 133 | Helix | TYR 78 | Platelet factor 4 antibody KKO light chain (L) | Hydrophobic |
| Leu 68 | 133 | Helix | TYR 78 | Platelet factor 4 antibody KKO light chain (L) | VdWContact |
| Glu 69 | 134 | Helix | TYR 78 | Platelet factor 4 antibody KKO light chain (L) | Hydrophobic |
| Ser 70 | 135 | Helix | ARG 79 | Platelet factor 4 antibody KKO light chain (L) | VdWContact |
| Ser 70 | 135 | Helix | LYS 31 | Platelet factor 4 (B) | HBAcceptor |
| Ser 70 | 135 | Helix | LYS 31 | Platelet factor 4 (B) | VdWContact |
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