Interactions for 4R9Y (chain D)
Structure details
- PDB ID: 4R9Y open_in_new
- Protein: CXCL4_HUMAN
- Organism: Homo sapiens
- UniProt ID: P02776 open_in_new
- Method: X-ray
- Resolution: 4.11 Å
- Date: Dec. 16, 2015
- Reference: 10.1038/NCOMMS9277 open_in_new
- State: tetramer
Chemokine diagram
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Interactions found in structure
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| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Asp 7 | 60 | N-term | CYS 52 | Platelet factor 4 (B) | HBAcceptor |
| Asp 7 | 60 | N-term | CYS 52 | Platelet factor 4 (B) | VdWContact |
| Asp 7 | 60 | N-term | VAL 13 | Platelet factor 4 (B) | Hydrophobic |
| Asp 7 | 60 | N-term | VAL 13 | Platelet factor 4 (B) | VdWContact |
| Asp 7 | 60 | N-term | LYS 14 | Platelet factor 4 (B) | Hydrophobic |
| Asp 7 | 60 | N-term | LYS 14 | Platelet factor 4 (B) | VdWContact |
| Leu 8 | 61 | N-term | LYS 50 | Platelet factor 4 (B) | Hydrophobic |
| Leu 8 | 61 | N-term | LYS 50 | Platelet factor 4 (B) | VdWContact |
| Leu 8 | 61 | N-term | VAL 13 | Platelet factor 4 (B) | VdWContact |
| Leu 8 | 61 | N-term | LEU 11 | Platelet factor 4 (B) | VdWContact |
| Gln 9 | 62 | N-term | CYS 10 | Platelet factor 4 (B) | VdWContact |
| Gln 9 | 62 | N-term | VAL 13 | Platelet factor 4 (B) | Hydrophobic |
| Gln 9 | 62 | N-term | VAL 13 | Platelet factor 4 (B) | VdWContact |
| Gln 9 | 62 | N-term | TYR 31 | Platelet factor 4 antibody KKO heavy chain (H) | VdWContact |
| Gln 9 | 62 | N-term | GLN 9 | Platelet factor 4 (B) | VdWContact |
| Gln 9 | 62 | N-term | LEU 11 | Platelet factor 4 (B) | VdWContact |
| Leu 11 | 66 | CX | GLN 9 | Platelet factor 4 (B) | HBAcceptor |
| Leu 11 | 66 | CX | GLN 9 | Platelet factor 4 (B) | VdWContact |
| Leu 11 | 66 | CX | LEU 11 | Platelet factor 4 (B) | Hydrophobic |
| Leu 11 | 66 | CX | LEU 11 | Platelet factor 4 (B) | VdWContact |
| Cys 12 | 67 | CX | TYR 26 | Platelet factor 4 antibody KKO heavy chain (H) | VdWContact |
| Val 13 | 68 | N-loop | ASP 7 | Platelet factor 4 (B) | VdWContact |
| Val 13 | 68 | N-loop | GLN 9 | Platelet factor 4 (B) | Hydrophobic |
| Val 13 | 68 | N-loop | TYR 26 | Platelet factor 4 antibody KKO heavy chain (H) | Hydrophobic |
| Val 13 | 68 | N-loop | TYR 26 | Platelet factor 4 antibody KKO heavy chain (H) | VdWContact |
| Lys 14 | 69 | N-loop | ASP 7 | Platelet factor 4 (B) | Hydrophobic |
| Lys 14 | 69 | N-loop | ASP 7 | Platelet factor 4 (B) | Cationic |
| Lys 14 | 69 | N-loop | ASP 7 | Platelet factor 4 (B) | VdWContact |
| Leu 27 | 86 | B1 | GLU 28 | Platelet factor 4 (C) | VdWContact |
| Leu 27 | 86 | B1 | VAL 29 | Platelet factor 4 (C) | HBAcceptor |
| Leu 27 | 86 | B1 | VAL 29 | Platelet factor 4 (C) | HBDonor |
| Leu 27 | 86 | B1 | VAL 29 | Platelet factor 4 (C) | VdWContact |
| Glu 28 | 87 | B1 | GLU 28 | Platelet factor 4 (C) | Hydrophobic |
| Glu 28 | 87 | B1 | GLU 28 | Platelet factor 4 (C) | VdWContact |
| Val 29 | 88 | B1 | SER 26 | Platelet factor 4 (C) | VdWContact |
| Val 29 | 88 | B1 | LEU 27 | Platelet factor 4 (C) | HBAcceptor |
| Val 29 | 88 | B1 | LEU 27 | Platelet factor 4 (C) | HBDonor |
| Val 29 | 88 | B1 | LEU 27 | Platelet factor 4 (C) | VdWContact |
| Lys 31 | 90 | 30s-loop | THR 25 | Platelet factor 4 (C) | Hydrophobic |
| Lys 31 | 90 | 30s-loop | THR 25 | Platelet factor 4 (C) | VdWContact |
| Lys 31 | 90 | 30s-loop | LEU 67 | Platelet factor 4 (C) | Hydrophobic |
| Lys 46 | 106 | 40s-loop | LYS 31 | Platelet factor 4 (C) | VdWContact |
| Asn 47 | 112 | 40s-loop | ASN 47 | Platelet factor 4 (A) | VdWContact |
| Cys 52 | 117 | B3 | LEU 8 | Platelet factor 4 (B) | VdWContact |
| Leu 55 | 120 | 50s-loop | LEU 68 | Platelet factor 4 (C) | Hydrophobic |
| Lys 61 | 126 | Helix | LYS 65 | Platelet factor 4 (C) | VdWContact |
| Leu 67 | 132 | Helix | LYS 31 | Platelet factor 4 (C) | Hydrophobic |
| Leu 68 | 133 | Helix | ALA 39 | Platelet factor 4 (C) | Hydrophobic |
| Leu 68 | 133 | Helix | LEU 55 | Platelet factor 4 (C) | Hydrophobic |
| Leu 68 | 133 | Helix | LEU 55 | Platelet factor 4 (C) | VdWContact |
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