Interactions for 7VL9 (chain L)
Structure details
- PDB ID: 7VL9 open_in_new
- Protein: CCL15_HUMAN
- Organism: Homo sapiens
- UniProt ID: Q16663 open_in_new
- Method: Cryo-em
- Resolution: 2.6 Å
- Date: March 23, 2022
- Reference: 10.1038/S41589-021-00918-Z open_in_new
- State: monomer
Chemokine diagram
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Interactions found in structure
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| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Phe 26 | 57 | N-term | TYR 41 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Phe 26 | 57 | N-term | TYR 41 | C-C chemokine receptor type 1 (R) | VdWContact |
| Phe 26 | 57 | N-term | TYR 113 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Phe 26 | 57 | N-term | TYR 113 | C-C chemokine receptor type 1 (R) | VdWContact |
| Phe 26 | 57 | N-term | LEU 87 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Phe 26 | 57 | N-term | LYS 94 | C-C chemokine receptor type 1 (R) | VdWContact |
| Phe 26 | 57 | N-term | TYR 291 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Phe 26 | 57 | N-term | TYR 291 | C-C chemokine receptor type 1 (R) | VdWContact |
| Phe 26 | 57 | N-term | TRP 90 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Phe 26 | 57 | N-term | TRP 90 | C-C chemokine receptor type 1 (R) | PiStacking |
| His 27 | 58 | N-term | VAL 283 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| His 27 | 58 | N-term | VAL 283 | C-C chemokine receptor type 1 (R) | VdWContact |
| His 27 | 58 | N-term | ASP 280 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Phe 28 | 59 | N-term | ASP 97 | C-C chemokine receptor type 1 (R) | VdWContact |
| Phe 28 | 59 | N-term | THR 182 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Phe 28 | 59 | N-term | TYR 93 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Phe 28 | 59 | N-term | TYR 93 | C-C chemokine receptor type 1 (R) | VdWContact |
| Phe 28 | 59 | N-term | ARG 30 | C-C chemokine receptor type 1 (R) | VdWContact |
| Ala 29 | 60 | N-term | ARG 30 | C-C chemokine receptor type 1 (R) | VdWContact |
| Ala 29 | 60 | N-term | ASP 280 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Ala 30 | 61 | N-term | ARG 30 | C-C chemokine receptor type 1 (R) | VdWContact |
| Asp 31 | 62 | N-term | LYS 26 | C-C chemokine receptor type 1 (R) | HBAcceptor |
| Asp 31 | 62 | N-term | LYS 26 | C-C chemokine receptor type 1 (R) | VdWContact |
| Asp 31 | 62 | N-term | ARG 30 | C-C chemokine receptor type 1 (R) | HBAcceptor |
| Asp 31 | 62 | N-term | ARG 30 | C-C chemokine receptor type 1 (R) | Anionic |
| Asp 31 | 62 | N-term | ARG 30 | C-C chemokine receptor type 1 (R) | VdWContact |
| Cys 32 | 63 | CX | PRO 23 | C-C chemokine receptor type 1 (R) | VdWContact |
| Thr 34 | 68 | N-loop | CYS 273 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Thr 34 | 68 | N-loop | CYS 273 | C-C chemokine receptor type 1 (R) | VdWContact |
| Thr 34 | 68 | N-loop | GLU 272 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Ser 35 | 69 | N-loop | ALA 21 | C-C chemokine receptor type 1 (R) | VdWContact |
| Ile 37 | 71 | N-loop | ALA 21 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Leu 45 | 82 | N-loop | TYR 18 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Met 46 | 83 | B1 | TYR 18 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Met 46 | 83 | B1 | TYR 18 | C-C chemokine receptor type 1 (R) | VdWContact |
| Phe 50 | 87 | B1 | HIS 186 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Phe 50 | 87 | B1 | GLN 175 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Phe 50 | 87 | B1 | GLN 175 | C-C chemokine receptor type 1 (R) | VdWContact |
| Phe 50 | 87 | B1 | GLU 177 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Phe 50 | 87 | B1 | GLU 177 | C-C chemokine receptor type 1 (R) | VdWContact |
| Glu 51 | 88 | B1 | HIS 186 | C-C chemokine receptor type 1 (R) | VdWContact |
| Glu 51 | 88 | B1 | HIS 189 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Glu 51 | 88 | B1 | LYS 173 | C-C chemokine receptor type 1 (R) | Anionic |
| Glu 51 | 88 | B1 | GLN 175 | C-C chemokine receptor type 1 (R) | VdWContact |
| Ser 53 | 90 | 30s-loop | SER 184 | C-C chemokine receptor type 1 (R) | HBDonor |
| Ser 53 | 90 | 30s-loop | SER 184 | C-C chemokine receptor type 1 (R) | VdWContact |
| Ser 54 | 91 | 30s-loop | PHE 187 | C-C chemokine receptor type 1 (R) | HBAcceptor |
| Ser 54 | 91 | 30s-loop | PHE 187 | C-C chemokine receptor type 1 (R) | VdWContact |
| Ser 54 | 91 | 30s-loop | LEU 192 | C-C chemokine receptor type 1 (R) | VdWContact |
| Ser 54 | 91 | 30s-loop | LYS 196 | C-C chemokine receptor type 1 (R) | HBAcceptor |
| Ser 54 | 91 | 30s-loop | LYS 196 | C-C chemokine receptor type 1 (R) | VdWContact |
| Cys 56 | 95 | 30s-loop | LYS 196 | C-C chemokine receptor type 1 (R) | HBAcceptor |
| Cys 56 | 95 | 30s-loop | LYS 196 | C-C chemokine receptor type 1 (R) | VdWContact |
| Ser 57 | 96 | 30s-loop | GLN 265 | C-C chemokine receptor type 1 (R) | VdWContact |
| Ser 57 | 96 | 30s-loop | ASP 266 | C-C chemokine receptor type 1 (R) | VdWContact |
| Ser 57 | 96 | 30s-loop | ARG 193 | C-C chemokine receptor type 1 (R) | HBAcceptor |
| Ser 57 | 96 | 30s-loop | ARG 193 | C-C chemokine receptor type 1 (R) | VdWContact |
| Pro 59 | 99 | 30s-loop | LEU 192 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Pro 59 | 99 | 30s-loop | HIS 189 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Pro 59 | 99 | 30s-loop | HIS 189 | C-C chemokine receptor type 1 (R) | VdWContact |
| Ile 62 | 102 | B2 | PHE 178 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Ile 62 | 102 | B2 | PHE 178 | C-C chemokine receptor type 1 (R) | VdWContact |
| Ile 62 | 102 | B2 | PRO 23 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Leu 64 | 104 | B2 | PHE 178 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Leu 64 | 104 | B2 | PHE 178 | C-C chemokine receptor type 1 (R) | VdWContact |
| Thr 65 | 105 | B2 | TYR 18 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Thr 65 | 105 | B2 | TYR 18 | C-C chemokine receptor type 1 (R) | VdWContact |
| Lys 67 | 112 | 40s-loop | TYR 18 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Lys 67 | 112 | 40s-loop | TYR 18 | C-C chemokine receptor type 1 (R) | VdWContact |
| Arg 69 | 114 | 40s-loop | TYR 18 | C-C chemokine receptor type 1 (R) | CationPi |
| Arg 69 | 114 | 40s-loop | GLY 19 | C-C chemokine receptor type 1 (R) | VdWContact |
| Gln 70 | 115 | B3 | GLN 25 | C-C chemokine receptor type 1 (R) | VdWContact |
| Gln 70 | 115 | B3 | PRO 23 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Gln 70 | 115 | B3 | PRO 23 | C-C chemokine receptor type 1 (R) | VdWContact |
| Val 71 | 116 | B3 | TYR 18 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Val 71 | 116 | B3 | TYR 18 | C-C chemokine receptor type 1 (R) | VdWContact |
| Cys 72 | 117 | B3 | PRO 23 | C-C chemokine receptor type 1 (R) | VdWContact |
| Pro 75 | 120 | 50s-loop | HIS 189 | C-C chemokine receptor type 1 (R) | Hydrophobic |
| Pro 75 | 120 | 50s-loop | HIS 189 | C-C chemokine receptor type 1 (R) | VdWContact |
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