ChemoPar-db - the chemokine partner database

Interactions for 7F1R — Binding Partner: CCR5

Structure details

PDB ID: 7F1R open_in_new
Protein: CCL5_HUMAN
Organism: Homo sapiens
UniProt ID: P13501 open_in_new

Method: Cryo-em
Resolution: 3.0 Å
Date: July 14, 2021
Reference: 10.1038/S41467-021-24438-5 open_in_new
State: Monomer

Chemokine Chain: R
Partner Chain: R

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Interactions for this Binding Partner

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Chemokine Residue	Generic Number	Segment	Partner Residue	Partner Chain	Interaction Type

Chemokine Residue	Generic Number	Segment	Partner Residue	Partner Chain	Interaction Type
Ala 13	69	N-loop	ALA 13	R	Hydrophobic
Ala 13	69	N-loop	ALA 13	R	VdWContact
Ala 13	69	N-loop	PHE 12	R	VdWContact
Ala 13	69	N-loop	TYR 14	R	VdWContact
Ala 38	100	30s-loop	ALA 38	R	Hydrophobic
Ala 38	100	30s-loop	ALA 38	R	VdWContact
Ala 38	100	30s-loop	VAL 39	R	VdWContact
Ala 38	100	30s-loop	CYS 11	R	Hydrophobic
Ala 38	100	30s-loop	CYS 11	R	VdWContact
Ala 38	100	30s-loop	PRO 37	R	VdWContact
Ala 38	100	30s-loop	CYS 50	R	Hydrophobic
Ala 38	100	30s-loop	PRO 53	R	VdWContact
Ala 38	100	30s-loop	TYR 14	R	Hydrophobic
Ala 51	118	B3	CYS 50	R	VdWContact
Ala 51	118	B3	ASN 52	R	VdWContact
Ala 51	118	B3	ALA 51	R	Hydrophobic
Ala 51	118	B3	ALA 51	R	VdWContact
Arg 47	114	40s-loop	ARG 47	R	VdWContact
Arg 47	114	40s-loop	GLN 48	R	VdWContact
Arg 59	126	Helix	ARG 59	R	VdWContact
Arg 59	126	Helix	ASN 63	R	HBAcceptor
Arg 59	126	Helix	ASN 63	R	VdWContact
Arg 59	126	Helix	VAL 58	R	VdWContact
Arg 59	126	Helix	GLU 60	R	VdWContact
Asn 36	97	30s-loop	ASN 36	R	VdWContact
Asn 36	97	30s-loop	PRO 37	R	VdWContact
Asn 36	97	30s-loop	SER 35	R	VdWContact
Asn 36	97	30s-loop	TYR 14	R	VdWContact
Asn 52	119	50s-loop	PRO 53	R	VdWContact
Asn 52	119	50s-loop	ALA 51	R	VdWContact
Asn 52	119	50s-loop	LYS 56	R	VdWContact
Asn 52	119	50s-loop	ASN 52	R	VdWContact
Asn 63	130	Helix	ARG 59	R	HBDonor
Asn 63	130	Helix	ARG 59	R	VdWContact
Asn 63	130	Helix	ILE 62	R	VdWContact
Asn 63	130	Helix	ASN 63	R	VdWContact
Asn 63	130	Helix	SER 64	R	VdWContact
Asp 6	59	N-term	SER 275	R	HBAcceptor
Asp 6	59	N-term	SER 275	R	VdWContact
Asp 6	59	N-term	SER 1	R	VdWContact
Asp 6	59	N-term	THR 7	R	VdWContact
Asp 6	59	N-term	ASP 6	R	Hydrophobic
Asp 6	59	N-term	ASP 6	R	VdWContact
Asp 6	59	N-term	SER 31	R	HBAcceptor
Asp 6	59	N-term	SER 31	R	VdWContact
Asp 6	59	N-term	TYR 3	R	HBDonor
Asp 6	59	N-term	TYR 3	R	VdWContact
Asp 6	59	N-term	SER 274	R	HBAcceptor
Asp 6	59	N-term	SER 274	R	VdWContact
Asp 6	59	N-term	PRO 2	R	Hydrophobic
Asp 6	59	N-term	PRO 2	R	VdWContact
Asp 6	59	N-term	SER 4	R	VdWContact
Asp 6	59	N-term	SER 5	R	VdWContact
Asp 6	59	N-term	CYS 273	R	VdWContact
Cys 10	63	CX	CYS 11	R	VdWContact
Cys 10	63	CX	PRO 9	R	VdWContact
Cys 10	63	CX	CYS 34	R	Hydrophobic
Cys 10	63	CX	CYS 34	R	VdWContact
Cys 10	63	CX	CYS 10	R	Hydrophobic
Cys 10	63	CX	CYS 10	R	VdWContact
Cys 10	63	CX	PHE 12	R	Hydrophobic
Cys 10	63	CX	PHE 12	R	VdWContact
Cys 11	67	CX	ALA 38	R	Hydrophobic
Cys 11	67	CX	ALA 38	R	VdWContact
Cys 11	67	CX	CYS 11	R	Hydrophobic
Cys 11	67	CX	CYS 11	R	VdWContact
Cys 11	67	CX	CYS 50	R	Hydrophobic
Cys 11	67	CX	CYS 50	R	VdWContact
Cys 11	67	CX	CYS 10	R	VdWContact
Cys 11	67	CX	PHE 12	R	VdWContact
Cys 11	67	CX	TYR 14	R	Hydrophobic
Cys 34	95	30s-loop	PHE 12	R	Hydrophobic
Cys 34	95	30s-loop	TYR 282	R	HBAcceptor
Cys 34	95	30s-loop	SER 35	R	VdWContact
Cys 34	95	30s-loop	CYS 10	R	Hydrophobic
Cys 34	95	30s-loop	CYS 10	R	VdWContact
Cys 34	95	30s-loop	LYS 33	R	VdWContact
Cys 34	95	30s-loop	GLY 32	R	VdWContact
Cys 34	95	30s-loop	CYS 34	R	Hydrophobic
Cys 34	95	30s-loop	CYS 34	R	VdWContact
Cys 34	95	30s-loop	LYS 286	R	VdWContact
Cys 50	117	B3	ALA 38	R	Hydrophobic
Cys 50	117	B3	VAL 49	R	VdWContact
Cys 50	117	B3	VAL 39	R	VdWContact
Cys 50	117	B3	CYS 11	R	Hydrophobic
Cys 50	117	B3	CYS 11	R	VdWContact
Cys 50	117	B3	CYS 50	R	Hydrophobic
Cys 50	117	B3	CYS 50	R	VdWContact
Cys 50	117	B3	ALA 51	R	VdWContact
Cys 50	117	B3	TYR 14	R	Hydrophobic
Cys 50	117	B3	TYR 14	R	VdWContact
Gln 48	115	B3	VAL 49	R	VdWContact
Gln 48	115	B3	ARG 47	R	VdWContact
Gln 48	115	B3	GLN 48	R	VdWContact
Glu 26	85	B1	PHE 41	R	VdWContact
Glu 26	85	B1	TYR 27	R	VdWContact
Glu 26	85	B1	GLU 26	R	Hydrophobic
Glu 26	85	B1	GLU 26	R	VdWContact
Glu 26	85	B1	LYS 25	R	VdWContact
Glu 54	121	50s-loop	GLU 54	R	VdWContact
Glu 54	121	50s-loop	LYS 55	R	VdWContact
Glu 54	121	50s-loop	PRO 53	R	VdWContact
Glu 54	121	50s-loop	LYS 56	R	VdWContact
Glu 60	127	Helix	ARG 59	R	VdWContact
Glu 60	127	Helix	TYR 61	R	VdWContact
Glu 60	127	Helix	LYS 56	R	HBDonor
Glu 60	127	Helix	LYS 56	R	VdWContact
Glu 60	127	Helix	SER 64	R	HBAcceptor
Glu 60	127	Helix	SER 64	R	VdWContact
Glu 60	127	Helix	GLU 60	R	VdWContact
Gly 32	91	30s-loop	LYS 33	R	VdWContact
Gly 32	91	30s-loop	GLY 32	R	VdWContact
Gly 32	91	30s-loop	TYR 282	R	VdWContact
Gly 32	91	30s-loop	CYS 34	R	VdWContact
Gly 32	91	30s-loop	LYS 286	R	HBAcceptor
Gly 32	91	30s-loop	LYS 286	R	VdWContact
Gly 32	91	30s-loop	SER 31	R	VdWContact
Ile 62	129	Helix	TYR 61	R	VdWContact
Ile 62	129	Helix	ILE 62	R	VdWContact
Ile 62	129	Helix	ASN 63	R	VdWContact
Ile 62	129	Helix	SER 64	R	VdWContact
Ile 62	129	Helix	VAL 58	R	HBDonor
Ile 62	129	Helix	VAL 58	R	VdWContact
Leu 65	132	Helix	LEU 65	R	VdWContact
Leu 65	132	Helix	SER 64	R	VdWContact
Lys 25	84	B1	GLU 26	R	VdWContact
Lys 25	84	B1	LYS 25	R	Hydrophobic
Lys 25	84	B1	LYS 25	R	VdWContact
Lys 33	94	30s-loop	SER 31	R	VdWContact
Lys 33	94	30s-loop	LYS 33	R	VdWContact
Lys 33	94	30s-loop	GLY 32	R	VdWContact
Lys 33	94	30s-loop	CYS 34	R	VdWContact
Lys 55	122	50s-loop	GLU 54	R	VdWContact
Lys 55	122	50s-loop	LYS 55	R	VdWContact
Lys 55	122	50s-loop	LYS 56	R	VdWContact
Lys 56	123	Helix	GLU 54	R	VdWContact
Lys 56	123	Helix	TRP 57	R	VdWContact
Lys 56	123	Helix	LYS 55	R	VdWContact
Lys 56	123	Helix	ASN 52	R	VdWContact
Lys 56	123	Helix	LYS 56	R	VdWContact
Lys 56	123	Helix	GLU 60	R	HBAcceptor
Lys 56	123	Helix	GLU 60	R	VdWContact
Phe 12	68	N-loop	PHE 12	R	Hydrophobic
Phe 12	68	N-loop	PHE 12	R	VdWContact
Phe 12	68	N-loop	CYS 11	R	VdWContact
Phe 12	68	N-loop	CYS 10	R	Hydrophobic
Phe 12	68	N-loop	CYS 10	R	VdWContact
Phe 12	68	N-loop	CYS 34	R	Hydrophobic
Phe 12	68	N-loop	ALA 13	R	VdWContact
Phe 28	87	B1	CYS 267	R	Hydrophobic
Phe 28	87	B1	CYS 267	R	VdWContact
Phe 28	87	B1	TYR 29	R	VdWContact
Phe 28	87	B1	VAL 40	R	Hydrophobic
Phe 28	87	B1	VAL 40	R	VdWContact
Phe 28	87	B1	CYS 28	R	Hydrophobic
Phe 28	87	B1	CYS 28	R	VdWContact
Phe 28	87	B1	TYR 27	R	VdWContact
Phe 41	103	B2	PHE 41	R	Hydrophobic
Phe 41	103	B2	PHE 41	R	VdWContact
Phe 41	103	B2	GLU 26	R	VdWContact
Phe 41	103	B2	VAL 40	R	VdWContact
Pro 2	55	N-term	SER 1	R	VdWContact
Pro 2	55	N-term	TYR 3	R	VdWContact
Pro 2	55	N-term	ASP 6	R	Hydrophobic
Pro 2	55	N-term	ASP 6	R	VdWContact
Pro 2	55	N-term	TRP 181	R	Hydrophobic
Pro 2	55	N-term	PRO 2	R	Hydrophobic
Pro 2	55	N-term	PRO 2	R	VdWContact
Pro 2	55	N-term	THR 200	R	VdWContact
Pro 37	99	30s-loop	TYR 282	R	Hydrophobic
Pro 37	99	30s-loop	TYR 282	R	VdWContact
Pro 37	99	30s-loop	ALA 38	R	VdWContact
Pro 37	99	30s-loop	ASN 36	R	VdWContact
Pro 37	99	30s-loop	PRO 37	R	Hydrophobic
Pro 37	99	30s-loop	PRO 37	R	VdWContact
Pro 53	120	50s-loop	ALA 38	R	VdWContact
Pro 53	120	50s-loop	GLU 54	R	VdWContact
Pro 53	120	50s-loop	PRO 53	R	Hydrophobic
Pro 53	120	50s-loop	PRO 53	R	VdWContact
Pro 53	120	50s-loop	ASN 52	R	VdWContact
Pro 9	62	N-term	PRO 9	R	Hydrophobic
Pro 9	62	N-term	PRO 9	R	VdWContact
Pro 9	62	N-term	THR 8	R	VdWContact
Pro 9	62	N-term	CYS 10	R	VdWContact
Ser 1	54	N-term	SER 1	R	HBAcceptor
Ser 1	54	N-term	SER 1	R	HBDonor
Ser 1	54	N-term	SER 1	R	VdWContact
Ser 1	54	N-term	ASP 6	R	VdWContact
Ser 1	54	N-term	TYR 346	R	HBAcceptor
Ser 1	54	N-term	TYR 346	R	VdWContact
Ser 1	54	N-term	GLU 378	R	VdWContact
Ser 1	54	N-term	PRO 2	R	VdWContact
Ser 31	90	30s-loop	THR 8	R	HBDonor
Ser 31	90	30s-loop	THR 8	R	VdWContact
Ser 31	90	30s-loop	ASP 6	R	HBDonor
Ser 31	90	30s-loop	ASP 6	R	VdWContact
Ser 31	90	30s-loop	THR 30	R	VdWContact
Ser 31	90	30s-loop	SER 31	R	VdWContact
Ser 31	90	30s-loop	SER 275	R	VdWContact
Ser 31	90	30s-loop	LYS 33	R	VdWContact
Ser 31	90	30s-loop	GLY 32	R	VdWContact
Ser 35	96	30s-loop	ASN 36	R	VdWContact
Ser 35	96	30s-loop	CYS 34	R	VdWContact
Ser 35	96	30s-loop	SER 35	R	VdWContact
Ser 4	57	N-term	THR 7	R	HBAcceptor
Ser 4	57	N-term	THR 7	R	VdWContact
Ser 4	57	N-term	ASP 6	R	VdWContact
Ser 4	57	N-term	TYR 3	R	VdWContact
Ser 4	57	N-term	SER 4	R	VdWContact
Ser 4	57	N-term	SER 5	R	VdWContact
Ser 5	58	N-term	THR 7	R	VdWContact
Ser 5	58	N-term	ASP 6	R	VdWContact
Ser 5	58	N-term	THR 272	R	VdWContact
Ser 5	58	N-term	TYR 3	R	VdWContact
Ser 5	58	N-term	SER 4	R	VdWContact
Ser 5	58	N-term	SER 5	R	VdWContact
Ser 5	58	N-term	CYS 273	R	HBAcceptor
Ser 5	58	N-term	CYS 273	R	HBDonor
Ser 5	58	N-term	CYS 273	R	VdWContact
Ser 64	131	Helix	TYR 61	R	HBDonor
Ser 64	131	Helix	TYR 61	R	VdWContact
Ser 64	131	Helix	ILE 62	R	VdWContact
Ser 64	131	Helix	ASN 63	R	VdWContact
Ser 64	131	Helix	LEU 65	R	VdWContact
Ser 64	131	Helix	SER 64	R	VdWContact
Ser 64	131	Helix	GLU 60	R	HBDonor
Ser 64	131	Helix	GLU 60	R	VdWContact
Thr 30	89	B1	THR 30	R	Hydrophobic
Thr 30	89	B1	THR 30	R	VdWContact
Thr 30	89	B1	TYR 29	R	VdWContact
Thr 30	89	B1	SER 31	R	VdWContact
Thr 7	60	N-term	THR 7	R	Hydrophobic
Thr 7	60	N-term	THR 7	R	VdWContact
Thr 7	60	N-term	ASP 6	R	VdWContact
Thr 7	60	N-term	THR 8	R	VdWContact
Thr 7	60	N-term	SER 4	R	HBDonor
Thr 7	60	N-term	SER 4	R	VdWContact
Thr 7	60	N-term	SER 5	R	VdWContact
Thr 8	61	N-term	THR 8	R	Hydrophobic
Thr 8	61	N-term	THR 8	R	HBAcceptor
Thr 8	61	N-term	THR 8	R	HBDonor
Thr 8	61	N-term	THR 8	R	VdWContact
Thr 8	61	N-term	SER 31	R	HBAcceptor
Thr 8	61	N-term	SER 31	R	VdWContact
Thr 8	61	N-term	PRO 9	R	VdWContact
Thr 8	61	N-term	THR 7	R	VdWContact
Thr 8	61	N-term	SER 274	R	VdWContact
Trp 57	124	Helix	TRP 57	R	VdWContact
Trp 57	124	Helix	TYR 61	R	HBAcceptor
Trp 57	124	Helix	TYR 61	R	VdWContact
Trp 57	124	Helix	LYS 56	R	VdWContact
Trp 57	124	Helix	VAL 58	R	VdWContact
Tyr 14	70	N-loop	ALA 38	R	Hydrophobic
Tyr 14	70	N-loop	ASN 36	R	VdWContact
Tyr 14	70	N-loop	CYS 11	R	Hydrophobic
Tyr 14	70	N-loop	CYS 50	R	Hydrophobic
Tyr 14	70	N-loop	CYS 50	R	VdWContact
Tyr 14	70	N-loop	ALA 13	R	VdWContact
Tyr 14	70	N-loop	TYR 14	R	Hydrophobic
Tyr 14	70	N-loop	TYR 14	R	VdWContact
Tyr 27	86	B1	TYR 29	R	Hydrophobic
Tyr 27	86	B1	TYR 29	R	VdWContact
Tyr 27	86	B1	CYS 28	R	VdWContact
Tyr 27	86	B1	TYR 27	R	Hydrophobic
Tyr 27	86	B1	TYR 27	R	VdWContact
Tyr 27	86	B1	GLU 26	R	VdWContact
Tyr 29	88	B1	GLN 265	R	Hydrophobic
Tyr 29	88	B1	GLN 265	R	VdWContact
Tyr 29	88	B1	HIS 276	R	Hydrophobic
Tyr 29	88	B1	HIS 276	R	PiStacking
Tyr 29	88	B1	THR 30	R	VdWContact
Tyr 29	88	B1	TYR 29	R	Hydrophobic
Tyr 29	88	B1	TYR 29	R	VdWContact
Tyr 29	88	B1	CYS 28	R	VdWContact
Tyr 29	88	B1	TYR 27	R	Hydrophobic
Tyr 29	88	B1	TYR 27	R	VdWContact
Tyr 3	56	N-term	ASP 6	R	HBAcceptor
Tyr 3	56	N-term	ASP 6	R	VdWContact
Tyr 3	56	N-term	TYR 3	R	Hydrophobic
Tyr 3	56	N-term	TYR 3	R	VdWContact
Tyr 3	56	N-term	VAL 178	R	Hydrophobic
Tyr 3	56	N-term	VAL 178	R	VdWContact
Tyr 3	56	N-term	PRO 2	R	VdWContact
Tyr 3	56	N-term	SER 4	R	VdWContact
Tyr 3	56	N-term	SER 5	R	VdWContact
Tyr 3	56	N-term	TRP 181	R	Hydrophobic
Tyr 3	56	N-term	TRP 181	R	VdWContact
Tyr 61	128	Helix	TRP 57	R	HBDonor
Tyr 61	128	Helix	TRP 57	R	VdWContact
Tyr 61	128	Helix	TYR 61	R	VdWContact
Tyr 61	128	Helix	ILE 62	R	VdWContact
Tyr 61	128	Helix	SER 64	R	HBAcceptor
Tyr 61	128	Helix	SER 64	R	VdWContact
Tyr 61	128	Helix	GLU 60	R	VdWContact
Val 39	101	B2	VAL 39	R	VdWContact
Val 39	101	B2	ALA 38	R	VdWContact
Val 39	101	B2	CYS 50	R	VdWContact
Val 39	101	B2	VAL 40	R	VdWContact
Val 40	102	B2	PHE 41	R	VdWContact
Val 40	102	B2	VAL 39	R	VdWContact
Val 40	102	B2	CYS 28	R	Hydrophobic
Val 40	102	B2	CYS 28	R	VdWContact
Val 40	102	B2	VAL 40	R	Hydrophobic
Val 40	102	B2	VAL 40	R	VdWContact
Val 49	116	B3	VAL 49	R	VdWContact
Val 49	116	B3	GLN 48	R	VdWContact
Val 49	116	B3	CYS 50	R	VdWContact
Val 58	125	Helix	ARG 59	R	VdWContact
Val 58	125	Helix	TRP 57	R	VdWContact
Val 58	125	Helix	ILE 62	R	HBAcceptor
Val 58	125	Helix	ILE 62	R	VdWContact
Val 58	125	Helix	VAL 58	R	VdWContact

Showing 1 to 312 of 312 entries

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