Interactions for 2X6L — Binding Partner: CCL4
Structure details
- PDB ID: 2X6L open_in_new
- Protein: CCL4_HUMAN
- Organism: Homo sapiens
- UniProt ID: P13236 open_in_new
- Method: X-ray
- Resolution: 2.6 Å
- Date: Nov. 3, 2010
- Reference: 10.1038/EMBOJ.2010.256 open_in_new
- State: Oligomer
- Chemokine Chain: B
- Partner Chain: A,C,D,E
Chemokine diagram
Interactions for this Binding Partner
Download list as CSV
| Chemokine Residue | Generic Number | Segment | Partner Residue | Partner Chain | Interaction Type |
|---|---|---|---|---|---|
| Ser 5 | NTc.Cm6 | N-term | SER 32 | C | VdWContact |
| Ser 5 | NTc.Cm6 | N-term | GLU 30 | C | VdWContact |
| Ser 5 | NTc.Cm6 | N-term | ARG 18 | D | HBAcceptor |
| Ser 5 | NTc.Cm6 | N-term | ARG 18 | D | VdWContact |
| Asp 6 | NTc.Cm5 | N-term | SER 32 | C | HBAcceptor |
| Asp 6 | NTc.Cm5 | N-term | SER 32 | C | VdWContact |
| Asp 6 | NTc.Cm5 | N-term | SER 14 | D | VdWContact |
| Asp 6 | NTc.Cm5 | N-term | SER 33 | C | HBAcceptor |
| Asp 6 | NTc.Cm5 | N-term | SER 33 | C | VdWContact |
| Asp 6 | NTc.Cm5 | N-term | CYS 51 | D | HBAcceptor |
| Asp 6 | NTc.Cm5 | N-term | CYS 51 | D | VdWContact |
| Asp 6 | NTc.Cm5 | N-term | ARG 18 | D | Anionic |
| Pro 7 | NTc.Cm4 | N-term | GLN 49 | D | VdWContact |
| Pro 7 | NTc.Cm4 | N-term | CYS 51 | D | VdWContact |
| Pro 8 | NTc.Cm3 | N-term | GLN 49 | D | Hydrophobic |
| Pro 8 | NTc.Cm3 | N-term | ALA 10 | D | Hydrophobic |
| Pro 8 | NTc.Cm3 | N-term | VAL 41 | D | Hydrophobic |
| Pro 8 | NTc.Cm3 | N-term | CYS 51 | D | VdWContact |
| Thr 9 | NTc.Cm2 | N-term | PHE 13 | D | Hydrophobic |
| Thr 9 | NTc.Cm2 | N-term | PHE 13 | D | VdWContact |
| Thr 9 | NTc.Cm2 | N-term | CYS 11 | D | HBAcceptor |
| Thr 9 | NTc.Cm2 | N-term | CYS 11 | D | HBDonor |
| Thr 9 | NTc.Cm2 | N-term | CYS 11 | D | VdWContact |
| Ala 10 | NTc.Cm1 | N-term | PRO 8 | D | Hydrophobic |
| Ala 10 | NTc.Cm1 | N-term | PRO 8 | D | VdWContact |
| Cys 11 | CX.1 | CX | PHE 13 | D | VdWContact |
| Cys 11 | CX.1 | CX | THR 9 | D | HBAcceptor |
| Cys 11 | CX.1 | CX | THR 9 | D | HBDonor |
| Cys 11 | CX.1 | CX | THR 9 | D | VdWContact |
| Cys 11 | CX.1 | CX | PRO 8 | D | VdWContact |
| Phe 13 | cxb1.1 | N-loop | THR 9 | D | Hydrophobic |
| Phe 13 | cxb1.1 | N-loop | THR 9 | D | VdWContact |
| Phe 13 | cxb1.1 | N-loop | LEU 34 | D | Hydrophobic |
| Tyr 15 | cxb1.5 | N-loop | SER 33 | A | HBAcceptor |
| Tyr 15 | cxb1.5 | N-loop | SER 33 | A | VdWContact |
| Arg 18 | cxb1.8 | N-loop | GLU 30 | A | HBDonor |
| Arg 18 | cxb1.8 | N-loop | GLU 30 | A | Cationic |
| Arg 18 | cxb1.8 | N-loop | GLU 30 | A | VdWContact |
| Arg 18 | cxb1.8 | N-loop | THR 31 | A | HBDonor |
| Arg 18 | cxb1.8 | N-loop | THR 31 | A | VdWContact |
| Arg 18 | cxb1.8 | N-loop | PRO 38 | A | VdWContact |
| Arg 18 | cxb1.8 | N-loop | ALA 39 | A | VdWContact |
| Pro 21 | cxb1.14 | N-loop | TYR 64 | A | Hydrophobic |
| Phe 24 | B1.1 | B1 | TYR 64 | A | Hydrophobic |
| Phe 24 | B1.1 | B1 | TYR 64 | A | VdWContact |
| Phe 24 | B1.1 | B1 | GLU 67 | A | Hydrophobic |
| Phe 24 | B1.1 | B1 | GLU 67 | A | VdWContact |
| Phe 24 | B1.1 | B1 | LEU 68 | A | Hydrophobic |
| Phe 24 | B1.1 | B1 | LEU 68 | A | VdWContact |
| Phe 24 | B1.1 | B1 | VAL 63 | A | Hydrophobic |
| Asp 27 | B1.4 | B1 | ARG 46 | E | HBAcceptor |
| Asp 27 | B1.4 | B1 | ARG 46 | E | Anionic |
| Asp 27 | B1.4 | B1 | ARG 46 | E | VdWContact |
| Asp 27 | B1.4 | B1 | LYS 48 | E | Anionic |
| Tyr 28 | B1.5 | B1 | LYS 48 | E | HBAcceptor |
| Tyr 28 | B1.5 | B1 | LYS 48 | E | VdWContact |
| Glu 30 | B1.7 | B1 | SER 5 | C | VdWContact |
| Glu 30 | B1.7 | B1 | ARG 18 | E | Anionic |
| Glu 30 | B1.7 | B1 | ARG 18 | E | VdWContact |
| Thr 31 | b1b2.4 | 30s-loop | ARG 18 | E | VdWContact |
| Ser 32 | b1b2.6 | 30s-loop | SER 5 | C | VdWContact |
| Ser 33 | b1b2.9 | 30s-loop | TYR 15 | E | HBDonor |
| Ser 33 | b1b2.9 | 30s-loop | TYR 15 | E | VdWContact |
| Ser 33 | b1b2.9 | 30s-loop | ASP 6 | C | HBDonor |
| Ser 33 | b1b2.9 | 30s-loop | ASP 6 | C | VdWContact |
| Leu 34 | b1b2.10 | 30s-loop | PHE 13 | D | Hydrophobic |
| Pro 38 | b1b2.16 | 30s-loop | ARG 18 | E | VdWContact |
| Ala 39 | B2.1 | B2 | ARG 18 | E | VdWContact |
| Val 41 | B2.3 | B2 | PRO 8 | D | Hydrophobic |
| Lys 45 | b2b3.2 | 40s-loop | GLU 67 | A | Hydrophobic |
| Lys 45 | b2b3.2 | 40s-loop | GLU 67 | A | VdWContact |
| Lys 45 | b2b3.2 | 40s-loop | LEU 68 | A | Hydrophobic |
| Lys 45 | b2b3.2 | 40s-loop | LEU 68 | A | HBDonor |
| Lys 45 | b2b3.2 | 40s-loop | LEU 68 | A | VdWContact |
| Arg 46 | b2b3.4 | 40s-loop | GLU 67 | A | HBDonor |
| Arg 46 | b2b3.4 | 40s-loop | GLU 67 | A | VdWContact |
| Arg 46 | b2b3.4 | 40s-loop | LEU 66 | A | HBDonor |
| Arg 46 | b2b3.4 | 40s-loop | LEU 66 | A | VdWContact |
| Arg 46 | b2b3.4 | 40s-loop | ASP 27 | A | HBDonor |
| Arg 46 | b2b3.4 | 40s-loop | ASP 27 | A | Cationic |
| Arg 46 | b2b3.4 | 40s-loop | ASP 27 | A | VdWContact |
| Arg 46 | b2b3.4 | 40s-loop | VAL 26 | A | HBDonor |
| Lys 48 | b2b3.12 | 40s-loop | GLU 67 | A | Cationic |
| Lys 48 | b2b3.12 | 40s-loop | TYR 28 | A | CationPi |
| Lys 48 | b2b3.12 | 40s-loop | TYR 28 | A | VdWContact |
| Lys 48 | b2b3.12 | 40s-loop | ASP 27 | A | HBDonor |
| Lys 48 | b2b3.12 | 40s-loop | ASP 27 | A | Cationic |
| Lys 48 | b2b3.12 | 40s-loop | ASP 27 | A | VdWContact |
| Gln 49 | B3.1 | B3 | PRO 8 | D | Hydrophobic |
| Gln 49 | B3.1 | B3 | PRO 7 | D | VdWContact |
| Cys 51 | B3.3 | B3 | ASP 6 | D | HBDonor |
| Cys 51 | B3.3 | B3 | ASP 6 | D | VdWContact |
| Val 63 | H.7 | Helix | PHE 24 | E | Hydrophobic |
| Tyr 64 | H.8 | Helix | ASN 23 | E | VdWContact |
| Tyr 64 | H.8 | Helix | PRO 21 | E | Hydrophobic |
| Tyr 64 | H.8 | Helix | PHE 24 | E | Hydrophobic |
| Glu 67 | CT.1 | C-term | THR 44 | E | HBAcceptor |
| Glu 67 | CT.1 | C-term | THR 44 | E | VdWContact |
| Glu 67 | CT.1 | C-term | LYS 45 | E | Hydrophobic |
| Glu 67 | CT.1 | C-term | ARG 46 | E | HBAcceptor |
| Glu 67 | CT.1 | C-term | ARG 46 | E | VdWContact |
| Glu 67 | CT.1 | C-term | PHE 24 | E | Hydrophobic |
| Glu 67 | CT.1 | C-term | PHE 24 | E | VdWContact |
| Leu 68 | CT.2 | C-term | ASN 23 | E | VdWContact |
| Leu 68 | CT.2 | C-term | LYS 45 | E | Hydrophobic |
| Leu 68 | CT.2 | C-term | LYS 45 | E | HBAcceptor |
| Leu 68 | CT.2 | C-term | LYS 45 | E | VdWContact |
| Leu 68 | CT.2 | C-term | PHE 24 | E | Hydrophobic |
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