Interactions for 6WZM — Binding Partner: LY3041658
Structure details
- PDB ID: 6WZM open_in_new
- Protein: CXCL8_HUMAN
- Organism: Homo sapiens
- UniProt ID: P10145 open_in_new
- Method: X-ray
- Resolution: 2.28 Å
- Date: Nov. 25, 2020
- Reference: 10.1080/19420862.2020.1831880 open_in_new
- State: Dimer
- Chemokine Chain: E
- Partner Chain: A,B
Chemokine diagram
Interactions for this Binding Partner
Download list as CSV
| Chemokine Residue | Generic Number | Segment | Partner Residue | Partner Chain | Interaction Type |
|---|---|---|---|---|---|
| Leu 5 | NTc.Cm2 | N-term | TRP 94 | B | HBAcceptor |
| Leu 5 | NTc.Cm2 | N-term | TRP 94 | B | VdWContact |
| Leu 5 | NTc.Cm2 | N-term | GLU 93 | B | Hydrophobic |
| Leu 5 | NTc.Cm2 | N-term | GLU 93 | B | VdWContact |
| Arg 6 | NTc.Cm1 | N-term | TRP 94 | B | Hydrophobic |
| Arg 6 | NTc.Cm1 | N-term | GLU 99 | A | HBDonor |
| Arg 6 | NTc.Cm1 | N-term | GLU 99 | A | Cationic |
| Arg 6 | NTc.Cm1 | N-term | GLU 99 | A | VdWContact |
| Arg 6 | NTc.Cm1 | N-term | TYR 110 | A | Hydrophobic |
| Arg 6 | NTc.Cm1 | N-term | TYR 110 | A | CationPi |
| Arg 6 | NTc.Cm1 | N-term | TYR 110 | A | VdWContact |
| Arg 6 | NTc.Cm1 | N-term | ASN 91 | B | HBDonor |
| Arg 6 | NTc.Cm1 | N-term | ASN 91 | B | VdWContact |
| Cys 7 | CX.1 | CX | TRP 94 | B | Hydrophobic |
| Cys 7 | CX.1 | CX | TRP 94 | B | VdWContact |
| Cys 7 | CX.1 | CX | TRP 33 | A | Hydrophobic |
| Gln 8 | CX.4 | CX | PRO 106 | A | Hydrophobic |
| Ile 10 | cxb1.1 | N-loop | SER 52 | A | VdWContact |
| Ile 10 | cxb1.1 | N-loop | TRP 33 | A | Hydrophobic |
| Ile 10 | cxb1.1 | N-loop | TYR 32 | A | VdWContact |
| Ile 10 | cxb1.1 | N-loop | TYR 102 | A | Hydrophobic |
| Ile 10 | cxb1.1 | N-loop | TYR 102 | A | VdWContact |
| Lys 11 | cxb1.2 | N-loop | SER 103 | A | VdWContact |
| Lys 11 | cxb1.2 | N-loop | GLU 28 | A | Cationic |
| Lys 11 | cxb1.2 | N-loop | THR 30 | A | HBDonor |
| Lys 11 | cxb1.2 | N-loop | THR 30 | A | VdWContact |
| Lys 11 | cxb1.2 | N-loop | TYR 104 | A | Hydrophobic |
| Tyr 13 | cxb1.6 | N-loop | TYR 104 | A | Hydrophobic |
| His 33 | b1b2.10 | 30s-loop | TRP 94 | B | HBDonor |
| His 33 | b1b2.10 | 30s-loop | TRP 94 | B | VdWContact |
| Ala 35 | b1b2.13 | 30s-loop | ASN 59 | A | HBDonor |
| Ala 35 | b1b2.13 | 30s-loop | ASN 59 | A | VdWContact |
| Asn 36 | b1b2.14 | 30s-loop | SER 57 | A | VdWContact |
| Ile 40 | B2.3 | B2 | PRO 106 | A | Hydrophobic |
| Ile 40 | B2.3 | B2 | PRO 106 | A | VdWContact |
| Arg 47 | b2b3.12 | 40s-loop | TYR 105 | A | Hydrophobic |
| Arg 47 | b2b3.12 | 40s-loop | TYR 105 | A | VdWContact |
| Glu 48 | B3.1 | B3 | PRO 106 | A | Hydrophobic |
| Glu 48 | B3.1 | B3 | PRO 106 | A | VdWContact |
| Glu 48 | B3.1 | B3 | TYR 105 | A | VdWContact |
| Leu 49 | B3.2 | B3 | TYR 104 | A | Hydrophobic |
| Leu 49 | B3.2 | B3 | TYR 105 | A | Hydrophobic |
| Cys 50 | B3.3 | B3 | TYR 104 | A | Hydrophobic |
| Cys 50 | B3.3 | B3 | TYR 104 | A | HBDonor |
| Cys 50 | B3.3 | B3 | TYR 104 | A | VdWContact |
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