Interactions

8XVU | CXCL2_HUMAN — CXCR2

Residue contacts: 57
SUMMARY
Protein
CXCL2_HUMAN View protein entry
Organism
Homo sapiens
UniProt ID
P19875 View on UniProt
PDB ID
8XVU View on PDB
Method
Cryo-em
Resolution
3.09 Å
Date
Jan. 15, 2025
Reference
-
State
Dimer
Chain information
Chemokine chain
D
Partner chain
R
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INTERACTION TABLE
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Chemokine Residue Generic Number Segment Partner Residue Partner Chain Interaction Type
Ala 1 NTc.Cm8 N-term LYS 48 R VdWContact
Pro 2 NTc.Cm7 N-term ASN 191 R VdWContact
Pro 2 NTc.Cm7 N-term SER 193 R HBAcceptor
Pro 2 NTc.Cm7 N-term SER 193 R VdWContact
Leu 3 NTc.Cm6 N-term LYS 108 R VdWContact
Leu 3 NTc.Cm6 N-term LYS 48 R Hydrophobic
Leu 3 NTc.Cm6 N-term LYS 48 R VdWContact
Leu 3 NTc.Cm6 N-term SER 193 R VdWContact
Ala 4 NTc.Cm5 N-term VAL 192 R Hydrophobic
Glu 6 NTc.Cm3 N-term ARG 208 R HBAcceptor
Glu 6 NTc.Cm3 N-term ARG 208 R Anionic
Glu 6 NTc.Cm3 N-term ARG 208 R VdWContact
Glu 6 NTc.Cm3 N-term LEU 296 R Hydrophobic
Glu 6 NTc.Cm3 N-term LEU 296 R VdWContact
Glu 6 NTc.Cm3 N-term ARG 212 R Anionic
Glu 6 NTc.Cm3 N-term ARG 278 R Anionic
Glu 6 NTc.Cm3 N-term ARG 278 R VdWContact
Leu 7 NTc.Cm2 N-term VAL 187 R Hydrophobic
Leu 7 NTc.Cm2 N-term TYR 197 R Hydrophobic
Leu 7 NTc.Cm2 N-term ARG 278 R HBAcceptor
Leu 7 NTc.Cm2 N-term ARG 278 R VdWContact
Arg 8 NTc.Cm1 N-term ASP 293 R HBDonor
Arg 8 NTc.Cm1 N-term ASP 293 R Cationic
Arg 8 NTc.Cm1 N-term ASP 293 R VdWContact
Arg 8 NTc.Cm1 N-term MET 277 R VdWContact
Arg 8 NTc.Cm1 N-term ASP 274 R HBDonor
Arg 8 NTc.Cm1 N-term ASP 274 R Cationic
Arg 8 NTc.Cm1 N-term ASP 274 R VdWContact
Cys 9 CX.1 CX ARG 289 R HBAcceptor
Cys 9 CX.1 CX ARG 289 R VdWContact
Gln 10 CX.4 CX PRO 38 R VdWContact
Leu 12 cxb1.1 N-loop GLU 284 R Hydrophobic
Leu 12 cxb1.1 N-loop ARG 289 R VdWContact
Leu 12 cxb1.1 N-loop CYS 39 R VdWContact
Gln 13 cxb1.2 N-loop ASP 35 R VdWContact
Gln 13 cxb1.2 N-loop ALA 36 R Hydrophobic
Gln 13 cxb1.2 N-loop ALA 36 R VdWContact
Leu 15 cxb1.6 N-loop ALA 36 R Hydrophobic
Leu 15 cxb1.6 N-loop ALA 36 R VdWContact
Leu 15 cxb1.6 N-loop LEU 33 R Hydrophobic
Ile 18 cxb1.11 N-loop LEU 33 R Hydrophobic
Lys 27 B1.6 B1 SER 190 R HBDonor
Lys 27 B1.6 B1 SER 190 R VdWContact
Pro 31 b1b2.7 30s-loop ASN 202 R Hydrophobic
Pro 31 b1b2.7 30s-loop ASN 202 R VdWContact
Pro 33 b1b2.9 30s-loop VAL 187 R Hydrophobic
Pro 33 b1b2.9 30s-loop TYR 197 R Hydrophobic
Pro 33 b1b2.9 30s-loop TYR 197 R VdWContact
Pro 33 b1b2.9 30s-loop THR 204 R Hydrophobic
Pro 33 b1b2.9 30s-loop THR 204 R VdWContact
Pro 33 b1b2.9 30s-loop GLU 198 R VdWContact
His 34 b1b2.10 30s-loop VAL 187 R Hydrophobic
His 34 b1b2.10 30s-loop SER 189 R HBAcceptor
His 34 b1b2.10 30s-loop SER 189 R VdWContact
Ile 41 B2.3 B2 PRO 38 R Hydrophobic
Lys 49 B3.1 B3 PRO 38 R Hydrophobic
Cys 51 B3.3 B3 PRO 38 R VdWContact
CHEMOKINE DIAGRAM
K S P G P H C A Q T 30s-loop K N G Q 40s-loop N P A S 50s-loopC-term A P L A T E L R C Q C L Q T L Q G I H L K N-term V K V S Q I N E V I A T L L C A K P M V K K I I E K M L K N
INTERACTION PATTERN SEARCH
0.00 = no similarity, 1.00 = identical