Interactions for 7SK8 — Binding Partner: ACKR3
Structure details
- PDB ID: 7SK8 open_in_new
- Protein: CXCL12_HUMAN
- Organism: Homo sapiens
- UniProt ID: P48061 open_in_new
- Method: Cryo-em
- Resolution: 3.3 Å
- Date: July 27, 2022
- Reference: 10.1126/SCIADV.ABN8063 open_in_new
- State: Monomer
- Chemokine Chain: B
- Partner Chain: A
Chemokine diagram
Interactions for this Binding Partner
Download list as CSV
| Chemokine Residue | Generic Number | Segment | Partner Residue | Partner Chain | Interaction Type |
|---|---|---|---|---|---|
| Tyr 7 | NTc.Cm2 | N-term | ARG 197 | A | VdWContact |
| Tyr 7 | NTc.Cm2 | N-term | TYR 195 | A | Hydrophobic |
| Tyr 7 | NTc.Cm2 | N-term | TYR 195 | A | VdWContact |
| Arg 8 | NTc.Cm1 | N-term | ASP 275 | A | Cationic |
| Pro 10 | CX.4 | CX | PHE 285 | A | Hydrophobic |
| Pro 10 | CX.4 | CX | PHE 285 | A | VdWContact |
| Arg 12 | cxb1.1 | N-loop | LEU 209 | A | Hydrophobic |
| Arg 12 | cxb1.1 | N-loop | ASP 275 | A | Cationic |
| Arg 12 | cxb1.1 | N-loop | ILE 279 | A | Hydrophobic |
| Arg 12 | cxb1.1 | N-loop | ILE 279 | A | VdWContact |
| Phe 13 | cxb1.2 | N-loop | LEU 209 | A | Hydrophobic |
| Phe 13 | cxb1.2 | N-loop | LEU 280 | A | Hydrophobic |
| Phe 13 | cxb1.2 | N-loop | ILE 205 | A | Hydrophobic |
| Phe 13 | cxb1.2 | N-loop | LYS 206 | A | Hydrophobic |
| Phe 13 | cxb1.2 | N-loop | ILE 279 | A | Hydrophobic |
| Phe 13 | cxb1.2 | N-loop | ILE 279 | A | VdWContact |
| Val 23 | B1.2 | B1 | ILE 27 | A | Hydrophobic |
| His 25 | B1.4 | B1 | ASP 30 | A | HBDonor |
| His 25 | B1.4 | B1 | ASP 30 | A | VdWContact |
| His 25 | B1.4 | B1 | VAL 28 | A | Hydrophobic |
| His 25 | B1.4 | B1 | VAL 28 | A | VdWContact |
| Leu 26 | B1.5 | B1 | VAL 29 | A | Hydrophobic |
| Leu 26 | B1.5 | B1 | ILE 27 | A | Hydrophobic |
| Leu 26 | B1.5 | B1 | ASP 30 | A | HBAcceptor |
| Leu 26 | B1.5 | B1 | ASP 30 | A | VdWContact |
| Leu 26 | B1.5 | B1 | VAL 28 | A | HBDonor |
| Leu 26 | B1.5 | B1 | VAL 28 | A | VdWContact |
| Lys 27 | B1.6 | B1 | ASP 30 | A | VdWContact |
| Lys 27 | B1.6 | B1 | VAL 32 | A | Hydrophobic |
| Ile 28 | B1.7 | B1 | ASP 30 | A | HBDonor |
| Ile 28 | B1.7 | B1 | ASP 30 | A | VdWContact |
| Ile 28 | B1.7 | B1 | VAL 32 | A | HBAcceptor |
| Ile 28 | B1.7 | B1 | VAL 32 | A | VdWContact |
| Ile 28 | B1.7 | B1 | VAL 29 | A | Hydrophobic |
| Ile 28 | B1.7 | B1 | VAL 29 | A | VdWContact |
| Ile 28 | B1.7 | B1 | THR 31 | A | Hydrophobic |
| Ile 28 | B1.7 | B1 | THR 31 | A | VdWContact |
| Leu 29 | b1b2.4 | 30s-loop | PHE 285 | A | Hydrophobic |
| Leu 29 | b1b2.4 | 30s-loop | VAL 32 | A | Hydrophobic |
| Leu 29 | b1b2.4 | 30s-loop | VAL 32 | A | VdWContact |
| Asn 30 | b1b2.7 | 30s-loop | MET 33 | A | Hydrophobic |
| Asn 30 | b1b2.7 | 30s-loop | MET 33 | A | VdWContact |
| Asn 30 | b1b2.7 | 30s-loop | CYS 34 | A | HBAcceptor |
| Asn 30 | b1b2.7 | 30s-loop | CYS 34 | A | VdWContact |
| Asn 30 | b1b2.7 | 30s-loop | VAL 32 | A | HBDonor |
| Asn 30 | b1b2.7 | 30s-loop | VAL 32 | A | VdWContact |
| Val 39 | B2.3 | B2 | HIS 281 | A | Hydrophobic |
| Arg 47 | b2b3.12 | 40s-loop | TYR 282 | A | CationPi |
| Arg 47 | b2b3.12 | 40s-loop | LEU 280 | A | HBDonor |
| Arg 47 | b2b3.12 | 40s-loop | LEU 280 | A | VdWContact |
| Arg 47 | b2b3.12 | 40s-loop | HIS 281 | A | VdWContact |
| Gln 48 | B3.1 | B3 | HIS 281 | A | Hydrophobic |
| Gln 48 | B3.1 | B3 | HIS 281 | A | VdWContact |
| Cys 50 | B3.3 | B3 | HIS 281 | A | VdWContact |
| Tyr 61 | H.6 | Helix | VAL 29 | A | Hydrophobic |
| Tyr 61 | H.6 | Helix | ILE 27 | A | Hydrophobic |
| Tyr 61 | H.6 | Helix | ILE 27 | A | HBDonor |
| Tyr 61 | H.6 | Helix | ILE 27 | A | VdWContact |
| Leu 62 | H.7 | Helix | VAL 29 | A | Hydrophobic |
| Ala 65 | H.10 | Helix | VAL 29 | A | Hydrophobic |
| Ala 65 | H.10 | Helix | VAL 29 | A | VdWContact |
| Leu 66 | CT.1 | C-term | THR 31 | A | Hydrophobic |
, 'snake_.png', {scale: 3});){kind=link}
, 'snake_.jpg', {scale: 3});){kind=link}