Protein
CCL14_HUMAN
SUMMARY
- Gene
- CCL14_HUMAN
- Full name
- C-C motif chemokine 14
- Organism
- Homo sapiens
- Subfamily
- CCL
- Sequence type
- Wild-type
- UniProt ID
- Q16627 Open UniProt
- IUPHAR ID
- 753 Open Guide to Pharmacology
- GtoP partners
- -
DIAGRAM
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SEQUENCE
Residues are colour-coded by structural context. Hover to view sequence and CCN numbering.
| N-term | |||||||||
|
M
|
K
|
I
|
S
|
V
|
A
|
A
|
I
|
P
|
F
|
| 10 | |||||||||
|
F
|
L
|
L
|
I
|
T
|
I
|
A
|
L
|
G
|
T
|
| 20 | |||||||||
|
K
|
T
|
E
|
S
|
S
|
S
|
R
|
G
|
P
|
Y
|
| 30 | |||||||||
| CX | N-loop | ||||||||
|
H
|
P
|
S
|
E
|
C
|
C
|
F
|
T
|
Y
|
T
|
| 40 | |||||||||
| B1 | |||||||||
|
T
|
Y
|
K
|
I
|
P
|
R
|
Q
|
R
|
I
|
M
|
| 50 | |||||||||
| 30s-loop | |||||||||
|
D
|
Y
|
Y
|
E
|
T
|
N
|
S
|
Q
|
C
|
S
|
| 60 | |||||||||
| B2 | 40s-loop | ||||||||
|
K
|
P
|
G
|
I
|
V
|
F
|
I
|
T
|
K
|
R
|
| 70 | |||||||||
| B3 | 50s-loop | ||||||||
|
G
|
H
|
S
|
V
|
C
|
T
|
N
|
P
|
S
|
D
|
| 80 | |||||||||
| Helix | |||||||||
|
K
|
W
|
V
|
Q
|
D
|
Y
|
I
|
K
|
D
|
M
|
| 90 | |||||||||
| C-term | ||
|
K
|
E
|
N
|
| 93 | ||
STRUCTURES
Experimental structures
| PDB | Method | Resolution | State | Publication date | Reference |
|---|---|---|---|---|---|
| 2Q8R - E,F,G,H | X-ray | 1.82 | Dimer | 2007-09-11 | 10.1021/BI700936W open_in_new |
| 2Q8T - A,B,C,D | X-ray | 2.23 | Dimer | 2007-09-11 | 10.1021/BI700936W open_in_new |
Predicted models and complexes
| Type | Partner | Method | State | Date | View |
|---|---|---|---|---|---|
| Complex | XCR1 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CXCR6 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CXCR5 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CXCR4 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CXCR3 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CXCR2 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CXCR1 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CX3CR1 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CCRL2 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CCR9 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CCR8 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CCR7 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CCR6 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CCR5 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CCR4 | AlphaFold-Multimer | - | 2025-11-10 | Open |
| Complex | CCR3 | AlphaFold-Multimer | - | 2025-11-10 | Open |
| Complex | CCR2 | AlphaFold-Multimer | - | 2025-11-10 | Open |
| Complex | CCR1 | AlphaFold-Multimer | - | 2025-11-10 | Open |
| Complex | CCR10 | AlphaFold-Multimer | - | 2025-11-10 | Open |
| Complex | ACKR4 | AlphaFold-Multimer | - | 2025-11-10 | Open |
| Complex | ACKR3 | AlphaFold-Multimer | - | 2025-11-10 | Open |
| Complex | ACKR2 | AlphaFold-Multimer | - | 2025-11-10 | Open |
| Complex | ACKR1 | AlphaFold-Multimer | - | 2025-11-10 | Open |
| Model | - | AlphaFold Monomer v2.0 pipeline (AlphaFold DB v6) | - | 2025-08-01 | Open |
SEQUENCE ALIGNMENT
Canonical residues are compared against each available structure at matched CCN positions.
| Position | NTc.Cm34 | NTc.Cm33 | NTc.Cm32 | NTc.Cm31 | NTc.Cm30 | NTc.Cm29 | NTc.Cm28 | NTc.Cm27 | NTc.Cm26 | NTc.Cm25 | NTc.Cm24 | NTc.Cm23 | NTc.Cm22 | NTc.Cm21 | NTc.Cm20 | NTc.Cm19 | NTc.Cm18 | NTc.Cm17 | NTc.Cm16 | NTc.Cm15 | NTc.Cm14 | NTc.Cm13 | NTc.Cm12 | NTc.Cm11 | NTc.Cm10 | NTc.Cm9 | NTc.Cm8 | NTc.Cm7 | NTc.Cm6 | NTc.Cm5 | NTc.Cm4 | NTc.Cm3 | NTc.Cm2 | NTc.Cm1 | CX.1 | CX.5 | cxb1.1 | cxb1.2 | cxb1.5 | cxb1.6 | cxb1.7 | cxb1.8 | cxb1.10 | cxb1.11 | cxb1.14 | cxb1.15 | cxb1.16 | B1.1 | B1.2 | B1.3 | B1.4 | B1.5 | B1.6 | B1.7 | b1b2.4 | b1b2.6 | b1b2.9 | b1b2.10 | b1b2.12 | b1b2.13 | b1b2.14 | b1b2.16 | B2.1 | B2.2 | B2.3 | B2.4 | B2.5 | B2.6 | b2b3.2 | b2b3.4 | b2b3.11 | b2b3.12 | B3.1 | B3.2 | B3.3 | B3.4 | b3h.1 | b3h.2 | b3h.3 | b3h.4 | H.1 | H.2 | H.3 | H.4 | H.5 | H.6 | H.7 | H.8 | H.9 | H.10 | CT.1 | CT.2 | CT.3 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Canonical sequence | M | K | I | S | V | A | A | I | P | F | F | L | L | I | T | I | A | L | G | T | K | T | E | S | S | S | R | G | P | Y | H | P | S | E | C | C | F | T | Y | T | T | Y | K | I | P | R | Q | R | I | M | D | Y | Y | E | T | N | S | Q | C | S | K | P | G | I | V | F | I | T | K | R | G | H | S | V | C | T | N | P | S | D | K | W | V | Q | D | Y | I | K | D | M | K | E | N |
| 2Q8R | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | G | P | Y | H | P | S | E | C | C | F | T | Y | T | T | Y | K | I | P | R | Q | R | I | M | D | Y | Y | E | T | N | S | Q | C | S | K | P | G | I | V | F | I | T | K | R | G | H | S | V | C | T | N | P | S | D | K | W | V | Q | D | Y | I | K | D | M | K | E | N |
| 2Q8T | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | P | Y | H | P | S | E | C | C | F | T | Y | T | T | Y | K | I | P | R | Q | R | I | M | D | Y | Y | E | T | N | S | Q | C | S | K | P | G | I | V | F | I | T | K | R | G | H | S | V | C | T | N | P | S | D | K | W | V | Q | D | Y | I | K | D | M | K | E | N |
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