Protein
CCL23_HUMAN
SUMMARY
- Gene
- CCL23_HUMAN
- Full name
- C-C motif chemokine 23
- Organism
- Homo sapiens
- Subfamily
- CCL
- Sequence type
- Wild-type
- UniProt ID
- P55773 Open UniProt
- IUPHAR ID
- 755 Open Guide to Pharmacology
- GtoP partners
- -
DIAGRAM
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SEQUENCE
Residues are colour-coded by structural context. Hover to view sequence and CCN numbering.
| N-term | |||||||||
|
M
|
K
|
V
|
S
|
V
|
A
|
A
|
L
|
S
|
C
|
| 10 | |||||||||
|
L
|
M
|
L
|
V
|
T
|
A
|
L
|
G
|
S
|
Q
|
| 20 | |||||||||
|
A
|
R
|
V
|
T
|
K
|
D
|
A
|
E
|
T
|
E
|
| 30 | |||||||||
|
F
|
M
|
M
|
S
|
K
|
L
|
P
|
L
|
E
|
N
|
| 40 | |||||||||
|
P
|
V
|
L
|
L
|
D
|
R
|
F
|
H
|
A
|
T
|
| 50 | |||||||||
|
S
|
A
|
D
|
C
|
C
|
I
|
S
|
Y
|
T
|
P
|
| 60 | |||||||||
|
R
|
S
|
I
|
P
|
C
|
S
|
L
|
L
|
E
|
S
|
| 70 | |||||||||
| CX | N-loop | ||||||||
|
Y
|
F
|
E
|
T
|
N
|
S
|
E
|
C
|
S
|
K
|
| 80 | |||||||||
| B1 | |||||||||
|
P
|
G
|
V
|
I
|
F
|
L
|
T
|
K
|
K
|
G
|
| 90 | |||||||||
| 30s-loop | B2 | ||||||||
|
R
|
R
|
F
|
C
|
A
|
N
|
P
|
S
|
D
|
K
|
| 100 | |||||||||
| 40s-loop | B3 | ||||||||
|
Q
|
V
|
Q
|
V
|
C
|
M
|
R
|
M
|
L
|
K
|
| 110 | |||||||||
| 50s-loop | Helix | ||||||||
|
L
|
D
|
T
|
R
|
I
|
K
|
T
|
R
|
K
|
N
|
| 120 | |||||||||
STRUCTURES
Experimental structures
| PDB | Method | Resolution | State | Publication date | Reference |
|---|---|---|---|---|---|
| 1G91 - A | Nmr | None | Monomer | 2001-03-07 | 10.1074/JBC.M005085200 open_in_new |
Predicted models and complexes
| Type | Partner | Method | State | Date | View |
|---|---|---|---|---|---|
| Complex | XCR1 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CXCR6 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CXCR5 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CXCR4 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CXCR3 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CXCR2 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CXCR1 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CX3CR1 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CCRL2 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CCR9 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CCR8 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CCR7 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CCR6 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CCR5 | AlphaFold-Multimer | - | 2025-11-11 | Open |
| Complex | CCR4 | AlphaFold-Multimer | - | 2025-11-10 | Open |
| Complex | CCR3 | AlphaFold-Multimer | - | 2025-11-10 | Open |
| Complex | CCR2 | AlphaFold-Multimer | - | 2025-11-10 | Open |
| Complex | CCR1 | AlphaFold-Multimer | - | 2025-11-10 | Open |
| Complex | CCR10 | AlphaFold-Multimer | - | 2025-11-10 | Open |
| Complex | ACKR4 | AlphaFold-Multimer | - | 2025-11-10 | Open |
| Complex | ACKR3 | AlphaFold-Multimer | - | 2025-11-10 | Open |
| Complex | ACKR2 | AlphaFold-Multimer | - | 2025-11-10 | Open |
| Complex | ACKR1 | AlphaFold-Multimer | - | 2025-11-10 | Open |
| Model | - | AlphaFold Monomer v2.0 pipeline (AlphaFold DB v6) | - | 2025-08-01 | Open |
SEQUENCE ALIGNMENT
Canonical residues are compared against each available structure at matched CCN positions.
| Position | NTc.Cm70 | NTc.Cm69 | NTc.Cm68 | NTc.Cm67 | NTc.Cm66 | NTc.Cm65 | NTc.Cm64 | NTc.Cm63 | NTc.Cm62 | NTc.Cm61 | NTc.Cm60 | NTc.Cm59 | NTc.Cm58 | NTc.Cm57 | NTc.Cm56 | NTc.Cm55 | NTc.Cm54 | NTc.Cm53 | NTc.Cm52 | NTc.Cm51 | NTc.Cm50 | NTc.Cm49 | NTc.Cm48 | NTc.Cm47 | NTc.Cm46 | NTc.Cm45 | NTc.Cm44 | NTc.Cm43 | NTc.Cm42 | NTc.Cm41 | NTc.Cm40 | NTc.Cm39 | NTc.Cm38 | NTc.Cm37 | NTc.Cm36 | NTc.Cm35 | NTc.Cm34 | NTc.Cm33 | NTc.Cm32 | NTc.Cm31 | NTc.Cm30 | NTc.Cm29 | NTc.Cm28 | NTc.Cm27 | NTc.Cm26 | NTc.Cm25 | NTc.Cm24 | NTc.Cm23 | NTc.Cm22 | NTc.Cm21 | NTc.Cm20 | NTc.Cm19 | NTc.Cm18 | NTc.Cm17 | NTc.Cm16 | NTc.Cm15 | NTc.Cm14 | NTc.Cm13 | NTc.Cm12 | NTc.Cm11 | NTc.Cm10 | NTc.Cm9 | NTc.Cm8 | NTc.Cm7 | NTc.Cm6 | NTc.Cm5 | NTc.Cm4 | NTc.Cm3 | NTc.Cm2 | NTc.Cm1 | CX.1 | CX.5 | cxb1.1 | cxb1.2 | cxb1.5 | cxb1.6 | cxb1.7 | cxb1.8 | cxb1.10 | cxb1.11 | cxb1.14 | cxb1.15 | cxb1.16 | B1.1 | B1.2 | B1.3 | B1.4 | B1.5 | B1.6 | B1.7 | b1b2.4 | b1b2.6 | b1b2.9 | b1b2.10 | b1b2.12 | b1b2.13 | b1b2.14 | b1b2.16 | B2.1 | B2.2 | B2.3 | B2.4 | B2.5 | B2.6 | b2b3.2 | b2b3.4 | b2b3.11 | b2b3.12 | B3.1 | B3.2 | B3.3 | B3.4 | b3h.1 | b3h.2 | b3h.3 | b3h.4 | H.1 | H.2 | H.3 | H.4 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Canonical sequence | M | K | V | S | V | A | A | L | S | C | L | M | L | V | T | A | L | G | S | Q | A | R | V | T | K | D | A | E | T | E | F | M | M | S | K | L | P | L | E | N | P | V | L | L | D | R | F | H | A | T | S | A | D | C | C | I | S | Y | T | P | R | S | I | P | C | S | L | L | E | S | Y | F | E | T | N | S | E | C | S | K | P | G | V | I | F | L | T | K | K | G | R | R | F | C | A | N | P | S | D | K | Q | V | Q | V | C | M | R | M | L | K | L | D | T | R | I | K | T | R | K | N |
| 1G91 | M | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | D | R | F | H | A | T | S | A | D | C | C | I | S | Y | T | P | R | S | I | P | C | S | L | L | E | S | Y | F | E | T | N | S | E | C | S | K | P | G | V | I | F | L | T | K | K | G | R | R | F | C | A | N | P | S | D | K | Q | V | Q | V | C | M | R | M | L | K | L | D | T | R | I | K | T | R | K | N |
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