CCL2_HUMAN

  • Alternate name(s): C-C motif chemokine 2, HC11, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte chemotactic protein 1, MCP-1, Monocyte secretory protein JE, Small-inducible cytokine A2
  • Organism: Homo sapiens
  • UniProt ID: P13500 open_in_new


Sequence

N-term   CX   N-loop   B1   30s-loop   B2   40s-loop   B3   50s-loop   Helix   C-term  
30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62   63 67   68 69 70 71 72 73 74 75 76 80 81 82   83 84 85 86 87 88 89   90 91 92 94 95 96 97 99 100   101 102 103 104 105   106 112 113 114   115 116 117 118   119 120 121 122   123 124 125 126 127 128 129 130 131 132 133 134 135   136 137 138 139 140 141  
M K V S A A L L C L L L I A A T F I P Q G L A Q P D A I N A P V T   C C   Y N F T N R K I S V Q R   L A S Y R R I   T S S K C P K E A   V I F K T   I V A K   E I C A   D P K Q   K W V Q D S M D H L D K Q   T Q T P K T  

Snake Plot

T S S K C P K E A 30s-loop I V A K 40s-loop D P K Q 50s-loopN-term M K V S A A L L C L L L I A A T F I P Q G L A Q P D A I N A P V T C C Y N F T N R K I S V Q R N-termC-term T Q T P K T C-term I R R Y S A L V I F K T A C I E K W V Q D S M D H L D K Q
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List of structures

PDB Method Resolution State Publication date Reference
1DOK X-ray 1.85 dimer 1997-03-12 10.1038/NSB0197-64 open_in_new
1DOL X-ray 2.4 monomer 1997-03-12 10.1038/NSB0197-64 open_in_new
1DOM Solution nmr 0.0 dimer 1996-10-14 10.1021/BI9602270 open_in_new
1DON Solution nmr 0.0 dimer 1996-10-14 10.1021/BI9602270 open_in_new
1ML0 X-ray 2.8 monomer 2002-11-13 10.1016/S0092-8674(02)01007-3 open_in_new
2BDN X-ray 2.53 monomer 2006-06-13 10.1093/PROTEIN/GZL015 open_in_new
2NZ1 X-ray 2.5 monomer 2007-12-25 10.1084/JEM.20071677 open_in_new
3IFD X-ray 1.9 dimer 2009-08-04 10.1002/BIP.21390 open_in_new
4DN4 X-ray 2.8 monomer 2012-10-03 10.1016/J.MOLIMM.2012.03.022 open_in_new
4R8I X-ray 2.05 dimer 2015-04-29 10.1038/NCOMMS7923 open_in_new
4ZK9 X-ray 2.6 monomer 2015-07-08 10.1016/J.STR.2015.04.023 open_in_new
7SO0 X-ray 1.74 monomer 2022-03-16 10.1073/PNAS.2122105119 open_in_new
7XA3 Cryo-em 2.9 monomer 2022-08-24 10.1038/S41421-022-00403-4 open_in_new
8FJ0 X-ray 2.91 monomer 2023-03-29 10.1038/S41467-023-39879-3 open_in_new

Targets (Guide to Pharmacology)

No targets found