CCL2_HUMAN

  • Alternate name(s): C-C motif chemokine 2
  • Organism: Homo sapiens
  • UniProt ID: P13500 open_in_new


Wild type sequence

Residue N-term   CX   N-loop   B1   30s-loop   B2   40s-loop   B3   50s-loop   Helix   C-term  
  NTc.Cm33 NTc.Cm32 NTc.Cm31 NTc.Cm30 NTc.Cm29 NTc.Cm28 NTc.Cm27 NTc.Cm26 NTc.Cm25 NTc.Cm24 NTc.Cm23 NTc.Cm22 NTc.Cm21 NTc.Cm20 NTc.Cm19 NTc.Cm18 NTc.Cm17 NTc.Cm16 NTc.Cm15 NTc.Cm14 NTc.Cm13 NTc.Cm12 NTc.Cm11 NTc.Cm10 NTc.Cm9 NTc.Cm8 NTc.Cm7 NTc.Cm6 NTc.Cm5 NTc.Cm4 NTc.Cm3 NTc.Cm2 NTc.Cm1   CX.1 CX.5   cxb1.1 cxb1.2 cxb1.5 cxb1.6 cxb1.7 cxb1.8 cxb1.10 cxb1.11 cxb1.14 cxb1.15 cxb1.16   B1.1 B1.2 B1.3 B1.4 B1.5 B1.6 B1.7   b1b2.4 b1b2.6 b1b2.7 b1b2.9 b1b2.10 b1b2.12 b1b2.13 b1b2.14 b1b2.16   B2.1 B2.2 B2.3 B2.4 B2.5 B2.6   b2b3.2 b2b3.4 b2b3.11 b2b3.12   B3.1 B3.2 B3.3 B3.4   b3h.1 b3h.2 b3h.3 b3h.4   H.1 H.2 H.3 H.4 H.5 H.6 H.7 H.8 H.9 H.10   CT.1 CT.2 CT.3 CT.4 CT.5 CT.6 CT.7 CT.8 CT.9  
Wild Type M K V S A A L L C L L L I A A T F I P Q G L A Q P D A I N A P V T   C C   Y N F T N R K I S V Q   R L A S Y R R   I T S S K C P K E   A V I F K T   I V A K   E I C A   D P K Q   K W V Q D S M D H L   D K Q T Q T P K T  

Snake Plot

I T S S K C P K E 30s-loop I V A K 40s-loop D P K Q 50s-loopC-term M K V S A A L L C L L L I A A T F I P Q G L A Q P D A I N A P V T C C Y N F T N R K I S V Q N-term R R Y S A L R A V I F K T A C I E K W V Q D S M D H L D K Q T Q T P K T
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List of structures

PDB Method Resolution State Publication date Reference
1DOK - A,B X-ray 1.85 Dimer 1997-03-12 10.1038/NSB0197-64 open_in_new
1DOL - A X-ray 2.4 Monomer 1997-03-12 10.1038/NSB0197-64 open_in_new
1DOM - A,B Nmr None Dimer 1996-10-14 10.1021/BI9602270 open_in_new
1DON - A,B Nmr None Dimer 1996-10-14 10.1021/BI9602270 open_in_new
1ML0 - D X-ray 2.8 Monomer 2002-11-13 10.1016/S0092-8674(02)01007-3 open_in_new
4DN4 - M X-ray 2.8 Monomer 2012-10-03 10.1016/J.MOLIMM.2012.03.022 open_in_new
2BDN - A X-ray 2.53 Monomer 2006-06-13 10.1093/PROTEIN/GZL015 open_in_new
2NZ1 - E,D,Y X-ray 2.5 Monomer 2007-12-25 10.1084/JEM.20071677 open_in_new
3IFD - A X-ray 1.9 Monomer 2009-08-04 10.1002/BIP.21390 open_in_new
4R8I - A X-ray 2.05 Dimer 2015-04-29 10.1038/NCOMMS7923 open_in_new
4ZK9 - B X-ray 2.6 Monomer 2015-07-08 10.1016/J.STR.2015.04.023 open_in_new
7SO0 - B X-ray 1.74 Monomer 2022-03-16 10.1073/PNAS.2122105119 open_in_new
7XA3 - L Cryo-em 2.9 Monomer 2022-08-24 10.1038/S41421-022-00403-4 open_in_new
8FJ0 - E, F, D X-ray 2.91 Monomer 2023-03-29 10.1038/S41467-023-39879-3 open_in_new

Sequence alignment from structures

Position NTc.Cm33 NTc.Cm32 NTc.Cm31 NTc.Cm30 NTc.Cm29 NTc.Cm28 NTc.Cm27 NTc.Cm26 NTc.Cm25 NTc.Cm24 NTc.Cm23 NTc.Cm22 NTc.Cm21 NTc.Cm20 NTc.Cm19 NTc.Cm18 NTc.Cm17 NTc.Cm16 NTc.Cm15 NTc.Cm14 NTc.Cm13 NTc.Cm12 NTc.Cm11 NTc.Cm10 NTc.Cm9 NTc.Cm8 NTc.Cm7 NTc.Cm6 NTc.Cm5 NTc.Cm4 NTc.Cm3 NTc.Cm2 NTc.Cm1 CX.1 CX.5 cxb1.1 cxb1.2 cxb1.5 cxb1.6 cxb1.7 cxb1.8 cxb1.10 cxb1.11 cxb1.14 cxb1.15 cxb1.16 B1.1 B1.2 B1.3 B1.4 B1.5 B1.6 B1.7 b1b2.4 b1b2.6 b1b2.7 b1b2.9 b1b2.10 b1b2.12 b1b2.13 b1b2.14 b1b2.16 B2.1 B2.2 B2.3 B2.4 B2.5 B2.6 b2b3.2 b2b3.4 b2b3.11 b2b3.12 B3.1 B3.2 B3.3 B3.4 b3h.1 b3h.2 b3h.3 b3h.4 H.1 H.2 H.3 H.4 H.5 H.6 H.7 H.8 H.9 H.10 CT.1 CT.2 CT.3 CT.4 CT.5 CT.6 CT.7 CT.8 CT.9
Canonical Sequence M K V S A A L L C L L L I A A T F I P Q G L A Q P D A I N A P V T C C Y N F T N R K I S V Q R L A S Y R R I T S S K C P K E A V I F K T I V A K E I C A D P K Q K W V Q D S M D H L D K Q T Q T P K T
1DOK - A,B M - - - - - - - - - - - - - - - - - - - - - - Q P D A I N A P V T C C Y N F T N R K I S V Q R L A S Y R R I T S S K C P K E A V I F K T I V A K E I C A D P K Q K W V Q D S M D H L D K Q - - - - - T
1DOL - A M - - - - - - - - - - - - - - - - - - - - - - Q P D A I N A P V T C C Y N F T N R K I S V Q R L A S Y R R I T S S K C P K E A V I F K T I V A K E I C A D P K Q K W V Q D S M D H L D K Q - - - - - -
1DOM - A,B - - - - - - - - - - - - - - - - - - - - - - - Q P D A I N A P V T C C Y N F T N R K I S V Q R L A S Y R R I T S S K C P K E A V I F K T I V A K E I C A D P K Q K W V Q D S M D H L D K Q T Q T P K T
1DON - A,B - - - - - - - - - - - - - - - - - - - - - - - Q P D A I N A P V T C C Y N F T N R K I S V Q R L A S Y R R I T S S K C P K E A V I F K T I V A K E I C A D P K Q K W V Q D S M D H L D K Q T Q T P K T
1ML0 - D - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A V T C C Y N F T N R K I S V Q R L A S Y R R I T S S K C P K E A V I F K T I V A K E I C A D P K Q K W V Q D S I D H L D K Q - - - - - T
4DN4 - M - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - V T C C Y N F T N R K I S V Q R L A S Y R R I T S S K C P K E A V I F K T I V A K E I C A D P K Q K W V Q D S M D H L D K - - - - - - -
2BDN - A - - - - - - - - - - - - - - - - - - - - - - - - - - A I N A P V T C C Y N F T N R K I S V Q R L A S Y R R I T S S K C P K E A V I F K T I V A K E I C A D P K Q K W V Q D S M D H L D K Q - - - - - T
2NZ1 - E,D,Y - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - P V T C C Y N F T N R K I S V Q R L A S Y R R I T S S K C P K E A V I F K T I V A K E I C A D P K Q K W V Q D S I D H L D K Q - - - - - T
3IFD - A - - - - - - - - - - - - - - - - - - - - - - - - - - - I N A P V T C C Y N F T N R K I S V Q R L A S Y R R I T S S K C P K E A V I F K T I V A K E I C A D P K Q K W V Q D S M D H L D K Q - - - - - -
4R8I - A - - - - - - - - - - - - - - - - - - - - - - - - - D A I N A P V T C C Y N F T N R K I S V Q R L A S Y R R I T S S K C P K E A V I F K T I V A K E I C A D P K Q K W V Q D S M D H L D K Q - - - - - -
4ZK9 - B - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - V T C C Y N F T N R K I S V Q R L A S Y R R I T S S K C P K E A V I F K T I V A K E I C A D P K Q K W V Q D S M D H L D K - - - - - - -
7SO0 - B - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A A V T C C Y N F T N R K I S V Q R L A S Y R R I T S S K C P K E A V I F K T I V A K E I C A D P K Q K W V Q D S M D H L D K Q T Q T P K T
7XA3 - L - - - - - - - - - - - - - - - - - - - - - - - Q P D A I N A P V T C C Y N F T N R K I S V Q R L A S Y R R I T S S K C P K E A V I F K T I V A K E I C A D P K Q K W V Q D S M D H L D K - - - - - - -
8FJ0 - E, F, D A A V - - - - - - - - - - - - - - - - - - - - - - - - - - - A V T C C Y Y N F N N R I S V Q R L A S Y R R I T S S K C P K E A V I F K T I V A K E I C A D P K Q K W V Q D S M D H L D K Q T Q T P K -