Protein

CCL4_HUMAN

SUMMARY
Gene
CCL4_HUMAN
Full name
C-C motif chemokine 4
Organism
Homo sapiens
Subfamily
CCL
Sequence type
Wild-type
UniProt ID
P13236 Open UniProt
IUPHAR ID
757 Open Guide to Pharmacology
GtoP partners
-
DIAGRAM
T S S L C S Q P 30s-loop K R S K 40s-loop D P S E 50s-loopC-term M K L C V T V L S L L M L V A A F C S P A L S A P M G S D P P T A C C F S Y T A R K L P R N N-term E Y Y D V V F A V V F Q T A C V Q S W V Q E Y V Y D L E L N
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SEQUENCE

Residues are colour-coded by structural context. Hover to view sequence and CCN numbering.

N-term
M
K
L
C
V
T
V
L
S
L
10
 
L
M
L
V
A
A
F
C
S
P
20
 
A
L
S
A
P
M
G
S
D
P
30
  CX N-loop
P
T
A
C
C
F
S
Y
T
A
40
  B1
R
K
L
P
R
N
F
V
V
D
50
  30s-loop
Y
Y
E
T
S
S
L
C
S
Q
60
  B2 40s-loop
P
A
V
V
F
Q
T
K
R
S
70
  B3 50s-loop Helix
K
Q
V
C
A
D
P
S
E
S
80
  C-term
W
V
Q
E
Y
V
Y
D
L
E
90
 
L
N
92
STRUCTURES

Experimental structures

PDB Method Resolution State Publication date Reference
1HUM - A,B Nmr None Dimer 1994-04-30 -
1HUN - A,B Nmr None Dimer 1994-04-30 -
1JE4 - A Nmr None Monomer 2001-10-03 10.1021/BI011065X open_in_new
2FFK - B Nmr None Monomer 2006-08-22 10.1073/PNAS.0602142103 open_in_new
2FIN - B Nmr None Monomer 2006-08-22 10.1073/PNAS.0602142103 open_in_new
2X6L - A,B,C,D,E X-ray 2.6 Oligomer 2010-11-03 10.1038/EMBOJ.2010.256 open_in_new
3TN2 - A X-ray 1.6 Monomer 2012-09-05 10.1016/J.JMB.2015.01.012 open_in_new
4RAL - D,E X-ray 3.15 Monomer 2015-05-13 10.1016/J.JMB.2015.01.012 open_in_new

Predicted models and complexes

Type Partner Method State Date View
Complex XCR1 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR6 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR5 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR4 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR3 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR2 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR1 AlphaFold-Multimer - 2025-11-11 Open
Complex CX3CR1 AlphaFold-Multimer - 2025-11-11 Open
Complex CCRL2 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR9 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR8 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR7 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR6 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR5 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR4 AlphaFold-Multimer - 2025-11-10 Open
Complex CCR3 AlphaFold-Multimer - 2025-11-10 Open
Complex CCR2 AlphaFold-Multimer - 2025-11-10 Open
Complex CCR1 AlphaFold-Multimer - 2025-11-10 Open
Complex CCR10 AlphaFold-Multimer - 2025-11-10 Open
Complex ACKR4 AlphaFold-Multimer - 2025-11-10 Open
Complex ACKR3 AlphaFold-Multimer - 2025-11-10 Open
Complex ACKR2 AlphaFold-Multimer - 2025-11-10 Open
Complex ACKR1 AlphaFold-Multimer - 2025-11-10 Open
Model - AlphaFold Monomer v2.0 pipeline (AlphaFold DB v6) - 2025-08-01 Open
SEQUENCE ALIGNMENT

Canonical residues are compared against each available structure at matched CCN positions.

Position NTc.Cm33 NTc.Cm32 NTc.Cm31 NTc.Cm30 NTc.Cm29 NTc.Cm28 NTc.Cm27 NTc.Cm26 NTc.Cm25 NTc.Cm24 NTc.Cm23 NTc.Cm22 NTc.Cm21 NTc.Cm20 NTc.Cm19 NTc.Cm18 NTc.Cm17 NTc.Cm16 NTc.Cm15 NTc.Cm14 NTc.Cm13 NTc.Cm12 NTc.Cm11 NTc.Cm10 NTc.Cm9 NTc.Cm8 NTc.Cm7 NTc.Cm6 NTc.Cm5 NTc.Cm4 NTc.Cm3 NTc.Cm2 NTc.Cm1 CX.1 CX.5 cxb1.1 cxb1.2 cxb1.5 cxb1.6 cxb1.7 cxb1.8 cxb1.10 cxb1.11 cxb1.14 cxb1.15 cxb1.16 B1.1 B1.2 B1.3 B1.4 B1.5 B1.6 B1.7 b1b2.4 b1b2.6 b1b2.9 b1b2.10 b1b2.12 b1b2.13 b1b2.14 b1b2.16 B2.1 B2.2 B2.3 B2.4 B2.5 B2.6 b2b3.2 b2b3.4 b2b3.11 b2b3.12 B3.1 B3.2 B3.3 B3.4 b3h.1 b3h.2 b3h.3 b3h.4 H.1 H.2 H.3 H.4 H.5 H.6 H.7 H.8 H.9 H.10 CT.1 CT.2 CT.3
Canonical sequence M K L C V T V L S L L M L V A A F C S P A L S A P M G S D P P T A C C F S Y T A R K L P R N F V V D Y Y E T S S L C S Q P A V V F Q T K R S K Q V C A D P S E S W V Q E Y V Y D L E L N
1HUM - - - - - - - - - - - - - - - - - - - - - - - A P M G S D P P T A C C F S Y T A R K L P R N F V V D Y Y E T S S L C S Q P A V V F Q T K R S K Q V C A D P S E S W V Q E Y V Y D L E L N
1HUN - - - - - - - - - - - - - - - - - - - - - - - A P M G S D P P T A C C F S Y T A R K L P R N F V V D Y Y E T S S L C S Q P A V V F Q T K R S K Q V C A D P S E S W V Q E Y V Y D L E L N
1JE4 - - - - - - - - - - - - - - - - - - - - - - - A P M G S D P P T A C C A S Y T A R K L P R N F V V D Y Y E T S S L C S Q P A V V F Q T K R S K Q V C A D P S E S W V Q E Y V Y D L E L N
2FFK - - - - - - - - - - - - - - - - - - - - - - - A P M G S D P P T A C C F S Y T A R K L P R N F V V D Y Y E T S S L C S Q P A V V F Q T A A S A Q V C A D P S E S W V Q E Y V Y D L E L N
2FIN - - - - - - - - - - - - - - - - - - - - - - - A P M G S D P P T A C C F S Y T A R K L P R N F V V D Y Y E T S S L C S Q P A V V F Q T A A S A Q V C A D P S E S W V Q E Y V Y D L E L N
2X6L - - - - - - - - - - - - - - - - - - - - - - - - - - G S D P P T A C C F S Y T A R K L P R N F V V D Y Y E T S S L C S Q P A V V F Q T K R S K Q V C A D P S E S W V Q E Y V Y D L E L N
3TN2 - - - - - - - - - - - - - - - - - - - - - - - A P M G S D P A T A C C F S Y T A R K L P R N F V V D Y Y E T S S L C S Q P A V V F Q T K R S K Q V C A D P S E S W V Q E Y V Y D L E L -
4RAL A P M F Q T K R S - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A P M G F Q T K R S K