CX3CL1_HUMAN

  • Alternate name(s): Fractalkine, C-X3-C motif chemokine 1, CX3C membrane-anchored chemokine, Neurotactin, Small-inducible cytokine D1, Processed fractalkine
  • Organism: Homo sapiens
  • UniProt ID: P78423 open_in_new


Sequence

N-term   CX   N-loop   B1   30s-loop   B2   40s-loop   B3   50s-loop   Helix   C-term  
32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62   63 64 65 66 67   68 69 70 71 72 74 75 76 80 81 82   83 84 85 86 87 88 89   90 92 94 95 96 97 99 100   101 102 103 104 105   106 112 113 114   115 116 117 118   119 120 121 122   123 124 125 126 127 128 129 130 131 132 133 134 135   136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440  
M A P I S L S W L L R L A T F C H L T V L L A G Q H H G V T K   C N I T C   S K M T S K I P V A L   L I H Y Q Q N   Q A S C G K R A   I I L E T   R Q H R   L F C A   D P K E   Q W V K D A M Q H L D R Q   A A A L T R N G G T F E K Q I G E V K P R T T P A A G G M D E S V V L E P E A T G E S S S L E P T P S S Q E A Q R A L G T S P E L P T G V T G S S G T R L P P T P K A Q D G G P V G T E L F R V P P V S T A A T W Q S S A P H Q P G P S L W A E A K T S E A P S T Q D P S T Q A S T A S S P A P E E N A P S E G Q R V W G Q G Q S P R P E N S L E R E E M G P V P A H T D A F Q D W G P G S M A H V S V V P V S S E G T P S R E P V A S G S W T P K A E E P I H A T M D P Q R L G V L I T P V P D A Q A A T R R Q A V G L L A F L G L L F C L G V A M F T Y Q S L Q G C P R K M A G E M A E G L R Y I P R S C G S N S Y V L V P V  

Snake Plot

Q A S C G K R A 30s-loop R Q H R 40s-loop D P K E 50s-loopN-term M A P I S L S W L L R L A T F C H L T V L L A G Q H H G V T K C N I T C S K M T S K I P V A L N-termC-term A A A L T R N G G T F E K Q I G E V K P R T T P A A G G M D E S V V L E P E A T G E S S S L E P T P S S Q E A Q R A L G T S P E L P T G V T G S S G T R L P P T P K A Q D G G P V G T E L F R V P P V S T A A T W Q S S A P H Q P G P S L W A E A K T S E A P S T Q D P S T Q A S T A S S P A P E E N A P S E G Q R V W G Q G Q S P R P E N S L E R E E M G P V P A H T D A F Q D W G P G S M A H V S V V P V S S E G T P S R E P V A S G S W T P K A E E P I H A T M D P Q R L G V L I T P V P D A Q A A T R R Q A V G L L A F L G L L F C L G V A M F T Y Q S L Q G C P R K M A G E M A E G L R Y I P R S C G S N S Y V L V P V C-term N Q Q Y H I L I I L E T A C F L Q W V K D A M Q H L D R Q
Pick color:
 
 
 
 
 
 
 
 
 
 
 
 



List of structures

PDB Method Resolution State Publication date Reference
1B2T Solution nmr 0.0 monomer 1999-04-08 10.1021/BI9820614 open_in_new
1F2L X-ray 2.0 dimer 2000-09-06 10.1074/JBC.M002584200 open_in_new
3ONA X-ray 2.6 monomer 2011-08-17 10.1371/JOURNAL.PPAT.1002162 open_in_new
4XT1 X-ray 2.89 monomer 2015-03-04 10.1126/SCIENCE.AAA5026 open_in_new
4XT3 X-ray 3.8 monomer 2015-03-04 10.1126/SCIENCE.AAA5026 open_in_new
5WB2 X-ray 3.5 monomer 2018-06-13 10.7554/ELIFE.35850 open_in_new
7RKF Cryo-em 4.0 monomer 2022-01-26 10.1126/SCIADV.ABL5442 open_in_new
7RKM Cryo-em 3.5 monomer 2022-01-26 10.1126/SCIADV.ABL5442 open_in_new
7RKN Cryo-em 3.6 monomer 2022-01-26 10.1126/SCIADV.ABL5442 open_in_new

Targets (Guide to Pharmacology)

No targets found