Protein

CXCL8_HUMAN

SUMMARY
Gene
CXCL8_HUMAN
Full name
Interleukin-8
Organism
Homo sapiens
Subfamily
CXCL
Sequence type
Wild-type
UniProt ID
P10145 Open UniProt
IUPHAR ID
821 Open Guide to Pharmacology
GtoP partners
-
DIAGRAM
I E S G P H C A N T 30s-loop S D G R 40s-loop D P K E 50s-loopC-term M T S K L A V A L L A A F L I S A A L C E G A V L P R S A K E L R C Q C I K T Y S K P F H P K N-term V R L E K I F E I I V K L L C L E N W V Q R V V E K F L K R A E N S
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SEQUENCE

Residues are colour-coded by structural context. Hover to view sequence and CCN numbering.

N-term
M
T
S
K
L
A
V
A
L
L
10
 
A
A
F
L
I
S
A
A
L
C
20
 
E
G
A
V
L
P
R
S
A
K
30
  CX N-loop
E
L
R
C
Q
C
I
K
T
Y
40
  B1
S
K
P
F
H
P
K
F
I
K
50
  30s-loop
E
L
R
V
I
E
S
G
P
H
60
  B2
C
A
N
T
E
I
I
V
K
L
70
40s-loop B3 50s-loop
S
D
G
R
E
L
C
L
D
P
80
  Helix
K
E
N
W
V
Q
R
V
V
E
90
  C-term
K
F
L
K
R
A
E
N
S
99
STRUCTURES

Experimental structures

PDB Method Resolution State Publication date Reference
1ICW - A,B X-ray 2.01 Dimer 1997-03-12 S open_in_new
1IKL - A Nmr None Monomer 1995-10-15 10.1021/BI00040A008 open_in_new
1IKM - A Nmr None Monomer 1995-10-15 10.1021/BI00040A008 open_in_new
1IL8 - A,B Nmr None Dimer 1991-01-15 10.1021/BI00459A004 open_in_new
1ILP - A,B Nmr None Dimer 1998-12-23 10.1016/S0969-2126(99)80022-7 open_in_new
1ILQ - A,B Nmr None Dimer 1998-12-23 10.1016/S0969-2126(99)80022-7 open_in_new
1QE6 - A,B,C,D X-ray 2.35 Dimer 2000-03-22 2-S open_in_new
1ROD - A,B Nmr None Dimer 1996-06-10 10.1111/J.1432-1033.1996.00026.X open_in_new
2IL8 - A,B Nmr None Dimer 1991-01-15 10.1021/BI00459A004 open_in_new
3IL8 - A X-ray 2.0 Monomer 1992-10-15 10.1073/PNAS.88.2.502 open_in_new
4XDX - A X-ray 0.95 Monomer 2015-12-23 -
5D14 - A X-ray 1.0 Monomer 2015-12-23 -
5WDZ - A Nmr None Monomer 2017-11-29 10.1007/S10858-017-0128-3 open_in_new
6WZM - E, F X-ray 2.28 Dimer 2020-11-25 10.1080/19420862.2020.1831880 open_in_new
6LFM - E, D Cryo-em 3.5 Dimer 2020-09-02 10.1038/S41586-020-2492-5 open_in_new
6LFO - D Cryo-em 3.4 Monomer 2020-09-02 10.1038/S41586-020-2492-5 open_in_new
6N2U - A X-ray 1.25 Monomer 2019-11-20 -
6XMN - A Nmr None Monomer 2021-07-07 -
8IC0 - F Cryo-em 3.41 Monomer 2023-07-19 10.1038/S41467-023-39799-2 open_in_new
8XWN - D,E Cryo-em 3.29 Dimer 2025-01-15 -
8XX6 - D,E Cryo-em 2.99 Dimer 2025-01-15 -

Predicted models and complexes

Type Partner Method State Date View
Complex XCR1 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR6 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR5 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR4 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR3 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR2 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR1 AlphaFold-Multimer - 2025-11-11 Open
Complex CX3CR1 AlphaFold-Multimer - 2025-11-11 Open
Complex CCRL2 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR9 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR8 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR7 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR6 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR5 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR4 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR3 AlphaFold-Multimer - 2025-11-10 Open
Complex CCR2 AlphaFold-Multimer - 2025-11-10 Open
Complex CCR1 AlphaFold-Multimer - 2025-11-10 Open
Complex CCR10 AlphaFold-Multimer - 2025-11-10 Open
Complex ACKR4 AlphaFold-Multimer - 2025-11-10 Open
Complex ACKR3 AlphaFold-Multimer - 2025-11-10 Open
Complex ACKR2 AlphaFold-Multimer - 2025-11-10 Open
Complex ACKR1 AlphaFold-Multimer - 2025-11-10 Open
SEQUENCE ALIGNMENT

Canonical residues are compared against each available structure at matched CCN positions.

Position NTc.Cm33 NTc.Cm32 NTc.Cm31 NTc.Cm30 NTc.Cm29 NTc.Cm28 NTc.Cm27 NTc.Cm26 NTc.Cm25 NTc.Cm24 NTc.Cm23 NTc.Cm22 NTc.Cm21 NTc.Cm20 NTc.Cm19 NTc.Cm18 NTc.Cm17 NTc.Cm16 NTc.Cm15 NTc.Cm14 NTc.Cm13 NTc.Cm12 NTc.Cm11 NTc.Cm10 NTc.Cm9 NTc.Cm8 NTc.Cm7 NTc.Cm6 NTc.Cm5 NTc.Cm4 NTc.Cm3 NTc.Cm2 NTc.Cm1 CX.1 CX.4 CX.5 cxb1.1 cxb1.2 cxb1.5 cxb1.6 cxb1.7 cxb1.8 cxb1.10 cxb1.11 cxb1.14 cxb1.15 cxb1.16 B1.1 B1.2 B1.3 B1.4 B1.5 B1.6 B1.7 b1b2.4 b1b2.6 b1b2.7 b1b2.8 b1b2.9 b1b2.10 b1b2.12 b1b2.13 b1b2.14 b1b2.16 B2.1 B2.2 B2.3 B2.4 B2.5 B2.6 b2b3.2 b2b3.4 b2b3.11 b2b3.12 B3.1 B3.2 B3.3 B3.4 b3h.1 b3h.2 b3h.3 b3h.4 H.1 H.2 H.3 H.4 H.5 H.6 H.7 H.8 H.9 H.10 CT.1 CT.2 CT.3 CT.4 CT.5 CT.6 CT.7
Canonical sequence M T S K L A V A L L A A F L I S A A L C E G A V L P R S A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
1ICW - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T C I I V K L S D G R E L A L D P K E N W V Q R V V E K F L K R A E N S
1IKL - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - E L R C Q C I K T Y S K P F H P K F I K E - R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
1IKM - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - E L R C Q C I K T Y S K P F H P K F I K E - R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
1IL8 - - - - - - - - - - - - - - - - - - - - - - - - - - - - A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
1ILP - - - - - - - - - - - - - - - - - - - - - - - - - - - - A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
1ILQ - - - - - - - - - - - - - - - - - - - - - - - - - - - - A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
1QE6 - - - - - - - - - - - - - - - - - - - - - - - - - - - S A K E C R C Q C I K T Y S K P F H P K F I K E L R V I E S G P C C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
1ROD - - - - - - - - - - - - - - - - - - - - - - - - - - - S A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P A S P I V K K I I E K M L N S D K S N
2IL8 - - - - - - - - - - - - - - - - - - - - - - - - - - - - A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
3IL8 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
4XDX - - - - - - - - - - - - - - - - - - - - - - - - - - - - - K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
5D14 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
5WDZ - - - - - - - - - - - - - - - - - - - - - - - - - - - S A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L - - - - - -
6WZM - - - - - - - - - - - - - - - - - - - - - - - - - - - - A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L - - - - - -
6LFM - - - - - - - - - - - - - - - - - - - - - - - - - - - - A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
6LFO - - - - - - - - - - - - - - - - - - - - - - - - - - - - A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F - - - - - - -
6N2U - - - - - - - - - - - - - - - - - - - - - - - - - - - - - K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N -
6XMN - - - - - - - - - - - - - - - - - - - - - - - - - - - S A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L - - - - - -
8IC0 - - - - - - - - - - - - - - - - - - - - - - - - - - - S A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A - - -
8XWN - - - - - - - - - - - - - - - - - - - - - - - - - P R S A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N -
8XX6 - - - - - - - - - - - - - - - - - - - - - - - - - P R S A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N -