CXCL8_HUMAN

  • Alternate name(s): Interleukin-8, IL-8, C-X-C motif chemokine 8, Chemokine (C-X-C motif) ligand 8, Emoctakin, Granulocyte chemotactic protein 1, GCP-1, Monocyte-derived neutrophil chemotactic factor, MDNCF, Monocyte-derived neutrophil-activating peptide, MONAP, Neutrophil-activating protein 1, NAP-1, Protein 3-10C, T-cell chemotactic factor, MDNCF-a, GCP/IL-8 protein IV, IL8/NAP1 form I, Interleukin-8, (Ala-IL-8)77, GCP/IL-8 protein II, IL-8(1-77), IL8/NAP1 form II, MDNCF-b, IL-8(5-77), IL-8(6-77), (Ser-IL-8)72, GCP/IL-8 protein I, IL8/NAP1 form III, Lymphocyte-derived neutrophil-activating factor, LYNAP, MDNCF-c, Neutrophil-activating factor, NAF, IL-8(7-77), GCP/IL-8 protein V, IL8/NAP1 form IV, IL-8(8-77), GCP/IL-8 protein VI, IL8/NAP1 form V, IL-8(9-77), GCP/IL-8 protein III, IL8/NAP1 form VI
  • Organism: Homo sapiens
  • UniProt ID: P10145 open_in_new


Sequence

N-term   CX   N-loop   B1   30s-loop   B2   40s-loop   B3   50s-loop   Helix   C-term  
30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62   63 66 67   68 69 70 71 72 73 74 75 76 80 81 82   83 84 85 86 87 88 89   90 91 92 93 94 95 96 97 99 100   101 102 103 104 105   106 112 113 114   115 116 117 118   119 120 121 122   123 124 125 126 127 128 129 130 131 132 133 134 135   136 137 138 139  
M T S K L A V A L L A A F L I S A A L C E G A V L P R S A K E L R   C Q C   I K T Y S K P F H P K F   I K E L R V I   E S G P H C A N T E   I I V K L   S D G R   E L C L   D P K E   N W V Q R V V E K F L K R   A E N S  

Snake Plot

E S G P H C A N T E 30s-loop S D G R 40s-loop D P K E 50s-loopN-term M T S K L A V A L L A A F L I S A A L C E G A V L P R S A K E L R C Q C I K T Y S K P F H P K F N-termC-term A E N S C-term I V R L E K I I I V K L L C L E N W V Q R V V E K F L K R
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List of structures

PDB Method Resolution State Publication date Reference
1ICW X-ray 2.01 dimer 1997-03-12 S open_in_new
1IKL Solution nmr 0.0 monomer 1995-10-15 10.1021/BI00040A008 open_in_new
1IKM Solution nmr 0.0 monomer 1995-10-15 10.1021/BI00040A008 open_in_new
1IL8 Solution nmr 0.0 dimer 1991-01-15 10.1021/BI00459A004 open_in_new
1ILP Solution nmr 0.0 dimer 1998-12-23 10.1016/S0969-2126(99)80022-7 open_in_new
1ILQ Solution nmr 0.0 dimer 1998-12-23 10.1016/S0969-2126(99)80022-7 open_in_new
1QE6 X-ray 2.35 dimer 2000-03-22 2-S open_in_new
1ROD Solution nmr 0.0 dimer 1996-06-10 10.1111/J.1432-1033.1996.00026.X open_in_new
2IL8 Solution nmr 0.0 dimer 1991-01-15 10.1021/BI00459A004 open_in_new
3IL8 X-ray 2.0 dimer 1992-10-15 10.1073/PNAS.88.2.502 open_in_new
4XDX X-ray 0.95 monomer 2015-12-23 -
5D14 X-ray 1.0 monomer 2015-12-23 -
5WDZ Solution nmr 0.0 monomer 2017-11-29 10.1007/S10858-017-0128-3 open_in_new
6LFM Cryo-em 3.5 dimer 2020-09-02 10.1038/S41586-020-2492-5 open_in_new
6LFO Cryo-em 3.4 monomer 2020-09-02 10.1038/S41586-020-2492-5 open_in_new
6N2U X-ray 1.25 dimer 2019-11-20 -
6WZM X-ray 2.28 dimer 2020-11-25 10.1080/19420862.2020.1831880 open_in_new
6XMN Solution nmr 0.0 monomer 2021-07-07 -
8IC0 Cryo-em 3.41 monomer 2023-07-19 10.1038/S41467-023-39799-2 open_in_new

Targets (Guide to Pharmacology)

No targets found