CXCL8_HUMAN

  • Alternate name(s): Interleukin-8
  • Organism: Homo sapiens
  • UniProt ID: P10145 open_in_new


Wild type sequence

Residue N-term   CX   N-loop   B1   30s-loop   B2   40s-loop   B3   50s-loop   Helix   C-term  
  NTc.Cm33 NTc.Cm32 NTc.Cm31 NTc.Cm30 NTc.Cm29 NTc.Cm28 NTc.Cm27 NTc.Cm26 NTc.Cm25 NTc.Cm24 NTc.Cm23 NTc.Cm22 NTc.Cm21 NTc.Cm20 NTc.Cm19 NTc.Cm18 NTc.Cm17 NTc.Cm16 NTc.Cm15 NTc.Cm14 NTc.Cm13 NTc.Cm12 NTc.Cm11 NTc.Cm10 NTc.Cm9 NTc.Cm8 NTc.Cm7 NTc.Cm6 NTc.Cm5 NTc.Cm4 NTc.Cm3 NTc.Cm2 NTc.Cm1   CX.1 CX.4 CX.5   cxb1.1 cxb1.2 cxb1.5 cxb1.6 cxb1.7 cxb1.8 cxb1.10 cxb1.11 cxb1.14 cxb1.15 cxb1.16   B1.1 B1.2 B1.3 B1.4 B1.5 B1.6 B1.7   b1b2.4 b1b2.6 b1b2.7 b1b2.8 b1b2.9 b1b2.10 b1b2.12 b1b2.13 b1b2.14 b1b2.16   B2.1 B2.2 B2.3 B2.4 B2.5 B2.6   b2b3.2 b2b3.4 b2b3.11 b2b3.12   B3.1 B3.2 B3.3 B3.4   b3h.1 b3h.2 b3h.3 b3h.4   H.1 H.2 H.3 H.4 H.5 H.6 H.7 H.8 H.9 H.10   CT.1 CT.2 CT.3 CT.4 CT.5 CT.6 CT.7  
Wild Type M T S K L A V A L L A A F L I S A A L C E G A V L P R S A K E L R   C Q C   I K T Y S K P F H P K   F I K E L R V   I E S G P H C A N T   E I I V K L   S D G R   E L C L   D P K E   N W V Q R V V E K F   L K R A E N S  

Snake Plot

I E S G P H C A N T 30s-loop S D G R 40s-loop D P K E 50s-loopC-term M T S K L A V A L L A A F L I S A A L C E G A V L P R S A K E L R C Q C I K T Y S K P F H P K N-term V R L E K I F E I I V K L L C L E N W V Q R V V E K F L K R A E N S
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List of structures

PDB Method Resolution State Publication date Reference
1ICW - A,B X-ray 2.01 Dimer 1997-03-12 S open_in_new
1IKL - A Nmr None Monomer 1995-10-15 10.1021/BI00040A008 open_in_new
1IKM - A Nmr None Monomer 1995-10-15 10.1021/BI00040A008 open_in_new
1IL8 - A,B Nmr None Dimer 1991-01-15 10.1021/BI00459A004 open_in_new
1ILP - A,B Nmr None Dimer 1998-12-23 10.1016/S0969-2126(99)80022-7 open_in_new
1ILQ - A,B Nmr None Dimer 1998-12-23 10.1016/S0969-2126(99)80022-7 open_in_new
1QE6 - A,B,C,D X-ray 2.35 Dimer 2000-03-22 2-S open_in_new
1ROD - A,B Nmr None Dimer 1996-06-10 10.1111/J.1432-1033.1996.00026.X open_in_new
2IL8 - A,B Nmr None Dimer 1991-01-15 10.1021/BI00459A004 open_in_new
3IL8 - A X-ray 2.0 Monomer 1992-10-15 10.1073/PNAS.88.2.502 open_in_new
4XDX - A X-ray 0.95 Monomer 2015-12-23 -
5D14 - A X-ray 1.0 Monomer 2015-12-23 -
5WDZ - A Nmr None Monomer 2017-11-29 10.1007/S10858-017-0128-3 open_in_new
6WZM - E, F X-ray 2.28 Dimer 2020-11-25 10.1080/19420862.2020.1831880 open_in_new
6LFM - E, D Cryo-em 3.5 Dimer 2020-09-02 10.1038/S41586-020-2492-5 open_in_new
6LFO - D Cryo-em 3.4 Monomer 2020-09-02 10.1038/S41586-020-2492-5 open_in_new
6N2U - A X-ray 1.25 Monomer 2019-11-20 -
6XMN - A Nmr None Monomer 2021-07-07 -
8IC0 - F Cryo-em 3.41 Monomer 2023-07-19 10.1038/S41467-023-39799-2 open_in_new
8XWN - D,E Cryo-em 3.29 Dimer 2025-01-15 -
8XX6 - D,E Cryo-em 2.99 Dimer 2025-01-15 -

Sequence alignment from structures

Position NTc.Cm33 NTc.Cm32 NTc.Cm31 NTc.Cm30 NTc.Cm29 NTc.Cm28 NTc.Cm27 NTc.Cm26 NTc.Cm25 NTc.Cm24 NTc.Cm23 NTc.Cm22 NTc.Cm21 NTc.Cm20 NTc.Cm19 NTc.Cm18 NTc.Cm17 NTc.Cm16 NTc.Cm15 NTc.Cm14 NTc.Cm13 NTc.Cm12 NTc.Cm11 NTc.Cm10 NTc.Cm9 NTc.Cm8 NTc.Cm7 NTc.Cm6 NTc.Cm5 NTc.Cm4 NTc.Cm3 NTc.Cm2 NTc.Cm1 CX.1 CX.4 CX.5 cxb1.1 cxb1.2 cxb1.5 cxb1.6 cxb1.7 cxb1.8 cxb1.10 cxb1.11 cxb1.14 cxb1.15 cxb1.16 B1.1 B1.2 B1.3 B1.4 B1.5 B1.6 B1.7 b1b2.4 b1b2.6 b1b2.7 b1b2.8 b1b2.9 b1b2.10 b1b2.12 b1b2.13 b1b2.14 b1b2.16 B2.1 B2.2 B2.3 B2.4 B2.5 B2.6 b2b3.2 b2b3.4 b2b3.11 b2b3.12 B3.1 B3.2 B3.3 B3.4 b3h.1 b3h.2 b3h.3 b3h.4 H.1 H.2 H.3 H.4 H.5 H.6 H.7 H.8 H.9 H.10 CT.1 CT.2 CT.3 CT.4 CT.5 CT.6 CT.7
Canonical Sequence M T S K L A V A L L A A F L I S A A L C E G A V L P R S A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
1ICW - A,B - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T C I I V K L S D G R E L A L D P K E N W V Q R V V E K F L K R A E N S
1IKL - A - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - E L R C Q C I K T Y S K P F H P K F I K E - R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
1IKM - A - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - E L R C Q C I K T Y S K P F H P K F I K E - R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
1IL8 - A,B - - - - - - - - - - - - - - - - - - - - - - - - - - - - A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
1ILP - A,B - - - - - - - - - - - - - - - - - - - - - - - - - - - - A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
1ILQ - A,B - - - - - - - - - - - - - - - - - - - - - - - - - - - - A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
1QE6 - A,B,C,D - - - - - - - - - - - - - - - - - - - - - - - - - - - S A K E C R C Q C I K T Y S K P F H P K F I K E L R V I E S G P C C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
1ROD - A,B - - - - - - - - - - - - - - - - - - - - - - - - - - - S A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P A S P I V K K I I E K M L N S D K S N
2IL8 - A,B - - - - - - - - - - - - - - - - - - - - - - - - - - - - A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
3IL8 - A - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
4XDX - A - - - - - - - - - - - - - - - - - - - - - - - - - - - - - K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
5D14 - A - - - - - - - - - - - - - - - - - - - - - - - - - - - - - K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
5WDZ - A - - - - - - - - - - - - - - - - - - - - - - - - - - - S A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L - - - - - -
6WZM - E, F - - - - - - - - - - - - - - - - - - - - - - - - - - - - A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L - - - - - -
6LFM - E, D - - - - - - - - - - - - - - - - - - - - - - - - - - - - A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N S
6LFO - D - - - - - - - - - - - - - - - - - - - - - - - - - - - - A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F - - - - - - -
6N2U - A - - - - - - - - - - - - - - - - - - - - - - - - - - - - - K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N -
6XMN - A - - - - - - - - - - - - - - - - - - - - - - - - - - - S A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L - - - - - -
8IC0 - F - - - - - - - - - - - - - - - - - - - - - - - - - - - S A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A - - -
8XWN - D,E - - - - - - - - - - - - - - - - - - - - - - - - - P R S A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N -
8XX6 - D,E - - - - - - - - - - - - - - - - - - - - - - - - - P R S A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N -