Structure

1A15 | CXCL12_HUMAN

SUMMARY
PDB ID
1A15 Open RCSB entry
Protein
CXCL12_HUMAN View protein entry
Organism
Homo sapiens
UniProt ID
P48061 Open UniProt
Method
X-ray
Resolution
2.2 Å
State
Dimer
Publication
10.1073/PNAS.95.12.6941 Open DOI
Release date
1998-08-12
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SEQUENCE ALIGNMENT

Comparison between the canonical chemokine sequence and residues observed in the experimental structure across canonical numbering positions.

Segment N-term   CX   N-loop   B1   30s-loop   B2   40s-loop   B3   50s-loop   Helix   C-term  
  NTc.Cm29 NTc.Cm28 NTc.Cm27 NTc.Cm26 NTc.Cm25 NTc.Cm24 NTc.Cm23 NTc.Cm22 NTc.Cm21 NTc.Cm20 NTc.Cm19 NTc.Cm18 NTc.Cm17 NTc.Cm16 NTc.Cm15 NTc.Cm14 NTc.Cm13 NTc.Cm12 NTc.Cm11 NTc.Cm10 NTc.Cm9 NTc.Cm8 NTc.Cm7 NTc.Cm6 NTc.Cm5 NTc.Cm4 NTc.Cm3 NTc.Cm2 NTc.Cm1   CX.1 CX.4 CX.5   cxb1.1 cxb1.2 cxb1.5 cxb1.6 cxb1.8 cxb1.10 cxb1.11 cxb1.14 cxb1.15 cxb1.16   B1.1 B1.2 B1.3 B1.4 B1.5 B1.6 B1.7   b1b2.4 b1b2.7 b1b2.8 b1b2.9 b1b2.10 b1b2.12 b1b2.14 b1b2.16   B2.1 B2.2 B2.3 B2.4 B2.5 B2.6   b2b3.2 b2b3.3 b2b3.4 b2b3.11 b2b3.12   B3.1 B3.2 B3.3 B3.4   b3h.1 b3h.2 b3h.3 b3h.4   H.1 H.2 H.3 H.4 H.5 H.6 H.7 H.8 H.9 H.10   CT.1 CT.2 CT.3 CT.4 CT.5 CT.6 CT.7  
UniProt sequence M N A K V V V V L V L V L T A L C L S D G K P V S L S Y R   C P C   R F F E S H V A R A   N V K H L K I   L N T P N C A L   Q I V A R L   K N N N R   Q V C I   D P K L   K W I Q E Y L E K A   L N K R F K M  
Structure (chain A) - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R   C P C   R F F E S H V A R A   N V K H L K I   L N T P A C A L   Q I V A R L   K N N N R   Q V C I   D P K L   K W I Q E Y L E K A   L N - - - - -  
Structure (chain B) - - - - - - - - - - - - - - - - - - - - - - - - - - - - R   C P C   R F F E S H V A R A   N V K H L K I   L N T P A C A L   Q I V A R L   K N N N R   Q V C I   D P K L   K W I Q E Y L E K -   - - - - - - -  
Chemokine-partner complexes

No chemokine binding partners are registered for this structure.