UniProt Sequence |
M
|
A
|
Q
|
S
|
L
|
A
|
L
|
S
|
L
|
L
|
I
|
L
|
V
|
L
|
A
|
F
|
G
|
I
|
P
|
R
|
T
|
Q
|
G
|
S
|
D
|
G
|
G
|
A
|
Q
|
D
|
C
|
C
|
L
|
K
|
Y
|
S
|
Q
|
R
|
K
|
I
|
P
|
A
|
K
|
V
|
V
|
R
|
S
|
Y
|
R
|
K
|
Q
|
E
|
P
|
S
|
L
|
G
|
C
|
S
|
I
|
P
|
A
|
I
|
L
|
F
|
L
|
P
|
R
|
K
|
R
|
S
|
Q
|
A
|
E
|
L
|
C
|
A
|
D
|
P
|
K
|
E
|
L
|
W
|
V
|
Q
|
Q
|
L
|
M
|
Q
|
H
|
L
|
D
|
K
|
T
|
P
|
S
|
P
|
Q
|
K
|
P
|
A
|
Q
|
G
|
C
|
R
|
K
|
D
|
R
|
G
|
A
|
S
|
K
|
T
|
G
|
K
|
K
|
G
|
K
|
G
|
S
|
K
|
G
|
C
|
K
|
R
|
T
|
E
|
R
|
S
|
Q
|
T
|
P
|
K
|
G
|
P
|
Structure Sequence (Chain E) |
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
A
|
Q
|
D
|
C
|
C
|
L
|
K
|
Y
|
S
|
Q
|
R
|
K
|
I
|
P
|
A
|
K
|
V
|
V
|
R
|
S
|
Y
|
R
|
K
|
Q
|
E
|
P
|
S
|
L
|
G
|
C
|
S
|
I
|
P
|
A
|
I
|
L
|
F
|
L
|
P
|
R
|
K
|
R
|
S
|
Q
|
A
|
E
|
L
|
C
|
A
|
D
|
P
|
K
|
E
|
L
|
W
|
V
|
Q
|
Q
|
L
|
M
|
Q
|
H
|
L
|
D
|
K
|
T
|
P
|
S
|
P
|
Q
|
K
|
P
|
A
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
Structure Sequence (Chain A) |
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
Q
|
D
|
C
|
C
|
L
|
K
|
Y
|
S
|
Q
|
R
|
K
|
I
|
P
|
A
|
K
|
V
|
V
|
R
|
S
|
Y
|
R
|
K
|
Q
|
E
|
P
|
S
|
L
|
G
|
C
|
S
|
I
|
P
|
A
|
I
|
L
|
F
|
L
|
P
|
R
|
K
|
R
|
S
|
Q
|
A
|
E
|
L
|
C
|
A
|
D
|
P
|
K
|
E
|
L
|
W
|
V
|
Q
|
Q
|
L
|
M
|
Q
|
H
|
L
|
D
|
K
|
T
|
P
|
S
|
P
|
Q
|
K
|
P
|
A
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
Structure Sequence (Chain D) |
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
Q
|
D
|
C
|
C
|
L
|
K
|
Y
|
S
|
Q
|
R
|
K
|
I
|
P
|
A
|
K
|
V
|
V
|
R
|
S
|
Y
|
R
|
K
|
Q
|
E
|
P
|
S
|
L
|
G
|
C
|
S
|
I
|
P
|
A
|
I
|
L
|
F
|
L
|
P
|
R
|
K
|
R
|
S
|
Q
|
A
|
E
|
L
|
C
|
A
|
D
|
P
|
K
|
E
|
L
|
W
|
V
|
Q
|
Q
|
L
|
M
|
Q
|
H
|
L
|
D
|
K
|
T
|
P
|
S
|
P
|
Q
|
K
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
P
|
Structure Sequence (Chain B) |
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
Q
|
D
|
C
|
C
|
L
|
K
|
Y
|
S
|
Q
|
R
|
K
|
I
|
P
|
A
|
K
|
V
|
V
|
R
|
S
|
Y
|
R
|
K
|
Q
|
E
|
P
|
S
|
L
|
G
|
C
|
S
|
I
|
P
|
A
|
I
|
L
|
F
|
L
|
P
|
R
|
K
|
R
|
S
|
Q
|
A
|
E
|
L
|
C
|
A
|
D
|
P
|
K
|
E
|
L
|
W
|
V
|
Q
|
Q
|
L
|
M
|
Q
|
H
|
L
|
D
|
K
|
T
|
P
|
S
|
P
|
Q
|
K
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
P
|
Structure Sequence (Chain C) |
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
D
|
C
|
C
|
L
|
K
|
Y
|
S
|
Q
|
R
|
K
|
I
|
P
|
A
|
K
|
V
|
V
|
R
|
S
|
Y
|
R
|
K
|
Q
|
E
|
P
|
S
|
L
|
G
|
C
|
S
|
I
|
P
|
A
|
I
|
L
|
F
|
L
|
P
|
R
|
K
|
R
|
S
|
Q
|
A
|
E
|
L
|
C
|
A
|
D
|
P
|
K
|
E
|
L
|
W
|
V
|
Q
|
Q
|
L
|
M
|
Q
|
H
|
L
|
D
|
K
|
T
|
P
|
S
|
P
|
Q
|
K
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
P
|
Structure Sequence (Chain F) |
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
D
|
C
|
C
|
L
|
K
|
Y
|
S
|
Q
|
R
|
K
|
I
|
P
|
A
|
K
|
V
|
V
|
R
|
S
|
Y
|
R
|
K
|
Q
|
E
|
P
|
S
|
L
|
G
|
C
|
S
|
I
|
P
|
A
|
I
|
L
|
F
|
L
|
P
|
R
|
K
|
R
|
S
|
Q
|
A
|
E
|
L
|
C
|
A
|
D
|
P
|
K
|
E
|
L
|
W
|
V
|
Q
|
Q
|
L
|
M
|
Q
|
H
|
L
|
D
|
K
|
T
|
P
|
S
|
P
|
Q
|
K
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
P
|
Mutation |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|