| UniProt Sequence |
M
|
K
|
V
|
S
|
A
|
A
|
A
|
L
|
A
|
V
|
I
|
L
|
I
|
A
|
T
|
A
|
L
|
C
|
A
|
P
|
A
|
S
|
A
|
S
|
P
|
Y
|
S
|
S
|
D
|
T
|
T
|
P
|
C
|
C
|
F
|
A
|
Y
|
I
|
A
|
R
|
P
|
L
|
P
|
R
|
A
|
H
|
I
|
K
|
E
|
Y
|
F
|
Y
|
T
|
S
|
G
|
K
|
C
|
S
|
N
|
P
|
A
|
V
|
V
|
F
|
V
|
T
|
R
|
K
|
N
|
R
|
Q
|
V
|
C
|
A
|
N
|
P
|
E
|
K
|
K
|
W
|
V
|
R
|
E
|
Y
|
I
|
N
|
S
|
L
|
E
|
M
|
S
|
| Structure Sequence (Chain I) |
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
S
|
S
|
D
|
T
|
T
|
P
|
C
|
C
|
F
|
A
|
Y
|
I
|
A
|
R
|
P
|
L
|
P
|
R
|
A
|
H
|
I
|
K
|
E
|
Y
|
F
|
Y
|
T
|
S
|
G
|
K
|
C
|
S
|
N
|
P
|
A
|
V
|
V
|
F
|
V
|
T
|
R
|
K
|
N
|
R
|
Q
|
V
|
C
|
A
|
N
|
P
|
E
|
K
|
K
|
W
|
V
|
R
|
E
|
Y
|
I
|
N
|
S
|
L
|
E
|
M
|
S
|
| Structure Sequence (Chain A) |
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
S
|
S
|
D
|
T
|
T
|
P
|
C
|
C
|
F
|
A
|
Y
|
I
|
A
|
R
|
P
|
L
|
P
|
R
|
A
|
H
|
I
|
K
|
E
|
Y
|
F
|
Y
|
T
|
S
|
G
|
K
|
C
|
S
|
N
|
P
|
A
|
V
|
V
|
F
|
V
|
T
|
R
|
K
|
N
|
R
|
Q
|
V
|
C
|
A
|
N
|
P
|
E
|
K
|
K
|
W
|
V
|
R
|
E
|
Y
|
I
|
N
|
S
|
L
|
E
|
M
|
S
|
| Structure Sequence (Chain B) |
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
S
|
S
|
D
|
T
|
T
|
P
|
C
|
C
|
F
|
A
|
Y
|
I
|
A
|
R
|
P
|
L
|
P
|
R
|
A
|
H
|
I
|
K
|
E
|
Y
|
F
|
Y
|
T
|
S
|
G
|
K
|
C
|
S
|
N
|
P
|
A
|
V
|
V
|
F
|
V
|
T
|
R
|
K
|
N
|
R
|
Q
|
V
|
C
|
A
|
N
|
P
|
E
|
K
|
K
|
W
|
V
|
R
|
E
|
Y
|
I
|
N
|
S
|
L
|
E
|
M
|
S
|
| Structure Sequence (Chain C) |
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
S
|
S
|
D
|
T
|
T
|
P
|
C
|
C
|
F
|
A
|
Y
|
I
|
A
|
R
|
P
|
L
|
P
|
R
|
A
|
H
|
I
|
K
|
E
|
Y
|
F
|
Y
|
T
|
S
|
G
|
K
|
C
|
S
|
N
|
P
|
A
|
V
|
V
|
F
|
V
|
T
|
R
|
K
|
N
|
R
|
Q
|
V
|
C
|
A
|
N
|
P
|
E
|
K
|
K
|
W
|
V
|
R
|
E
|
Y
|
I
|
N
|
S
|
L
|
E
|
M
|
S
|
| Structure Sequence (Chain E) |
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
S
|
S
|
D
|
T
|
T
|
P
|
C
|
C
|
F
|
A
|
Y
|
I
|
A
|
R
|
P
|
L
|
P
|
R
|
A
|
H
|
I
|
K
|
E
|
Y
|
F
|
Y
|
T
|
S
|
G
|
K
|
C
|
S
|
N
|
P
|
A
|
V
|
V
|
F
|
V
|
T
|
R
|
K
|
N
|
R
|
Q
|
V
|
C
|
A
|
N
|
P
|
E
|
K
|
K
|
W
|
V
|
R
|
E
|
Y
|
I
|
N
|
S
|
L
|
E
|
M
|
S
|
| Structure Sequence (Chain D) |
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
S
|
D
|
T
|
T
|
P
|
C
|
C
|
F
|
A
|
Y
|
I
|
A
|
R
|
P
|
L
|
P
|
R
|
A
|
H
|
I
|
K
|
E
|
Y
|
F
|
Y
|
T
|
S
|
G
|
K
|
C
|
S
|
N
|
P
|
A
|
V
|
V
|
F
|
V
|
T
|
R
|
K
|
N
|
R
|
Q
|
V
|
C
|
A
|
N
|
P
|
E
|
K
|
K
|
W
|
V
|
R
|
E
|
Y
|
I
|
N
|
S
|
L
|
E
|
M
|
S
|
| Structure Sequence (Chain F) |
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
S
|
D
|
T
|
T
|
P
|
C
|
C
|
F
|
A
|
Y
|
I
|
A
|
R
|
P
|
L
|
P
|
R
|
A
|
H
|
I
|
K
|
E
|
Y
|
F
|
Y
|
T
|
S
|
G
|
K
|
C
|
S
|
N
|
P
|
A
|
V
|
V
|
F
|
V
|
T
|
R
|
K
|
N
|
R
|
Q
|
V
|
C
|
A
|
N
|
P
|
E
|
K
|
K
|
W
|
V
|
R
|
E
|
Y
|
I
|
N
|
S
|
L
|
E
|
M
|
S
|
| Structure Sequence (Chain G) |
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
S
|
D
|
T
|
T
|
P
|
C
|
C
|
F
|
A
|
Y
|
I
|
A
|
R
|
P
|
L
|
P
|
R
|
A
|
H
|
I
|
K
|
E
|
Y
|
F
|
Y
|
T
|
S
|
G
|
K
|
C
|
S
|
N
|
P
|
A
|
V
|
V
|
F
|
V
|
T
|
R
|
K
|
N
|
R
|
Q
|
V
|
C
|
A
|
N
|
P
|
E
|
K
|
K
|
W
|
V
|
R
|
E
|
Y
|
I
|
N
|
S
|
L
|
E
|
M
|
S
|
| Structure Sequence (Chain H) |
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
S
|
D
|
T
|
T
|
P
|
C
|
C
|
F
|
A
|
Y
|
I
|
A
|
R
|
P
|
L
|
P
|
R
|
A
|
H
|
I
|
K
|
E
|
Y
|
F
|
Y
|
T
|
S
|
G
|
K
|
C
|
S
|
N
|
P
|
A
|
V
|
V
|
F
|
V
|
T
|
R
|
K
|
N
|
R
|
Q
|
V
|
C
|
A
|
N
|
P
|
E
|
K
|
K
|
W
|
V
|
R
|
E
|
Y
|
I
|
N
|
S
|
L
|
E
|
M
|
S
|
| Mutation |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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