Predicted complex interactions
CXCL12_HUMAN + ACKR3
SUMMARY
- Chemokine
- CXCL12_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- ACKR3 View partner entry
- Partner description
- UniProt: P25106; Gene: ackr3_human; Family: Chemokine
- Interactions detected
- 139
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LYS 1 | NTc.Cm29 | LEU 128 | 3.36x36 | Hydrophobic |
| LYS 1 | NTc.Cm29 | LEU 128 | 3.36x36 | VdWContact |
| LYS 1 | NTc.Cm29 | PHE 129 | 3.37x37 | VdWContact |
| LYS 1 | NTc.Cm29 | ASP 179 | 4.60x61 | Cationic |
| LYS 1 | NTc.Cm29 | ASP 179 | 4.60x61 | HBDonor |
| LYS 1 | NTc.Cm29 | ASP 179 | 4.60x61 | VdWContact |
| LYS 1 | NTc.Cm29 | SER 216 | 5.42x43 | HBDonor |
| LYS 1 | NTc.Cm29 | SER 216 | 5.42x43 | VdWContact |
| LYS 1 | NTc.Cm29 | TYR 268 | 6.51x51 | Hydrophobic |
| LYS 1 | NTc.Cm29 | TYR 268 | 6.51x51 | VdWContact |
| PRO 2 | NTc.Cm28 | TRP 100 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm28 | HIS 121 | 3.29x29 | Hydrophobic |
| PRO 2 | NTc.Cm28 | HIS 121 | 3.29x29 | VdWContact |
| PRO 2 | NTc.Cm28 | PHE 124 | 3.32x32 | Hydrophobic |
| VAL 3 | NTc.Cm27 | LEU 183 | 4.64x65 | Hydrophobic |
| VAL 3 | NTc.Cm27 | LEU 183 | 4.64x65 | VdWContact |
| VAL 3 | NTc.Cm27 | SER 198 | 45.52x52 | VdWContact |
| LEU 5 | NTc.Cm25 | ASN 108 | - | VdWContact |
| LEU 5 | NTc.Cm25 | LEU 297 | 7.35x34 | Hydrophobic |
| LEU 5 | NTc.Cm25 | LEU 297 | 7.35x34 | VdWContact |
| LEU 5 | NTc.Cm25 | HIS 298 | 7.36x35 | Hydrophobic |
| LEU 5 | NTc.Cm25 | HIS 298 | 7.36x35 | VdWContact |
| LEU 5 | NTc.Cm25 | GLN 301 | 7.39x38 | Hydrophobic |
| LEU 5 | NTc.Cm25 | GLN 301 | 7.39x38 | VdWContact |
| SER 6 | NTc.Cm24 | ASN 108 | - | VdWContact |
| SER 6 | NTc.Cm24 | CYS 196 | 45.50x50 | HBDonor |
| SER 6 | NTc.Cm24 | CYS 196 | 45.50x50 | VdWContact |
| TYR 7 | NTc.Cm23 | TYR 195 | - | PiStacking |
| TYR 7 | NTc.Cm23 | ARG 197 | 45.51x51 | Hydrophobic |
| TYR 7 | NTc.Cm23 | ARG 197 | 45.51x51 | PiCation |
| TYR 7 | NTc.Cm23 | ARG 197 | 45.51x51 | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 275 | 6.58x58 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 275 | 6.58x58 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 275 | 6.58x58 | VdWContact |
| ARG 8 | NTc.Cm22 | GLU 290 | 7.28x27 | Cationic |
| ARG 8 | NTc.Cm22 | GLU 290 | 7.28x27 | HBDonor |
| ARG 8 | NTc.Cm22 | GLU 290 | 7.28x27 | VdWContact |
| ARG 8 | NTc.Cm22 | LEU 293 | 7.31x30 | VdWContact |
| ARG 8 | NTc.Cm22 | PHE 294 | 7.32x31 | VdWContact |
| ARG 8 | NTc.Cm22 | LEU 297 | 7.35x34 | VdWContact |
| PRO 10 | NTc.Cm20 | PHE 285 | - | Hydrophobic |
| PRO 10 | NTc.Cm20 | PHE 285 | - | VdWContact |
| ARG 12 | NTc.Cm18 | LEU 209 | 5.35x36 | Hydrophobic |
| ARG 12 | NTc.Cm18 | LEU 209 | 5.35x36 | VdWContact |
| ARG 12 | NTc.Cm18 | GLU 213 | 5.39x40 | Cationic |
| ARG 12 | NTc.Cm18 | ASP 275 | 6.58x58 | Cationic |
| ARG 12 | NTc.Cm18 | ASP 275 | 6.58x58 | HBDonor |
| ARG 12 | NTc.Cm18 | ASP 275 | 6.58x58 | VdWContact |
| ARG 12 | NTc.Cm18 | ILE 279 | 6.62x62 | VdWContact |
| PHE 13 | NTc.Cm17 | ILE 205 | 5.31x32 | Hydrophobic |
| PHE 13 | NTc.Cm17 | LYS 206 | 5.32x33 | Hydrophobic |
| PHE 13 | NTc.Cm17 | ILE 279 | 6.62x62 | Hydrophobic |
| PHE 13 | NTc.Cm17 | ILE 279 | 6.62x62 | VdWContact |
| PHE 13 | NTc.Cm17 | LEU 280 | 6.63x63 | Hydrophobic |
| ARG 20 | NTc.Cm10 | ILE 27 | - | Hydrophobic |
| ARG 20 | NTc.Cm10 | ILE 27 | - | VdWContact |
| VAL 23 | NTc.Cm7 | ILE 27 | - | Hydrophobic |
| LYS 24 | NTc.Cm6 | VAL 28 | - | HBAcceptor |
| LYS 24 | NTc.Cm6 | VAL 28 | - | VdWContact |
| HIS 25 | NTc.Cm5 | VAL 28 | - | Hydrophobic |
| HIS 25 | NTc.Cm5 | VAL 28 | - | VdWContact |
| HIS 25 | NTc.Cm5 | ASP 30 | - | HBDonor |
| HIS 25 | NTc.Cm5 | ASP 30 | - | Hydrophobic |
| HIS 25 | NTc.Cm5 | ASP 30 | - | VdWContact |
| LEU 26 | NTc.Cm4 | ILE 27 | - | Hydrophobic |
| LEU 26 | NTc.Cm4 | ILE 27 | - | VdWContact |
| LEU 26 | NTc.Cm4 | VAL 28 | - | HBDonor |
| LEU 26 | NTc.Cm4 | VAL 28 | - | VdWContact |
| LEU 26 | NTc.Cm4 | VAL 29 | - | Hydrophobic |
| LEU 26 | NTc.Cm4 | VAL 29 | - | VdWContact |
| LEU 26 | NTc.Cm4 | ASP 30 | - | HBAcceptor |
| LEU 26 | NTc.Cm4 | ASP 30 | - | VdWContact |
| LYS 27 | NTc.Cm3 | ASP 30 | - | VdWContact |
| LYS 27 | NTc.Cm3 | VAL 32 | - | Hydrophobic |
| LYS 27 | NTc.Cm3 | VAL 32 | - | VdWContact |
| LYS 27 | NTc.Cm3 | PHE 285 | - | HBDonor |
| LYS 27 | NTc.Cm3 | PHE 285 | - | VdWContact |
| ILE 28 | NTc.Cm2 | PHE 14 | - | Hydrophobic |
| ILE 28 | NTc.Cm2 | TRP 19 | - | Hydrophobic |
| ILE 28 | NTc.Cm2 | VAL 29 | - | Hydrophobic |
| ILE 28 | NTc.Cm2 | ASP 30 | - | HBDonor |
| ILE 28 | NTc.Cm2 | ASP 30 | - | VdWContact |
| ILE 28 | NTc.Cm2 | THR 31 | - | Hydrophobic |
| ILE 28 | NTc.Cm2 | THR 31 | - | VdWContact |
| ILE 28 | NTc.Cm2 | VAL 32 | - | HBAcceptor |
| ILE 28 | NTc.Cm2 | VAL 32 | - | VdWContact |
| LEU 29 | NTc.Cm1 | VAL 32 | - | Hydrophobic |
| LEU 29 | NTc.Cm1 | PHE 285 | - | Hydrophobic |
| ASN 30 | CX.1 | PRO 11 | - | VdWContact |
| ASN 30 | CX.1 | VAL 32 | - | HBDonor |
| ASN 30 | CX.1 | VAL 32 | - | VdWContact |
| ASN 30 | CX.1 | MET 33 | - | VdWContact |
| ASN 30 | CX.1 | CYS 34 | - | HBAcceptor |
| ASN 30 | CX.1 | CYS 34 | - | VdWContact |
| THR 31 | CX.4 | CYS 34 | - | Hydrophobic |
| THR 31 | CX.4 | CYS 34 | - | VdWContact |
| THR 31 | CX.4 | PHE 285 | - | Hydrophobic |
| PRO 32 | CX.5 | CYS 34 | - | VdWContact |
| PRO 32 | CX.5 | ASN 36 | - | VdWContact |
| ASN 33 | cxb1.1 | ASN 191 | - | VdWContact |
| ASN 33 | cxb1.1 | TYR 195 | - | Hydrophobic |
| LEU 36 | cxb1.6 | TYR 8 | - | HBDonor |
| LEU 36 | cxb1.6 | TYR 8 | - | Hydrophobic |
| LEU 36 | cxb1.6 | TYR 8 | - | VdWContact |
| LEU 36 | cxb1.6 | PHE 14 | - | Hydrophobic |
| LEU 36 | cxb1.6 | PHE 14 | - | VdWContact |
| ILE 38 | cxb1.10 | TYR 8 | - | Hydrophobic |
| LYS 43 | B1.1 | ASP 25 | - | Cationic |
| GLN 48 | B1.6 | HIS 281 | 6.64x64 | Hydrophobic |
| GLN 48 | B1.6 | HIS 281 | 6.64x64 | VdWContact |
| GLN 48 | B1.6 | PRO 284 | - | VdWContact |
| CYS 50 | b1b2.4 | HIS 281 | 6.64x64 | VdWContact |
| PRO 53 | b1b2.9 | TYR 8 | - | HBAcceptor |
| PRO 53 | b1b2.9 | TYR 8 | - | Hydrophobic |
| PRO 53 | b1b2.9 | TYR 8 | - | VdWContact |
| TRP 57 | b1b2.16 | ILE 27 | - | Hydrophobic |
| TYR 61 | B2.4 | TRP 19 | - | Hydrophobic |
| TYR 61 | B2.4 | ILE 27 | - | HBDonor |
| TYR 61 | B2.4 | ILE 27 | - | Hydrophobic |
| TYR 61 | B2.4 | ILE 27 | - | VdWContact |
| TYR 61 | B2.4 | VAL 29 | - | Hydrophobic |
| TYR 61 | B2.4 | VAL 29 | - | VdWContact |
| LEU 62 | B2.5 | PHE 6 | - | Hydrophobic |
| LEU 62 | B2.5 | PHE 6 | - | VdWContact |
| LEU 62 | B2.5 | TYR 8 | - | Hydrophobic |
| LEU 62 | B2.5 | TRP 19 | - | Hydrophobic |
| LEU 62 | B2.5 | TRP 19 | - | VdWContact |
| GLU 63 | B2.6 | LEU 5 | - | Hydrophobic |
| GLU 63 | B2.6 | LEU 5 | - | VdWContact |
| GLU 63 | B2.6 | PHE 6 | - | Hydrophobic |
| ALA 65 | b2b3.3 | ILE 17 | - | Hydrophobic |
| ALA 65 | b2b3.3 | TRP 19 | - | Hydrophobic |
| ALA 65 | b2b3.3 | TRP 19 | - | VdWContact |
| LEU 66 | b2b3.4 | PHE 6 | - | Hydrophobic |
| LEU 66 | b2b3.4 | PHE 6 | - | VdWContact |
| LEU 66 | b2b3.4 | PHE 14 | - | Hydrophobic |
| LEU 66 | b2b3.4 | ILE 17 | - | Hydrophobic |
| LYS 68 | b2b3.12 | PRO 20 | - | Hydrophobic |
| LYS 68 | b2b3.12 | PRO 20 | - | VdWContact |
