Predicted complex interactions
CXCL8_HUMAN + ACKR3
SUMMARY
- Chemokine
- CXCL8_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- ACKR3 View partner entry
- Partner description
- UniProt: P25106; Gene: ackr3_human; Family: Chemokine
- Interactions detected
- 176
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| GLU 1 | NTc.Cm33 | MET 1 | - | VdWContact |
| GLU 1 | NTc.Cm33 | ASP 2 | - | Cationic |
| GLU 1 | NTc.Cm33 | VAL 186 | - | Hydrophobic |
| GLU 1 | NTc.Cm33 | VAL 186 | - | VdWContact |
| GLU 1 | NTc.Cm33 | PHE 199 | - | Hydrophobic |
| GLU 1 | NTc.Cm33 | PHE 199 | - | VdWContact |
| GLY 2 | NTc.Cm32 | VAL 186 | - | VdWContact |
| GLY 2 | NTc.Cm32 | ARG 197 | 45.51x51 | VdWContact |
| GLY 2 | NTc.Cm32 | PHE 199 | - | VdWContact |
| ALA 3 | NTc.Cm31 | TYR 195 | - | Hydrophobic |
| ALA 3 | NTc.Cm31 | TYR 195 | - | VdWContact |
| ALA 3 | NTc.Cm31 | CYS 196 | 45.50x50 | VdWContact |
| ALA 3 | NTc.Cm31 | ARG 197 | 45.51x51 | HBAcceptor |
| ALA 3 | NTc.Cm31 | ARG 197 | 45.51x51 | VdWContact |
| VAL 4 | NTc.Cm30 | LEU 183 | 4.64x65 | Hydrophobic |
| VAL 4 | NTc.Cm30 | CYS 196 | 45.50x50 | HBDonor |
| VAL 4 | NTc.Cm30 | CYS 196 | 45.50x50 | VdWContact |
| VAL 4 | NTc.Cm30 | ARG 197 | 45.51x51 | HBAcceptor |
| VAL 4 | NTc.Cm30 | ARG 197 | 45.51x51 | HBDonor |
| VAL 4 | NTc.Cm30 | ARG 197 | 45.51x51 | Hydrophobic |
| VAL 4 | NTc.Cm30 | ARG 197 | 45.51x51 | VdWContact |
| VAL 4 | NTc.Cm30 | SER 198 | 45.52x52 | VdWContact |
| LEU 5 | NTc.Cm29 | ASN 108 | - | VdWContact |
| LEU 5 | NTc.Cm29 | TYR 195 | - | Hydrophobic |
| LEU 5 | NTc.Cm29 | TYR 195 | - | VdWContact |
| PRO 6 | NTc.Cm28 | TRP 100 | 2.60x60 | Hydrophobic |
| PRO 6 | NTc.Cm28 | TRP 100 | 2.60x60 | VdWContact |
| PRO 6 | NTc.Cm28 | HIS 121 | 3.29x29 | Hydrophobic |
| ARG 7 | NTc.Cm27 | ASP 179 | 4.60x61 | Cationic |
| ARG 7 | NTc.Cm27 | MET 212 | 5.38x39 | HBDonor |
| ARG 7 | NTc.Cm27 | MET 212 | 5.38x39 | VdWContact |
| ARG 7 | NTc.Cm27 | GLU 213 | 5.39x40 | Cationic |
| ARG 7 | NTc.Cm27 | GLU 213 | 5.39x40 | VdWContact |
| ARG 7 | NTc.Cm27 | SER 216 | 5.42x43 | VdWContact |
| ARG 7 | NTc.Cm27 | LEU 297 | 7.35x34 | VdWContact |
| SER 8 | NTc.Cm26 | LEU 297 | 7.35x34 | VdWContact |
| SER 8 | NTc.Cm26 | HIS 298 | 7.36x35 | VdWContact |
| ALA 9 | NTc.Cm25 | ARG 197 | 45.51x51 | HBAcceptor |
| ALA 9 | NTc.Cm25 | ARG 197 | 45.51x51 | VdWContact |
| LYS 10 | NTc.Cm24 | MET 37 | - | VdWContact |
| LYS 10 | NTc.Cm24 | GLU 290 | 7.28x27 | Cationic |
| LYS 10 | NTc.Cm24 | GLU 290 | 7.28x27 | Hydrophobic |
| LYS 10 | NTc.Cm24 | GLU 290 | 7.28x27 | VdWContact |
| LYS 10 | NTc.Cm24 | HIS 291 | 7.29x28 | VdWContact |
| LYS 10 | NTc.Cm24 | PHE 294 | 7.32x31 | Hydrophobic |
| LYS 10 | NTc.Cm24 | PHE 294 | 7.32x31 | VdWContact |
| GLU 11 | NTc.Cm23 | LYS 40 | - | Anionic |
| GLU 11 | NTc.Cm23 | LYS 40 | - | HBAcceptor |
| GLU 11 | NTc.Cm23 | LYS 40 | - | VdWContact |
| GLU 11 | NTc.Cm23 | TYR 195 | - | VdWContact |
| LEU 12 | NTc.Cm22 | MET 1 | - | Hydrophobic |
| LEU 12 | NTc.Cm22 | MET 1 | - | VdWContact |
| LEU 12 | NTc.Cm22 | ARG 197 | 45.51x51 | HBAcceptor |
| LEU 12 | NTc.Cm22 | ARG 197 | 45.51x51 | VdWContact |
| ARG 13 | NTc.Cm21 | ASP 275 | 6.58x58 | Cationic |
| ARG 13 | NTc.Cm21 | ASP 275 | 6.58x58 | HBDonor |
| ARG 13 | NTc.Cm21 | ASP 275 | 6.58x58 | VdWContact |
| ARG 13 | NTc.Cm21 | PHE 285 | - | VdWContact |
| GLN 15 | NTc.Cm19 | MET 33 | - | Hydrophobic |
| GLN 15 | NTc.Cm19 | MET 33 | - | VdWContact |
| ILE 17 | NTc.Cm17 | THR 31 | - | VdWContact |
| ILE 17 | NTc.Cm17 | VAL 32 | - | VdWContact |
| ILE 17 | NTc.Cm17 | PHE 285 | - | Hydrophobic |
| ILE 17 | NTc.Cm17 | PHE 285 | - | VdWContact |
| ILE 17 | NTc.Cm17 | CYS 287 | 7.25x24 | VdWContact |
| LYS 18 | NTc.Cm16 | ASP 30 | - | Cationic |
| LYS 18 | NTc.Cm16 | ASP 30 | - | HBDonor |
| LYS 18 | NTc.Cm16 | ASP 30 | - | Hydrophobic |
| LYS 18 | NTc.Cm16 | ASP 30 | - | VdWContact |
| LYS 18 | NTc.Cm16 | VAL 32 | - | VdWContact |
| TYR 20 | NTc.Cm14 | CYS 26 | - | VdWContact |
| TYR 20 | NTc.Cm14 | ILE 27 | - | Hydrophobic |
| TYR 20 | NTc.Cm14 | ILE 27 | - | VdWContact |
| PRO 23 | NTc.Cm11 | TRP 19 | - | Hydrophobic |
| PRO 23 | NTc.Cm11 | PRO 20 | - | Hydrophobic |
| PRO 23 | NTc.Cm11 | PRO 20 | - | VdWContact |
| PHE 24 | NTc.Cm10 | TRP 19 | - | VdWContact |
| PHE 24 | NTc.Cm10 | CYS 21 | - | Hydrophobic |
| PHE 24 | NTc.Cm10 | CYS 21 | - | VdWContact |
| PHE 24 | NTc.Cm10 | ILE 27 | - | Hydrophobic |
| PHE 24 | NTc.Cm10 | ILE 27 | - | VdWContact |
| HIS 25 | NTc.Cm9 | PHE 14 | - | Hydrophobic |
| HIS 25 | NTc.Cm9 | TRP 19 | - | Hydrophobic |
| HIS 25 | NTc.Cm9 | TRP 19 | - | PiStacking |
| HIS 25 | NTc.Cm9 | TRP 19 | - | VdWContact |
| HIS 25 | NTc.Cm9 | CYS 21 | - | HBDonor |
| HIS 25 | NTc.Cm9 | CYS 21 | - | VdWContact |
| PRO 26 | NTc.Cm8 | TYR 8 | - | Hydrophobic |
| PRO 26 | NTc.Cm8 | TYR 8 | - | VdWContact |
| PRO 26 | NTc.Cm8 | PHE 14 | - | Hydrophobic |
| PRO 26 | NTc.Cm8 | PHE 14 | - | VdWContact |
| PRO 26 | NTc.Cm8 | TRP 19 | - | Hydrophobic |
| PRO 26 | NTc.Cm8 | TRP 19 | - | VdWContact |
| LYS 27 | NTc.Cm7 | TYR 8 | - | VdWContact |
| LYS 27 | NTc.Cm7 | ASN 22 | - | HBDonor |
| LYS 27 | NTc.Cm7 | ASN 22 | - | VdWContact |
| PHE 28 | NTc.Cm6 | ASN 22 | - | VdWContact |
| PHE 28 | NTc.Cm6 | SER 23 | - | VdWContact |
| PHE 28 | NTc.Cm6 | ILE 27 | - | Hydrophobic |
| ILE 29 | NTc.Cm5 | TYR 8 | - | VdWContact |
| LYS 30 | NTc.Cm4 | TYR 8 | - | HBAcceptor |
| LYS 30 | NTc.Cm4 | TYR 8 | - | VdWContact |
| GLU 31 | NTc.Cm3 | LEU 5 | - | Hydrophobic |
| GLU 31 | NTc.Cm3 | PHE 6 | - | VdWContact |
| LEU 32 | NTc.Cm2 | LEU 5 | - | VdWContact |
| LEU 32 | NTc.Cm2 | PHE 6 | - | HBAcceptor |
| LEU 32 | NTc.Cm2 | PHE 6 | - | HBDonor |
| LEU 32 | NTc.Cm2 | PHE 6 | - | Hydrophobic |
| LEU 32 | NTc.Cm2 | PHE 6 | - | VdWContact |
| ARG 33 | NTc.Cm1 | LEU 3 | - | Hydrophobic |
| ARG 33 | NTc.Cm1 | HIS 4 | - | VdWContact |
| ARG 33 | NTc.Cm1 | LEU 5 | - | Hydrophobic |
| VAL 34 | CX.1 | LEU 3 | - | VdWContact |
| VAL 34 | CX.1 | HIS 4 | - | HBAcceptor |
| VAL 34 | CX.1 | HIS 4 | - | HBDonor |
| VAL 34 | CX.1 | HIS 4 | - | Hydrophobic |
| VAL 34 | CX.1 | HIS 4 | - | VdWContact |
| VAL 34 | CX.1 | PHE 6 | - | Hydrophobic |
| ILE 35 | CX.4 | MET 1 | - | Hydrophobic |
| ILE 35 | CX.4 | MET 1 | - | VdWContact |
| ILE 35 | CX.4 | LEU 3 | - | Hydrophobic |
| GLY 38 | cxb1.2 | GLU 202 | - | VdWContact |
| GLY 38 | cxb1.2 | ILE 205 | 5.31x32 | VdWContact |
| PRO 39 | cxb1.5 | ARG 197 | 45.51x51 | HBAcceptor |
| PRO 39 | cxb1.5 | ARG 197 | 45.51x51 | VdWContact |
| PRO 39 | cxb1.5 | PHE 199 | - | Hydrophobic |
| PRO 39 | cxb1.5 | PHE 199 | - | VdWContact |
| PRO 39 | cxb1.5 | TYR 200 | - | Hydrophobic |
| PRO 39 | cxb1.5 | ILE 205 | 5.31x32 | Hydrophobic |
| PRO 39 | cxb1.5 | ILE 205 | 5.31x32 | VdWContact |
| HIS 40 | cxb1.6 | MET 1 | - | Hydrophobic |
| HIS 40 | cxb1.6 | ARG 197 | 45.51x51 | VdWContact |
| ALA 42 | cxb1.8 | ILE 205 | 5.31x32 | Hydrophobic |
| ALA 42 | cxb1.8 | ILE 205 | 5.31x32 | VdWContact |
| ALA 42 | cxb1.8 | LYS 206 | 5.32x33 | Hydrophobic |
| ILE 47 | cxb1.16 | MET 33 | - | Hydrophobic |
| ILE 47 | cxb1.16 | MET 33 | - | VdWContact |
| LEU 50 | B1.3 | ILE 27 | - | Hydrophobic |
| ARG 54 | B1.7 | SER 24 | - | HBDonor |
| ARG 54 | B1.7 | SER 24 | - | VdWContact |
| ARG 54 | B1.7 | ILE 27 | - | HBDonor |
| ARG 54 | B1.7 | ILE 27 | - | VdWContact |
| ARG 54 | B1.7 | VAL 29 | - | Hydrophobic |
| ARG 54 | B1.7 | VAL 29 | - | VdWContact |
| GLU 55 | b1b2.4 | VAL 32 | - | VdWContact |
| LEU 56 | b1b2.6 | ILE 27 | - | Hydrophobic |
| LEU 56 | b1b2.6 | ILE 27 | - | VdWContact |
| LEU 56 | b1b2.6 | VAL 29 | - | Hydrophobic |
| LEU 56 | b1b2.6 | VAL 29 | - | VdWContact |
| LEU 56 | b1b2.6 | VAL 32 | - | VdWContact |
| CYS 57 | b1b2.7 | VAL 32 | - | Hydrophobic |
| CYS 57 | b1b2.7 | VAL 32 | - | VdWContact |
| TRP 64 | b1b2.16 | TRP 19 | - | Hydrophobic |
| ARG 67 | B2.3 | ASP 16 | - | Cationic |
| ARG 67 | B2.3 | ILE 17 | - | Hydrophobic |
| VAL 68 | B2.4 | PHE 14 | - | Hydrophobic |
| VAL 68 | B2.4 | TRP 19 | - | Hydrophobic |
| LYS 71 | b2b3.2 | ASN 13 | - | HBDonor |
| LYS 71 | b2b3.2 | ASN 13 | - | VdWContact |
| LYS 71 | b2b3.2 | PHE 14 | - | Hydrophobic |
| LYS 71 | b2b3.2 | PHE 14 | - | VdWContact |
| LYS 71 | b2b3.2 | ASP 16 | - | Cationic |
| LYS 71 | b2b3.2 | ASP 16 | - | HBDonor |
| LYS 71 | b2b3.2 | ASP 16 | - | VdWContact |
| PHE 72 | b2b3.4 | PHE 6 | - | Hydrophobic |
| PHE 72 | b2b3.4 | PHE 6 | - | VdWContact |
| PHE 72 | b2b3.4 | TYR 8 | - | Hydrophobic |
| PHE 72 | b2b3.4 | TYR 8 | - | VdWContact |
| LEU 73 | b2b3.11 | PHE 6 | - | Hydrophobic |
| LEU 73 | b2b3.11 | PHE 6 | - | VdWContact |
| ARG 75 | B3.1 | SER 9 | - | HBDonor |
| ARG 75 | B3.1 | SER 9 | - | VdWContact |
| ARG 75 | B3.1 | GLU 10 | - | Cationic |
| ARG 75 | B3.1 | GLU 10 | - | VdWContact |
| ALA 76 | B3.2 | PHE 6 | - | Hydrophobic |
| ALA 76 | B3.2 | PHE 6 | - | VdWContact |
