Predicted complex interactions
CCL2_HUMAN + ACKR4
SUMMARY
- Chemokine
- CCL2_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- ACKR4 View partner entry
- Partner description
- UniProt: Q9NPB9; Gene: ackr4_human; Family: Chemokine
- Interactions detected
- 95
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| GLN 1 | NTc.Cm33 | GLU 34 | - | HBDonor |
| GLN 1 | NTc.Cm33 | GLU 34 | - | VdWContact |
| GLN 1 | NTc.Cm33 | ARG 37 | 1.28x28 | Hydrophobic |
| GLN 1 | NTc.Cm33 | ARG 37 | 1.28x28 | VdWContact |
| GLN 1 | NTc.Cm33 | GLU 38 | 1.29x29 | HBDonor |
| GLN 1 | NTc.Cm33 | GLU 38 | 1.29x29 | VdWContact |
| GLN 1 | NTc.Cm33 | LYS 41 | 1.32x32 | VdWContact |
| GLN 1 | NTc.Cm33 | ARG 183 | - | HBAcceptor |
| GLN 1 | NTc.Cm33 | ARG 183 | - | VdWContact |
| PRO 2 | NTc.Cm32 | ASN 100 | 2.63x63 | VdWContact |
| PRO 2 | NTc.Cm32 | ALA 101 | 2.64x64 | VdWContact |
| PRO 2 | NTc.Cm32 | VAL 102 | 2.65x65 | VdWContact |
| PRO 2 | NTc.Cm32 | HIS 103 | 2.66x66 | VdWContact |
| PRO 2 | NTc.Cm32 | GLY 104 | 23.49x49 | VdWContact |
| ASP 3 | NTc.Cm31 | ARG 37 | 1.28x28 | VdWContact |
| ASP 3 | NTc.Cm31 | ASN 100 | 2.63x63 | HBAcceptor |
| ASP 3 | NTc.Cm31 | ASN 100 | 2.63x63 | VdWContact |
| ASP 3 | NTc.Cm31 | ARG 183 | - | Anionic |
| ASP 3 | NTc.Cm31 | ARG 183 | - | HBAcceptor |
| ASP 3 | NTc.Cm31 | ARG 183 | - | Hydrophobic |
| ASP 3 | NTc.Cm31 | ARG 183 | - | VdWContact |
| ALA 4 | NTc.Cm30 | LEU 44 | 1.35x35 | Hydrophobic |
| ALA 4 | NTc.Cm30 | ASN 100 | 2.63x63 | VdWContact |
| ILE 5 | NTc.Cm29 | TRP 97 | 2.60x60 | Hydrophobic |
| ILE 5 | NTc.Cm29 | TRP 97 | 2.60x60 | VdWContact |
| ILE 5 | NTc.Cm29 | TYR 119 | 3.32x32 | Hydrophobic |
| ILE 5 | NTc.Cm29 | TYR 119 | 3.32x32 | VdWContact |
| ASN 6 | NTc.Cm28 | ARG 263 | 6.58x58 | VdWContact |
| ASN 6 | NTc.Cm28 | ILE 285 | 7.35x34 | Hydrophobic |
| ASN 6 | NTc.Cm28 | ILE 285 | 7.35x34 | VdWContact |
| ASN 6 | NTc.Cm28 | GLU 289 | 7.39x38 | HBDonor |
| ASN 6 | NTc.Cm28 | GLU 289 | 7.39x38 | VdWContact |
| ALA 7 | NTc.Cm27 | ILE 185 | 45.51x51 | Hydrophobic |
| PRO 8 | NTc.Cm26 | LYS 33 | - | Hydrophobic |
| PRO 8 | NTc.Cm26 | VAL 36 | 1.27x27 | Hydrophobic |
| PRO 8 | NTc.Cm26 | ARG 37 | 1.28x28 | Hydrophobic |
| PRO 8 | NTc.Cm26 | ASP 282 | 7.32x31 | Hydrophobic |
| VAL 9 | NTc.Cm25 | LYS 33 | - | HBAcceptor |
| VAL 9 | NTc.Cm25 | LYS 33 | - | VdWContact |
| VAL 9 | NTc.Cm25 | ILE 185 | 45.51x51 | Hydrophobic |
| THR 10 | NTc.Cm24 | ILE 30 | - | Hydrophobic |
| THR 10 | NTc.Cm24 | CYS 31 | - | VdWContact |
| CYS 11 | NTc.Cm23 | CYS 31 | - | HBAcceptor |
| CYS 11 | NTc.Cm23 | CYS 31 | - | VdWContact |
| TYR 13 | NTc.Cm21 | CYS 31 | - | Hydrophobic |
| TYR 13 | NTc.Cm21 | ILE 272 | - | Hydrophobic |
| TYR 13 | NTc.Cm21 | ILE 272 | - | VdWContact |
| TYR 13 | NTc.Cm21 | THR 273 | - | VdWContact |
| TYR 13 | NTc.Cm21 | SER 278 | 7.28x27 | VdWContact |
| ASN 14 | NTc.Cm20 | GLU 28 | - | HBDonor |
| ASN 14 | NTc.Cm20 | GLU 28 | - | Hydrophobic |
| ASN 14 | NTc.Cm20 | GLU 28 | - | VdWContact |
| PHE 15 | NTc.Cm19 | GLU 28 | - | VdWContact |
| THR 16 | NTc.Cm18 | TYR 27 | - | Hydrophobic |
| THR 16 | NTc.Cm18 | TYR 27 | - | VdWContact |
| ARG 18 | NTc.Cm16 | GLN 26 | - | VdWContact |
| ARG 18 | NTc.Cm16 | TYR 27 | - | Hydrophobic |
| ARG 18 | NTc.Cm16 | TYR 27 | - | VdWContact |
| ILE 20 | NTc.Cm14 | TYR 27 | - | Hydrophobic |
| ILE 20 | NTc.Cm14 | TYR 27 | - | VdWContact |
| SER 21 | NTc.Cm13 | GLU 14 | - | HBDonor |
| SER 21 | NTc.Cm13 | GLU 14 | - | VdWContact |
| ARG 24 | NTc.Cm10 | GLU 17 | - | Cationic |
| ARG 24 | NTc.Cm10 | GLU 17 | - | HBDonor |
| ARG 24 | NTc.Cm10 | GLU 17 | - | VdWContact |
| ARG 24 | NTc.Cm10 | TYR 22 | - | CationPi |
| ARG 24 | NTc.Cm10 | TYR 22 | - | VdWContact |
| ARG 29 | NTc.Cm5 | ILE 30 | - | VdWContact |
| SER 34 | CX.1 | PRO 186 | 45.52x52 | VdWContact |
| SER 34 | CX.1 | PHE 188 | - | VdWContact |
| LYS 35 | CX.5 | PRO 186 | 45.52x52 | Hydrophobic |
| LYS 35 | CX.5 | PRO 186 | 45.52x52 | VdWContact |
| ILE 42 | cxb1.10 | ILE 30 | - | Hydrophobic |
| ILE 42 | cxb1.10 | ILE 30 | - | VdWContact |
| THR 45 | cxb1.15 | TYR 24 | - | Hydrophobic |
| THR 45 | cxb1.15 | TYR 24 | - | VdWContact |
| ILE 46 | cxb1.16 | MET 18 | - | Hydrophobic |
| VAL 47 | B1.1 | TYR 24 | - | Hydrophobic |
| VAL 47 | B1.1 | TYR 24 | - | VdWContact |
| LYS 49 | B1.3 | TYR 24 | - | Hydrophobic |
| LYS 49 | B1.3 | TYR 24 | - | VdWContact |
| LYS 49 | B1.3 | LEU 29 | - | Hydrophobic |
| GLU 50 | B1.4 | ILE 30 | - | HBAcceptor |
| GLU 50 | B1.4 | ILE 30 | - | Hydrophobic |
| GLU 50 | B1.4 | ILE 30 | - | VdWContact |
| ILE 51 | B1.5 | TYR 24 | - | Hydrophobic |
| ILE 51 | B1.5 | TYR 24 | - | VdWContact |
| ILE 51 | B1.5 | TYR 27 | - | Hydrophobic |
| ILE 51 | B1.5 | TYR 27 | - | VdWContact |
| ILE 51 | B1.5 | GLU 28 | - | VdWContact |
| ILE 51 | B1.5 | LEU 29 | - | Hydrophobic |
| CYS 52 | B1.6 | GLU 28 | - | HBDonor |
| CYS 52 | B1.6 | GLU 28 | - | Hydrophobic |
| CYS 52 | B1.6 | GLU 28 | - | VdWContact |
| CYS 52 | B1.6 | ILE 30 | - | VdWContact |
