Predicted complex interactions
CXCL10_HUMAN + ACKR4
SUMMARY
- Chemokine
- CXCL10_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- ACKR4 View partner entry
- Partner description
- UniProt: Q9NPB9; Gene: ackr4_human; Family: Chemokine
- Interactions detected
- 126
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| VAL 1 | NTc.Cm29 | TRP 97 | 2.60x60 | Hydrophobic |
| VAL 1 | NTc.Cm29 | GLN 172 | 4.60x61 | Hydrophobic |
| VAL 1 | NTc.Cm29 | TYR 176 | 4.64x65 | Hydrophobic |
| VAL 1 | NTc.Cm29 | TYR 176 | 4.64x65 | VdWContact |
| VAL 1 | NTc.Cm29 | GLU 289 | 7.39x38 | Cationic |
| PRO 2 | NTc.Cm28 | TRP 97 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TYR 119 | 3.32x32 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TYR 119 | 3.32x32 | VdWContact |
| PRO 2 | NTc.Cm28 | GLU 289 | 7.39x38 | Hydrophobic |
| PRO 2 | NTc.Cm28 | GLU 289 | 7.39x38 | VdWContact |
| LEU 3 | NTc.Cm27 | LEU 44 | 1.35x35 | Hydrophobic |
| LEU 3 | NTc.Cm27 | LEU 44 | 1.35x35 | VdWContact |
| LEU 3 | NTc.Cm27 | LEU 48 | 1.39x39 | Hydrophobic |
| LEU 3 | NTc.Cm27 | LEU 48 | 1.39x39 | VdWContact |
| LEU 3 | NTc.Cm27 | TRP 97 | 2.60x60 | Hydrophobic |
| LEU 3 | NTc.Cm27 | LEU 293 | 7.43x42 | Hydrophobic |
| SER 4 | NTc.Cm26 | ASN 100 | 2.63x63 | VdWContact |
| ARG 5 | NTc.Cm25 | ARG 37 | 1.28x28 | Hydrophobic |
| ARG 5 | NTc.Cm25 | LYS 41 | 1.32x32 | VdWContact |
| ARG 5 | NTc.Cm25 | ALA 101 | 2.64x64 | HBDonor |
| ARG 5 | NTc.Cm25 | ALA 101 | 2.64x64 | VdWContact |
| ARG 5 | NTc.Cm25 | VAL 102 | 2.65x65 | HBDonor |
| ARG 5 | NTc.Cm25 | VAL 102 | 2.65x65 | VdWContact |
| THR 6 | NTc.Cm24 | ILE 185 | 45.51x51 | Hydrophobic |
| THR 6 | NTc.Cm24 | ILE 185 | 45.51x51 | VdWContact |
| VAL 7 | NTc.Cm23 | LYS 33 | - | Hydrophobic |
| VAL 7 | NTc.Cm23 | LYS 33 | - | VdWContact |
| VAL 7 | NTc.Cm23 | VAL 36 | 1.27x27 | Hydrophobic |
| VAL 7 | NTc.Cm23 | ARG 37 | 1.28x28 | Hydrophobic |
| VAL 7 | NTc.Cm23 | ASP 282 | 7.32x31 | VdWContact |
| ARG 8 | NTc.Cm22 | LYS 33 | - | HBAcceptor |
| ARG 8 | NTc.Cm22 | LYS 33 | - | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 266 | 6.61x61 | Cationic |
| ARG 8 | NTc.Cm22 | ILE 272 | - | VdWContact |
| ARG 8 | NTc.Cm22 | SER 278 | 7.28x27 | VdWContact |
| ARG 8 | NTc.Cm22 | MET 281 | 7.31x30 | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 282 | 7.32x31 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 282 | 7.32x31 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 282 | 7.32x31 | VdWContact |
| CYS 9 | NTc.Cm21 | LYS 33 | - | VdWContact |
| THR 10 | NTc.Cm20 | CYS 31 | - | HBAcceptor |
| THR 10 | NTc.Cm20 | CYS 31 | - | VdWContact |
| ILE 12 | NTc.Cm18 | CYS 31 | - | Hydrophobic |
| ILE 12 | NTc.Cm18 | ILE 272 | - | VdWContact |
| ILE 12 | NTc.Cm18 | THR 273 | - | VdWContact |
| ILE 12 | NTc.Cm18 | SER 274 | 7.24x23 | VdWContact |
| ILE 12 | NTc.Cm18 | CYS 275 | 7.25x24 | Hydrophobic |
| ILE 12 | NTc.Cm18 | CYS 275 | 7.25x24 | VdWContact |
| ILE 12 | NTc.Cm18 | SER 278 | 7.28x27 | VdWContact |
| SER 13 | NTc.Cm17 | GLU 28 | - | HBDonor |
| SER 13 | NTc.Cm17 | GLU 28 | - | VdWContact |
| SER 15 | NTc.Cm15 | GLN 26 | - | HBDonor |
| SER 15 | NTc.Cm15 | GLN 26 | - | VdWContact |
| GLN 17 | NTc.Cm13 | GLN 26 | - | VdWContact |
| GLN 17 | NTc.Cm13 | TYR 27 | - | Hydrophobic |
| GLN 17 | NTc.Cm13 | TYR 27 | - | VdWContact |
| PRO 18 | NTc.Cm12 | TYR 27 | - | VdWContact |
| VAL 19 | NTc.Cm11 | TYR 24 | - | Hydrophobic |
| VAL 19 | NTc.Cm11 | TYR 24 | - | VdWContact |
| VAL 19 | NTc.Cm11 | TYR 27 | - | Hydrophobic |
| VAL 19 | NTc.Cm11 | TYR 27 | - | VdWContact |
| ASN 20 | NTc.Cm10 | MET 18 | - | HBDonor |
| ASN 20 | NTc.Cm10 | MET 18 | - | VdWContact |
| ASN 20 | NTc.Cm10 | TYR 22 | - | Hydrophobic |
| ASN 20 | NTc.Cm10 | TYR 22 | - | VdWContact |
| ASN 20 | NTc.Cm10 | TYR 24 | - | VdWContact |
| PRO 21 | NTc.Cm9 | TYR 13 | - | Hydrophobic |
| PRO 21 | NTc.Cm9 | TYR 13 | - | VdWContact |
| ARG 22 | NTc.Cm8 | TYR 13 | - | Hydrophobic |
| ARG 22 | NTc.Cm8 | ASN 16 | - | VdWContact |
| ARG 22 | NTc.Cm8 | GLU 17 | - | HBDonor |
| ARG 22 | NTc.Cm8 | GLU 17 | - | VdWContact |
| ARG 22 | NTc.Cm8 | MET 18 | - | VdWContact |
| SER 23 | NTc.Cm7 | TYR 24 | - | HBAcceptor |
| SER 23 | NTc.Cm7 | TYR 24 | - | VdWContact |
| GLU 25 | NTc.Cm5 | TYR 11 | - | HBAcceptor |
| GLU 25 | NTc.Cm5 | TYR 11 | - | VdWContact |
| LYS 26 | NTc.Cm4 | SER 8 | - | VdWContact |
| LEU 27 | NTc.Cm3 | SER 8 | - | VdWContact |
| ILE 29 | NTc.Cm1 | LEU 3 | - | Hydrophobic |
| ILE 29 | NTc.Cm1 | LEU 3 | - | VdWContact |
| ILE 29 | NTc.Cm1 | ASN 6 | - | VdWContact |
| ILE 30 | CX.1 | ASN 6 | - | VdWContact |
| PRO 31 | CX.4 | ILE 187 | - | Hydrophobic |
| ALA 32 | CX.5 | PHE 188 | - | HBAcceptor |
| ALA 32 | CX.5 | PHE 188 | - | VdWContact |
| SER 33 | cxb1.1 | PRO 186 | 45.52x52 | VdWContact |
| GLN 34 | cxb1.2 | TYR 176 | 4.64x65 | HBAcceptor |
| GLN 34 | cxb1.2 | TYR 176 | 4.64x65 | VdWContact |
| GLN 34 | cxb1.2 | PRO 186 | 45.52x52 | Hydrophobic |
| GLN 34 | cxb1.2 | PRO 186 | 45.52x52 | VdWContact |
| GLN 34 | cxb1.2 | PHE 188 | - | Hydrophobic |
| GLN 34 | cxb1.2 | ARG 263 | 6.58x58 | HBAcceptor |
| GLN 34 | cxb1.2 | ARG 263 | 6.58x58 | VdWContact |
| PHE 35 | cxb1.5 | ARG 263 | 6.58x58 | HBAcceptor |
| PHE 35 | cxb1.5 | ARG 263 | 6.58x58 | VdWContact |
| PRO 37 | cxb1.7 | THR 194 | - | Hydrophobic |
| PRO 37 | cxb1.7 | LYS 197 | 5.35x36 | HBAcceptor |
| PRO 37 | cxb1.7 | LYS 197 | 5.35x36 | VdWContact |
| PRO 37 | cxb1.7 | ILE 267 | 6.62x62 | Hydrophobic |
| PRO 37 | cxb1.7 | ILE 267 | 6.62x62 | VdWContact |
| ILE 42 | cxb1.15 | ILE 30 | - | Hydrophobic |
| MET 45 | B1.2 | TYR 24 | - | Hydrophobic |
| MET 45 | B1.2 | TYR 24 | - | VdWContact |
| GLU 50 | B1.7 | LEU 29 | - | Hydrophobic |
| GLU 50 | B1.7 | LEU 29 | - | VdWContact |
| LYS 51 | b1b2.4 | ILE 30 | - | HBAcceptor |
| LYS 51 | b1b2.4 | ILE 30 | - | Hydrophobic |
| LYS 51 | b1b2.4 | ILE 30 | - | VdWContact |
| ARG 52 | b1b2.6 | TYR 24 | - | HBDonor |
| ARG 52 | b1b2.6 | TYR 24 | - | VdWContact |
| ARG 52 | b1b2.6 | TYR 27 | - | Hydrophobic |
| ARG 52 | b1b2.6 | TYR 27 | - | VdWContact |
| CYS 53 | b1b2.7 | GLU 28 | - | HBDonor |
| CYS 53 | b1b2.7 | GLU 28 | - | VdWContact |
| CYS 53 | b1b2.7 | ILE 30 | - | VdWContact |
| LEU 54 | b1b2.8 | TYR 27 | - | Hydrophobic |
| GLU 57 | b1b2.12 | ARG 190 | - | Anionic |
| LEU 65 | B2.5 | LEU 3 | - | Hydrophobic |
| VAL 68 | b2b3.3 | THR 9 | - | Hydrophobic |
| VAL 68 | b2b3.3 | THR 9 | - | VdWContact |
| VAL 68 | b2b3.3 | TYR 11 | - | Hydrophobic |
| VAL 68 | b2b3.3 | TYR 11 | - | VdWContact |
| SER 69 | b2b3.4 | MET 1 | - | VdWContact |
| ARG 72 | B3.1 | SER 8 | - | VdWContact |
| ARG 72 | B3.1 | THR 9 | - | Hydrophobic |
