Predicted complex interactions
CXCL12_HUMAN + ACKR4
SUMMARY
- Chemokine
- CXCL12_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- ACKR4 View partner entry
- Partner description
- UniProt: Q9NPB9; Gene: ackr4_human; Family: Chemokine
- Interactions detected
- 110
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LYS 1 | NTc.Cm29 | TRP 97 | 2.60x60 | Hydrophobic |
| LYS 1 | NTc.Cm29 | TRP 97 | 2.60x60 | VdWContact |
| LYS 1 | NTc.Cm29 | SER 116 | 3.29x29 | HBDonor |
| LYS 1 | NTc.Cm29 | SER 116 | 3.29x29 | VdWContact |
| LYS 1 | NTc.Cm29 | TYR 119 | 3.32x32 | CationPi |
| LYS 1 | NTc.Cm29 | TYR 119 | 3.32x32 | Hydrophobic |
| LYS 1 | NTc.Cm29 | TYR 119 | 3.32x32 | VdWContact |
| LYS 1 | NTc.Cm29 | GLN 172 | 4.60x61 | VdWContact |
| LYS 1 | NTc.Cm29 | TYR 176 | 4.64x65 | CationPi |
| LYS 1 | NTc.Cm29 | TYR 176 | 4.64x65 | HBDonor |
| LYS 1 | NTc.Cm29 | TYR 176 | 4.64x65 | Hydrophobic |
| LYS 1 | NTc.Cm29 | TYR 176 | 4.64x65 | VdWContact |
| LYS 1 | NTc.Cm29 | GLU 289 | 7.39x38 | Cationic |
| LYS 1 | NTc.Cm29 | GLU 289 | 7.39x38 | HBDonor |
| LYS 1 | NTc.Cm29 | GLU 289 | 7.39x38 | VdWContact |
| PRO 2 | NTc.Cm28 | LEU 44 | 1.35x35 | Hydrophobic |
| PRO 2 | NTc.Cm28 | LEU 44 | 1.35x35 | VdWContact |
| PRO 2 | NTc.Cm28 | TRP 97 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TRP 97 | 2.60x60 | VdWContact |
| VAL 3 | NTc.Cm27 | ARG 263 | 6.58x58 | VdWContact |
| VAL 3 | NTc.Cm27 | ILE 285 | 7.35x34 | Hydrophobic |
| SER 4 | NTc.Cm26 | ILE 185 | 45.51x51 | VdWContact |
| LEU 5 | NTc.Cm25 | LYS 33 | - | Hydrophobic |
| LEU 5 | NTc.Cm25 | VAL 36 | 1.27x27 | Hydrophobic |
| LEU 5 | NTc.Cm25 | VAL 36 | 1.27x27 | VdWContact |
| LEU 5 | NTc.Cm25 | ARG 37 | 1.28x28 | Hydrophobic |
| LEU 5 | NTc.Cm25 | ARG 37 | 1.28x28 | VdWContact |
| LEU 5 | NTc.Cm25 | ASP 282 | 7.32x31 | Hydrophobic |
| LEU 5 | NTc.Cm25 | ASP 282 | 7.32x31 | VdWContact |
| TYR 7 | NTc.Cm23 | TYR 176 | 4.64x65 | HBDonor |
| TYR 7 | NTc.Cm23 | TYR 176 | 4.64x65 | VdWContact |
| TYR 7 | NTc.Cm23 | PRO 186 | 45.52x52 | Hydrophobic |
| TYR 7 | NTc.Cm23 | PRO 186 | 45.52x52 | VdWContact |
| TYR 7 | NTc.Cm23 | PHE 188 | - | Hydrophobic |
| ARG 8 | NTc.Cm22 | ASP 266 | 6.61x61 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 266 | 6.61x61 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 266 | 6.61x61 | VdWContact |
| ARG 8 | NTc.Cm22 | ILE 272 | - | VdWContact |
| ARG 8 | NTc.Cm22 | SER 278 | 7.28x27 | HBDonor |
| ARG 8 | NTc.Cm22 | SER 278 | 7.28x27 | VdWContact |
| ARG 8 | NTc.Cm22 | MET 281 | 7.31x30 | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 282 | 7.32x31 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 282 | 7.32x31 | HBDonor |
| PRO 10 | NTc.Cm20 | ILE 30 | - | Hydrophobic |
| ARG 12 | NTc.Cm18 | ASP 266 | 6.61x61 | Cationic |
| ARG 12 | NTc.Cm18 | ASP 266 | 6.61x61 | HBDonor |
| ARG 12 | NTc.Cm18 | ASP 266 | 6.61x61 | VdWContact |
| ARG 12 | NTc.Cm18 | ILE 272 | - | VdWContact |
| PHE 13 | NTc.Cm17 | GLU 28 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | GLU 28 | - | VdWContact |
| PHE 13 | NTc.Cm17 | THR 273 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | THR 273 | - | VdWContact |
| GLU 15 | NTc.Cm15 | TYR 27 | - | Hydrophobic |
| GLU 15 | NTc.Cm15 | TYR 27 | - | VdWContact |
| HIS 17 | NTc.Cm13 | TYR 27 | - | Hydrophobic |
| HIS 17 | NTc.Cm13 | TYR 27 | - | VdWContact |
| VAL 18 | NTc.Cm12 | TYR 24 | - | Hydrophobic |
| VAL 18 | NTc.Cm12 | TYR 24 | - | VdWContact |
| VAL 18 | NTc.Cm12 | TYR 27 | - | Hydrophobic |
| VAL 18 | NTc.Cm12 | TYR 27 | - | VdWContact |
| ALA 19 | NTc.Cm11 | TYR 22 | - | Hydrophobic |
| ALA 19 | NTc.Cm11 | TYR 24 | - | HBDonor |
| ALA 19 | NTc.Cm11 | TYR 24 | - | VdWContact |
| ARG 20 | NTc.Cm10 | TYR 13 | - | CationPi |
| ARG 20 | NTc.Cm10 | TYR 13 | - | VdWContact |
| ALA 21 | NTc.Cm9 | GLU 17 | - | Hydrophobic |
| ALA 21 | NTc.Cm9 | GLU 17 | - | VdWContact |
| ASN 22 | NTc.Cm8 | GLY 20 | - | HBDonor |
| ASN 22 | NTc.Cm8 | GLY 20 | - | VdWContact |
| ASN 22 | NTc.Cm8 | TYR 24 | - | HBDonor |
| ASN 22 | NTc.Cm8 | TYR 24 | - | Hydrophobic |
| ASN 22 | NTc.Cm8 | TYR 24 | - | VdWContact |
| ILE 28 | NTc.Cm2 | ASN 6 | - | VdWContact |
| LEU 29 | NTc.Cm1 | ILE 30 | - | Hydrophobic |
| ASN 30 | CX.1 | LEU 3 | - | HBDonor |
| ASN 30 | CX.1 | LEU 3 | - | VdWContact |
| PRO 32 | CX.5 | ILE 187 | - | Hydrophobic |
| PRO 32 | CX.5 | ILE 187 | - | VdWContact |
| ASN 33 | cxb1.1 | PRO 186 | 45.52x52 | HBDonor |
| ASN 33 | cxb1.1 | PRO 186 | 45.52x52 | VdWContact |
| ASN 33 | cxb1.1 | ILE 187 | - | VdWContact |
| ASN 33 | cxb1.1 | PHE 188 | - | HBAcceptor |
| ASN 33 | cxb1.1 | PHE 188 | - | VdWContact |
| LEU 36 | cxb1.6 | LEU 3 | - | Hydrophobic |
| VAL 39 | cxb1.11 | ILE 30 | - | Hydrophobic |
| LEU 42 | cxb1.16 | TYR 24 | - | Hydrophobic |
| LEU 42 | cxb1.16 | TYR 24 | - | VdWContact |
| ARG 47 | B1.5 | SER 25 | - | VdWContact |
| ARG 47 | B1.5 | LEU 29 | - | Hydrophobic |
| ARG 47 | B1.5 | LEU 29 | - | VdWContact |
| GLN 48 | B1.6 | LEU 29 | - | VdWContact |
| GLN 48 | B1.6 | ILE 30 | - | HBAcceptor |
| GLN 48 | B1.6 | ILE 30 | - | Hydrophobic |
| GLN 48 | B1.6 | ILE 30 | - | VdWContact |
| VAL 49 | B1.7 | TYR 27 | - | Hydrophobic |
| VAL 49 | B1.7 | TYR 27 | - | VdWContact |
| TYR 61 | B2.4 | THR 9 | - | HBDonor |
| TYR 61 | B2.4 | THR 9 | - | VdWContact |
| TYR 61 | B2.4 | TYR 11 | - | Hydrophobic |
| TYR 61 | B2.4 | TYR 11 | - | VdWContact |
| TYR 61 | B2.4 | TYR 13 | - | Hydrophobic |
| LYS 64 | b2b3.2 | TYR 11 | - | Hydrophobic |
| LYS 64 | b2b3.2 | TYR 11 | - | VdWContact |
| LYS 64 | b2b3.2 | TYR 13 | - | HBDonor |
| LYS 64 | b2b3.2 | TYR 13 | - | VdWContact |
| LEU 66 | b2b3.4 | LEU 3 | - | Hydrophobic |
| LEU 66 | b2b3.4 | LEU 3 | - | VdWContact |
| ARG 69 | B3.1 | GLN 7 | - | VdWContact |
| PHE 70 | B3.2 | MET 1 | - | Hydrophobic |
| PHE 70 | B3.2 | MET 1 | - | VdWContact |
