Predicted complex interactions
CCL8_HUMAN + CCR2
SUMMARY
- Chemokine
- CCL8_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CCR2 View partner entry
- Partner description
- UniProt: P41597; Gene: ccr2_human; Family: Chemokine
- Interactions detected
- 77
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| GLN 1 | NTc.Cm33 | TRP 98 | 2.60x60 | Hydrophobic |
| GLN 1 | NTc.Cm33 | THR 117 | 3.29x29 | VdWContact |
| GLN 1 | NTc.Cm33 | TYR 120 | 3.32x32 | VdWContact |
| GLN 1 | NTc.Cm33 | HIS 121 | 3.33x33 | VdWContact |
| GLN 1 | NTc.Cm33 | THR 179 | 4.64x65 | Hydrophobic |
| GLN 1 | NTc.Cm33 | PRO 192 | 45.52x52 | VdWContact |
| PRO 2 | NTc.Cm32 | TRP 98 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm32 | TRP 98 | 2.60x60 | VdWContact |
| PRO 2 | NTc.Cm32 | TYR 120 | 3.32x32 | Hydrophobic |
| PRO 2 | NTc.Cm32 | TYR 120 | 3.32x32 | VdWContact |
| PRO 2 | NTc.Cm32 | GLU 291 | 7.39x38 | VdWContact |
| PRO 2 | NTc.Cm32 | MET 295 | 7.43x42 | Hydrophobic |
| PRO 2 | NTc.Cm32 | MET 295 | 7.43x42 | VdWContact |
| ASP 3 | NTc.Cm31 | ARG 206 | 5.42x43 | Anionic |
| ASP 3 | NTc.Cm31 | TYR 259 | 6.51x51 | HBAcceptor |
| ASP 3 | NTc.Cm31 | TYR 259 | 6.51x51 | VdWContact |
| ASP 3 | NTc.Cm31 | THR 287 | 7.35x34 | Hydrophobic |
| ASP 3 | NTc.Cm31 | GLU 291 | 7.39x38 | HBDonor |
| ASP 3 | NTc.Cm31 | GLU 291 | 7.39x38 | VdWContact |
| SER 4 | NTc.Cm30 | LEU 45 | 1.35x35 | VdWContact |
| SER 4 | NTc.Cm30 | GLN 288 | 7.36x35 | VdWContact |
| SER 4 | NTc.Cm30 | GLU 291 | 7.39x38 | HBDonor |
| SER 4 | NTc.Cm30 | GLU 291 | 7.39x38 | VdWContact |
| VAL 5 | NTc.Cm29 | LEU 45 | 1.35x35 | Hydrophobic |
| VAL 5 | NTc.Cm29 | TYR 49 | 1.39x39 | Hydrophobic |
| VAL 5 | NTc.Cm29 | TRP 98 | 2.60x60 | Hydrophobic |
| VAL 5 | NTc.Cm29 | ALA 102 | 2.64x64 | Hydrophobic |
| ILE 7 | NTc.Cm27 | ASP 284 | 7.32x31 | Hydrophobic |
| ILE 7 | NTc.Cm27 | ASP 284 | 7.32x31 | VdWContact |
| ILE 7 | NTc.Cm27 | THR 287 | 7.35x34 | Hydrophobic |
| ILE 7 | NTc.Cm27 | GLN 288 | 7.36x35 | Hydrophobic |
| PRO 8 | NTc.Cm26 | LYS 34 | - | Hydrophobic |
| PRO 8 | NTc.Cm26 | LYS 34 | - | VdWContact |
| PRO 8 | NTc.Cm26 | VAL 37 | 1.27x27 | Hydrophobic |
| PRO 8 | NTc.Cm26 | LYS 38 | 1.28x28 | Hydrophobic |
| THR 10 | NTc.Cm24 | PRO 31 | - | Hydrophobic |
| THR 10 | NTc.Cm24 | CYS 32 | - | VdWContact |
| THR 10 | NTc.Cm24 | HIS 33 | - | HBDonor |
| THR 10 | NTc.Cm24 | HIS 33 | - | Hydrophobic |
| THR 10 | NTc.Cm24 | HIS 33 | - | VdWContact |
| CYS 11 | NTc.Cm23 | CYS 32 | - | HBAcceptor |
| CYS 11 | NTc.Cm23 | CYS 32 | - | HBDonor |
| CYS 11 | NTc.Cm23 | CYS 32 | - | VdWContact |
| PHE 13 | NTc.Cm21 | CYS 32 | - | Hydrophobic |
| PHE 13 | NTc.Cm21 | ASN 276 | - | VdWContact |
| PHE 13 | NTc.Cm21 | CYS 277 | - | Hydrophobic |
| PHE 13 | NTc.Cm21 | THR 280 | 7.28x27 | Hydrophobic |
| ASN 14 | NTc.Cm20 | TYR 28 | - | Hydrophobic |
| ASN 14 | NTc.Cm20 | TYR 28 | - | VdWContact |
| ILE 16 | NTc.Cm18 | PHE 24 | - | Hydrophobic |
| ILE 16 | NTc.Cm18 | PHE 24 | - | VdWContact |
| ARG 18 | NTc.Cm16 | PHE 24 | - | Hydrophobic |
| ILE 20 | NTc.Cm14 | PHE 24 | - | Hydrophobic |
| ILE 20 | NTc.Cm14 | PHE 24 | - | VdWContact |
| ILE 20 | NTc.Cm14 | TYR 26 | - | Hydrophobic |
| ARG 24 | NTc.Cm10 | GLU 19 | - | Cationic |
| ILE 34 | CX.1 | PHE 194 | - | Hydrophobic |
| ILE 34 | CX.1 | PHE 194 | - | VdWContact |
| ILE 34 | CX.1 | ARG 196 | 5.32x33 | HBAcceptor |
| ILE 34 | CX.1 | ARG 196 | 5.32x33 | VdWContact |
| ILE 34 | CX.1 | ASN 199 | 5.35x36 | Hydrophobic |
| ILE 34 | CX.1 | ASN 199 | 5.35x36 | VdWContact |
| ILE 42 | cxb1.10 | PRO 31 | - | Hydrophobic |
| THR 45 | cxb1.15 | TYR 26 | - | Hydrophobic |
| LYS 49 | B1.3 | TYR 26 | - | Hydrophobic |
| LYS 49 | B1.3 | TYR 26 | - | VdWContact |
| LYS 49 | B1.3 | ASP 27 | - | Cationic |
| LYS 49 | B1.3 | ASP 27 | - | HBDonor |
| LYS 49 | B1.3 | ASP 27 | - | VdWContact |
| GLU 50 | B1.4 | PRO 31 | - | Hydrophobic |
| GLU 50 | B1.4 | HIS 33 | - | HBAcceptor |
| GLU 50 | B1.4 | HIS 33 | - | VdWContact |
| VAL 51 | B1.5 | TYR 26 | - | Hydrophobic |
| VAL 51 | B1.5 | TYR 26 | - | VdWContact |
| CYS 52 | B1.6 | GLY 29 | - | HBDonor |
| CYS 52 | B1.6 | GLY 29 | - | VdWContact |
| CYS 52 | B1.6 | PRO 31 | - | VdWContact |
