Predicted complex interactions
CXCL12_HUMAN + CCR2
SUMMARY
- Chemokine
- CXCL12_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CCR2 View partner entry
- Partner description
- UniProt: P41597; Gene: ccr2_human; Family: Chemokine
- Interactions detected
- 85
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LYS 1 | NTc.Cm29 | TRP 98 | 2.60x60 | Hydrophobic |
| LYS 1 | NTc.Cm29 | TRP 98 | 2.60x60 | VdWContact |
| LYS 1 | NTc.Cm29 | CYS 113 | 3.25x25 | Cationic |
| LYS 1 | NTc.Cm29 | CYS 113 | 3.25x25 | VdWContact |
| LYS 1 | NTc.Cm29 | THR 117 | 3.29x29 | VdWContact |
| LYS 1 | NTc.Cm29 | TYR 120 | 3.32x32 | CationPi |
| LYS 1 | NTc.Cm29 | TYR 120 | 3.32x32 | VdWContact |
| LYS 1 | NTc.Cm29 | THR 179 | 4.64x65 | Hydrophobic |
| LYS 1 | NTc.Cm29 | THR 179 | 4.64x65 | VdWContact |
| LYS 1 | NTc.Cm29 | CYS 190 | 45.50x50 | Cationic |
| LYS 1 | NTc.Cm29 | CYS 190 | 45.50x50 | VdWContact |
| LYS 1 | NTc.Cm29 | GLY 191 | 45.51x51 | HBDonor |
| LYS 1 | NTc.Cm29 | GLY 191 | 45.51x51 | VdWContact |
| LYS 1 | NTc.Cm29 | GLU 291 | 7.39x38 | VdWContact |
| PRO 2 | NTc.Cm28 | TRP 98 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm28 | GLU 291 | 7.39x38 | VdWContact |
| VAL 3 | NTc.Cm27 | TYR 259 | 6.51x51 | VdWContact |
| VAL 3 | NTc.Cm27 | THR 287 | 7.35x34 | Hydrophobic |
| VAL 3 | NTc.Cm27 | GLU 291 | 7.39x38 | HBDonor |
| VAL 3 | NTc.Cm27 | GLU 291 | 7.39x38 | VdWContact |
| SER 4 | NTc.Cm26 | GLU 291 | 7.39x38 | HBDonor |
| SER 4 | NTc.Cm26 | GLU 291 | 7.39x38 | VdWContact |
| LEU 5 | NTc.Cm25 | SER 101 | 2.63x63 | VdWContact |
| LEU 5 | NTc.Cm25 | ALA 102 | 2.64x64 | Hydrophobic |
| LEU 5 | NTc.Cm25 | ALA 102 | 2.64x64 | VdWContact |
| SER 6 | NTc.Cm24 | PRO 192 | 45.52x52 | VdWContact |
| TYR 7 | NTc.Cm23 | LYS 34 | - | Hydrophobic |
| TYR 7 | NTc.Cm23 | LYS 38 | 1.28x28 | Hydrophobic |
| ARG 8 | NTc.Cm22 | ASN 266 | 6.58x58 | VdWContact |
| ARG 8 | NTc.Cm22 | GLN 269 | 6.61x61 | VdWContact |
| ARG 8 | NTc.Cm22 | LEU 283 | 7.31x30 | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 284 | 7.32x31 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 284 | 7.32x31 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 284 | 7.32x31 | VdWContact |
| ARG 8 | NTc.Cm22 | THR 287 | 7.35x34 | VdWContact |
| PRO 10 | NTc.Cm20 | CYS 32 | - | HBAcceptor |
| PRO 10 | NTc.Cm20 | CYS 32 | - | VdWContact |
| ARG 12 | NTc.Cm18 | LYS 34 | - | VdWContact |
| ARG 12 | NTc.Cm18 | GLN 269 | 6.61x61 | HBDonor |
| ARG 12 | NTc.Cm18 | GLN 269 | 6.61x61 | VdWContact |
| ARG 12 | NTc.Cm18 | THR 280 | 7.28x27 | VdWContact |
| ARG 12 | NTc.Cm18 | ASP 284 | 7.32x31 | Cationic |
| ARG 12 | NTc.Cm18 | ASP 284 | 7.32x31 | HBDonor |
| ARG 12 | NTc.Cm18 | ASP 284 | 7.32x31 | VdWContact |
| PHE 13 | NTc.Cm17 | TYR 28 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | TYR 28 | - | VdWContact |
| PHE 13 | NTc.Cm17 | ASN 276 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | ASN 276 | - | VdWContact |
| PHE 13 | NTc.Cm17 | CYS 277 | - | VdWContact |
| GLU 15 | NTc.Cm15 | TYR 26 | - | Hydrophobic |
| GLU 15 | NTc.Cm15 | TYR 26 | - | VdWContact |
| HIS 17 | NTc.Cm13 | TYR 26 | - | Hydrophobic |
| HIS 17 | NTc.Cm13 | TYR 26 | - | VdWContact |
| ALA 21 | NTc.Cm9 | GLU 19 | - | Hydrophobic |
| ALA 21 | NTc.Cm9 | GLU 19 | - | VdWContact |
| ASN 22 | NTc.Cm8 | THR 21 | - | VdWContact |
| LYS 27 | NTc.Cm3 | ASP 185 | - | Cationic |
| LYS 27 | NTc.Cm3 | ASP 185 | - | VdWContact |
| PRO 32 | CX.5 | TYR 193 | - | Hydrophobic |
| PRO 32 | CX.5 | TYR 193 | - | VdWContact |
| ASN 33 | cxb1.1 | PRO 192 | 45.52x52 | HBDonor |
| ASN 33 | cxb1.1 | PRO 192 | 45.52x52 | VdWContact |
| ASN 33 | cxb1.1 | TYR 193 | - | Hydrophobic |
| ASN 33 | cxb1.1 | TYR 193 | - | VdWContact |
| ASN 33 | cxb1.1 | PHE 194 | - | HBAcceptor |
| ASN 33 | cxb1.1 | PHE 194 | - | VdWContact |
| VAL 39 | cxb1.11 | PRO 31 | - | Hydrophobic |
| LYS 43 | B1.1 | GLU 19 | - | Cationic |
| ASN 44 | B1.2 | THR 21 | - | VdWContact |
| ASN 44 | B1.2 | PHE 23 | - | Hydrophobic |
| ASN 44 | B1.2 | PHE 23 | - | VdWContact |
| ASN 45 | B1.3 | PHE 23 | - | Hydrophobic |
| ARG 47 | B1.5 | ASP 25 | - | Cationic |
| ARG 47 | B1.5 | ASP 25 | - | HBDonor |
| ARG 47 | B1.5 | ASP 25 | - | VdWContact |
| ARG 47 | B1.5 | ASP 27 | - | Cationic |
| ARG 47 | B1.5 | ASP 27 | - | HBDonor |
| ARG 47 | B1.5 | ASP 27 | - | VdWContact |
| GLN 48 | B1.6 | ALA 30 | - | VdWContact |
| GLN 48 | B1.6 | PRO 31 | - | Hydrophobic |
| GLN 48 | B1.6 | PRO 31 | - | VdWContact |
| VAL 49 | B1.7 | TYR 26 | - | Hydrophobic |
| VAL 49 | B1.7 | GLY 29 | - | VdWContact |
| CYS 50 | b1b2.4 | GLY 29 | - | HBDonor |
| CYS 50 | b1b2.4 | GLY 29 | - | VdWContact |
