Predicted complex interactions
CXCL12_HUMAN + ACKR1
SUMMARY
- Chemokine
- CXCL12_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- ACKR1 View partner entry
- Partner description
- UniProt: Q16570; Gene: ackr1_human; Family: Chemokine
- Interactions detected
- 115
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LYS 1 | NTc.Cm29 | ASP 59 | 1.33x33 | Cationic |
| LYS 1 | NTc.Cm29 | ASP 59 | 1.33x33 | HBDonor |
| LYS 1 | NTc.Cm29 | ASP 59 | 1.33x33 | VdWContact |
| LYS 1 | NTc.Cm29 | LEU 116 | 2.60x60 | VdWContact |
| LYS 1 | NTc.Cm29 | PRO 118 | - | Hydrophobic |
| LYS 1 | NTc.Cm29 | PRO 118 | - | VdWContact |
| LYS 1 | NTc.Cm29 | TYR 133 | 3.29x29 | VdWContact |
| LYS 1 | NTc.Cm29 | LEU 194 | - | Hydrophobic |
| LYS 1 | NTc.Cm29 | LEU 194 | - | VdWContact |
| LYS 1 | NTc.Cm29 | CYS 195 | 45.50x50 | Cationic |
| LYS 1 | NTc.Cm29 | CYS 195 | 45.50x50 | HBDonor |
| LYS 1 | NTc.Cm29 | CYS 195 | 45.50x50 | VdWContact |
| PRO 2 | NTc.Cm28 | LEU 57 | - | Hydrophobic |
| PRO 2 | NTc.Cm28 | PHE 65 | 1.39x39 | Hydrophobic |
| PRO 2 | NTc.Cm28 | PHE 65 | 1.39x39 | VdWContact |
| PRO 2 | NTc.Cm28 | GLU 290 | 7.39x38 | Hydrophobic |
| PRO 2 | NTc.Cm28 | GLU 290 | 7.39x38 | VdWContact |
| VAL 3 | NTc.Cm27 | TYR 133 | 3.29x29 | Hydrophobic |
| VAL 3 | NTc.Cm27 | TYR 137 | 3.33x33 | Hydrophobic |
| VAL 3 | NTc.Cm27 | TYR 137 | 3.33x33 | VdWContact |
| VAL 3 | NTc.Cm27 | LEU 197 | 45.52x52 | Hydrophobic |
| VAL 3 | NTc.Cm27 | LEU 197 | 45.52x52 | VdWContact |
| VAL 3 | NTc.Cm27 | LEU 260 | 6.55x55 | Hydrophobic |
| VAL 3 | NTc.Cm27 | GLU 290 | 7.39x38 | HBDonor |
| VAL 3 | NTc.Cm27 | GLU 290 | 7.39x38 | VdWContact |
| SER 4 | NTc.Cm26 | ASN 287 | 7.36x35 | HBDonor |
| SER 4 | NTc.Cm26 | ASN 287 | 7.36x35 | VdWContact |
| SER 4 | NTc.Cm26 | GLU 290 | 7.39x38 | HBDonor |
| SER 4 | NTc.Cm26 | GLU 290 | 7.39x38 | VdWContact |
| LEU 5 | NTc.Cm25 | ASN 55 | - | VdWContact |
| LEU 5 | NTc.Cm25 | LEU 57 | - | Hydrophobic |
| LEU 5 | NTc.Cm25 | LEU 57 | - | VdWContact |
| LEU 5 | NTc.Cm25 | PRO 118 | - | Hydrophobic |
| SER 6 | NTc.Cm24 | ARG 267 | 6.62x62 | HBAcceptor |
| SER 6 | NTc.Cm24 | ARG 267 | 6.62x62 | VdWContact |
| TYR 7 | NTc.Cm23 | ASN 55 | - | VdWContact |
| TYR 7 | NTc.Cm23 | LEU 194 | - | Hydrophobic |
| ARG 8 | NTc.Cm22 | ASP 263 | 6.58x58 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 263 | 6.58x58 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 263 | 6.58x58 | VdWContact |
| ARG 8 | NTc.Cm22 | GLN 279 | 7.28x27 | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 283 | 7.32x31 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 283 | 7.32x31 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 283 | 7.32x31 | VdWContact |
| ARG 8 | NTc.Cm22 | LEU 286 | 7.35x34 | VdWContact |
| PRO 10 | NTc.Cm20 | PRO 50 | - | Hydrophobic |
| PRO 10 | NTc.Cm20 | CYS 51 | - | HBAcceptor |
| PRO 10 | NTc.Cm20 | CYS 51 | - | VdWContact |
| PRO 10 | NTc.Cm20 | HIS 52 | - | Hydrophobic |
| ARG 12 | NTc.Cm18 | LEU 273 | - | HBDonor |
| ARG 12 | NTc.Cm18 | LEU 273 | - | VdWContact |
| ARG 12 | NTc.Cm18 | SER 274 | - | HBDonor |
| ARG 12 | NTc.Cm18 | SER 274 | - | VdWContact |
| ARG 12 | NTc.Cm18 | THR 275 | 7.24x23 | VdWContact |
| ARG 12 | NTc.Cm18 | GLN 279 | 7.28x27 | VdWContact |
| PHE 13 | NTc.Cm17 | ALA 47 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | ALA 47 | - | VdWContact |
| GLU 15 | NTc.Cm15 | ASN 44 | - | VdWContact |
| GLU 15 | NTc.Cm15 | ALA 48 | - | Hydrophobic |
| HIS 17 | NTc.Cm13 | TYR 41 | - | Hydrophobic |
| ALA 19 | NTc.Cm11 | ASP 34 | - | VdWContact |
| ALA 19 | NTc.Cm11 | PHE 36 | - | Hydrophobic |
| ARG 20 | NTc.Cm10 | PHE 22 | - | Hydrophobic |
| ARG 20 | NTc.Cm10 | PHE 22 | - | VdWContact |
| ARG 20 | NTc.Cm10 | TRP 26 | - | CationPi |
| ARG 20 | NTc.Cm10 | TRP 26 | - | VdWContact |
| VAL 23 | NTc.Cm7 | PHE 22 | - | Hydrophobic |
| HIS 25 | NTc.Cm5 | PHE 22 | - | VdWContact |
| LEU 26 | NTc.Cm4 | PHE 22 | - | Hydrophobic |
| LYS 27 | NTc.Cm3 | LEU 10 | - | Hydrophobic |
| LYS 27 | NTc.Cm3 | LEU 10 | - | VdWContact |
| LYS 27 | NTc.Cm3 | GLU 15 | - | Cationic |
| LYS 27 | NTc.Cm3 | SER 17 | - | VdWContact |
| LYS 27 | NTc.Cm3 | GLN 19 | - | Hydrophobic |
| ILE 28 | NTc.Cm2 | SER 17 | - | VdWContact |
| ILE 28 | NTc.Cm2 | LEU 20 | - | Hydrophobic |
| LEU 29 | NTc.Cm1 | LEU 10 | - | Hydrophobic |
| LEU 29 | NTc.Cm1 | GLU 15 | - | VdWContact |
| THR 31 | CX.4 | GLU 15 | - | Hydrophobic |
| THR 31 | CX.4 | GLU 15 | - | VdWContact |
| ASN 33 | cxb1.1 | LEU 197 | 45.52x52 | HBDonor |
| ASN 33 | cxb1.1 | LEU 197 | 45.52x52 | VdWContact |
| ASN 33 | cxb1.1 | ILE 198 | - | VdWContact |
| ASN 33 | cxb1.1 | TYR 199 | - | HBAcceptor |
| ASN 33 | cxb1.1 | TYR 199 | - | Hydrophobic |
| ASN 33 | cxb1.1 | TYR 199 | - | VdWContact |
| VAL 39 | cxb1.11 | PRO 50 | - | Hydrophobic |
| LEU 42 | cxb1.16 | LEU 45 | - | Hydrophobic |
| GLN 48 | B1.6 | ALA 49 | - | VdWContact |
| GLN 48 | B1.6 | PRO 50 | - | Hydrophobic |
| GLN 48 | B1.6 | PRO 50 | - | VdWContact |
| VAL 49 | B1.7 | LEU 45 | - | Hydrophobic |
| VAL 49 | B1.7 | LEU 45 | - | VdWContact |
| VAL 49 | B1.7 | ALA 48 | - | Hydrophobic |
| CYS 50 | b1b2.4 | ALA 48 | - | HBDonor |
| CYS 50 | b1b2.4 | ALA 48 | - | VdWContact |
| TRP 57 | b1b2.16 | PHE 22 | - | Hydrophobic |
| TRP 57 | b1b2.16 | PHE 22 | - | VdWContact |
| GLU 60 | B2.3 | TRP 26 | - | Hydrophobic |
| GLU 60 | B2.3 | TRP 26 | - | VdWContact |
| TYR 61 | B2.4 | LEU 20 | - | Hydrophobic |
| TYR 61 | B2.4 | PHE 22 | - | Hydrophobic |
| TYR 61 | B2.4 | PHE 22 | - | VdWContact |
| TYR 61 | B2.4 | VAL 25 | - | Hydrophobic |
| TYR 61 | B2.4 | VAL 25 | - | VdWContact |
| TYR 61 | B2.4 | TRP 26 | - | Hydrophobic |
| LYS 64 | b2b3.2 | VAL 25 | - | Hydrophobic |
| LYS 64 | b2b3.2 | TRP 26 | - | Hydrophobic |
| LYS 64 | b2b3.2 | TRP 26 | - | VdWContact |
| LYS 64 | b2b3.2 | SER 29 | - | HBDonor |
| LYS 64 | b2b3.2 | SER 29 | - | VdWContact |
| ALA 65 | b2b3.3 | LEU 20 | - | Hydrophobic |
| ALA 65 | b2b3.3 | LEU 20 | - | VdWContact |
| LYS 68 | b2b3.12 | ASP 24 | - | HBDonor |
| LYS 68 | b2b3.12 | ASP 24 | - | VdWContact |
