Predicted complex interactions
CXCL12_HUMAN + CCR3
SUMMARY
- Chemokine
- CXCL12_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CCR3 View partner entry
- Partner description
- UniProt: P51677; Gene: ccr3_human; Family: Chemokine
- Interactions detected
- 114
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LYS 1 | NTc.Cm29 | TRP 90 | 2.60x60 | Hydrophobic |
| LYS 1 | NTc.Cm29 | TRP 90 | 2.60x60 | VdWContact |
| LYS 1 | NTc.Cm29 | TYR 93 | 2.63x63 | HBDonor |
| LYS 1 | NTc.Cm29 | TYR 93 | 2.63x63 | VdWContact |
| LYS 1 | NTc.Cm29 | SER 110 | 3.29x29 | VdWContact |
| LYS 1 | NTc.Cm29 | HIS 114 | 3.33x33 | VdWContact |
| LYS 1 | NTc.Cm29 | TYR 172 | 4.64x65 | Hydrophobic |
| LYS 1 | NTc.Cm29 | TYR 172 | 4.64x65 | VdWContact |
| LYS 1 | NTc.Cm29 | CYS 183 | 45.50x50 | HBDonor |
| LYS 1 | NTc.Cm29 | CYS 183 | 45.50x50 | VdWContact |
| PRO 2 | NTc.Cm28 | TYR 41 | 1.39x39 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TRP 90 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TYR 113 | 3.32x32 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TYR 113 | 3.32x32 | VdWContact |
| PRO 2 | NTc.Cm28 | GLU 287 | 7.39x38 | VdWContact |
| PRO 2 | NTc.Cm28 | TYR 291 | 7.43x42 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TYR 291 | 7.43x42 | VdWContact |
| VAL 3 | NTc.Cm27 | HIS 199 | 5.38x39 | Hydrophobic |
| VAL 3 | NTc.Cm27 | MET 283 | 7.35x34 | Hydrophobic |
| VAL 3 | NTc.Cm27 | GLU 287 | 7.39x38 | HBDonor |
| VAL 3 | NTc.Cm27 | GLU 287 | 7.39x38 | VdWContact |
| SER 4 | NTc.Cm26 | MET 33 | 1.31x31 | VdWContact |
| SER 4 | NTc.Cm26 | GLU 287 | 7.39x38 | HBDonor |
| SER 4 | NTc.Cm26 | GLU 287 | 7.39x38 | VdWContact |
| LEU 5 | NTc.Cm25 | MET 33 | 1.31x31 | Hydrophobic |
| LEU 5 | NTc.Cm25 | TYR 41 | 1.39x39 | Hydrophobic |
| LEU 5 | NTc.Cm25 | TRP 90 | 2.60x60 | Hydrophobic |
| LEU 5 | NTc.Cm25 | TYR 93 | 2.63x63 | Hydrophobic |
| LEU 5 | NTc.Cm25 | VAL 94 | 2.64x64 | Hydrophobic |
| LEU 5 | NTc.Cm25 | VAL 94 | 2.64x64 | VdWContact |
| SER 6 | NTc.Cm24 | TYR 172 | 4.64x65 | HBDonor |
| SER 6 | NTc.Cm24 | TYR 172 | 4.64x65 | VdWContact |
| TYR 7 | NTc.Cm23 | MET 33 | 1.31x31 | Hydrophobic |
| TYR 7 | NTc.Cm23 | ASP 280 | 7.32x31 | Hydrophobic |
| TYR 7 | NTc.Cm23 | ASP 280 | 7.32x31 | VdWContact |
| TYR 7 | NTc.Cm23 | MET 283 | 7.35x34 | Hydrophobic |
| TYR 7 | NTc.Cm23 | MET 283 | 7.35x34 | VdWContact |
| ARG 8 | NTc.Cm22 | LYS 26 | 1.24x24 | HBDonor |
| ARG 8 | NTc.Cm22 | LYS 26 | 1.24x24 | Hydrophobic |
| ARG 8 | NTc.Cm22 | LYS 26 | 1.24x24 | VdWContact |
| ARG 8 | NTc.Cm22 | THR 29 | 1.27x27 | HBDonor |
| ARG 8 | NTc.Cm22 | THR 29 | 1.27x27 | VdWContact |
| ARG 8 | NTc.Cm22 | ARG 30 | 1.28x28 | HBDonor |
| ARG 8 | NTc.Cm22 | ARG 30 | 1.28x28 | VdWContact |
| ARG 8 | NTc.Cm22 | MET 33 | 1.31x31 | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 280 | 7.32x31 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 280 | 7.32x31 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 280 | 7.32x31 | VdWContact |
| CYS 9 | NTc.Cm21 | LYS 26 | 1.24x24 | Anionic |
| PRO 10 | NTc.Cm20 | LEU 177 | - | Hydrophobic |
| PRO 10 | NTc.Cm20 | LEU 177 | - | VdWContact |
| CYS 11 | NTc.Cm19 | LEU 23 | - | Hydrophobic |
| CYS 11 | NTc.Cm19 | LEU 23 | - | VdWContact |
| ARG 12 | NTc.Cm18 | LEU 23 | - | VdWContact |
| ARG 12 | NTc.Cm18 | GLU 25 | - | VdWContact |
| ARG 12 | NTc.Cm18 | LYS 26 | 1.24x24 | HBDonor |
| ARG 12 | NTc.Cm18 | LYS 26 | 1.24x24 | Hydrophobic |
| ARG 12 | NTc.Cm18 | LYS 26 | 1.24x24 | VdWContact |
| ARG 12 | NTc.Cm18 | ARG 30 | 1.28x28 | VdWContact |
| PHE 13 | NTc.Cm17 | LEU 23 | - | VdWContact |
| PHE 13 | NTc.Cm17 | GLU 25 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | GLU 25 | - | VdWContact |
| PHE 13 | NTc.Cm17 | ALA 27 | 1.25x25 | Hydrophobic |
| PHE 13 | NTc.Cm17 | ALA 27 | 1.25x25 | VdWContact |
| PHE 14 | NTc.Cm16 | GLY 21 | - | VdWContact |
| PHE 14 | NTc.Cm16 | LEU 22 | - | VdWContact |
| PHE 14 | NTc.Cm16 | LEU 23 | - | Hydrophobic |
| PHE 14 | NTc.Cm16 | LEU 23 | - | VdWContact |
| LYS 27 | NTc.Cm3 | GLU 175 | - | Cationic |
| LYS 27 | NTc.Cm3 | GLU 175 | - | VdWContact |
| LEU 29 | NTc.Cm1 | TYR 17 | - | Hydrophobic |
| LEU 29 | NTc.Cm1 | TYR 17 | - | VdWContact |
| LEU 29 | NTc.Cm1 | LEU 177 | - | Hydrophobic |
| ASN 30 | CX.1 | TYR 17 | - | HBDonor |
| ASN 30 | CX.1 | TYR 17 | - | Hydrophobic |
| ASN 30 | CX.1 | TYR 17 | - | VdWContact |
| ASN 30 | CX.1 | ASP 18 | - | VdWContact |
| THR 31 | CX.4 | TYR 16 | - | VdWContact |
| THR 31 | CX.4 | TYR 17 | - | Hydrophobic |
| THR 31 | CX.4 | TYR 17 | - | VdWContact |
| THR 31 | CX.4 | ASP 18 | - | VdWContact |
| THR 31 | CX.4 | ASP 19 | - | HBAcceptor |
| THR 31 | CX.4 | ASP 19 | - | VdWContact |
| PRO 32 | CX.5 | TYR 16 | - | Hydrophobic |
| PRO 32 | CX.5 | TYR 16 | - | VdWContact |
| PRO 32 | CX.5 | TYR 17 | - | VdWContact |
| PRO 32 | CX.5 | ASP 18 | - | HBAcceptor |
| PRO 32 | CX.5 | ASP 18 | - | Hydrophobic |
| PRO 32 | CX.5 | ASP 18 | - | VdWContact |
| PRO 32 | CX.5 | ASP 19 | - | VdWContact |
| PRO 32 | CX.5 | TYR 193 | 5.32x33 | Hydrophobic |
| PRO 32 | CX.5 | TYR 193 | 5.32x33 | VdWContact |
| ASN 33 | cxb1.1 | TYR 16 | - | Hydrophobic |
| ASN 33 | cxb1.1 | TYR 16 | - | VdWContact |
| ASN 33 | cxb1.1 | ARG 196 | 5.35x36 | VdWContact |
| ALA 35 | cxb1.5 | ASP 19 | - | VdWContact |
| ALA 35 | cxb1.5 | GLY 21 | - | VdWContact |
| ALA 35 | cxb1.5 | LEU 22 | - | VdWContact |
| LEU 36 | cxb1.6 | ASP 19 | - | HBDonor |
| LEU 36 | cxb1.6 | ASP 19 | - | VdWContact |
| VAL 39 | cxb1.11 | PHE 178 | - | Hydrophobic |
| ARG 47 | B1.5 | GLU 179 | - | Cationic |
| ARG 47 | B1.5 | GLU 179 | - | HBDonor |
| ARG 47 | B1.5 | GLU 179 | - | VdWContact |
| GLN 48 | B1.6 | PHE 178 | - | Hydrophobic |
| GLN 48 | B1.6 | PHE 178 | - | VdWContact |
| VAL 49 | B1.7 | PHE 178 | - | VdWContact |
| CYS 50 | b1b2.4 | LEU 23 | - | Hydrophobic |
| CYS 50 | b1b2.4 | PHE 178 | - | VdWContact |
| PRO 53 | b1b2.9 | GLY 21 | - | VdWContact |
| LYS 54 | b1b2.10 | LEU 22 | - | Hydrophobic |
| LYS 54 | b1b2.10 | LEU 22 | - | VdWContact |
| ARG 69 | B3.1 | PHE 11 | - | CationPi |
| ARG 69 | B3.1 | PHE 11 | - | VdWContact |
