Predicted complex interactions
CCL21_HUMAN + CCR4
SUMMARY
- Chemokine
- CCL21_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CCR4 View partner entry
- Partner description
- UniProt: P51679; Gene: ccr4_human; Family: Chemokine
- Interactions detected
- 111
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| SER 1 | NTc.Cm30 | ILE 286 | 7.35x34 | VdWContact |
| SER 1 | NTc.Cm30 | GLU 290 | 7.39x38 | Cationic |
| SER 1 | NTc.Cm30 | GLU 290 | 7.39x38 | HBDonor |
| SER 1 | NTc.Cm30 | GLU 290 | 7.39x38 | VdWContact |
| ASP 2 | NTc.Cm29 | TYR 98 | 2.63x63 | HBAcceptor |
| ASP 2 | NTc.Cm29 | TYR 98 | 2.63x63 | VdWContact |
| ASP 2 | NTc.Cm29 | LYS 188 | 45.51x51 | Anionic |
| ASP 2 | NTc.Cm29 | LYS 188 | 45.51x51 | Hydrophobic |
| ASP 2 | NTc.Cm29 | LYS 188 | 45.51x51 | VdWContact |
| GLY 3 | NTc.Cm28 | GLN 287 | 7.36x35 | HBAcceptor |
| GLY 3 | NTc.Cm28 | GLN 287 | 7.36x35 | VdWContact |
| GLY 4 | NTc.Cm27 | LYS 31 | 1.24x24 | HBAcceptor |
| GLY 4 | NTc.Cm27 | LYS 31 | 1.24x24 | VdWContact |
| GLY 4 | NTc.Cm27 | ASP 283 | 7.32x31 | VdWContact |
| ALA 5 | NTc.Cm26 | LYS 31 | 1.24x24 | Hydrophobic |
| ALA 5 | NTc.Cm26 | LYS 31 | 1.24x24 | VdWContact |
| ALA 5 | NTc.Cm26 | ILE 34 | 1.27x27 | Hydrophobic |
| ALA 5 | NTc.Cm26 | LYS 35 | 1.28x28 | Hydrophobic |
| GLN 6 | NTc.Cm25 | LYS 31 | 1.24x24 | VdWContact |
| GLN 6 | NTc.Cm25 | TYR 179 | - | HBAcceptor |
| GLN 6 | NTc.Cm25 | TYR 179 | - | VdWContact |
| GLN 6 | NTc.Cm25 | GLU 181 | - | VdWContact |
| GLN 6 | NTc.Cm25 | LYS 188 | 45.51x51 | HBAcceptor |
| GLN 6 | NTc.Cm25 | LYS 188 | 45.51x51 | VdWContact |
| ASP 7 | NTc.Cm24 | CYS 29 | - | VdWContact |
| ASP 7 | NTc.Cm24 | THR 30 | - | VdWContact |
| ASP 7 | NTc.Cm24 | LYS 31 | 1.24x24 | HBAcceptor |
| ASP 7 | NTc.Cm24 | LYS 31 | 1.24x24 | VdWContact |
| ASP 7 | NTc.Cm24 | ARG 182 | - | Anionic |
| ASP 7 | NTc.Cm24 | ARG 182 | - | HBAcceptor |
| ASP 7 | NTc.Cm24 | ARG 182 | - | VdWContact |
| CYS 8 | NTc.Cm23 | CYS 29 | - | HBAcceptor |
| CYS 8 | NTc.Cm23 | CYS 29 | - | VdWContact |
| LEU 10 | NTc.Cm21 | CYS 29 | - | Hydrophobic |
| LEU 10 | NTc.Cm21 | CYS 276 | 7.25x24 | Hydrophobic |
| LEU 10 | NTc.Cm21 | GLU 279 | 7.28x27 | VdWContact |
| SER 13 | NTc.Cm18 | TYR 19 | - | VdWContact |
| SER 13 | NTc.Cm18 | PRO 26 | - | VdWContact |
| ARG 15 | NTc.Cm16 | TYR 19 | - | Hydrophobic |
| ARG 15 | NTc.Cm16 | TYR 22 | - | CationPi |
| ARG 15 | NTc.Cm16 | TYR 22 | - | HBDonor |
| ARG 15 | NTc.Cm16 | TYR 22 | - | VdWContact |
| ILE 17 | NTc.Cm14 | TYR 19 | - | Hydrophobic |
| ILE 17 | NTc.Cm14 | TYR 19 | - | VdWContact |
| PRO 18 | NTc.Cm13 | ILE 15 | - | Hydrophobic |
| PRO 18 | NTc.Cm13 | TYR 19 | - | Hydrophobic |
| PRO 18 | NTc.Cm13 | TYR 19 | - | VdWContact |
| LYS 20 | NTc.Cm11 | ASP 8 | - | Cationic |
| LYS 20 | NTc.Cm11 | ASP 8 | - | VdWContact |
| LYS 20 | NTc.Cm11 | ASP 12 | - | Cationic |
| LYS 20 | NTc.Cm11 | ASP 12 | - | HBDonor |
| LYS 20 | NTc.Cm11 | ASP 12 | - | VdWContact |
| LYS 20 | NTc.Cm11 | ILE 15 | - | Hydrophobic |
| VAL 21 | NTc.Cm10 | ILE 15 | - | Hydrophobic |
| VAL 21 | NTc.Cm10 | TYR 16 | - | Hydrophobic |
| VAL 21 | NTc.Cm10 | TYR 16 | - | VdWContact |
| VAL 21 | NTc.Cm10 | TYR 20 | - | Hydrophobic |
| ARG 26 | NTc.Cm5 | GLU 181 | - | Cationic |
| ARG 26 | NTc.Cm5 | ARG 182 | - | VdWContact |
| GLU 29 | NTc.Cm2 | LYS 190 | - | Anionic |
| GLU 29 | NTc.Cm2 | LYS 190 | - | HBAcceptor |
| GLU 29 | NTc.Cm2 | LYS 190 | - | VdWContact |
| PRO 30 | NTc.Cm1 | SER 195 | 5.31x32 | VdWContact |
| PRO 30 | NTc.Cm1 | LYS 199 | 5.35x36 | HBAcceptor |
| PRO 30 | NTc.Cm1 | LYS 199 | 5.35x36 | VdWContact |
| SER 31 | CX.1 | LYS 190 | - | VdWContact |
| SER 31 | CX.1 | TYR 191 | - | VdWContact |
| LEU 32 | CX.5 | TYR 179 | - | Hydrophobic |
| LEU 32 | CX.5 | TYR 179 | - | VdWContact |
| LEU 32 | CX.5 | LYS 190 | - | Hydrophobic |
| CYS 34 | cxb1.2 | LYS 199 | 5.35x36 | HBAcceptor |
| CYS 34 | cxb1.2 | LYS 199 | 5.35x36 | VdWContact |
| ILE 36 | cxb1.6 | GLU 271 | 6.64x64 | Hydrophobic |
| LEU 40 | cxb1.11 | PRO 28 | - | Hydrophobic |
| PRO 43 | cxb1.16 | TYR 16 | - | Hydrophobic |
| PRO 43 | cxb1.16 | TYR 16 | - | VdWContact |
| PRO 43 | cxb1.16 | TYR 20 | - | Hydrophobic |
| PRO 43 | cxb1.16 | TYR 20 | - | VdWContact |
| ARG 44 | B1.1 | ASP 12 | - | Cationic |
| ARG 44 | B1.1 | ASP 12 | - | HBDonor |
| ARG 44 | B1.1 | ASP 12 | - | VdWContact |
| ARG 44 | B1.1 | TYR 16 | - | Hydrophobic |
| LYS 45 | B1.2 | GLU 13 | - | Cationic |
| LYS 45 | B1.2 | GLU 13 | - | HBDonor |
| LYS 45 | B1.2 | GLU 13 | - | VdWContact |
| LYS 45 | B1.2 | TYR 16 | - | HBDonor |
| LYS 45 | B1.2 | TYR 16 | - | Hydrophobic |
| LYS 45 | B1.2 | TYR 16 | - | VdWContact |
| GLN 48 | B1.5 | TYR 16 | - | Hydrophobic |
| GLN 48 | B1.5 | TYR 16 | - | VdWContact |
| GLN 48 | B1.5 | TYR 20 | - | Hydrophobic |
| GLN 48 | B1.5 | TYR 20 | - | VdWContact |
| ALA 49 | B1.6 | TYR 20 | - | HBAcceptor |
| ALA 49 | B1.6 | TYR 20 | - | VdWContact |
| ALA 49 | B1.6 | LYS 27 | - | Hydrophobic |
| GLU 50 | B1.7 | LYS 27 | - | VdWContact |
| GLU 50 | B1.7 | PRO 28 | - | Hydrophobic |
| GLU 50 | B1.7 | PRO 28 | - | VdWContact |
| GLU 50 | B1.7 | ARG 182 | - | Anionic |
| GLU 50 | B1.7 | ARG 182 | - | HBAcceptor |
| GLU 50 | B1.7 | ARG 182 | - | VdWContact |
| LEU 51 | b1b2.4 | TYR 19 | - | Hydrophobic |
| LEU 51 | b1b2.4 | TYR 20 | - | Hydrophobic |
| LEU 51 | b1b2.4 | ILE 25 | - | Hydrophobic |
| LEU 51 | b1b2.4 | ILE 25 | - | VdWContact |
| CYS 52 | b1b2.6 | PRO 26 | - | HBDonor |
| CYS 52 | b1b2.6 | PRO 26 | - | Hydrophobic |
| CYS 52 | b1b2.6 | PRO 26 | - | VdWContact |
| LYS 75 | B3.3 | GLU 181 | - | Cationic |
| LYS 75 | B3.3 | GLU 181 | - | HBDonor |
| LYS 75 | B3.3 | GLU 181 | - | VdWContact |
