Predicted complex interactions
CCL22_HUMAN + CCR4
SUMMARY
- Chemokine
- CCL22_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CCR4 View partner entry
- Partner description
- UniProt: P51679; Gene: ccr4_human; Family: Chemokine
- Interactions detected
- 112
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| GLY 1 | NTc.Cm35 | TRP 95 | 2.60x60 | VdWContact |
| GLY 1 | NTc.Cm35 | SER 114 | 3.29x29 | HBDonor |
| GLY 1 | NTc.Cm35 | SER 114 | 3.29x29 | VdWContact |
| PRO 2 | NTc.Cm34 | TRP 95 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm34 | TRP 95 | 2.60x60 | VdWContact |
| PRO 2 | NTc.Cm34 | TYR 117 | 3.32x32 | Hydrophobic |
| PRO 2 | NTc.Cm34 | GLU 290 | 7.39x38 | VdWContact |
| PRO 2 | NTc.Cm34 | PHE 294 | 7.43x42 | Hydrophobic |
| PRO 2 | NTc.Cm34 | PHE 294 | 7.43x42 | VdWContact |
| TYR 3 | NTc.Cm33 | ILE 206 | 5.42x43 | Hydrophobic |
| TYR 3 | NTc.Cm33 | ILE 206 | 5.42x43 | VdWContact |
| TYR 3 | NTc.Cm33 | TYR 258 | 6.51x51 | Hydrophobic |
| TYR 3 | NTc.Cm33 | TYR 258 | 6.51x51 | VdWContact |
| TYR 3 | NTc.Cm33 | LEU 262 | 6.55x55 | Hydrophobic |
| TYR 3 | NTc.Cm33 | ILE 286 | 7.35x34 | Hydrophobic |
| TYR 3 | NTc.Cm33 | GLU 290 | 7.39x38 | HBDonor |
| TYR 3 | NTc.Cm33 | GLU 290 | 7.39x38 | VdWContact |
| GLY 4 | NTc.Cm32 | GLN 287 | 7.36x35 | VdWContact |
| GLY 4 | NTc.Cm32 | GLU 290 | 7.39x38 | HBDonor |
| GLY 4 | NTc.Cm32 | GLU 290 | 7.39x38 | VdWContact |
| ALA 5 | NTc.Cm31 | LEU 42 | 1.35x35 | Hydrophobic |
| ALA 5 | NTc.Cm31 | TYR 98 | 2.63x63 | Hydrophobic |
| ALA 5 | NTc.Cm31 | TYR 98 | 2.63x63 | VdWContact |
| ALA 5 | NTc.Cm31 | ALA 99 | 2.64x64 | Hydrophobic |
| ASN 6 | NTc.Cm30 | TYR 98 | 2.63x63 | HBAcceptor |
| ASN 6 | NTc.Cm30 | TYR 98 | 2.63x63 | VdWContact |
| ASN 6 | NTc.Cm30 | LYS 188 | 45.51x51 | VdWContact |
| MET 7 | NTc.Cm29 | ILE 34 | 1.27x27 | Hydrophobic |
| MET 7 | NTc.Cm29 | ILE 34 | 1.27x27 | VdWContact |
| MET 7 | NTc.Cm29 | ASP 283 | 7.32x31 | Hydrophobic |
| MET 7 | NTc.Cm29 | ILE 286 | 7.35x34 | Hydrophobic |
| MET 7 | NTc.Cm29 | GLN 287 | 7.36x35 | Hydrophobic |
| GLU 8 | NTc.Cm28 | TYR 186 | - | Hydrophobic |
| GLU 8 | NTc.Cm28 | TYR 186 | - | VdWContact |
| GLU 8 | NTc.Cm28 | LYS 188 | 45.51x51 | Anionic |
| GLU 8 | NTc.Cm28 | LYS 188 | 45.51x51 | HBAcceptor |
| GLU 8 | NTc.Cm28 | LYS 188 | 45.51x51 | VdWContact |
| ASP 9 | NTc.Cm27 | LYS 31 | 1.24x24 | VdWContact |
| ASP 9 | NTc.Cm27 | GLU 32 | 1.25x25 | VdWContact |
| ASP 9 | NTc.Cm27 | GLY 33 | 1.26x26 | HBAcceptor |
| ASP 9 | NTc.Cm27 | GLY 33 | 1.26x26 | VdWContact |
| ASP 9 | NTc.Cm27 | ILE 34 | 1.27x27 | HBAcceptor |
| ASP 9 | NTc.Cm27 | ILE 34 | 1.27x27 | VdWContact |
| ASP 9 | NTc.Cm27 | LYS 35 | 1.28x28 | HBAcceptor |
| ASP 9 | NTc.Cm27 | LYS 35 | 1.28x28 | VdWContact |
| SER 10 | NTc.Cm26 | LYS 31 | 1.24x24 | HBAcceptor |
| SER 10 | NTc.Cm26 | LYS 31 | 1.24x24 | HBDonor |
| SER 10 | NTc.Cm26 | LYS 31 | 1.24x24 | VdWContact |
| VAL 11 | NTc.Cm25 | PRO 28 | - | Hydrophobic |
| VAL 11 | NTc.Cm25 | PRO 28 | - | VdWContact |
| VAL 11 | NTc.Cm25 | CYS 29 | - | VdWContact |
| VAL 11 | NTc.Cm25 | THR 30 | - | Hydrophobic |
| CYS 12 | NTc.Cm24 | CYS 29 | - | HBAcceptor |
| CYS 12 | NTc.Cm24 | CYS 29 | - | HBDonor |
| CYS 12 | NTc.Cm24 | CYS 29 | - | VdWContact |
| ARG 14 | NTc.Cm22 | CYS 29 | - | Cationic |
| ARG 14 | NTc.Cm22 | GLN 274 | - | VdWContact |
| ARG 14 | NTc.Cm22 | ASP 275 | 7.24x23 | HBDonor |
| ARG 14 | NTc.Cm22 | ASP 275 | 7.24x23 | VdWContact |
| ARG 14 | NTc.Cm22 | CYS 276 | 7.25x24 | Cationic |
| ARG 14 | NTc.Cm22 | CYS 276 | 7.25x24 | HBDonor |
| ARG 14 | NTc.Cm22 | CYS 276 | 7.25x24 | VdWContact |
| ARG 14 | NTc.Cm22 | GLU 279 | 7.28x27 | Cationic |
| ARG 14 | NTc.Cm22 | GLU 279 | 7.28x27 | HBDonor |
| ARG 14 | NTc.Cm22 | GLU 279 | 7.28x27 | VdWContact |
| ASP 15 | NTc.Cm21 | PRO 26 | - | Hydrophobic |
| ASP 15 | NTc.Cm21 | PRO 26 | - | VdWContact |
| TYR 16 | NTc.Cm20 | PRO 26 | - | VdWContact |
| VAL 17 | NTc.Cm19 | TYR 19 | - | VdWContact |
| VAL 17 | NTc.Cm19 | PRO 26 | - | Hydrophobic |
| VAL 17 | NTc.Cm19 | PRO 26 | - | VdWContact |
| TYR 19 | NTc.Cm17 | TYR 19 | - | HBDonor |
| TYR 19 | NTc.Cm17 | TYR 19 | - | Hydrophobic |
| TYR 19 | NTc.Cm17 | TYR 19 | - | VdWContact |
| TYR 19 | NTc.Cm17 | TYR 22 | - | Hydrophobic |
| TYR 19 | NTc.Cm17 | TYR 22 | - | PiStacking |
| TYR 19 | NTc.Cm17 | ILE 25 | - | VdWContact |
| LEU 21 | NTc.Cm15 | TYR 19 | - | Hydrophobic |
| LEU 21 | NTc.Cm15 | TYR 19 | - | VdWContact |
| PRO 22 | NTc.Cm14 | ILE 15 | - | Hydrophobic |
| ARG 24 | NTc.Cm12 | ASP 12 | - | Cationic |
| ARG 24 | NTc.Cm12 | ASP 12 | - | HBDonor |
| ARG 24 | NTc.Cm12 | ASP 12 | - | VdWContact |
| ARG 24 | NTc.Cm12 | GLU 13 | - | HBDonor |
| ARG 24 | NTc.Cm12 | GLU 13 | - | VdWContact |
| ARG 24 | NTc.Cm12 | TYR 16 | - | Hydrophobic |
| ARG 24 | NTc.Cm12 | TYR 16 | - | VdWContact |
| VAL 25 | NTc.Cm11 | TYR 16 | - | Hydrophobic |
| VAL 25 | NTc.Cm11 | TYR 16 | - | VdWContact |
| VAL 25 | NTc.Cm11 | TYR 19 | - | Hydrophobic |
| VAL 25 | NTc.Cm11 | TYR 20 | - | Hydrophobic |
| VAL 25 | NTc.Cm11 | TYR 20 | - | VdWContact |
| ARG 38 | cxb1.1 | GLU 271 | 6.64x64 | Cationic |
| ARG 38 | cxb1.1 | GLU 271 | 6.64x64 | HBDonor |
| ARG 38 | cxb1.1 | GLU 271 | 6.64x64 | VdWContact |
| VAL 42 | cxb1.7 | PRO 28 | - | Hydrophobic |
| THR 45 | cxb1.11 | TYR 20 | - | Hydrophobic |
| PHE 46 | cxb1.14 | TYR 16 | - | VdWContact |
| ARG 47 | cxb1.15 | TYR 20 | - | CationPi |
| ARG 47 | cxb1.15 | TYR 20 | - | Hydrophobic |
| ARG 47 | cxb1.15 | TYR 20 | - | VdWContact |
| LYS 49 | B1.1 | TYR 20 | - | Hydrophobic |
| LYS 49 | B1.1 | TYR 20 | - | VdWContact |
| LYS 49 | B1.1 | ILE 25 | - | Hydrophobic |
| GLU 50 | B1.2 | PRO 28 | - | Hydrophobic |
| ILE 51 | B1.3 | TYR 19 | - | Hydrophobic |
| ILE 51 | B1.3 | TYR 19 | - | VdWContact |
| ILE 51 | B1.3 | ILE 25 | - | Hydrophobic |
| CYS 52 | B1.4 | PRO 26 | - | HBDonor |
| CYS 52 | B1.4 | PRO 26 | - | Hydrophobic |
| CYS 52 | B1.4 | PRO 26 | - | VdWContact |
| CYS 52 | B1.4 | PRO 28 | - | VdWContact |
