Predicted complex interactions
CCL8_HUMAN + CCR4
SUMMARY
- Chemokine
- CCL8_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CCR4 View partner entry
- Partner description
- UniProt: P51679; Gene: ccr4_human; Family: Chemokine
- Interactions detected
- 91
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| GLN 1 | NTc.Cm33 | TRP 95 | 2.60x60 | Hydrophobic |
| GLN 1 | NTc.Cm33 | CYS 187 | 45.50x50 | VdWContact |
| GLN 1 | NTc.Cm33 | LYS 188 | 45.51x51 | VdWContact |
| GLN 1 | NTc.Cm33 | THR 189 | 45.52x52 | VdWContact |
| PRO 2 | NTc.Cm32 | TRP 95 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm32 | TRP 95 | 2.60x60 | VdWContact |
| PRO 2 | NTc.Cm32 | TYR 117 | 3.32x32 | Hydrophobic |
| PRO 2 | NTc.Cm32 | TYR 117 | 3.32x32 | VdWContact |
| PRO 2 | NTc.Cm32 | GLU 290 | 7.39x38 | VdWContact |
| PRO 2 | NTc.Cm32 | PHE 294 | 7.43x42 | Hydrophobic |
| ASP 3 | NTc.Cm31 | ILE 286 | 7.35x34 | Hydrophobic |
| ASP 3 | NTc.Cm31 | GLU 290 | 7.39x38 | HBDonor |
| ASP 3 | NTc.Cm31 | GLU 290 | 7.39x38 | VdWContact |
| SER 4 | NTc.Cm30 | TYR 46 | 1.39x39 | VdWContact |
| SER 4 | NTc.Cm30 | GLN 287 | 7.36x35 | VdWContact |
| SER 4 | NTc.Cm30 | GLU 290 | 7.39x38 | HBDonor |
| SER 4 | NTc.Cm30 | GLU 290 | 7.39x38 | VdWContact |
| VAL 5 | NTc.Cm29 | LEU 42 | 1.35x35 | Hydrophobic |
| VAL 5 | NTc.Cm29 | TYR 46 | 1.39x39 | Hydrophobic |
| VAL 5 | NTc.Cm29 | TRP 95 | 2.60x60 | Hydrophobic |
| VAL 5 | NTc.Cm29 | TYR 98 | 2.63x63 | Hydrophobic |
| VAL 5 | NTc.Cm29 | ALA 99 | 2.64x64 | Hydrophobic |
| SER 6 | NTc.Cm28 | LYS 188 | 45.51x51 | HBAcceptor |
| SER 6 | NTc.Cm28 | LYS 188 | 45.51x51 | VdWContact |
| ILE 7 | NTc.Cm27 | LYS 31 | 1.24x24 | Hydrophobic |
| ILE 7 | NTc.Cm27 | ILE 34 | 1.27x27 | Hydrophobic |
| ILE 7 | NTc.Cm27 | ILE 34 | 1.27x27 | VdWContact |
| ILE 7 | NTc.Cm27 | ASP 283 | 7.32x31 | Hydrophobic |
| ILE 7 | NTc.Cm27 | GLN 287 | 7.36x35 | Hydrophobic |
| ILE 7 | NTc.Cm27 | GLN 287 | 7.36x35 | VdWContact |
| PRO 8 | NTc.Cm26 | LYS 31 | 1.24x24 | Hydrophobic |
| PRO 8 | NTc.Cm26 | LYS 31 | 1.24x24 | VdWContact |
| ILE 9 | NTc.Cm25 | LYS 31 | 1.24x24 | HBAcceptor |
| ILE 9 | NTc.Cm25 | LYS 31 | 1.24x24 | VdWContact |
| ILE 9 | NTc.Cm25 | GLU 32 | 1.25x25 | Hydrophobic |
| ILE 9 | NTc.Cm25 | LYS 35 | 1.28x28 | Hydrophobic |
| THR 10 | NTc.Cm24 | PRO 28 | - | Hydrophobic |
| THR 10 | NTc.Cm24 | PRO 28 | - | VdWContact |
| THR 10 | NTc.Cm24 | CYS 29 | - | VdWContact |
| THR 10 | NTc.Cm24 | THR 30 | - | Hydrophobic |
| CYS 11 | NTc.Cm23 | CYS 29 | - | HBAcceptor |
| CYS 11 | NTc.Cm23 | CYS 29 | - | HBDonor |
| CYS 11 | NTc.Cm23 | CYS 29 | - | VdWContact |
| PHE 13 | NTc.Cm21 | CYS 29 | - | Hydrophobic |
| PHE 13 | NTc.Cm21 | CYS 29 | - | VdWContact |
| PHE 13 | NTc.Cm21 | VAL 268 | 6.61x61 | Hydrophobic |
| PHE 13 | NTc.Cm21 | GLN 274 | - | Hydrophobic |
| PHE 13 | NTc.Cm21 | CYS 276 | 7.25x24 | Hydrophobic |
| PHE 13 | NTc.Cm21 | GLU 279 | 7.28x27 | Hydrophobic |
| PHE 13 | NTc.Cm21 | GLU 279 | 7.28x27 | VdWContact |
| ASN 14 | NTc.Cm20 | PRO 26 | - | Hydrophobic |
| ASN 14 | NTc.Cm20 | PRO 26 | - | VdWContact |
| VAL 15 | NTc.Cm19 | PRO 26 | - | VdWContact |
| ILE 16 | NTc.Cm18 | PRO 26 | - | Hydrophobic |
| ARG 18 | NTc.Cm16 | TYR 19 | - | CationPi |
| ARG 18 | NTc.Cm16 | TYR 19 | - | Hydrophobic |
| ARG 18 | NTc.Cm16 | TYR 19 | - | VdWContact |
| LYS 19 | NTc.Cm15 | TYR 19 | - | VdWContact |
| ARG 24 | NTc.Cm10 | ASP 12 | - | Cationic |
| ARG 24 | NTc.Cm10 | TYR 16 | - | CationPi |
| ARG 24 | NTc.Cm10 | TYR 16 | - | HBDonor |
| ARG 24 | NTc.Cm10 | TYR 16 | - | Hydrophobic |
| ARG 24 | NTc.Cm10 | TYR 16 | - | VdWContact |
| ARG 24 | NTc.Cm10 | TYR 19 | - | VdWContact |
| ARG 24 | NTc.Cm10 | TYR 20 | - | VdWContact |
| THR 29 | NTc.Cm5 | ARG 182 | - | VdWContact |
| ASN 33 | NTc.Cm1 | LYS 199 | 5.35x36 | HBAcceptor |
| ASN 33 | NTc.Cm1 | LYS 199 | 5.35x36 | VdWContact |
| ILE 34 | CX.1 | TYR 179 | - | Hydrophobic |
| ILE 34 | CX.1 | LYS 188 | 45.51x51 | Hydrophobic |
| ILE 34 | CX.1 | LYS 188 | 45.51x51 | VdWContact |
| ILE 34 | CX.1 | LYS 190 | - | Hydrophobic |
| ILE 34 | CX.1 | LYS 190 | - | VdWContact |
| GLN 35 | CX.5 | TYR 179 | - | HBDonor |
| GLN 35 | CX.5 | TYR 179 | - | VdWContact |
| GLN 35 | CX.5 | TYR 186 | - | VdWContact |
| GLN 35 | CX.5 | LYS 188 | 45.51x51 | VdWContact |
| ILE 42 | cxb1.10 | PRO 28 | - | Hydrophobic |
| ILE 42 | cxb1.10 | PRO 28 | - | VdWContact |
| LYS 49 | B1.3 | TYR 20 | - | VdWContact |
| LYS 49 | B1.3 | TYR 22 | - | CationPi |
| LYS 49 | B1.3 | TYR 22 | - | Hydrophobic |
| LYS 49 | B1.3 | TYR 22 | - | VdWContact |
| GLU 50 | B1.4 | PRO 28 | - | Hydrophobic |
| VAL 51 | B1.5 | ILE 25 | - | Hydrophobic |
| VAL 51 | B1.5 | ILE 25 | - | VdWContact |
| VAL 51 | B1.5 | PRO 26 | - | VdWContact |
| CYS 52 | B1.6 | PRO 26 | - | HBDonor |
| CYS 52 | B1.6 | PRO 26 | - | Hydrophobic |
| CYS 52 | B1.6 | PRO 26 | - | VdWContact |
| CYS 52 | B1.6 | PRO 28 | - | VdWContact |
