Predicted complex interactions
CXCL12_HUMAN + CCR4
SUMMARY
- Chemokine
- CXCL12_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CCR4 View partner entry
- Partner description
- UniProt: P51679; Gene: ccr4_human; Family: Chemokine
- Interactions detected
- 78
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LYS 1 | NTc.Cm29 | TRP 95 | 2.60x60 | Hydrophobic |
| LYS 1 | NTc.Cm29 | TRP 95 | 2.60x60 | VdWContact |
| LYS 1 | NTc.Cm29 | SER 114 | 3.29x29 | VdWContact |
| LYS 1 | NTc.Cm29 | TYR 117 | 3.32x32 | VdWContact |
| LYS 1 | NTc.Cm29 | CYS 187 | 45.50x50 | HBDonor |
| LYS 1 | NTc.Cm29 | CYS 187 | 45.50x50 | VdWContact |
| PRO 2 | NTc.Cm28 | TRP 95 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TYR 117 | 3.32x32 | Hydrophobic |
| PRO 2 | NTc.Cm28 | GLU 290 | 7.39x38 | VdWContact |
| PRO 2 | NTc.Cm28 | PHE 294 | 7.43x42 | Hydrophobic |
| VAL 3 | NTc.Cm27 | ILE 206 | 5.42x43 | Hydrophobic |
| VAL 3 | NTc.Cm27 | LEU 262 | 6.55x55 | Hydrophobic |
| VAL 3 | NTc.Cm27 | LEU 262 | 6.55x55 | VdWContact |
| VAL 3 | NTc.Cm27 | ILE 286 | 7.35x34 | Hydrophobic |
| VAL 3 | NTc.Cm27 | GLU 290 | 7.39x38 | HBDonor |
| VAL 3 | NTc.Cm27 | GLU 290 | 7.39x38 | VdWContact |
| SER 4 | NTc.Cm26 | GLN 287 | 7.36x35 | VdWContact |
| SER 4 | NTc.Cm26 | GLU 290 | 7.39x38 | HBDonor |
| SER 4 | NTc.Cm26 | GLU 290 | 7.39x38 | VdWContact |
| LEU 5 | NTc.Cm25 | LEU 42 | 1.35x35 | Hydrophobic |
| LEU 5 | NTc.Cm25 | TYR 46 | 1.39x39 | Hydrophobic |
| LEU 5 | NTc.Cm25 | TRP 95 | 2.60x60 | Hydrophobic |
| LEU 5 | NTc.Cm25 | TYR 98 | 2.63x63 | Hydrophobic |
| LEU 5 | NTc.Cm25 | TYR 98 | 2.63x63 | VdWContact |
| LEU 5 | NTc.Cm25 | ALA 99 | 2.64x64 | Hydrophobic |
| TYR 7 | NTc.Cm23 | ILE 34 | 1.27x27 | Hydrophobic |
| TYR 7 | NTc.Cm23 | LYS 35 | 1.28x28 | Hydrophobic |
| ARG 8 | NTc.Cm22 | GLU 265 | 6.58x58 | Cationic |
| ARG 8 | NTc.Cm22 | GLU 265 | 6.58x58 | HBDonor |
| ARG 8 | NTc.Cm22 | GLU 265 | 6.58x58 | VdWContact |
| ARG 8 | NTc.Cm22 | GLU 269 | 6.62x62 | Cationic |
| ARG 8 | NTc.Cm22 | GLU 279 | 7.28x27 | Cationic |
| ARG 8 | NTc.Cm22 | GLU 279 | 7.28x27 | HBDonor |
| ARG 8 | NTc.Cm22 | GLU 279 | 7.28x27 | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 283 | 7.32x31 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 283 | 7.32x31 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 283 | 7.32x31 | VdWContact |
| PRO 10 | NTc.Cm20 | PRO 28 | - | Hydrophobic |
| PRO 10 | NTc.Cm20 | PRO 28 | - | VdWContact |
| PRO 10 | NTc.Cm20 | CYS 29 | - | HBAcceptor |
| PRO 10 | NTc.Cm20 | CYS 29 | - | VdWContact |
| ARG 12 | NTc.Cm18 | VAL 268 | 6.61x61 | VdWContact |
| ARG 12 | NTc.Cm18 | GLN 274 | - | HBDonor |
| ARG 12 | NTc.Cm18 | GLN 274 | - | VdWContact |
| ARG 12 | NTc.Cm18 | ASP 275 | 7.24x23 | HBDonor |
| ARG 12 | NTc.Cm18 | ASP 275 | 7.24x23 | VdWContact |
| ARG 12 | NTc.Cm18 | GLU 279 | 7.28x27 | Cationic |
| ARG 12 | NTc.Cm18 | GLU 279 | 7.28x27 | HBDonor |
| ARG 12 | NTc.Cm18 | GLU 279 | 7.28x27 | VdWContact |
| PHE 13 | NTc.Cm17 | PRO 26 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | PRO 26 | - | VdWContact |
| PHE 13 | NTc.Cm17 | GLN 274 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | GLN 274 | - | VdWContact |
| PHE 14 | NTc.Cm16 | PRO 26 | - | VdWContact |
| GLU 15 | NTc.Cm15 | PRO 26 | - | Hydrophobic |
| GLU 15 | NTc.Cm15 | PRO 26 | - | VdWContact |
| LYS 27 | NTc.Cm3 | GLU 32 | 1.25x25 | Cationic |
| PRO 32 | CX.5 | TYR 179 | - | Hydrophobic |
| PRO 32 | CX.5 | LYS 190 | - | Hydrophobic |
| ASN 33 | cxb1.1 | THR 189 | 45.52x52 | HBDonor |
| ASN 33 | cxb1.1 | THR 189 | 45.52x52 | VdWContact |
| ASN 33 | cxb1.1 | LYS 190 | - | VdWContact |
| ASN 33 | cxb1.1 | TYR 191 | - | HBAcceptor |
| ASN 33 | cxb1.1 | TYR 191 | - | VdWContact |
| VAL 39 | cxb1.11 | PRO 28 | - | Hydrophobic |
| LEU 42 | cxb1.16 | TYR 22 | - | Hydrophobic |
| LEU 42 | cxb1.16 | TYR 22 | - | VdWContact |
| LEU 42 | cxb1.16 | ILE 25 | - | Hydrophobic |
| ASN 45 | B1.3 | TYR 22 | - | VdWContact |
| ARG 47 | B1.5 | TYR 22 | - | HBDonor |
| ARG 47 | B1.5 | TYR 22 | - | VdWContact |
| GLN 48 | B1.6 | PRO 28 | - | Hydrophobic |
| VAL 49 | B1.7 | ILE 25 | - | Hydrophobic |
| VAL 49 | B1.7 | ILE 25 | - | VdWContact |
| VAL 49 | B1.7 | PRO 26 | - | VdWContact |
| CYS 50 | b1b2.4 | PRO 26 | - | HBDonor |
| CYS 50 | b1b2.4 | PRO 26 | - | Hydrophobic |
| CYS 50 | b1b2.4 | PRO 26 | - | VdWContact |
