Predicted complex interactions
CXCL8_HUMAN + CCR4
SUMMARY
- Chemokine
- CXCL8_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CCR4 View partner entry
- Partner description
- UniProt: P51679; Gene: ccr4_human; Family: Chemokine
- Interactions detected
- 113
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| GLU 1 | NTc.Cm33 | THR 189 | 45.52x52 | VdWContact |
| GLU 1 | NTc.Cm33 | LYS 190 | - | Anionic |
| GLU 1 | NTc.Cm33 | LYS 190 | - | Hydrophobic |
| GLU 1 | NTc.Cm33 | LYS 190 | - | VdWContact |
| GLU 1 | NTc.Cm33 | TYR 191 | - | VdWContact |
| GLU 1 | NTc.Cm33 | SER 195 | 5.31x32 | VdWContact |
| GLU 1 | NTc.Cm33 | LYS 199 | 5.35x36 | VdWContact |
| GLY 2 | NTc.Cm32 | THR 189 | 45.52x52 | HBAcceptor |
| GLY 2 | NTc.Cm32 | THR 189 | 45.52x52 | VdWContact |
| GLY 2 | NTc.Cm32 | TYR 191 | - | VdWContact |
| GLY 2 | NTc.Cm32 | LYS 199 | 5.35x36 | VdWContact |
| ALA 3 | NTc.Cm31 | THR 189 | 45.52x52 | HBAcceptor |
| VAL 4 | NTc.Cm30 | LEU 118 | 3.33x33 | Hydrophobic |
| VAL 4 | NTc.Cm30 | LEU 118 | 3.33x33 | VdWContact |
| VAL 4 | NTc.Cm30 | THR 189 | 45.52x52 | HBDonor |
| VAL 4 | NTc.Cm30 | THR 189 | 45.52x52 | VdWContact |
| LEU 5 | NTc.Cm29 | TRP 95 | 2.60x60 | Hydrophobic |
| LEU 5 | NTc.Cm29 | TRP 95 | 2.60x60 | VdWContact |
| LEU 5 | NTc.Cm29 | SER 114 | 3.29x29 | VdWContact |
| LEU 5 | NTc.Cm29 | CYS 187 | 45.50x50 | VdWContact |
| LEU 5 | NTc.Cm29 | LYS 188 | 45.51x51 | VdWContact |
| PRO 6 | NTc.Cm28 | TRP 95 | 2.60x60 | Hydrophobic |
| PRO 6 | NTc.Cm28 | TRP 95 | 2.60x60 | VdWContact |
| PRO 6 | NTc.Cm28 | TYR 117 | 3.32x32 | Hydrophobic |
| PRO 6 | NTc.Cm28 | GLU 290 | 7.39x38 | VdWContact |
| PRO 6 | NTc.Cm28 | PHE 294 | 7.43x42 | Hydrophobic |
| ARG 7 | NTc.Cm27 | SER 203 | 5.39x40 | HBDonor |
| ARG 7 | NTc.Cm27 | SER 203 | 5.39x40 | VdWContact |
| ARG 7 | NTc.Cm27 | LEU 262 | 6.55x55 | Hydrophobic |
| ARG 7 | NTc.Cm27 | LEU 262 | 6.55x55 | VdWContact |
| ARG 7 | NTc.Cm27 | GLU 265 | 6.58x58 | Cationic |
| ARG 7 | NTc.Cm27 | GLU 265 | 6.58x58 | HBDonor |
| ARG 7 | NTc.Cm27 | GLU 265 | 6.58x58 | VdWContact |
| ARG 7 | NTc.Cm27 | ILE 286 | 7.35x34 | Hydrophobic |
| ARG 7 | NTc.Cm27 | GLU 290 | 7.39x38 | HBDonor |
| ARG 7 | NTc.Cm27 | GLU 290 | 7.39x38 | VdWContact |
| SER 8 | NTc.Cm26 | TYR 46 | 1.39x39 | VdWContact |
| SER 8 | NTc.Cm26 | GLN 287 | 7.36x35 | VdWContact |
| SER 8 | NTc.Cm26 | GLU 290 | 7.39x38 | HBDonor |
| SER 8 | NTc.Cm26 | GLU 290 | 7.39x38 | VdWContact |
| ALA 9 | NTc.Cm25 | TYR 98 | 2.63x63 | Hydrophobic |
| ALA 9 | NTc.Cm25 | TYR 98 | 2.63x63 | VdWContact |
| LYS 10 | NTc.Cm24 | LYS 35 | 1.28x28 | Hydrophobic |
| LYS 10 | NTc.Cm24 | LYS 35 | 1.28x28 | VdWContact |
| LYS 10 | NTc.Cm24 | GLU 39 | 1.32x32 | Cationic |
| LYS 10 | NTc.Cm24 | GLU 39 | 1.32x32 | HBDonor |
| LYS 10 | NTc.Cm24 | GLU 39 | 1.32x32 | VdWContact |
| LYS 10 | NTc.Cm24 | ALA 99 | 2.64x64 | VdWContact |
| LYS 10 | NTc.Cm24 | ALA 100 | 2.65x65 | HBDonor |
| LYS 10 | NTc.Cm24 | ALA 100 | 2.65x65 | VdWContact |
| LYS 10 | NTc.Cm24 | ASP 101 | 2.66x66 | HBDonor |
| LYS 10 | NTc.Cm24 | ASP 101 | 2.66x66 | VdWContact |
| GLU 11 | NTc.Cm23 | LYS 188 | 45.51x51 | Anionic |
| GLU 11 | NTc.Cm23 | LYS 188 | 45.51x51 | Hydrophobic |
| GLU 11 | NTc.Cm23 | LYS 188 | 45.51x51 | VdWContact |
| LEU 12 | NTc.Cm22 | LYS 31 | 1.24x24 | Hydrophobic |
| LEU 12 | NTc.Cm22 | LYS 31 | 1.24x24 | VdWContact |
| LEU 12 | NTc.Cm22 | ILE 34 | 1.27x27 | Hydrophobic |
| LEU 12 | NTc.Cm22 | LYS 35 | 1.28x28 | Hydrophobic |
| LEU 12 | NTc.Cm22 | LYS 35 | 1.28x28 | VdWContact |
| ARG 13 | NTc.Cm21 | LYS 31 | 1.24x24 | VdWContact |
| ARG 13 | NTc.Cm21 | VAL 268 | 6.61x61 | VdWContact |
| ARG 13 | NTc.Cm21 | GLU 279 | 7.28x27 | Cationic |
| ARG 13 | NTc.Cm21 | GLU 279 | 7.28x27 | VdWContact |
| ARG 13 | NTc.Cm21 | LEU 282 | 7.31x30 | VdWContact |
| ARG 13 | NTc.Cm21 | ASP 283 | 7.32x31 | Cationic |
| ARG 13 | NTc.Cm21 | ASP 283 | 7.32x31 | HBDonor |
| ARG 13 | NTc.Cm21 | ASP 283 | 7.32x31 | VdWContact |
| GLN 15 | NTc.Cm19 | PRO 28 | - | Hydrophobic |
| GLN 15 | NTc.Cm19 | CYS 29 | - | HBAcceptor |
| GLN 15 | NTc.Cm19 | CYS 29 | - | VdWContact |
| ILE 17 | NTc.Cm17 | CYS 29 | - | Hydrophobic |
| ILE 17 | NTc.Cm17 | GLN 274 | - | Hydrophobic |
| ILE 17 | NTc.Cm17 | CYS 276 | 7.25x24 | Hydrophobic |
| ILE 17 | NTc.Cm17 | CYS 276 | 7.25x24 | VdWContact |
| ILE 17 | NTc.Cm17 | GLU 279 | 7.28x27 | VdWContact |
| LYS 18 | NTc.Cm16 | PRO 26 | - | Hydrophobic |
| LYS 18 | NTc.Cm16 | PRO 26 | - | VdWContact |
| TYR 20 | NTc.Cm14 | PRO 26 | - | Hydrophobic |
| TYR 20 | NTc.Cm14 | PRO 26 | - | VdWContact |
| LYS 22 | NTc.Cm12 | GLU 23 | - | Cationic |
| LYS 22 | NTc.Cm12 | GLU 23 | - | HBDonor |
| LYS 22 | NTc.Cm12 | GLU 23 | - | VdWContact |
| PRO 23 | NTc.Cm11 | ILE 15 | - | Hydrophobic |
| PHE 24 | NTc.Cm10 | TYR 16 | - | VdWContact |
| PHE 24 | NTc.Cm10 | TYR 19 | - | Hydrophobic |
| PHE 24 | NTc.Cm10 | TYR 19 | - | VdWContact |
| HIS 25 | NTc.Cm9 | GLU 13 | - | Hydrophobic |
| HIS 25 | NTc.Cm9 | TYR 16 | - | Hydrophobic |
| HIS 25 | NTc.Cm9 | TYR 16 | - | VdWContact |
| LYS 27 | NTc.Cm7 | GLU 13 | - | Cationic |
| PHE 28 | NTc.Cm6 | TYR 19 | - | Hydrophobic |
| PHE 28 | NTc.Cm6 | TYR 19 | - | PiStacking |
| ARG 33 | NTc.Cm1 | GLU 32 | 1.25x25 | Cationic |
| ARG 33 | NTc.Cm1 | ARG 182 | - | VdWContact |
| VAL 34 | CX.1 | ARG 182 | - | VdWContact |
| ILE 35 | CX.4 | ARG 182 | - | VdWContact |
| PRO 39 | cxb1.5 | TYR 179 | - | Hydrophobic |
| PRO 39 | cxb1.5 | TYR 179 | - | VdWContact |
| PRO 39 | cxb1.5 | LYS 188 | 45.51x51 | Hydrophobic |
| PRO 39 | cxb1.5 | LYS 188 | 45.51x51 | VdWContact |
| ILE 47 | cxb1.16 | PRO 28 | - | Hydrophobic |
| LEU 50 | B1.3 | TYR 19 | - | Hydrophobic |
| LEU 50 | B1.3 | TYR 19 | - | VdWContact |
| ARG 54 | B1.7 | ILE 25 | - | VdWContact |
| GLU 55 | b1b2.4 | PRO 28 | - | Hydrophobic |
| LEU 56 | b1b2.6 | ILE 25 | - | Hydrophobic |
| LEU 56 | b1b2.6 | ILE 25 | - | VdWContact |
| CYS 57 | b1b2.7 | PRO 28 | - | VdWContact |
| VAL 68 | B2.4 | TYR 16 | - | Hydrophobic |
| LYS 71 | b2b3.2 | ASP 12 | - | Cationic |
| LYS 71 | b2b3.2 | ASP 12 | - | HBDonor |
| LYS 71 | b2b3.2 | ASP 12 | - | VdWContact |
