Predicted complex interactions
CCL2_HUMAN + CCR5
SUMMARY
- Chemokine
- CCL2_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CCR5 View partner entry
- Partner description
- UniProt: P51681; Gene: ccr5_human; Family: Chemokine
- Interactions detected
- 91
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| GLN 1 | NTc.Cm33 | TRP 86 | 2.60x60 | Hydrophobic |
| GLN 1 | NTc.Cm33 | TRP 86 | 2.60x60 | VdWContact |
| GLN 1 | NTc.Cm33 | THR 105 | 3.29x29 | HBDonor |
| GLN 1 | NTc.Cm33 | THR 105 | 3.29x29 | VdWContact |
| GLN 1 | NTc.Cm33 | SER 179 | 45.51x51 | VdWContact |
| PRO 2 | NTc.Cm32 | TRP 86 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm32 | TRP 86 | 2.60x60 | VdWContact |
| PRO 2 | NTc.Cm32 | TYR 108 | 3.32x32 | Hydrophobic |
| PRO 2 | NTc.Cm32 | TYR 108 | 3.32x32 | VdWContact |
| PRO 2 | NTc.Cm32 | GLU 283 | 7.39x38 | VdWContact |
| PRO 2 | NTc.Cm32 | MET 287 | 7.43x42 | Hydrophobic |
| ASP 3 | NTc.Cm31 | TYR 251 | 6.51x51 | HBAcceptor |
| ASP 3 | NTc.Cm31 | TYR 251 | 6.51x51 | VdWContact |
| ASP 3 | NTc.Cm31 | MET 279 | 7.35x34 | Hydrophobic |
| ASP 3 | NTc.Cm31 | GLU 283 | 7.39x38 | HBDonor |
| ASP 3 | NTc.Cm31 | GLU 283 | 7.39x38 | VdWContact |
| ALA 4 | NTc.Cm30 | LEU 33 | 1.35x35 | Hydrophobic |
| ALA 4 | NTc.Cm30 | GLN 280 | 7.36x35 | Hydrophobic |
| ALA 4 | NTc.Cm30 | GLN 280 | 7.36x35 | VdWContact |
| ALA 4 | NTc.Cm30 | GLU 283 | 7.39x38 | HBDonor |
| ALA 4 | NTc.Cm30 | GLU 283 | 7.39x38 | Hydrophobic |
| ALA 4 | NTc.Cm30 | GLU 283 | 7.39x38 | VdWContact |
| ILE 5 | NTc.Cm29 | LEU 33 | 1.35x35 | Hydrophobic |
| ILE 5 | NTc.Cm29 | TYR 37 | 1.39x39 | Hydrophobic |
| ILE 5 | NTc.Cm29 | TYR 37 | 1.39x39 | VdWContact |
| ILE 5 | NTc.Cm29 | TRP 86 | 2.60x60 | Hydrophobic |
| ILE 5 | NTc.Cm29 | TRP 86 | 2.60x60 | VdWContact |
| ILE 5 | NTc.Cm29 | TYR 89 | 2.63x63 | Hydrophobic |
| ILE 5 | NTc.Cm29 | ALA 90 | 2.64x64 | Hydrophobic |
| ASN 6 | NTc.Cm28 | VAL 25 | 1.27x27 | Hydrophobic |
| ASN 6 | NTc.Cm28 | VAL 25 | 1.27x27 | VdWContact |
| ASN 6 | NTc.Cm28 | LYS 26 | 1.28x28 | VdWContact |
| ASN 6 | NTc.Cm28 | ASP 276 | 7.32x31 | VdWContact |
| ALA 7 | NTc.Cm27 | TYR 89 | 2.63x63 | Hydrophobic |
| ALA 7 | NTc.Cm27 | THR 177 | - | Hydrophobic |
| PRO 8 | NTc.Cm26 | HIS 175 | - | Hydrophobic |
| VAL 9 | NTc.Cm25 | LYS 22 | 1.24x24 | HBAcceptor |
| VAL 9 | NTc.Cm25 | LYS 22 | 1.24x24 | VdWContact |
| THR 10 | NTc.Cm24 | PRO 19 | - | Hydrophobic |
| THR 10 | NTc.Cm24 | PRO 19 | - | VdWContact |
| THR 10 | NTc.Cm24 | CYS 20 | - | VdWContact |
| THR 10 | NTc.Cm24 | GLN 21 | - | Hydrophobic |
| CYS 11 | NTc.Cm23 | CYS 20 | - | HBAcceptor |
| CYS 11 | NTc.Cm23 | CYS 20 | - | HBDonor |
| CYS 11 | NTc.Cm23 | CYS 20 | - | VdWContact |
| TYR 13 | NTc.Cm21 | CYS 20 | - | Hydrophobic |
| TYR 13 | NTc.Cm21 | CYS 20 | - | VdWContact |
| TYR 13 | NTc.Cm21 | LYS 22 | 1.24x24 | VdWContact |
| TYR 13 | NTc.Cm21 | GLN 261 | 6.61x61 | VdWContact |
| TYR 13 | NTc.Cm21 | ASN 267 | - | VdWContact |
| TYR 13 | NTc.Cm21 | CYS 269 | 7.25x24 | Hydrophobic |
| TYR 13 | NTc.Cm21 | SER 272 | 7.28x27 | VdWContact |
| ASN 14 | NTc.Cm20 | THR 16 | - | HBDonor |
| ASN 14 | NTc.Cm20 | THR 16 | - | VdWContact |
| ARG 18 | NTc.Cm16 | ILE 12 | - | VdWContact |
| ILE 20 | NTc.Cm14 | TYR 14 | - | Hydrophobic |
| ARG 30 | NTc.Cm4 | TYR 184 | - | CationPi |
| THR 32 | NTc.Cm2 | HIS 181 | - | HBAcceptor |
| THR 32 | NTc.Cm2 | HIS 181 | - | VdWContact |
| THR 32 | NTc.Cm2 | PHE 182 | - | HBAcceptor |
| THR 32 | NTc.Cm2 | PHE 182 | - | VdWContact |
| THR 32 | NTc.Cm2 | TYR 187 | 5.31x32 | VdWContact |
| SER 33 | NTc.Cm1 | SER 179 | 45.51x51 | HBDonor |
| SER 33 | NTc.Cm1 | SER 179 | 45.51x51 | VdWContact |
| SER 33 | NTc.Cm1 | SER 180 | 45.52x52 | VdWContact |
| SER 33 | NTc.Cm1 | TYR 187 | 5.31x32 | HBAcceptor |
| SER 33 | NTc.Cm1 | TYR 187 | 5.31x32 | VdWContact |
| SER 34 | CX.1 | SER 180 | 45.52x52 | HBDonor |
| SER 34 | CX.1 | SER 180 | 45.52x52 | VdWContact |
| SER 34 | CX.1 | LYS 191 | 5.35x36 | VdWContact |
| CYS 36 | cxb1.1 | TYR 187 | 5.31x32 | VdWContact |
| CYS 36 | cxb1.1 | LYS 191 | 5.35x36 | HBAcceptor |
| CYS 36 | cxb1.1 | LYS 191 | 5.35x36 | VdWContact |
| PRO 37 | cxb1.2 | LYS 191 | 5.35x36 | VdWContact |
| PRO 37 | cxb1.2 | GLN 261 | 6.61x61 | VdWContact |
| GLU 39 | cxb1.6 | TYR 184 | - | HBAcceptor |
| GLU 39 | cxb1.6 | TYR 184 | - | Hydrophobic |
| GLU 39 | cxb1.6 | TYR 184 | - | VdWContact |
| GLU 39 | cxb1.6 | TYR 187 | 5.31x32 | Hydrophobic |
| ILE 42 | cxb1.10 | PRO 19 | - | Hydrophobic |
| LYS 49 | B1.3 | ASP 11 | - | Cationic |
| LYS 49 | B1.3 | ASP 11 | - | HBDonor |
| LYS 49 | B1.3 | ASP 11 | - | VdWContact |
| GLU 50 | B1.4 | PRO 19 | - | Hydrophobic |
| ILE 51 | B1.5 | TYR 14 | - | Hydrophobic |
| ILE 51 | B1.5 | TYR 14 | - | VdWContact |
| CYS 52 | B1.6 | SER 17 | - | HBDonor |
| CYS 52 | B1.6 | SER 17 | - | VdWContact |
| CYS 52 | B1.6 | PRO 19 | - | VdWContact |
| PRO 55 | b1b2.6 | TYR 184 | - | Hydrophobic |
| PRO 55 | b1b2.6 | TYR 184 | - | VdWContact |
