Predicted complex interactions
CCL22_HUMAN + CCR5
SUMMARY
- Chemokine
- CCL22_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CCR5 View partner entry
- Partner description
- UniProt: P51681; Gene: ccr5_human; Family: Chemokine
- Interactions detected
- 92
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| GLY 1 | NTc.Cm35 | TYR 37 | 1.39x39 | VdWContact |
| GLY 1 | NTc.Cm35 | TRP 86 | 2.60x60 | VdWContact |
| GLY 1 | NTc.Cm35 | GLU 283 | 7.39x38 | Cationic |
| GLY 1 | NTc.Cm35 | GLU 283 | 7.39x38 | HBDonor |
| GLY 1 | NTc.Cm35 | GLU 283 | 7.39x38 | VdWContact |
| GLY 1 | NTc.Cm35 | MET 287 | 7.43x42 | VdWContact |
| PRO 2 | NTc.Cm34 | TRP 86 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm34 | TYR 108 | 3.32x32 | Hydrophobic |
| PRO 2 | NTc.Cm34 | TYR 108 | 3.32x32 | VdWContact |
| PRO 2 | NTc.Cm34 | PHE 109 | 3.33x33 | Hydrophobic |
| TYR 3 | NTc.Cm33 | PHE 109 | 3.33x33 | Hydrophobic |
| TYR 3 | NTc.Cm33 | PHE 109 | 3.33x33 | VdWContact |
| TYR 3 | NTc.Cm33 | ILE 198 | 5.42x43 | Hydrophobic |
| TYR 3 | NTc.Cm33 | ILE 198 | 5.42x43 | VdWContact |
| TYR 3 | NTc.Cm33 | TYR 251 | 6.51x51 | Hydrophobic |
| TYR 3 | NTc.Cm33 | TYR 251 | 6.51x51 | VdWContact |
| TYR 3 | NTc.Cm33 | LEU 255 | 6.55x55 | Hydrophobic |
| TYR 3 | NTc.Cm33 | MET 279 | 7.35x34 | Hydrophobic |
| TYR 3 | NTc.Cm33 | GLU 283 | 7.39x38 | HBDonor |
| TYR 3 | NTc.Cm33 | GLU 283 | 7.39x38 | VdWContact |
| GLY 4 | NTc.Cm32 | GLN 280 | 7.36x35 | VdWContact |
| GLY 4 | NTc.Cm32 | GLU 283 | 7.39x38 | HBDonor |
| GLY 4 | NTc.Cm32 | GLU 283 | 7.39x38 | VdWContact |
| ALA 5 | NTc.Cm31 | TRP 86 | 2.60x60 | Hydrophobic |
| ALA 5 | NTc.Cm31 | TYR 89 | 2.63x63 | Hydrophobic |
| ALA 5 | NTc.Cm31 | ALA 90 | 2.64x64 | Hydrophobic |
| ASN 6 | NTc.Cm30 | TYR 89 | 2.63x63 | HBAcceptor |
| ASN 6 | NTc.Cm30 | TYR 89 | 2.63x63 | Hydrophobic |
| ASN 6 | NTc.Cm30 | TYR 89 | 2.63x63 | VdWContact |
| ASN 6 | NTc.Cm30 | CYS 178 | 45.50x50 | VdWContact |
| ASN 6 | NTc.Cm30 | SER 179 | 45.51x51 | VdWContact |
| MET 7 | NTc.Cm29 | VAL 25 | 1.27x27 | Hydrophobic |
| MET 7 | NTc.Cm29 | VAL 25 | 1.27x27 | VdWContact |
| MET 7 | NTc.Cm29 | LYS 26 | 1.28x28 | Hydrophobic |
| MET 7 | NTc.Cm29 | LYS 26 | 1.28x28 | VdWContact |
| MET 7 | NTc.Cm29 | ALA 29 | 1.31x31 | Hydrophobic |
| MET 7 | NTc.Cm29 | ASP 276 | 7.32x31 | Hydrophobic |
| MET 7 | NTc.Cm29 | GLN 280 | 7.36x35 | VdWContact |
| GLU 8 | NTc.Cm28 | LYS 22 | 1.24x24 | Anionic |
| GLU 8 | NTc.Cm28 | LYS 22 | 1.24x24 | HBAcceptor |
| GLU 8 | NTc.Cm28 | LYS 22 | 1.24x24 | VdWContact |
| GLU 8 | NTc.Cm28 | LYS 26 | 1.28x28 | HBAcceptor |
| GLU 8 | NTc.Cm28 | LYS 26 | 1.28x28 | VdWContact |
| ASP 9 | NTc.Cm27 | LYS 26 | 1.28x28 | Anionic |
| ASP 9 | NTc.Cm27 | LYS 26 | 1.28x28 | HBAcceptor |
| ASP 9 | NTc.Cm27 | LYS 26 | 1.28x28 | VdWContact |
| ASP 9 | NTc.Cm27 | THR 177 | - | Hydrophobic |
| SER 10 | NTc.Cm26 | GLU 172 | - | VdWContact |
| VAL 11 | NTc.Cm25 | PRO 19 | - | Hydrophobic |
| VAL 11 | NTc.Cm25 | PRO 19 | - | VdWContact |
| ARG 14 | NTc.Cm22 | CYS 20 | - | Cationic |
| ARG 14 | NTc.Cm22 | ASN 267 | - | VdWContact |
| ARG 14 | NTc.Cm22 | ASN 268 | 7.24x23 | HBDonor |
| ARG 14 | NTc.Cm22 | ASN 268 | 7.24x23 | VdWContact |
| ARG 14 | NTc.Cm22 | CYS 269 | 7.25x24 | HBDonor |
| ARG 14 | NTc.Cm22 | CYS 269 | 7.25x24 | VdWContact |
| ARG 14 | NTc.Cm22 | SER 272 | 7.28x27 | VdWContact |
| VAL 17 | NTc.Cm19 | TYR 14 | - | Hydrophobic |
| TYR 19 | NTc.Cm17 | ILE 12 | - | Hydrophobic |
| LEU 21 | NTc.Cm15 | TYR 14 | - | Hydrophobic |
| LEU 21 | NTc.Cm15 | TYR 14 | - | VdWContact |
| SER 33 | NTc.Cm3 | GLN 170 | - | VdWContact |
| SER 33 | NTc.Cm3 | GLU 172 | - | HBDonor |
| SER 33 | NTc.Cm3 | GLU 172 | - | VdWContact |
| ASP 34 | NTc.Cm2 | ARG 168 | - | Anionic |
| ASP 34 | NTc.Cm2 | ARG 168 | - | HBAcceptor |
| ASP 34 | NTc.Cm2 | ARG 168 | - | VdWContact |
| ASP 34 | NTc.Cm2 | GLN 170 | - | VdWContact |
| ASP 34 | NTc.Cm2 | HIS 181 | - | HBAcceptor |
| ASP 34 | NTc.Cm2 | HIS 181 | - | Hydrophobic |
| ASP 34 | NTc.Cm2 | HIS 181 | - | VdWContact |
| ASP 34 | NTc.Cm2 | TYR 184 | - | HBAcceptor |
| ASP 34 | NTc.Cm2 | TYR 184 | - | VdWContact |
| SER 35 | NTc.Cm1 | HIS 181 | - | HBAcceptor |
| SER 35 | NTc.Cm1 | HIS 181 | - | VdWContact |
| SER 35 | NTc.Cm1 | TYR 187 | 5.31x32 | VdWContact |
| CYS 36 | CX.1 | TYR 184 | - | VdWContact |
| PRO 37 | CX.5 | TYR 187 | 5.31x32 | Hydrophobic |
| PRO 37 | CX.5 | TYR 187 | 5.31x32 | VdWContact |
| ARG 38 | cxb1.1 | TYR 184 | - | VdWContact |
| PRO 39 | cxb1.2 | TYR 184 | - | Hydrophobic |
| VAL 42 | cxb1.7 | PRO 19 | - | Hydrophobic |
| ARG 47 | cxb1.15 | ILE 9 | - | VdWContact |
| LYS 49 | B1.1 | ASP 11 | - | Cationic |
| GLU 50 | B1.2 | GLU 18 | - | VdWContact |
| GLU 50 | B1.2 | PRO 19 | - | Hydrophobic |
| GLU 50 | B1.2 | GLN 21 | - | HBAcceptor |
| GLU 50 | B1.2 | GLN 21 | - | VdWContact |
| ILE 51 | B1.3 | TYR 14 | - | Hydrophobic |
| ILE 51 | B1.3 | TYR 14 | - | VdWContact |
| CYS 52 | B1.4 | SER 17 | - | HBDonor |
| CYS 52 | B1.4 | SER 17 | - | VdWContact |
