Predicted complex interactions
CXCL12_HUMAN + CCR5
SUMMARY
- Chemokine
- CXCL12_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CCR5 View partner entry
- Partner description
- UniProt: P51681; Gene: ccr5_human; Family: Chemokine
- Interactions detected
- 74
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LYS 1 | NTc.Cm29 | TRP 86 | 2.60x60 | Hydrophobic |
| LYS 1 | NTc.Cm29 | TRP 86 | 2.60x60 | VdWContact |
| LYS 1 | NTc.Cm29 | TYR 89 | 2.63x63 | VdWContact |
| LYS 1 | NTc.Cm29 | THR 105 | 3.29x29 | HBDonor |
| LYS 1 | NTc.Cm29 | THR 105 | 3.29x29 | Hydrophobic |
| LYS 1 | NTc.Cm29 | THR 105 | 3.29x29 | VdWContact |
| LYS 1 | NTc.Cm29 | CYS 178 | 45.50x50 | HBDonor |
| LYS 1 | NTc.Cm29 | CYS 178 | 45.50x50 | VdWContact |
| PRO 2 | NTc.Cm28 | TRP 86 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TRP 86 | 2.60x60 | VdWContact |
| PRO 2 | NTc.Cm28 | TYR 108 | 3.32x32 | Hydrophobic |
| PRO 2 | NTc.Cm28 | GLU 283 | 7.39x38 | VdWContact |
| PRO 2 | NTc.Cm28 | MET 287 | 7.43x42 | Hydrophobic |
| VAL 3 | NTc.Cm27 | ILE 198 | 5.42x43 | Hydrophobic |
| VAL 3 | NTc.Cm27 | LEU 255 | 6.55x55 | Hydrophobic |
| VAL 3 | NTc.Cm27 | GLU 283 | 7.39x38 | HBDonor |
| VAL 3 | NTc.Cm27 | GLU 283 | 7.39x38 | VdWContact |
| SER 4 | NTc.Cm26 | MET 279 | 7.35x34 | VdWContact |
| SER 4 | NTc.Cm26 | GLN 280 | 7.36x35 | VdWContact |
| SER 4 | NTc.Cm26 | GLU 283 | 7.39x38 | HBDonor |
| SER 4 | NTc.Cm26 | GLU 283 | 7.39x38 | VdWContact |
| LEU 5 | NTc.Cm25 | LEU 33 | 1.35x35 | Hydrophobic |
| LEU 5 | NTc.Cm25 | TRP 86 | 2.60x60 | Hydrophobic |
| LEU 5 | NTc.Cm25 | TYR 89 | 2.63x63 | Hydrophobic |
| LEU 5 | NTc.Cm25 | ALA 90 | 2.64x64 | Hydrophobic |
| TYR 7 | NTc.Cm23 | LYS 22 | 1.24x24 | Hydrophobic |
| TYR 7 | NTc.Cm23 | VAL 25 | 1.27x27 | Hydrophobic |
| TYR 7 | NTc.Cm23 | VAL 25 | 1.27x27 | VdWContact |
| TYR 7 | NTc.Cm23 | LYS 26 | 1.28x28 | Hydrophobic |
| TYR 7 | NTc.Cm23 | LYS 26 | 1.28x28 | VdWContact |
| TYR 7 | NTc.Cm23 | ASP 276 | 7.32x31 | VdWContact |
| TYR 7 | NTc.Cm23 | GLN 280 | 7.36x35 | VdWContact |
| ARG 8 | NTc.Cm22 | ASN 258 | 6.58x58 | HBDonor |
| ARG 8 | NTc.Cm22 | ASN 258 | 6.58x58 | VdWContact |
| ARG 8 | NTc.Cm22 | GLN 261 | 6.61x61 | HBDonor |
| ARG 8 | NTc.Cm22 | GLN 261 | 6.61x61 | VdWContact |
| ARG 8 | NTc.Cm22 | SER 272 | 7.28x27 | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 276 | 7.32x31 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 276 | 7.32x31 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 276 | 7.32x31 | VdWContact |
| PRO 10 | NTc.Cm20 | PRO 19 | - | Hydrophobic |
| PRO 10 | NTc.Cm20 | CYS 20 | - | HBAcceptor |
| PRO 10 | NTc.Cm20 | CYS 20 | - | VdWContact |
| ARG 12 | NTc.Cm18 | CYS 20 | - | Cationic |
| ARG 12 | NTc.Cm18 | CYS 20 | - | VdWContact |
| ARG 12 | NTc.Cm18 | ASN 267 | - | HBDonor |
| ARG 12 | NTc.Cm18 | ASN 267 | - | VdWContact |
| ARG 12 | NTc.Cm18 | ASN 268 | 7.24x23 | VdWContact |
| ARG 12 | NTc.Cm18 | CYS 269 | 7.25x24 | VdWContact |
| ARG 12 | NTc.Cm18 | SER 272 | 7.28x27 | VdWContact |
| PHE 13 | NTc.Cm17 | THR 16 | - | VdWContact |
| GLU 15 | NTc.Cm15 | TYR 14 | - | Hydrophobic |
| GLU 15 | NTc.Cm15 | TYR 14 | - | VdWContact |
| VAL 18 | NTc.Cm12 | TYR 14 | - | Hydrophobic |
| PRO 32 | CX.5 | GLN 170 | - | VdWContact |
| PRO 32 | CX.5 | GLU 172 | - | VdWContact |
| PRO 32 | CX.5 | HIS 181 | - | Hydrophobic |
| PRO 32 | CX.5 | HIS 181 | - | VdWContact |
| ASN 33 | cxb1.1 | SER 180 | 45.52x52 | VdWContact |
| ASN 33 | cxb1.1 | TYR 187 | 5.31x32 | Hydrophobic |
| ASN 33 | cxb1.1 | TYR 187 | 5.31x32 | VdWContact |
| ALA 35 | cxb1.5 | TYR 184 | - | Hydrophobic |
| ALA 35 | cxb1.5 | TYR 184 | - | VdWContact |
| VAL 39 | cxb1.11 | PRO 19 | - | Hydrophobic |
| VAL 39 | cxb1.11 | PRO 19 | - | VdWContact |
| LEU 42 | cxb1.16 | TYR 14 | - | Hydrophobic |
| LEU 42 | cxb1.16 | TYR 14 | - | VdWContact |
| ARG 47 | B1.5 | ASP 11 | - | Cationic |
| GLN 48 | B1.6 | GLU 18 | - | VdWContact |
| GLN 48 | B1.6 | PRO 19 | - | Hydrophobic |
| VAL 49 | B1.7 | TYR 14 | - | Hydrophobic |
| VAL 49 | B1.7 | SER 17 | - | VdWContact |
| CYS 50 | b1b2.4 | SER 17 | - | HBDonor |
| CYS 50 | b1b2.4 | SER 17 | - | VdWContact |
