Predicted complex interactions
CXCL8_HUMAN + CCR5
SUMMARY
- Chemokine
- CXCL8_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CCR5 View partner entry
- Partner description
- UniProt: P51681; Gene: ccr5_human; Family: Chemokine
- Interactions detected
- 120
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| GLU 1 | NTc.Cm33 | ARG 168 | - | Anionic |
| GLU 1 | NTc.Cm33 | ARG 168 | - | HBAcceptor |
| GLU 1 | NTc.Cm33 | ARG 168 | - | VdWContact |
| GLU 1 | NTc.Cm33 | GLN 170 | - | HBAcceptor |
| GLU 1 | NTc.Cm33 | GLN 170 | - | VdWContact |
| GLU 1 | NTc.Cm33 | HIS 181 | - | HBAcceptor |
| GLU 1 | NTc.Cm33 | HIS 181 | - | Hydrophobic |
| GLU 1 | NTc.Cm33 | HIS 181 | - | VdWContact |
| GLU 1 | NTc.Cm33 | PHE 182 | - | VdWContact |
| GLU 1 | NTc.Cm33 | TYR 187 | 5.31x32 | VdWContact |
| GLY 2 | NTc.Cm32 | SER 180 | 45.52x52 | HBDonor |
| GLY 2 | NTc.Cm32 | SER 180 | 45.52x52 | VdWContact |
| GLY 2 | NTc.Cm32 | HIS 181 | - | VdWContact |
| GLY 2 | NTc.Cm32 | PHE 182 | - | HBAcceptor |
| GLY 2 | NTc.Cm32 | PHE 182 | - | VdWContact |
| ALA 3 | NTc.Cm31 | SER 179 | 45.51x51 | VdWContact |
| ALA 3 | NTc.Cm31 | SER 180 | 45.52x52 | HBAcceptor |
| ALA 3 | NTc.Cm31 | SER 180 | 45.52x52 | VdWContact |
| VAL 4 | NTc.Cm30 | PHE 109 | 3.33x33 | Hydrophobic |
| VAL 4 | NTc.Cm30 | PHE 109 | 3.33x33 | VdWContact |
| VAL 4 | NTc.Cm30 | PHE 182 | - | Hydrophobic |
| VAL 4 | NTc.Cm30 | GLN 194 | 5.38x39 | Hydrophobic |
| VAL 4 | NTc.Cm30 | ILE 198 | 5.42x43 | Hydrophobic |
| VAL 4 | NTc.Cm30 | ILE 198 | 5.42x43 | VdWContact |
| LEU 5 | NTc.Cm29 | TRP 86 | 2.60x60 | Hydrophobic |
| LEU 5 | NTc.Cm29 | TRP 86 | 2.60x60 | VdWContact |
| LEU 5 | NTc.Cm29 | THR 105 | 3.29x29 | Hydrophobic |
| LEU 5 | NTc.Cm29 | THR 105 | 3.29x29 | VdWContact |
| LEU 5 | NTc.Cm29 | CYS 178 | 45.50x50 | Hydrophobic |
| LEU 5 | NTc.Cm29 | CYS 178 | 45.50x50 | VdWContact |
| PRO 6 | NTc.Cm28 | TRP 86 | 2.60x60 | Hydrophobic |
| PRO 6 | NTc.Cm28 | TRP 86 | 2.60x60 | VdWContact |
| PRO 6 | NTc.Cm28 | TYR 108 | 3.32x32 | Hydrophobic |
| PRO 6 | NTc.Cm28 | TYR 108 | 3.32x32 | VdWContact |
| PRO 6 | NTc.Cm28 | GLU 283 | 7.39x38 | VdWContact |
| PRO 6 | NTc.Cm28 | MET 287 | 7.43x42 | Hydrophobic |
| PRO 6 | NTc.Cm28 | MET 287 | 7.43x42 | VdWContact |
| ARG 7 | NTc.Cm27 | LEU 255 | 6.55x55 | VdWContact |
| ARG 7 | NTc.Cm27 | MET 279 | 7.35x34 | Hydrophobic |
| ARG 7 | NTc.Cm27 | GLU 283 | 7.39x38 | HBDonor |
| ARG 7 | NTc.Cm27 | GLU 283 | 7.39x38 | VdWContact |
| SER 8 | NTc.Cm26 | TYR 37 | 1.39x39 | HBDonor |
| SER 8 | NTc.Cm26 | GLN 280 | 7.36x35 | HBAcceptor |
| SER 8 | NTc.Cm26 | GLN 280 | 7.36x35 | VdWContact |
| SER 8 | NTc.Cm26 | GLU 283 | 7.39x38 | HBDonor |
| SER 8 | NTc.Cm26 | GLU 283 | 7.39x38 | VdWContact |
| ALA 9 | NTc.Cm25 | TYR 89 | 2.63x63 | Hydrophobic |
| ALA 9 | NTc.Cm25 | TYR 89 | 2.63x63 | VdWContact |
| LYS 10 | NTc.Cm24 | LYS 26 | 1.28x28 | Hydrophobic |
| LYS 10 | NTc.Cm24 | LYS 26 | 1.28x28 | VdWContact |
| LYS 10 | NTc.Cm24 | ALA 92 | 2.66x66 | HBDonor |
| LYS 10 | NTc.Cm24 | ALA 92 | 2.66x66 | VdWContact |
| GLU 11 | NTc.Cm23 | SER 179 | 45.51x51 | VdWContact |
| LEU 12 | NTc.Cm22 | LYS 22 | 1.24x24 | Hydrophobic |
| LEU 12 | NTc.Cm22 | LYS 22 | 1.24x24 | VdWContact |
| LEU 12 | NTc.Cm22 | LYS 26 | 1.28x28 | Hydrophobic |
| LEU 12 | NTc.Cm22 | LYS 26 | 1.28x28 | VdWContact |
| ARG 13 | NTc.Cm21 | LYS 22 | 1.24x24 | HBAcceptor |
| ARG 13 | NTc.Cm21 | LYS 22 | 1.24x24 | VdWContact |
| ARG 13 | NTc.Cm21 | ASN 258 | 6.58x58 | VdWContact |
| ARG 13 | NTc.Cm21 | GLN 261 | 6.61x61 | VdWContact |
| ARG 13 | NTc.Cm21 | SER 272 | 7.28x27 | HBDonor |
| ARG 13 | NTc.Cm21 | SER 272 | 7.28x27 | VdWContact |
| ARG 13 | NTc.Cm21 | LEU 275 | 7.31x30 | HBDonor |
| ARG 13 | NTc.Cm21 | LEU 275 | 7.31x30 | VdWContact |
| ARG 13 | NTc.Cm21 | ASP 276 | 7.32x31 | Cationic |
| ARG 13 | NTc.Cm21 | ASP 276 | 7.32x31 | HBDonor |
| ARG 13 | NTc.Cm21 | ASP 276 | 7.32x31 | VdWContact |
| GLN 15 | NTc.Cm19 | PRO 19 | - | Hydrophobic |
| GLN 15 | NTc.Cm19 | CYS 20 | - | HBAcceptor |
| GLN 15 | NTc.Cm19 | CYS 20 | - | VdWContact |
| ILE 17 | NTc.Cm17 | CYS 20 | - | Hydrophobic |
| ILE 17 | NTc.Cm17 | ASN 267 | - | Hydrophobic |
| ILE 17 | NTc.Cm17 | ASN 267 | - | VdWContact |
| LYS 18 | NTc.Cm16 | THR 16 | - | VdWContact |
| TYR 20 | NTc.Cm14 | PRO 8 | - | Hydrophobic |
| TYR 20 | NTc.Cm14 | ASP 11 | - | HBDonor |
| TYR 20 | NTc.Cm14 | ASP 11 | - | Hydrophobic |
| TYR 20 | NTc.Cm14 | ASP 11 | - | VdWContact |
| TYR 20 | NTc.Cm14 | ASN 13 | - | Hydrophobic |
| TYR 20 | NTc.Cm14 | SER 17 | - | VdWContact |
| LYS 22 | NTc.Cm12 | ASP 11 | - | Cationic |
| LYS 22 | NTc.Cm12 | ASP 11 | - | HBDonor |
| LYS 22 | NTc.Cm12 | ASP 11 | - | VdWContact |
| PHE 24 | NTc.Cm10 | VAL 5 | - | Hydrophobic |
| PHE 24 | NTc.Cm10 | VAL 5 | - | VdWContact |
| PHE 24 | NTc.Cm10 | PRO 8 | - | Hydrophobic |
| HIS 25 | NTc.Cm9 | VAL 5 | - | Hydrophobic |
| HIS 25 | NTc.Cm9 | VAL 5 | - | VdWContact |
| PHE 28 | NTc.Cm6 | VAL 5 | - | Hydrophobic |
| PRO 39 | cxb1.5 | SER 179 | 45.51x51 | VdWContact |
| PRO 39 | cxb1.5 | SER 180 | 45.52x52 | VdWContact |
| PRO 39 | cxb1.5 | HIS 181 | - | Hydrophobic |
| PRO 39 | cxb1.5 | HIS 181 | - | VdWContact |
| HIS 40 | cxb1.6 | GLU 172 | - | HBDonor |
| HIS 40 | cxb1.6 | GLU 172 | - | VdWContact |
| ALA 42 | cxb1.8 | TYR 184 | - | VdWContact |
| ALA 42 | cxb1.8 | TYR 187 | 5.31x32 | Hydrophobic |
| ALA 42 | cxb1.8 | TYR 187 | 5.31x32 | VdWContact |
| ASN 43 | cxb1.10 | TYR 184 | - | HBAcceptor |
| ASN 43 | cxb1.10 | TYR 184 | - | VdWContact |
| ILE 47 | cxb1.16 | PRO 19 | - | Hydrophobic |
| ILE 47 | cxb1.16 | PRO 19 | - | VdWContact |
| LEU 50 | B1.3 | PRO 8 | - | Hydrophobic |
| LEU 50 | B1.3 | TYR 14 | - | Hydrophobic |
| ARG 54 | B1.7 | ILE 9 | - | HBDonor |
| ARG 54 | B1.7 | ILE 9 | - | VdWContact |
| ARG 54 | B1.7 | TYR 14 | - | CationPi |
| ARG 54 | B1.7 | TYR 14 | - | Hydrophobic |
| ARG 54 | B1.7 | TYR 14 | - | VdWContact |
| GLU 55 | b1b2.4 | GLU 18 | - | VdWContact |
| GLU 55 | b1b2.4 | PRO 19 | - | Hydrophobic |
| LEU 56 | b1b2.6 | PRO 8 | - | Hydrophobic |
| LEU 56 | b1b2.6 | TYR 14 | - | Hydrophobic |
| LEU 56 | b1b2.6 | TYR 14 | - | VdWContact |
| LEU 56 | b1b2.6 | SER 17 | - | VdWContact |
| CYS 57 | b1b2.7 | SER 17 | - | HBDonor |
| CYS 57 | b1b2.7 | SER 17 | - | VdWContact |
| LYS 61 | b1b2.12 | TYR 184 | - | HBDonor |
| LYS 61 | b1b2.12 | TYR 184 | - | VdWContact |
