Predicted complex interactions
CXCL12_HUMAN + CCR6
SUMMARY
- Chemokine
- CXCL12_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CCR6 View partner entry
- Partner description
- UniProt: P51684; Gene: ccr6_human; Family: Chemokine
- Interactions detected
- 91
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LYS 1 | NTc.Cm29 | GLN 192 | - | VdWContact |
| PRO 2 | NTc.Cm28 | ARG 42 | 1.28x28 | VdWContact |
| PRO 2 | NTc.Cm28 | GLN 192 | - | VdWContact |
| VAL 3 | NTc.Cm27 | ARG 42 | 1.28x28 | HBAcceptor |
| VAL 3 | NTc.Cm27 | ARG 42 | 1.28x28 | VdWContact |
| VAL 3 | NTc.Cm27 | GLY 109 | 2.67x67 | VdWContact |
| VAL 3 | NTc.Cm27 | SER 194 | - | VdWContact |
| SER 4 | NTc.Cm26 | VAL 196 | - | VdWContact |
| LEU 5 | NTc.Cm25 | VAL 41 | 1.27x27 | Hydrophobic |
| LEU 5 | NTc.Cm25 | ARG 42 | 1.28x28 | Hydrophobic |
| LEU 5 | NTc.Cm25 | SER 45 | 1.31x31 | VdWContact |
| SER 6 | NTc.Cm24 | GLU 198 | 45.51x51 | VdWContact |
| SER 6 | NTc.Cm24 | LYS 298 | 7.35x34 | VdWContact |
| TYR 7 | NTc.Cm23 | THR 191 | - | Hydrophobic |
| TYR 7 | NTc.Cm23 | THR 191 | - | VdWContact |
| TYR 7 | NTc.Cm23 | GLN 192 | - | Hydrophobic |
| TYR 7 | NTc.Cm23 | VAL 196 | - | Hydrophobic |
| TYR 7 | NTc.Cm23 | VAL 196 | - | VdWContact |
| TYR 7 | NTc.Cm23 | GLU 198 | 45.51x51 | HBDonor |
| TYR 7 | NTc.Cm23 | GLU 198 | 45.51x51 | VdWContact |
| ARG 8 | NTc.Cm22 | ARG 286 | - | VdWContact |
| ARG 8 | NTc.Cm22 | GLU 291 | 7.28x27 | Cationic |
| ARG 8 | NTc.Cm22 | GLU 291 | 7.28x27 | HBDonor |
| ARG 8 | NTc.Cm22 | GLU 291 | 7.28x27 | VdWContact |
| ARG 8 | NTc.Cm22 | ILE 294 | 7.31x30 | VdWContact |
| CYS 9 | NTc.Cm21 | ARG 286 | - | HBAcceptor |
| CYS 9 | NTc.Cm21 | ARG 286 | - | VdWContact |
| PRO 10 | NTc.Cm20 | LEU 35 | - | Hydrophobic |
| PRO 10 | NTc.Cm20 | GLN 192 | - | VdWContact |
| CYS 11 | NTc.Cm19 | ARG 286 | - | HBAcceptor |
| CYS 11 | NTc.Cm19 | ARG 286 | - | VdWContact |
| ARG 12 | NTc.Cm18 | GLU 32 | - | HBDonor |
| ARG 12 | NTc.Cm18 | GLU 32 | - | VdWContact |
| ARG 12 | NTc.Cm18 | LEU 34 | - | HBDonor |
| ARG 12 | NTc.Cm18 | LEU 34 | - | VdWContact |
| ARG 12 | NTc.Cm18 | CYS 36 | - | VdWContact |
| ARG 12 | NTc.Cm18 | MET 284 | 6.65x65 | VdWContact |
| ARG 12 | NTc.Cm18 | ASN 285 | - | HBAcceptor |
| ARG 12 | NTc.Cm18 | ASN 285 | - | VdWContact |
| ARG 12 | NTc.Cm18 | ARG 286 | - | HBDonor |
| ARG 12 | NTc.Cm18 | ARG 286 | - | Hydrophobic |
| ARG 12 | NTc.Cm18 | ARG 286 | - | VdWContact |
| ARG 12 | NTc.Cm18 | GLU 291 | 7.28x27 | Cationic |
| ARG 12 | NTc.Cm18 | GLU 291 | 7.28x27 | VdWContact |
| PHE 13 | NTc.Cm17 | GLU 32 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | MET 33 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | MET 284 | 6.65x65 | VdWContact |
| PHE 13 | NTc.Cm17 | ASN 285 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | ASN 285 | - | VdWContact |
| PHE 14 | NTc.Cm16 | MET 284 | 6.65x65 | Hydrophobic |
| PHE 14 | NTc.Cm16 | MET 284 | 6.65x65 | VdWContact |
| HIS 17 | NTc.Cm13 | TYR 27 | - | Hydrophobic |
| HIS 17 | NTc.Cm13 | TYR 27 | - | VdWContact |
| ARG 20 | NTc.Cm10 | PHE 12 | - | Hydrophobic |
| ARG 20 | NTc.Cm10 | PHE 12 | - | VdWContact |
| ILE 28 | NTc.Cm2 | PHE 8 | - | Hydrophobic |
| THR 31 | CX.4 | THR 191 | - | Hydrophobic |
| PRO 32 | CX.5 | TYR 189 | - | Hydrophobic |
| PRO 32 | CX.5 | THR 191 | - | Hydrophobic |
| PRO 32 | CX.5 | THR 191 | - | VdWContact |
| PRO 32 | CX.5 | LYS 200 | - | Hydrophobic |
| ASN 33 | cxb1.1 | PRO 199 | 45.52x52 | HBDonor |
| ASN 33 | cxb1.1 | PRO 199 | 45.52x52 | VdWContact |
| ASN 33 | cxb1.1 | TYR 201 | - | HBAcceptor |
| ASN 33 | cxb1.1 | TYR 201 | - | VdWContact |
| ASN 33 | cxb1.1 | LEU 281 | 6.62x62 | Hydrophobic |
| ASN 33 | cxb1.1 | LEU 281 | 6.62x62 | VdWContact |
| VAL 39 | cxb1.11 | LEU 35 | - | Hydrophobic |
| LEU 42 | cxb1.16 | VAL 29 | - | Hydrophobic |
| LYS 43 | B1.1 | PHE 19 | - | VdWContact |
| ARG 47 | B1.5 | VAL 29 | - | HBDonor |
| ARG 47 | B1.5 | LEU 34 | - | Hydrophobic |
| ARG 47 | B1.5 | LEU 34 | - | VdWContact |
| GLN 48 | B1.6 | LEU 35 | - | HBAcceptor |
| GLN 48 | B1.6 | LEU 35 | - | Hydrophobic |
| GLN 48 | B1.6 | LEU 35 | - | VdWContact |
| VAL 49 | B1.7 | VAL 29 | - | Hydrophobic |
| VAL 49 | B1.7 | VAL 29 | - | VdWContact |
| VAL 49 | B1.7 | LEU 34 | - | Hydrophobic |
| TYR 61 | B2.4 | PHE 8 | - | Hydrophobic |
| TYR 61 | B2.4 | PHE 8 | - | VdWContact |
| TYR 61 | B2.4 | PHE 12 | - | Hydrophobic |
| TYR 61 | B2.4 | PHE 12 | - | VdWContact |
| ALA 65 | b2b3.3 | PHE 8 | - | Hydrophobic |
| ALA 65 | b2b3.3 | PHE 8 | - | VdWContact |
| LYS 68 | b2b3.12 | VAL 11 | - | HBDonor |
| LYS 68 | b2b3.12 | VAL 11 | - | Hydrophobic |
| LYS 68 | b2b3.12 | VAL 11 | - | VdWContact |
| ARG 69 | B3.1 | MET 6 | - | Hydrophobic |
| ARG 69 | B3.1 | MET 6 | - | VdWContact |
| ARG 69 | B3.1 | PHE 8 | - | Hydrophobic |
