Predicted complex interactions
CXCL12_HUMAN + CCR7
SUMMARY
- Chemokine
- CXCL12_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CCR7 View partner entry
- Partner description
- UniProt: P32248; Gene: ccr7_human; Family: Chemokine
- Interactions detected
- 85
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| SER 4 | NTc.Cm26 | THR 190 | 4.57x57 | VdWContact |
| SER 4 | NTc.Cm26 | GLU 191 | 4.58x59 | HBDonor |
| SER 4 | NTc.Cm26 | GLU 191 | 4.58x59 | VdWContact |
| SER 4 | NTc.Cm26 | VAL 193 | 4.60x61 | HBAcceptor |
| SER 4 | NTc.Cm26 | VAL 193 | 4.60x61 | VdWContact |
| LEU 5 | NTc.Cm25 | TYR 172 | 4.39x39 | Hydrophobic |
| LEU 5 | NTc.Cm25 | TYR 172 | 4.39x39 | VdWContact |
| LEU 5 | NTc.Cm25 | ILE 189 | 4.56x56 | VdWContact |
| LEU 5 | NTc.Cm25 | THR 190 | 4.57x57 | VdWContact |
| LEU 5 | NTc.Cm25 | GLU 191 | 4.58x59 | HBDonor |
| LEU 5 | NTc.Cm25 | GLU 191 | 4.58x59 | VdWContact |
| LEU 5 | NTc.Cm25 | HIS 192 | 4.59x60 | HBAcceptor |
| LEU 5 | NTc.Cm25 | HIS 192 | 4.59x60 | HBDonor |
| LEU 5 | NTc.Cm25 | HIS 192 | 4.59x60 | Hydrophobic |
| LEU 5 | NTc.Cm25 | HIS 192 | 4.59x60 | VdWContact |
| LEU 5 | NTc.Cm25 | VAL 193 | 4.60x61 | VdWContact |
| LEU 5 | NTc.Cm25 | ALA 195 | 4.62x63 | Hydrophobic |
| LEU 5 | NTc.Cm25 | PHE 196 | 4.63x64 | Hydrophobic |
| LEU 5 | NTc.Cm25 | PHE 196 | 4.63x64 | VdWContact |
| SER 6 | NTc.Cm24 | ILE 189 | 4.56x56 | VdWContact |
| SER 6 | NTc.Cm24 | THR 190 | 4.57x57 | HBDonor |
| SER 6 | NTc.Cm24 | THR 190 | 4.57x57 | VdWContact |
| SER 6 | NTc.Cm24 | GLU 191 | 4.58x59 | HBDonor |
| SER 6 | NTc.Cm24 | GLU 191 | 4.58x59 | VdWContact |
| TYR 7 | NTc.Cm23 | LEU 171 | 4.38x38 | HBDonor |
| TYR 7 | NTc.Cm23 | LEU 171 | 4.38x38 | VdWContact |
| TYR 7 | NTc.Cm23 | TYR 172 | 4.39x39 | VdWContact |
| TYR 7 | NTc.Cm23 | SER 173 | 4.40x40 | VdWContact |
| TYR 7 | NTc.Cm23 | ASP 174 | 4.41x41 | Hydrophobic |
| TYR 7 | NTc.Cm23 | ASP 174 | 4.41x41 | VdWContact |
| TYR 7 | NTc.Cm23 | GLN 176 | 4.43x43 | HBAcceptor |
| TYR 7 | NTc.Cm23 | GLN 176 | 4.43x43 | VdWContact |
| TYR 7 | NTc.Cm23 | ILE 189 | 4.56x56 | Hydrophobic |
| TYR 7 | NTc.Cm23 | ILE 189 | 4.56x56 | VdWContact |
| CYS 9 | NTc.Cm21 | GLN 176 | 4.43x43 | VdWContact |
| ARG 12 | NTc.Cm18 | GLU 191 | 4.58x59 | Cationic |
| ARG 12 | NTc.Cm18 | GLU 191 | 4.58x59 | HBDonor |
| ARG 12 | NTc.Cm18 | GLU 191 | 4.58x59 | VdWContact |
| ARG 20 | NTc.Cm10 | TYR 17 | - | CationPi |
| ARG 20 | NTc.Cm10 | TYR 17 | - | VdWContact |
| ALA 21 | NTc.Cm9 | TYR 8 | - | Hydrophobic |
| ALA 21 | NTc.Cm9 | TYR 8 | - | VdWContact |
| LEU 26 | NTc.Cm4 | PHE 20 | - | Hydrophobic |
| LYS 27 | NTc.Cm3 | ILE 269 | 6.41x41 | Hydrophobic |
| LYS 27 | NTc.Cm3 | ILE 269 | 6.41x41 | VdWContact |
| ILE 28 | NTc.Cm2 | LEU 23 | - | Hydrophobic |
| ILE 28 | NTc.Cm2 | LEU 23 | - | VdWContact |
| ASN 30 | CX.1 | CYS 24 | - | HBDonor |
| ASN 30 | CX.1 | CYS 24 | - | VdWContact |
| ASN 33 | cxb1.1 | GLN 176 | 4.43x43 | HBDonor |
| ASN 33 | cxb1.1 | GLN 176 | 4.43x43 | Hydrophobic |
| ASN 33 | cxb1.1 | GLN 176 | 4.43x43 | VdWContact |
| ASN 33 | cxb1.1 | ARG 177 | 4.44x44 | VdWContact |
| ASN 33 | cxb1.1 | ARG 185 | 4.52x52 | HBDonor |
| ASN 33 | cxb1.1 | ARG 185 | 4.52x52 | VdWContact |
| ASN 33 | cxb1.1 | SER 187 | 4.54x54 | VdWContact |
| CYS 34 | cxb1.2 | GLN 176 | 4.43x43 | VdWContact |
| CYS 34 | cxb1.2 | SER 178 | 4.45x45 | HBAcceptor |
| CYS 34 | cxb1.2 | SER 178 | 4.45x45 | VdWContact |
| CYS 34 | cxb1.2 | SER 179 | 4.46x46 | HBAcceptor |
| CYS 34 | cxb1.2 | SER 179 | 4.46x46 | VdWContact |
| ALA 35 | cxb1.5 | SER 179 | 4.46x46 | VdWContact |
| LEU 36 | cxb1.6 | LEU 23 | - | Hydrophobic |
| LEU 36 | cxb1.6 | LEU 23 | - | VdWContact |
| ILE 38 | cxb1.10 | LEU 23 | - | Hydrophobic |
| TYR 61 | B2.4 | PHE 20 | - | Hydrophobic |
| TYR 61 | B2.4 | PHE 20 | - | VdWContact |
| TYR 61 | B2.4 | GLU 21 | - | HBDonor |
| TYR 61 | B2.4 | GLU 21 | - | VdWContact |
| TYR 61 | B2.4 | LEU 23 | - | Hydrophobic |
| LEU 62 | B2.5 | LEU 23 | - | Hydrophobic |
| LEU 62 | B2.5 | LEU 23 | - | VdWContact |
| LYS 64 | b2b3.2 | TYR 17 | - | Hydrophobic |
| ALA 65 | b2b3.3 | SER 22 | - | VdWContact |
| LEU 66 | b2b3.4 | SER 25 | - | VdWContact |
| LYS 68 | b2b3.12 | ASP 16 | - | Cationic |
| LYS 68 | b2b3.12 | ASP 16 | - | VdWContact |
| LYS 68 | b2b3.12 | TYR 17 | - | Hydrophobic |
| LYS 68 | b2b3.12 | TYR 17 | - | VdWContact |
| LYS 68 | b2b3.12 | THR 18 | - | HBDonor |
| LYS 68 | b2b3.12 | THR 18 | - | VdWContact |
| ARG 69 | B3.1 | CYS 274 | 6.46x46 | Cationic |
| ARG 69 | B3.1 | GLU 275 | 6.47x47 | Cationic |
| ARG 69 | B3.1 | GLU 275 | 6.47x47 | HBDonor |
| ARG 69 | B3.1 | GLU 275 | 6.47x47 | VdWContact |
