Predicted complex interactions
CXCL12_HUMAN + CCR8
SUMMARY
- Chemokine
- CXCL12_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CCR8 View partner entry
- Partner description
- UniProt: P51685; Gene: ccr8_human; Family: Chemokine
- Interactions detected
- 78
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LYS 1 | NTc.Cm29 | TYR 94 | 2.63x63 | Hydrophobic |
| LYS 1 | NTc.Cm29 | TYR 94 | 2.63x63 | VdWContact |
| LYS 1 | NTc.Cm29 | SER 110 | 3.29x29 | HBDonor |
| LYS 1 | NTc.Cm29 | SER 110 | 3.29x29 | VdWContact |
| LYS 1 | NTc.Cm29 | TYR 114 | 3.33x33 | HBAcceptor |
| LYS 1 | NTc.Cm29 | TYR 172 | 4.64x65 | HBDonor |
| LYS 1 | NTc.Cm29 | TYR 172 | 4.64x65 | Hydrophobic |
| LYS 1 | NTc.Cm29 | TYR 172 | 4.64x65 | VdWContact |
| LYS 1 | NTc.Cm29 | CYS 183 | 45.50x50 | HBDonor |
| LYS 1 | NTc.Cm29 | CYS 183 | 45.50x50 | VdWContact |
| PRO 2 | NTc.Cm28 | GLN 91 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm28 | GLN 91 | 2.60x60 | VdWContact |
| PRO 2 | NTc.Cm28 | GLU 286 | 7.39x38 | VdWContact |
| PRO 2 | NTc.Cm28 | PHE 290 | 7.43x42 | Hydrophobic |
| VAL 3 | NTc.Cm27 | MET 202 | 5.42x43 | Hydrophobic |
| VAL 3 | NTc.Cm27 | MET 202 | 5.42x43 | VdWContact |
| VAL 3 | NTc.Cm27 | LEU 258 | 6.55x55 | Hydrophobic |
| VAL 3 | NTc.Cm27 | LEU 258 | 6.55x55 | VdWContact |
| VAL 3 | NTc.Cm27 | GLU 286 | 7.39x38 | HBDonor |
| VAL 3 | NTc.Cm27 | GLU 286 | 7.39x38 | VdWContact |
| SER 4 | NTc.Cm26 | THR 282 | 7.35x34 | VdWContact |
| SER 4 | NTc.Cm26 | HIS 283 | 7.36x35 | VdWContact |
| SER 4 | NTc.Cm26 | GLU 286 | 7.39x38 | HBDonor |
| SER 4 | NTc.Cm26 | GLU 286 | 7.39x38 | VdWContact |
| LEU 5 | NTc.Cm25 | LEU 95 | 2.64x64 | Hydrophobic |
| LEU 5 | NTc.Cm25 | HIS 283 | 7.36x35 | Hydrophobic |
| TYR 7 | NTc.Cm23 | GLU 177 | - | VdWContact |
| ARG 8 | NTc.Cm22 | ALA 27 | - | Hydrophobic |
| ARG 8 | NTc.Cm22 | ALA 27 | - | VdWContact |
| ARG 8 | NTc.Cm22 | SER 275 | 7.28x27 | HBDonor |
| ARG 8 | NTc.Cm22 | SER 275 | 7.28x27 | VdWContact |
| ARG 8 | NTc.Cm22 | THR 279 | 7.32x31 | HBDonor |
| ARG 8 | NTc.Cm22 | THR 279 | 7.32x31 | VdWContact |
| PRO 10 | NTc.Cm20 | PRO 24 | - | Hydrophobic |
| PRO 10 | NTc.Cm20 | CYS 25 | - | HBAcceptor |
| PRO 10 | NTc.Cm20 | CYS 25 | - | VdWContact |
| ARG 12 | NTc.Cm18 | HIS 264 | 6.61x61 | CationPi |
| ARG 12 | NTc.Cm18 | HIS 264 | 6.61x61 | VdWContact |
| ARG 12 | NTc.Cm18 | HIS 267 | 6.64x64 | CationPi |
| ARG 12 | NTc.Cm18 | HIS 267 | 6.64x64 | Hydrophobic |
| ARG 12 | NTc.Cm18 | HIS 267 | 6.64x64 | VdWContact |
| ARG 12 | NTc.Cm18 | LEU 269 | - | HBDonor |
| ARG 12 | NTc.Cm18 | LEU 269 | - | VdWContact |
| ARG 12 | NTc.Cm18 | ASP 270 | - | Cationic |
| ARG 12 | NTc.Cm18 | ASP 270 | - | VdWContact |
| PHE 13 | NTc.Cm17 | PHE 21 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | PHE 21 | - | VdWContact |
| PHE 13 | NTc.Cm17 | HIS 267 | 6.64x64 | Hydrophobic |
| PHE 13 | NTc.Cm17 | ASP 270 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | ASP 270 | - | VdWContact |
| GLU 15 | NTc.Cm15 | TYR 16 | - | HBAcceptor |
| GLU 15 | NTc.Cm15 | TYR 16 | - | Hydrophobic |
| GLU 15 | NTc.Cm15 | TYR 16 | - | VdWContact |
| GLU 15 | NTc.Cm15 | PRO 18 | - | Hydrophobic |
| HIS 17 | NTc.Cm13 | TYR 16 | - | Hydrophobic |
| HIS 17 | NTc.Cm13 | TYR 16 | - | VdWContact |
| LYS 27 | NTc.Cm3 | ASP 178 | - | Cationic |
| THR 31 | CX.4 | GLU 177 | - | Hydrophobic |
| THR 31 | CX.4 | GLU 177 | - | VdWContact |
| PRO 32 | CX.5 | ALA 175 | - | Hydrophobic |
| PRO 32 | CX.5 | TYR 184 | 45.51x51 | Hydrophobic |
| PRO 32 | CX.5 | TYR 184 | 45.51x51 | VdWContact |
| PRO 32 | CX.5 | PHE 186 | - | Hydrophobic |
| PRO 32 | CX.5 | PHE 186 | - | VdWContact |
| ASN 33 | cxb1.1 | TYR 184 | 45.51x51 | VdWContact |
| ASN 33 | cxb1.1 | THR 191 | 5.31x32 | Hydrophobic |
| VAL 39 | cxb1.11 | PRO 24 | - | Hydrophobic |
| VAL 39 | cxb1.11 | PRO 24 | - | VdWContact |
| LEU 42 | cxb1.16 | PRO 18 | - | Hydrophobic |
| LEU 42 | cxb1.16 | PRO 18 | - | VdWContact |
| GLN 48 | B1.6 | SER 23 | - | VdWContact |
| GLN 48 | B1.6 | PRO 24 | - | Hydrophobic |
| GLN 48 | B1.6 | PRO 24 | - | VdWContact |
| VAL 49 | B1.7 | PRO 18 | - | Hydrophobic |
| VAL 49 | B1.7 | PRO 18 | - | VdWContact |
| VAL 49 | B1.7 | SER 22 | - | VdWContact |
| CYS 50 | b1b2.4 | SER 22 | - | HBDonor |
| CYS 50 | b1b2.4 | SER 22 | - | VdWContact |
