Predicted complex interactions
CXCL10_HUMAN + ACKR2
SUMMARY
- Chemokine
- CXCL10_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- ACKR2 View partner entry
- Partner description
- UniProt: O00590; Gene: ackr2_human; Family: Chemokine
- Interactions detected
- 112
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| VAL 1 | NTc.Cm29 | TRP 102 | 2.60x60 | VdWContact |
| VAL 1 | NTc.Cm29 | VAL 106 | 2.64x64 | Hydrophobic |
| VAL 1 | NTc.Cm29 | CYS 195 | 45.50x50 | VdWContact |
| PRO 2 | NTc.Cm28 | TRP 102 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TRP 102 | 2.60x60 | VdWContact |
| PRO 2 | NTc.Cm28 | TYR 124 | 3.32x32 | Hydrophobic |
| PRO 2 | NTc.Cm28 | PHE 302 | 7.43x42 | Hydrophobic |
| LEU 3 | NTc.Cm27 | ASP 179 | 4.60x61 | VdWContact |
| LEU 3 | NTc.Cm27 | VAL 183 | 4.64x65 | Hydrophobic |
| LEU 3 | NTc.Cm27 | ALA 197 | 45.52x52 | Hydrophobic |
| LEU 3 | NTc.Cm27 | PHE 199 | - | Hydrophobic |
| LEU 3 | NTc.Cm27 | LEU 210 | 5.38x39 | Hydrophobic |
| SER 4 | NTc.Cm26 | TYR 266 | 6.51x51 | HBAcceptor |
| SER 4 | NTc.Cm26 | TYR 266 | 6.51x51 | VdWContact |
| SER 4 | NTc.Cm26 | LEU 270 | 6.55x55 | VdWContact |
| SER 4 | NTc.Cm26 | GLU 298 | 7.39x38 | HBDonor |
| SER 4 | NTc.Cm26 | GLU 298 | 7.39x38 | VdWContact |
| ARG 5 | NTc.Cm25 | LEU 49 | 1.35x35 | VdWContact |
| ARG 5 | NTc.Cm25 | TYR 53 | 1.39x39 | VdWContact |
| ARG 5 | NTc.Cm25 | LEU 294 | 7.35x34 | Hydrophobic |
| ARG 5 | NTc.Cm25 | LEU 294 | 7.35x34 | VdWContact |
| ARG 5 | NTc.Cm25 | GLN 295 | 7.36x35 | VdWContact |
| ARG 5 | NTc.Cm25 | GLU 298 | 7.39x38 | Cationic |
| ARG 5 | NTc.Cm25 | GLU 298 | 7.39x38 | HBDonor |
| ARG 5 | NTc.Cm25 | GLU 298 | 7.39x38 | VdWContact |
| THR 6 | NTc.Cm24 | HIS 196 | 45.51x51 | Hydrophobic |
| THR 6 | NTc.Cm24 | HIS 196 | 45.51x51 | VdWContact |
| VAL 7 | NTc.Cm23 | ALA 197 | 45.52x52 | Hydrophobic |
| VAL 7 | NTc.Cm23 | ALA 197 | 45.52x52 | VdWContact |
| VAL 7 | NTc.Cm23 | PHE 199 | - | Hydrophobic |
| VAL 7 | NTc.Cm23 | LYS 207 | 5.35x36 | VdWContact |
| ARG 8 | NTc.Cm22 | LYS 207 | 5.35x36 | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 291 | 7.32x31 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 291 | 7.32x31 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 291 | 7.32x31 | VdWContact |
| CYS 9 | NTc.Cm21 | LYS 207 | 5.35x36 | HBAcceptor |
| CYS 9 | NTc.Cm21 | LYS 207 | 5.35x36 | VdWContact |
| THR 10 | NTc.Cm20 | LEU 276 | 6.61x61 | Hydrophobic |
| THR 10 | NTc.Cm20 | ASP 277 | 6.62x62 | VdWContact |
| THR 10 | NTc.Cm20 | GLN 279 | 6.64x64 | HBAcceptor |
| ILE 12 | NTc.Cm18 | THR 204 | 5.32x33 | HBAcceptor |
| ILE 12 | NTc.Cm18 | THR 204 | 5.32x33 | Hydrophobic |
| ILE 12 | NTc.Cm18 | THR 204 | 5.32x33 | VdWContact |
| ILE 12 | NTc.Cm18 | LEU 208 | 5.36x37 | Hydrophobic |
| ILE 12 | NTc.Cm18 | ASP 277 | 6.62x62 | Hydrophobic |
| ILE 12 | NTc.Cm18 | LEU 278 | 6.63x63 | Hydrophobic |
| ASN 20 | NTc.Cm10 | TYR 24 | - | Hydrophobic |
| ASN 20 | NTc.Cm10 | TYR 24 | - | VdWContact |
| PRO 21 | NTc.Cm9 | TYR 24 | - | Hydrophobic |
| PRO 21 | NTc.Cm9 | TYR 24 | - | VdWContact |
| PRO 21 | NTc.Cm9 | TYR 27 | - | Hydrophobic |
| PRO 21 | NTc.Cm9 | LEU 28 | - | Hydrophobic |
| PRO 21 | NTc.Cm9 | LEU 28 | - | VdWContact |
| ARG 22 | NTc.Cm8 | TYR 27 | - | CationPi |
| ARG 22 | NTc.Cm8 | TYR 27 | - | Hydrophobic |
| ARG 22 | NTc.Cm8 | TYR 27 | - | VdWContact |
| LEU 24 | NTc.Cm6 | VAL 31 | - | Hydrophobic |
| GLU 25 | NTc.Cm5 | ALA 32 | - | HBAcceptor |
| GLU 25 | NTc.Cm5 | ALA 32 | - | VdWContact |
| LYS 26 | NTc.Cm4 | ALA 32 | - | Hydrophobic |
| LYS 26 | NTc.Cm4 | ALA 32 | - | VdWContact |
| LYS 26 | NTc.Cm4 | MET 34 | - | VdWContact |
| LEU 27 | NTc.Cm3 | VAL 31 | - | Hydrophobic |
| LEU 27 | NTc.Cm3 | ALA 32 | - | HBDonor |
| LEU 27 | NTc.Cm3 | ALA 32 | - | VdWContact |
| LEU 27 | NTc.Cm3 | PHE 33 | - | Hydrophobic |
| LEU 27 | NTc.Cm3 | PHE 33 | - | VdWContact |
| LEU 27 | NTc.Cm3 | MET 34 | - | HBAcceptor |
| LEU 27 | NTc.Cm3 | MET 34 | - | VdWContact |
| GLU 28 | NTc.Cm2 | MET 34 | - | Hydrophobic |
| GLU 28 | NTc.Cm2 | MET 34 | - | VdWContact |
| GLU 28 | NTc.Cm2 | CYS 284 | 7.25x24 | HBAcceptor |
| GLU 28 | NTc.Cm2 | CYS 284 | 7.25x24 | VdWContact |
| ILE 29 | NTc.Cm1 | PHE 33 | - | Hydrophobic |
| ILE 29 | NTc.Cm1 | PHE 33 | - | VdWContact |
| ILE 29 | NTc.Cm1 | MET 34 | - | HBDonor |
| ILE 29 | NTc.Cm1 | MET 34 | - | VdWContact |
| ILE 29 | NTc.Cm1 | LEU 35 | - | Hydrophobic |
| ILE 29 | NTc.Cm1 | CYS 36 | - | HBAcceptor |
| ILE 29 | NTc.Cm1 | CYS 36 | - | VdWContact |
| ILE 30 | CX.1 | CYS 36 | - | Hydrophobic |
| ILE 30 | CX.1 | CYS 36 | - | VdWContact |
| PRO 31 | CX.4 | LEU 35 | - | Hydrophobic |
| PRO 31 | CX.4 | CYS 36 | - | VdWContact |
| GLN 34 | cxb1.2 | VAL 42 | 1.28x28 | Hydrophobic |
| PHE 35 | cxb1.5 | VAL 42 | 1.28x28 | Hydrophobic |
| PRO 37 | cxb1.7 | ASN 188 | - | VdWContact |
| LYS 46 | B1.3 | GLU 30 | - | Cationic |
| LYS 46 | B1.3 | GLU 30 | - | HBDonor |
| LYS 46 | B1.3 | GLU 30 | - | VdWContact |
| LYS 51 | b1b2.4 | GLN 279 | 6.64x64 | Hydrophobic |
| LYS 51 | b1b2.4 | GLN 279 | 6.64x64 | VdWContact |
| LYS 51 | b1b2.4 | PHE 281 | - | HBDonor |
| LYS 51 | b1b2.4 | PHE 281 | - | VdWContact |
| LYS 51 | b1b2.4 | GLY 282 | - | HBDonor |
| LYS 51 | b1b2.4 | GLY 282 | - | VdWContact |
| LEU 64 | B2.4 | LEU 28 | - | Hydrophobic |
| LEU 64 | B2.4 | LEU 28 | - | VdWContact |
| LEU 65 | B2.5 | PHE 33 | - | Hydrophobic |
| ALA 67 | b2b3.2 | TYR 25 | - | Hydrophobic |
| ALA 67 | b2b3.2 | TYR 25 | - | VdWContact |
| ALA 67 | b2b3.2 | LEU 28 | - | Hydrophobic |
| ALA 67 | b2b3.2 | LEU 28 | - | VdWContact |
| VAL 68 | b2b3.3 | LEU 28 | - | Hydrophobic |
| VAL 68 | b2b3.3 | PHE 33 | - | Hydrophobic |
| VAL 68 | b2b3.3 | PHE 33 | - | VdWContact |
| GLU 71 | b2b3.12 | ASP 29 | - | VdWContact |
| ARG 72 | B3.1 | PHE 33 | - | HBDonor |
| ARG 72 | B3.1 | PHE 33 | - | VdWContact |
| ARG 75 | B3.4 | ASP 29 | - | Cationic |
| ARG 75 | B3.4 | ASP 29 | - | HBDonor |
| ARG 75 | B3.4 | ASP 29 | - | VdWContact |
