Predicted complex interactions
CXCL12_HUMAN + CXCR1
SUMMARY
- Chemokine
- CXCL12_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR1 View partner entry
- Partner description
- UniProt: P25024; Gene: cxcr1_human; Family: Chemokine
- Interactions detected
- 118
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LYS 1 | NTc.Cm29 | GLU 33 | - | VdWContact |
| LYS 1 | NTc.Cm29 | THR 34 | - | Hydrophobic |
| LYS 1 | NTc.Cm29 | THR 34 | - | VdWContact |
| LYS 1 | NTc.Cm29 | GLU 35 | - | Cationic |
| LYS 1 | NTc.Cm29 | GLU 35 | - | Hydrophobic |
| LYS 1 | NTc.Cm29 | GLU 35 | - | VdWContact |
| LYS 1 | NTc.Cm29 | SER 184 | - | VdWContact |
| PRO 2 | NTc.Cm28 | GLU 35 | - | VdWContact |
| PRO 2 | NTc.Cm28 | SER 98 | 2.63x63 | VdWContact |
| PRO 2 | NTc.Cm28 | LYS 99 | 2.64x64 | Hydrophobic |
| PRO 2 | NTc.Cm28 | LYS 99 | 2.64x64 | VdWContact |
| VAL 3 | NTc.Cm27 | THR 34 | - | Hydrophobic |
| VAL 3 | NTc.Cm27 | THR 34 | - | VdWContact |
| VAL 3 | NTc.Cm27 | VAL 186 | - | Hydrophobic |
| VAL 3 | NTc.Cm27 | VAL 186 | - | VdWContact |
| LEU 5 | NTc.Cm25 | TYR 188 | 45.51x51 | VdWContact |
| LEU 5 | NTc.Cm25 | ARG 199 | 5.35x36 | HBAcceptor |
| LEU 5 | NTc.Cm25 | ARG 199 | 5.35x36 | VdWContact |
| SER 6 | NTc.Cm24 | ARG 269 | 6.62x62 | VdWContact |
| TYR 7 | NTc.Cm23 | LEU 32 | - | Hydrophobic |
| TYR 7 | NTc.Cm23 | PRO 180 | - | Hydrophobic |
| TYR 7 | NTc.Cm23 | TYR 188 | 45.51x51 | Hydrophobic |
| TYR 7 | NTc.Cm23 | TYR 188 | 45.51x51 | VdWContact |
| TYR 7 | NTc.Cm23 | ARG 269 | 6.62x62 | HBAcceptor |
| TYR 7 | NTc.Cm23 | ARG 269 | 6.62x62 | VdWContact |
| ARG 8 | NTc.Cm22 | LEU 32 | - | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 265 | 6.58x58 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 265 | 6.58x58 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 265 | 6.58x58 | VdWContact |
| ARG 8 | NTc.Cm22 | MET 268 | 6.61x61 | VdWContact |
| ARG 8 | NTc.Cm22 | ARG 280 | 7.28x27 | HBDonor |
| ARG 8 | NTc.Cm22 | ARG 280 | 7.28x27 | VdWContact |
| ARG 8 | NTc.Cm22 | ILE 283 | 7.31x30 | VdWContact |
| CYS 9 | NTc.Cm21 | ARG 280 | 7.28x27 | HBAcceptor |
| CYS 9 | NTc.Cm21 | ARG 280 | 7.28x27 | VdWContact |
| PRO 10 | NTc.Cm20 | PRO 29 | - | Hydrophobic |
| PRO 10 | NTc.Cm20 | CYS 30 | - | HBAcceptor |
| PRO 10 | NTc.Cm20 | CYS 30 | - | VdWContact |
| PRO 10 | NTc.Cm20 | LEU 32 | - | Hydrophobic |
| PRO 10 | NTc.Cm20 | LEU 32 | - | VdWContact |
| ARG 12 | NTc.Cm18 | ASP 26 | - | Cationic |
| ARG 12 | NTc.Cm18 | ASP 26 | - | HBDonor |
| ARG 12 | NTc.Cm18 | ASP 26 | - | VdWContact |
| ARG 12 | NTc.Cm18 | CYS 30 | - | Cationic |
| ARG 12 | NTc.Cm18 | CYS 30 | - | VdWContact |
| ARG 12 | NTc.Cm18 | GLU 275 | - | HBDonor |
| ARG 12 | NTc.Cm18 | GLU 275 | - | VdWContact |
| ARG 12 | NTc.Cm18 | SER 276 | 7.24x23 | VdWContact |
| ARG 12 | NTc.Cm18 | CYS 277 | 7.25x24 | Cationic |
| ARG 12 | NTc.Cm18 | ARG 280 | 7.28x27 | VdWContact |
| PHE 13 | NTc.Cm17 | ASP 26 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | ASP 26 | - | VdWContact |
| PHE 13 | NTc.Cm17 | TYR 27 | - | Hydrophobic |
| GLU 15 | NTc.Cm15 | PRO 21 | - | Hydrophobic |
| GLU 15 | NTc.Cm15 | PRO 21 | - | VdWContact |
| GLU 15 | NTc.Cm15 | TYR 27 | - | Hydrophobic |
| VAL 18 | NTc.Cm12 | PRO 21 | - | Hydrophobic |
| ALA 19 | NTc.Cm11 | PHE 17 | - | Hydrophobic |
| ALA 19 | NTc.Cm11 | PHE 17 | - | VdWContact |
| ALA 19 | NTc.Cm11 | GLY 19 | - | VdWContact |
| ARG 20 | NTc.Cm10 | PHE 12 | - | Hydrophobic |
| ARG 20 | NTc.Cm10 | PHE 12 | - | VdWContact |
| ARG 20 | NTc.Cm10 | LEU 15 | - | Hydrophobic |
| ARG 20 | NTc.Cm10 | LEU 15 | - | VdWContact |
| ARG 20 | NTc.Cm10 | PHE 17 | - | Hydrophobic |
| ARG 20 | NTc.Cm10 | PHE 17 | - | VdWContact |
| ALA 21 | NTc.Cm9 | LEU 15 | - | VdWContact |
| ALA 21 | NTc.Cm9 | ASN 16 | - | Hydrophobic |
| ALA 21 | NTc.Cm9 | ASN 16 | - | VdWContact |
| ALA 21 | NTc.Cm9 | PHE 17 | - | HBAcceptor |
| ALA 21 | NTc.Cm9 | PHE 17 | - | HBDonor |
| ALA 21 | NTc.Cm9 | PHE 17 | - | VdWContact |
| ASN 22 | NTc.Cm8 | PHE 17 | - | HBDonor |
| ASN 22 | NTc.Cm8 | PHE 17 | - | VdWContact |
| ASN 22 | NTc.Cm8 | THR 18 | - | HBDonor |
| ASN 22 | NTc.Cm8 | THR 18 | - | VdWContact |
| ASN 22 | NTc.Cm8 | GLY 19 | - | HBDonor |
| ASN 22 | NTc.Cm8 | GLY 19 | - | VdWContact |
| ASN 22 | NTc.Cm8 | MET 20 | - | VdWContact |
| HIS 25 | NTc.Cm5 | MET 9 | - | Hydrophobic |
| HIS 25 | NTc.Cm5 | MET 9 | - | VdWContact |
| LEU 26 | NTc.Cm4 | PHE 12 | - | Hydrophobic |
| LEU 26 | NTc.Cm4 | PHE 12 | - | VdWContact |
| LYS 27 | NTc.Cm3 | PRO 7 | - | Hydrophobic |
| LYS 27 | NTc.Cm3 | ASN 182 | - | VdWContact |
| ASN 30 | CX.1 | ILE 4 | - | Hydrophobic |
| ASN 30 | CX.1 | ILE 4 | - | VdWContact |
| PRO 32 | CX.5 | TYR 178 | - | Hydrophobic |
| PRO 32 | CX.5 | TYR 178 | - | VdWContact |
| PRO 32 | CX.5 | VAL 190 | - | Hydrophobic |
| ASN 33 | cxb1.1 | TYR 188 | 45.51x51 | VdWContact |
| ASN 33 | cxb1.1 | THR 195 | 5.31x32 | VdWContact |
| VAL 39 | cxb1.11 | PRO 29 | - | Hydrophobic |
| VAL 39 | cxb1.11 | PRO 29 | - | VdWContact |
| LEU 42 | cxb1.16 | PRO 21 | - | Hydrophobic |
| ASN 44 | B1.2 | MET 20 | - | Hydrophobic |
| ASN 44 | B1.2 | MET 20 | - | VdWContact |
| ARG 47 | B1.5 | ALA 23 | - | HBDonor |
| ARG 47 | B1.5 | ALA 23 | - | VdWContact |
| GLN 48 | B1.6 | SER 28 | - | VdWContact |
| GLN 48 | B1.6 | PRO 29 | - | Hydrophobic |
| VAL 49 | B1.7 | TYR 27 | - | Hydrophobic |
| VAL 49 | B1.7 | TYR 27 | - | VdWContact |
| CYS 50 | b1b2.4 | TYR 27 | - | HBDonor |
| CYS 50 | b1b2.4 | TYR 27 | - | VdWContact |
| TRP 57 | b1b2.16 | PHE 12 | - | Hydrophobic |
| TYR 61 | B2.4 | TRP 10 | - | Hydrophobic |
| TYR 61 | B2.4 | TRP 10 | - | VdWContact |
| TYR 61 | B2.4 | PHE 12 | - | Hydrophobic |
| TYR 61 | B2.4 | PHE 12 | - | PiStacking |
| TYR 61 | B2.4 | PHE 12 | - | VdWContact |
| ALA 65 | b2b3.3 | TRP 10 | - | Hydrophobic |
| ALA 65 | b2b3.3 | TRP 10 | - | VdWContact |
| LYS 68 | b2b3.12 | TRP 10 | - | Hydrophobic |
| LYS 68 | b2b3.12 | TRP 10 | - | VdWContact |
| ARG 69 | B3.1 | ASN 3 | - | HBDonor |
| ARG 69 | B3.1 | ASN 3 | - | VdWContact |
| ARG 69 | B3.1 | THR 5 | - | VdWContact |
