Predicted complex interactions
CXCL12_HUMAN + ACKR2
SUMMARY
- Chemokine
- CXCL12_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- ACKR2 View partner entry
- Partner description
- UniProt: O00590; Gene: ackr2_human; Family: Chemokine
- Interactions detected
- 76
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LYS 1 | NTc.Cm29 | THR 98 | 2.56x56 | VdWContact |
| LYS 1 | NTc.Cm29 | LEU 99 | 2.57x57 | VdWContact |
| LYS 1 | NTc.Cm29 | TRP 102 | 2.60x60 | Hydrophobic |
| LYS 1 | NTc.Cm29 | TRP 102 | 2.60x60 | VdWContact |
| LYS 1 | NTc.Cm29 | TYR 124 | 3.32x32 | Hydrophobic |
| LYS 1 | NTc.Cm29 | TYR 124 | 3.32x32 | VdWContact |
| PRO 2 | NTc.Cm28 | TYR 53 | 1.39x39 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TRP 102 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TRP 102 | 2.60x60 | VdWContact |
| PRO 2 | NTc.Cm28 | GLU 298 | 7.39x38 | VdWContact |
| PRO 2 | NTc.Cm28 | PHE 302 | 7.43x42 | Hydrophobic |
| VAL 3 | NTc.Cm27 | LEU 270 | 6.55x55 | Hydrophobic |
| VAL 3 | NTc.Cm27 | LEU 294 | 7.35x34 | Hydrophobic |
| VAL 3 | NTc.Cm27 | LEU 294 | 7.35x34 | VdWContact |
| VAL 3 | NTc.Cm27 | GLU 298 | 7.39x38 | HBDonor |
| VAL 3 | NTc.Cm27 | GLU 298 | 7.39x38 | VdWContact |
| SER 4 | NTc.Cm26 | GLN 295 | 7.36x35 | VdWContact |
| SER 4 | NTc.Cm26 | GLU 298 | 7.39x38 | HBDonor |
| SER 4 | NTc.Cm26 | GLU 298 | 7.39x38 | VdWContact |
| LEU 5 | NTc.Cm25 | LEU 49 | 1.35x35 | Hydrophobic |
| LEU 5 | NTc.Cm25 | LEU 49 | 1.35x35 | VdWContact |
| LEU 5 | NTc.Cm25 | TRP 102 | 2.60x60 | Hydrophobic |
| LEU 5 | NTc.Cm25 | VAL 106 | 2.64x64 | Hydrophobic |
| LEU 5 | NTc.Cm25 | VAL 106 | 2.64x64 | VdWContact |
| TYR 7 | NTc.Cm23 | HIS 196 | 45.51x51 | Hydrophobic |
| ARG 8 | NTc.Cm22 | LYS 38 | 1.24x24 | VdWContact |
| ARG 8 | NTc.Cm22 | VAL 41 | 1.27x27 | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 291 | 7.32x31 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 291 | 7.32x31 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 291 | 7.32x31 | VdWContact |
| CYS 9 | NTc.Cm21 | LYS 207 | 5.35x36 | Anionic |
| ARG 12 | NTc.Cm18 | LYS 38 | 1.24x24 | VdWContact |
| ARG 12 | NTc.Cm18 | HIS 273 | 6.58x58 | VdWContact |
| ARG 12 | NTc.Cm18 | SER 287 | 7.28x27 | HBDonor |
| ARG 12 | NTc.Cm18 | SER 287 | 7.28x27 | VdWContact |
| ARG 12 | NTc.Cm18 | ASP 291 | 7.32x31 | Cationic |
| ARG 12 | NTc.Cm18 | ASP 291 | 7.32x31 | HBDonor |
| ARG 12 | NTc.Cm18 | ASP 291 | 7.32x31 | VdWContact |
| PHE 13 | NTc.Cm17 | LEU 276 | 6.61x61 | Hydrophobic |
| PHE 13 | NTc.Cm17 | LEU 276 | 6.61x61 | VdWContact |
| PHE 13 | NTc.Cm17 | GLY 282 | - | VdWContact |
| PHE 13 | NTc.Cm17 | ASN 283 | 7.24x23 | VdWContact |
| PHE 14 | NTc.Cm16 | GLN 279 | 6.64x64 | VdWContact |
| ARG 20 | NTc.Cm10 | TYR 23 | - | HBDonor |
| ARG 20 | NTc.Cm10 | TYR 23 | - | Hydrophobic |
| ARG 20 | NTc.Cm10 | TYR 23 | - | VdWContact |
| LYS 27 | NTc.Cm3 | LEU 28 | - | Hydrophobic |
| LYS 27 | NTc.Cm3 | LEU 28 | - | VdWContact |
| LYS 27 | NTc.Cm3 | ASP 29 | - | HBDonor |
| LYS 27 | NTc.Cm3 | ASP 29 | - | VdWContact |
| LYS 27 | NTc.Cm3 | VAL 31 | - | HBDonor |
| LYS 27 | NTc.Cm3 | VAL 31 | - | VdWContact |
| PRO 32 | CX.5 | HIS 186 | - | Hydrophobic |
| ASN 33 | cxb1.1 | ALA 197 | 45.52x52 | HBDonor |
| ASN 33 | cxb1.1 | ALA 197 | 45.52x52 | VdWContact |
| ASN 33 | cxb1.1 | ASP 198 | - | VdWContact |
| ASN 33 | cxb1.1 | PHE 199 | - | HBAcceptor |
| ASN 33 | cxb1.1 | PHE 199 | - | VdWContact |
| ASN 33 | cxb1.1 | LYS 207 | 5.35x36 | HBAcceptor |
| ASN 33 | cxb1.1 | LYS 207 | 5.35x36 | VdWContact |
| VAL 39 | cxb1.11 | LEU 35 | - | Hydrophobic |
| VAL 39 | cxb1.11 | LEU 35 | - | VdWContact |
| GLN 48 | B1.6 | PHE 33 | - | Hydrophobic |
| GLN 48 | B1.6 | PHE 33 | - | VdWContact |
| GLN 48 | B1.6 | LEU 35 | - | Hydrophobic |
| GLN 48 | B1.6 | LEU 35 | - | VdWContact |
| VAL 49 | B1.7 | LEU 35 | - | VdWContact |
| CYS 50 | b1b2.4 | LEU 35 | - | Hydrophobic |
| CYS 50 | b1b2.4 | LEU 35 | - | VdWContact |
| TYR 61 | B2.4 | TYR 23 | - | Hydrophobic |
| TYR 61 | B2.4 | TYR 23 | - | VdWContact |
| TYR 61 | B2.4 | TYR 25 | - | Hydrophobic |
| ALA 65 | b2b3.3 | TYR 25 | - | Hydrophobic |
| ALA 65 | b2b3.3 | TYR 25 | - | VdWContact |
| LYS 68 | b2b3.12 | TYR 25 | - | Hydrophobic |
| ARG 69 | B3.1 | TYR 27 | - | VdWContact |
