Predicted complex interactions
CXCL8_HUMAN + CXCR1
SUMMARY
- Chemokine
- CXCL8_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR1 View partner entry
- Partner description
- UniProt: P25024; Gene: cxcr1_human; Family: Chemokine
- Interactions detected
- 166
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| GLY 2 | NTc.Cm32 | ASN 101 | 2.66x66 | VdWContact |
| GLY 2 | NTc.Cm32 | GLY 102 | 23.49x49 | VdWContact |
| ALA 3 | NTc.Cm31 | VAL 100 | 2.65x65 | VdWContact |
| ALA 3 | NTc.Cm31 | ASN 101 | 2.66x66 | VdWContact |
| ALA 3 | NTc.Cm31 | GLY 102 | 23.49x49 | VdWContact |
| ALA 3 | NTc.Cm31 | SER 184 | - | VdWContact |
| VAL 4 | NTc.Cm30 | ALA 97 | 2.62x62 | VdWContact |
| VAL 4 | NTc.Cm30 | SER 98 | 2.63x63 | VdWContact |
| VAL 4 | NTc.Cm30 | VAL 100 | 2.65x65 | HBDonor |
| VAL 4 | NTc.Cm30 | VAL 100 | 2.65x65 | VdWContact |
| VAL 4 | NTc.Cm30 | ASN 101 | 2.66x66 | HBDonor |
| VAL 4 | NTc.Cm30 | ASN 101 | 2.66x66 | Hydrophobic |
| VAL 4 | NTc.Cm30 | ASN 101 | 2.66x66 | VdWContact |
| VAL 4 | NTc.Cm30 | GLY 102 | 23.49x49 | VdWContact |
| VAL 4 | NTc.Cm30 | TRP 103 | 23.50x50 | VdWContact |
| VAL 4 | NTc.Cm30 | ILE 104 | 23.51x51 | Hydrophobic |
| VAL 4 | NTc.Cm30 | ILE 104 | 23.51x51 | VdWContact |
| LEU 5 | NTc.Cm29 | SER 98 | 2.63x63 | VdWContact |
| LEU 5 | NTc.Cm29 | LYS 99 | 2.64x64 | Hydrophobic |
| LEU 5 | NTc.Cm29 | LYS 99 | 2.64x64 | VdWContact |
| PRO 6 | NTc.Cm28 | TYR 46 | 1.39x39 | Hydrophobic |
| PRO 6 | NTc.Cm28 | TYR 46 | 1.39x39 | VdWContact |
| PRO 6 | NTc.Cm28 | TRP 95 | 2.60x60 | Hydrophobic |
| PRO 6 | NTc.Cm28 | TRP 95 | 2.60x60 | VdWContact |
| PRO 6 | NTc.Cm28 | SER 98 | 2.63x63 | VdWContact |
| PRO 6 | NTc.Cm28 | LYS 99 | 2.64x64 | Hydrophobic |
| PRO 6 | NTc.Cm28 | LYS 99 | 2.64x64 | VdWContact |
| ARG 7 | NTc.Cm27 | TRP 95 | 2.60x60 | Hydrophobic |
| ARG 7 | NTc.Cm27 | TRP 95 | 2.60x60 | VdWContact |
| ARG 7 | NTc.Cm27 | VAL 113 | 3.28x28 | HBDonor |
| ARG 7 | NTc.Cm27 | VAL 113 | 3.28x28 | VdWContact |
| ARG 7 | NTc.Cm27 | SER 114 | 3.29x29 | HBDonor |
| ARG 7 | NTc.Cm27 | SER 114 | 3.29x29 | VdWContact |
| ARG 7 | NTc.Cm27 | LYS 117 | 3.32x32 | VdWContact |
| ARG 7 | NTc.Cm27 | GLU 118 | 3.33x33 | Cationic |
| ARG 7 | NTc.Cm27 | GLU 118 | 3.33x33 | HBDonor |
| ARG 7 | NTc.Cm27 | GLU 118 | 3.33x33 | VdWContact |
| SER 8 | NTc.Cm26 | TYR 46 | 1.39x39 | VdWContact |
| SER 8 | NTc.Cm26 | LYS 99 | 2.64x64 | HBAcceptor |
| SER 8 | NTc.Cm26 | LYS 99 | 2.64x64 | VdWContact |
| SER 8 | NTc.Cm26 | ASP 288 | 7.36x35 | HBDonor |
| SER 8 | NTc.Cm26 | ASP 288 | 7.36x35 | VdWContact |
| SER 8 | NTc.Cm26 | GLU 291 | 7.39x38 | VdWContact |
| ALA 9 | NTc.Cm25 | TYR 188 | 45.51x51 | Hydrophobic |
| LYS 10 | NTc.Cm24 | LEU 32 | - | HBDonor |
| LYS 10 | NTc.Cm24 | LEU 32 | - | VdWContact |
| LYS 10 | NTc.Cm24 | GLU 33 | - | VdWContact |
| LYS 10 | NTc.Cm24 | THR 34 | - | HBDonor |
| LYS 10 | NTc.Cm24 | THR 34 | - | VdWContact |
| GLU 11 | NTc.Cm23 | ARG 199 | 5.35x36 | Anionic |
| GLU 11 | NTc.Cm23 | ARG 199 | 5.35x36 | HBAcceptor |
| GLU 11 | NTc.Cm23 | ARG 199 | 5.35x36 | VdWContact |
| GLU 11 | NTc.Cm23 | ARG 203 | 5.39x40 | Anionic |
| GLU 11 | NTc.Cm23 | ARG 203 | 5.39x40 | HBAcceptor |
| GLU 11 | NTc.Cm23 | ARG 203 | 5.39x40 | VdWContact |
| GLU 11 | NTc.Cm23 | ARG 269 | 6.62x62 | Anionic |
| GLU 11 | NTc.Cm23 | ARG 269 | 6.62x62 | HBAcceptor |
| GLU 11 | NTc.Cm23 | ARG 269 | 6.62x62 | VdWContact |
| GLU 11 | NTc.Cm23 | LEU 287 | 7.35x34 | Hydrophobic |
| LEU 12 | NTc.Cm22 | TYR 178 | - | Hydrophobic |
| LEU 12 | NTc.Cm22 | PRO 180 | - | Hydrophobic |
| LEU 12 | NTc.Cm22 | VAL 186 | - | Hydrophobic |
| LEU 12 | NTc.Cm22 | TYR 188 | 45.51x51 | HBDonor |
| LEU 12 | NTc.Cm22 | TYR 188 | 45.51x51 | Hydrophobic |
| LEU 12 | NTc.Cm22 | TYR 188 | 45.51x51 | VdWContact |
| LEU 12 | NTc.Cm22 | ARG 269 | 6.62x62 | HBAcceptor |
| LEU 12 | NTc.Cm22 | ARG 269 | 6.62x62 | VdWContact |
| ARG 13 | NTc.Cm21 | ASP 265 | 6.58x58 | Cationic |
| ARG 13 | NTc.Cm21 | ASP 265 | 6.58x58 | HBDonor |
| ARG 13 | NTc.Cm21 | ASP 265 | 6.58x58 | VdWContact |
| ARG 13 | NTc.Cm21 | MET 268 | 6.61x61 | VdWContact |
| ARG 13 | NTc.Cm21 | GLU 275 | - | Cationic |
| CYS 14 | NTc.Cm20 | ARG 280 | 7.28x27 | HBAcceptor |
| CYS 14 | NTc.Cm20 | ARG 280 | 7.28x27 | VdWContact |
| GLN 15 | NTc.Cm19 | PRO 29 | - | Hydrophobic |
| GLN 15 | NTc.Cm19 | CYS 30 | - | HBAcceptor |
| GLN 15 | NTc.Cm19 | CYS 30 | - | VdWContact |
| GLN 15 | NTc.Cm19 | LEU 32 | - | Hydrophobic |
| ILE 17 | NTc.Cm17 | GLU 275 | - | Hydrophobic |
| ILE 17 | NTc.Cm17 | SER 276 | 7.24x23 | VdWContact |
| ILE 17 | NTc.Cm17 | ARG 280 | 7.28x27 | VdWContact |
| LYS 18 | NTc.Cm16 | ASP 26 | - | Cationic |
| LYS 18 | NTc.Cm16 | ASP 26 | - | HBDonor |
| LYS 18 | NTc.Cm16 | ASP 26 | - | Hydrophobic |
| LYS 18 | NTc.Cm16 | ASP 26 | - | VdWContact |
| LYS 18 | NTc.Cm16 | TYR 27 | - | Hydrophobic |
| TYR 20 | NTc.Cm14 | PRO 22 | - | Hydrophobic |
| TYR 20 | NTc.Cm14 | PRO 22 | - | VdWContact |
| TYR 20 | NTc.Cm14 | TYR 27 | - | Hydrophobic |
| TYR 20 | NTc.Cm14 | TYR 27 | - | PiStacking |
| TYR 20 | NTc.Cm14 | TYR 27 | - | VdWContact |
| PRO 23 | NTc.Cm11 | PHE 17 | - | Hydrophobic |
| PHE 24 | NTc.Cm10 | GLY 19 | - | VdWContact |
| PHE 24 | NTc.Cm10 | PRO 21 | - | Hydrophobic |
| HIS 25 | NTc.Cm9 | PHE 12 | - | Hydrophobic |
| HIS 25 | NTc.Cm9 | PHE 17 | - | VdWContact |
| HIS 25 | NTc.Cm9 | GLY 19 | - | HBDonor |
| HIS 25 | NTc.Cm9 | GLY 19 | - | VdWContact |
| PRO 26 | NTc.Cm8 | PHE 12 | - | Hydrophobic |
| PRO 26 | NTc.Cm8 | PHE 12 | - | VdWContact |
| PRO 26 | NTc.Cm8 | LEU 15 | - | Hydrophobic |
| PRO 26 | NTc.Cm8 | PHE 17 | - | Hydrophobic |
| PHE 28 | NTc.Cm6 | PRO 21 | - | Hydrophobic |
| PHE 28 | NTc.Cm6 | PRO 21 | - | VdWContact |
| ILE 29 | NTc.Cm5 | PRO 7 | - | VdWContact |
| LYS 30 | NTc.Cm4 | THR 5 | - | VdWContact |
| LYS 30 | NTc.Cm4 | ASP 6 | - | HBAcceptor |
| LYS 30 | NTc.Cm4 | ASP 6 | - | VdWContact |
| LYS 30 | NTc.Cm4 | PRO 7 | - | VdWContact |
| GLU 31 | NTc.Cm3 | ILE 4 | - | VdWContact |
| GLU 31 | NTc.Cm3 | THR 5 | - | Hydrophobic |
| GLU 31 | NTc.Cm3 | THR 5 | - | VdWContact |
| LEU 32 | NTc.Cm2 | ASN 3 | - | VdWContact |
| LEU 32 | NTc.Cm2 | ILE 4 | - | HBAcceptor |
| LEU 32 | NTc.Cm2 | ILE 4 | - | HBDonor |
| LEU 32 | NTc.Cm2 | ILE 4 | - | VdWContact |
| VAL 34 | CX.1 | MET 1 | - | VdWContact |
| ILE 35 | CX.4 | MET 1 | - | Hydrophobic |
| ILE 35 | CX.4 | MET 1 | - | VdWContact |
| GLY 38 | cxb1.2 | ASN 193 | - | VdWContact |
| PRO 39 | cxb1.5 | TYR 178 | - | Hydrophobic |
| PRO 39 | cxb1.5 | TYR 178 | - | VdWContact |
| PRO 39 | cxb1.5 | VAL 190 | - | Hydrophobic |
| PRO 39 | cxb1.5 | VAL 190 | - | VdWContact |
| PRO 39 | cxb1.5 | THR 195 | 5.31x32 | Hydrophobic |
| PRO 39 | cxb1.5 | THR 195 | 5.31x32 | VdWContact |
| HIS 40 | cxb1.6 | TYR 178 | - | HBDonor |
| HIS 40 | cxb1.6 | TYR 178 | - | VdWContact |
| ILE 47 | cxb1.16 | PRO 29 | - | Hydrophobic |
| ILE 47 | cxb1.16 | PRO 29 | - | VdWContact |
| LEU 50 | B1.3 | PRO 21 | - | Hydrophobic |
| ARG 54 | B1.7 | PRO 22 | - | HBDonor |
| ARG 54 | B1.7 | PRO 22 | - | VdWContact |
| GLU 55 | b1b2.4 | SER 28 | - | VdWContact |
| GLU 55 | b1b2.4 | PRO 29 | - | Hydrophobic |
| LEU 56 | b1b2.6 | PRO 21 | - | Hydrophobic |
| LEU 56 | b1b2.6 | PRO 22 | - | Hydrophobic |
| LEU 56 | b1b2.6 | TYR 27 | - | Hydrophobic |
| CYS 57 | b1b2.7 | TYR 27 | - | HBDonor |
| CYS 57 | b1b2.7 | TYR 27 | - | VdWContact |
| TRP 64 | b1b2.16 | PHE 17 | - | Hydrophobic |
| TRP 64 | b1b2.16 | PHE 17 | - | VdWContact |
| ARG 67 | B2.3 | LEU 15 | - | Hydrophobic |
| VAL 68 | B2.4 | LEU 15 | - | Hydrophobic |
| LYS 71 | b2b3.2 | TRP 10 | - | Hydrophobic |
| LYS 71 | b2b3.2 | TRP 10 | - | VdWContact |
| LYS 71 | b2b3.2 | ASP 11 | - | Cationic |
| LYS 71 | b2b3.2 | ASP 11 | - | HBDonor |
| LYS 71 | b2b3.2 | ASP 11 | - | VdWContact |
| LYS 71 | b2b3.2 | PHE 12 | - | Hydrophobic |
| LYS 71 | b2b3.2 | PHE 12 | - | VdWContact |
| LYS 71 | b2b3.2 | ASP 14 | - | Cationic |
| LYS 71 | b2b3.2 | LEU 15 | - | Hydrophobic |
| PHE 72 | b2b3.4 | ILE 4 | - | Hydrophobic |
| PHE 72 | b2b3.4 | ILE 4 | - | VdWContact |
| PHE 72 | b2b3.4 | TRP 10 | - | VdWContact |
| PHE 72 | b2b3.4 | PHE 12 | - | Hydrophobic |
| LEU 73 | b2b3.11 | ILE 4 | - | Hydrophobic |
| ARG 75 | B3.1 | THR 5 | - | VdWContact |
| ARG 75 | B3.1 | ASP 6 | - | Cationic |
| ARG 75 | B3.1 | ASP 6 | - | HBDonor |
| ARG 75 | B3.1 | ASP 6 | - | VdWContact |
| ARG 75 | B3.1 | TRP 10 | - | Hydrophobic |
| ARG 75 | B3.1 | TRP 10 | - | VdWContact |
| ALA 76 | B3.2 | ILE 4 | - | Hydrophobic |
| ALA 76 | B3.2 | ILE 4 | - | VdWContact |
