Predicted complex interactions
CXCL12_HUMAN + CXCR2
SUMMARY
- Chemokine
- CXCL12_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR2 View partner entry
- Partner description
- UniProt: P25025; Gene: cxcr2_human; Family: Chemokine
- Interactions detected
- 102
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LYS 1 | NTc.Cm29 | PRO 41 | - | VdWContact |
| LYS 1 | NTc.Cm29 | GLU 42 | - | VdWContact |
| LYS 1 | NTc.Cm29 | SER 43 | - | VdWContact |
| LYS 1 | NTc.Cm29 | GLU 45 | 1.29x29 | VdWContact |
| LYS 1 | NTc.Cm29 | VAL 192 | - | Hydrophobic |
| LYS 1 | NTc.Cm29 | VAL 192 | - | VdWContact |
| LYS 1 | NTc.Cm29 | SER 193 | - | HBDonor |
| LYS 1 | NTc.Cm29 | SER 193 | - | VdWContact |
| PRO 2 | NTc.Cm28 | GLU 45 | 1.29x29 | VdWContact |
| PRO 2 | NTc.Cm28 | LYS 108 | 2.64x64 | Hydrophobic |
| PRO 2 | NTc.Cm28 | LYS 108 | 2.64x64 | VdWContact |
| VAL 3 | NTc.Cm27 | VAL 192 | - | Hydrophobic |
| VAL 3 | NTc.Cm27 | ALA 195 | - | Hydrophobic |
| VAL 3 | NTc.Cm27 | ALA 195 | - | VdWContact |
| VAL 3 | NTc.Cm27 | TYR 197 | 45.51x51 | Hydrophobic |
| LEU 5 | NTc.Cm25 | ARG 208 | 5.35x36 | HBAcceptor |
| LEU 5 | NTc.Cm25 | ARG 208 | 5.35x36 | VdWContact |
| SER 6 | NTc.Cm24 | ASP 293 | 7.32x31 | HBDonor |
| SER 6 | NTc.Cm24 | ASP 293 | 7.32x31 | VdWContact |
| TYR 7 | NTc.Cm23 | TYR 197 | 45.51x51 | Hydrophobic |
| TYR 7 | NTc.Cm23 | TYR 197 | 45.51x51 | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 274 | 6.58x58 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 274 | 6.58x58 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 274 | 6.58x58 | VdWContact |
| ARG 8 | NTc.Cm22 | MET 277 | 6.61x61 | VdWContact |
| ARG 8 | NTc.Cm22 | ARG 289 | 7.28x27 | HBDonor |
| ARG 8 | NTc.Cm22 | ARG 289 | 7.28x27 | VdWContact |
| ARG 8 | NTc.Cm22 | ILE 292 | 7.31x30 | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 293 | 7.32x31 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 293 | 7.32x31 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 293 | 7.32x31 | VdWContact |
| CYS 9 | NTc.Cm21 | ARG 289 | 7.28x27 | HBAcceptor |
| CYS 9 | NTc.Cm21 | ARG 289 | 7.28x27 | VdWContact |
| PRO 10 | NTc.Cm20 | PRO 38 | - | Hydrophobic |
| PRO 10 | NTc.Cm20 | PRO 38 | - | VdWContact |
| PRO 10 | NTc.Cm20 | CYS 39 | - | HBAcceptor |
| PRO 10 | NTc.Cm20 | CYS 39 | - | VdWContact |
| ARG 12 | NTc.Cm18 | CYS 39 | - | Cationic |
| ARG 12 | NTc.Cm18 | CYS 39 | - | VdWContact |
| ARG 12 | NTc.Cm18 | GLU 284 | - | VdWContact |
| ARG 12 | NTc.Cm18 | THR 285 | 7.24x23 | VdWContact |
| ARG 12 | NTc.Cm18 | CYS 286 | 7.25x24 | Cationic |
| ARG 12 | NTc.Cm18 | ARG 289 | 7.28x27 | VdWContact |
| PHE 13 | NTc.Cm17 | ASP 35 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | ASP 35 | - | VdWContact |
| GLU 15 | NTc.Cm15 | ALA 36 | - | Hydrophobic |
| HIS 17 | NTc.Cm13 | PRO 30 | - | Hydrophobic |
| ALA 19 | NTc.Cm11 | TYR 25 | - | Hydrophobic |
| ARG 20 | NTc.Cm10 | PHE 11 | - | Hydrophobic |
| ARG 20 | NTc.Cm10 | PHE 11 | - | VdWContact |
| ARG 20 | NTc.Cm10 | TRP 15 | - | CationPi |
| ARG 20 | NTc.Cm10 | TRP 15 | - | VdWContact |
| ARG 20 | NTc.Cm10 | LEU 20 | - | VdWContact |
| VAL 23 | NTc.Cm7 | PHE 11 | - | Hydrophobic |
| LEU 26 | NTc.Cm4 | PHE 11 | - | Hydrophobic |
| LEU 26 | NTc.Cm4 | PHE 11 | - | VdWContact |
| ILE 28 | NTc.Cm2 | MET 6 | - | Hydrophobic |
| PRO 32 | CX.5 | VAL 187 | - | Hydrophobic |
| PRO 32 | CX.5 | VAL 187 | - | VdWContact |
| ASN 33 | cxb1.1 | TYR 197 | 45.51x51 | VdWContact |
| VAL 39 | cxb1.11 | PRO 38 | - | Hydrophobic |
| VAL 39 | cxb1.11 | PRO 38 | - | VdWContact |
| LEU 42 | cxb1.16 | PHE 32 | - | Hydrophobic |
| LEU 42 | cxb1.16 | PHE 32 | - | VdWContact |
| LYS 43 | B1.1 | GLU 12 | - | Cationic |
| LYS 43 | B1.1 | GLU 12 | - | HBDonor |
| LYS 43 | B1.1 | GLU 12 | - | VdWContact |
| ASN 45 | B1.3 | PHE 32 | - | VdWContact |
| GLN 48 | B1.6 | ALA 37 | - | VdWContact |
| GLN 48 | B1.6 | PRO 38 | - | Hydrophobic |
| VAL 49 | B1.7 | ALA 36 | - | Hydrophobic |
| CYS 50 | b1b2.4 | ALA 36 | - | HBDonor |
| CYS 50 | b1b2.4 | ALA 36 | - | VdWContact |
| CYS 50 | b1b2.4 | PRO 38 | - | VdWContact |
| LYS 56 | b1b2.14 | TYR 23 | - | HBDonor |
| LYS 56 | b1b2.14 | TYR 23 | - | Hydrophobic |
| LYS 56 | b1b2.14 | TYR 23 | - | VdWContact |
| TRP 57 | b1b2.16 | PHE 11 | - | Hydrophobic |
| GLU 60 | B2.3 | TRP 15 | - | Hydrophobic |
| GLU 60 | B2.3 | TRP 15 | - | VdWContact |
| TYR 61 | B2.4 | SER 8 | - | VdWContact |
| TYR 61 | B2.4 | PHE 11 | - | Hydrophobic |
| TYR 61 | B2.4 | PHE 14 | - | Hydrophobic |
| TYR 61 | B2.4 | TRP 15 | - | Hydrophobic |
| LYS 64 | b2b3.2 | PHE 14 | - | Hydrophobic |
| LYS 64 | b2b3.2 | PHE 14 | - | VdWContact |
| LYS 64 | b2b3.2 | TRP 15 | - | VdWContact |
| LYS 64 | b2b3.2 | GLU 18 | - | Cationic |
| LYS 64 | b2b3.2 | GLU 18 | - | HBDonor |
| LYS 64 | b2b3.2 | GLU 18 | - | VdWContact |
| ALA 65 | b2b3.3 | MET 6 | - | Hydrophobic |
| ALA 65 | b2b3.3 | MET 6 | - | VdWContact |
| ALA 65 | b2b3.3 | PHE 14 | - | Hydrophobic |
| ALA 65 | b2b3.3 | PHE 14 | - | VdWContact |
| LYS 68 | b2b3.12 | PHE 14 | - | Hydrophobic |
| LYS 68 | b2b3.12 | PHE 14 | - | VdWContact |
| ARG 69 | B3.1 | GLU 2 | - | Cationic |
| ARG 69 | B3.1 | GLU 2 | - | VdWContact |
| ARG 69 | B3.1 | PHE 4 | - | CationPi |
| ARG 69 | B3.1 | PHE 4 | - | Hydrophobic |
| ARG 69 | B3.1 | PHE 4 | - | VdWContact |
| ARG 69 | B3.1 | MET 6 | - | Hydrophobic |
