Predicted complex interactions
CXCL4_HUMAN + CXCR2
SUMMARY
- Chemokine
- CXCL4_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR2 View partner entry
- Partner description
- UniProt: P25025; Gene: cxcr2_human; Family: Chemokine
- Interactions detected
- 133
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| GLU 1 | NTc.Cm40 | SER 193 | - | VdWContact |
| ALA 2 | NTc.Cm39 | LYS 48 | 1.32x32 | VdWContact |
| ALA 2 | NTc.Cm39 | SER 193 | - | VdWContact |
| GLU 3 | NTc.Cm38 | PRO 41 | - | Hydrophobic |
| GLU 3 | NTc.Cm38 | PRO 41 | - | VdWContact |
| GLU 3 | NTc.Cm38 | VAL 192 | - | Hydrophobic |
| GLU 3 | NTc.Cm38 | VAL 192 | - | VdWContact |
| GLU 4 | NTc.Cm37 | LEU 44 | - | VdWContact |
| GLU 4 | NTc.Cm37 | LYS 108 | 2.64x64 | Anionic |
| GLU 4 | NTc.Cm37 | LYS 108 | 2.64x64 | HBAcceptor |
| GLU 4 | NTc.Cm37 | LYS 108 | 2.64x64 | Hydrophobic |
| GLU 4 | NTc.Cm37 | LYS 108 | 2.64x64 | VdWContact |
| GLU 4 | NTc.Cm37 | ASP 297 | 7.36x35 | VdWContact |
| ASP 5 | NTc.Cm36 | ARG 184 | 4.64x65 | Anionic |
| ASP 5 | NTc.Cm36 | ARG 184 | 4.64x65 | HBAcceptor |
| ASP 5 | NTc.Cm36 | ARG 184 | 4.64x65 | VdWContact |
| ASP 5 | NTc.Cm36 | CYS 196 | 45.50x50 | VdWContact |
| GLY 6 | NTc.Cm35 | TYR 197 | 45.51x51 | VdWContact |
| ASP 7 | NTc.Cm34 | TYR 197 | 45.51x51 | VdWContact |
| ASP 7 | NTc.Cm34 | ARG 208 | 5.35x36 | Anionic |
| ASP 7 | NTc.Cm34 | ARG 208 | 5.35x36 | HBAcceptor |
| ASP 7 | NTc.Cm34 | ARG 208 | 5.35x36 | VdWContact |
| ASP 7 | NTc.Cm34 | ARG 212 | 5.39x40 | Anionic |
| ASP 7 | NTc.Cm34 | ARG 212 | 5.39x40 | HBAcceptor |
| ASP 7 | NTc.Cm34 | ARG 212 | 5.39x40 | VdWContact |
| ASP 7 | NTc.Cm34 | ARG 278 | 6.62x62 | Anionic |
| ASP 7 | NTc.Cm34 | ARG 278 | 6.62x62 | VdWContact |
| LEU 8 | NTc.Cm33 | VAL 187 | - | Hydrophobic |
| LEU 8 | NTc.Cm33 | TYR 197 | 45.51x51 | Hydrophobic |
| LEU 8 | NTc.Cm33 | TYR 197 | 45.51x51 | VdWContact |
| GLN 9 | NTc.Cm32 | ARG 278 | 6.62x62 | VdWContact |
| GLN 9 | NTc.Cm32 | ARG 289 | 7.28x27 | HBAcceptor |
| GLN 9 | NTc.Cm32 | ARG 289 | 7.28x27 | VdWContact |
| GLN 9 | NTc.Cm32 | ASP 293 | 7.32x31 | HBDonor |
| GLN 9 | NTc.Cm32 | ASP 293 | 7.32x31 | VdWContact |
| CYS 10 | NTc.Cm31 | ARG 289 | 7.28x27 | HBAcceptor |
| CYS 10 | NTc.Cm31 | ARG 289 | 7.28x27 | VdWContact |
| LEU 11 | NTc.Cm30 | MET 1 | - | Hydrophobic |
| LEU 11 | NTc.Cm30 | PRO 38 | - | Hydrophobic |
| LEU 11 | NTc.Cm30 | PRO 38 | - | VdWContact |
| LEU 11 | NTc.Cm30 | CYS 39 | - | HBAcceptor |
| LEU 11 | NTc.Cm30 | CYS 39 | - | VdWContact |
| LEU 11 | NTc.Cm30 | PRO 41 | - | Hydrophobic |
| VAL 13 | NTc.Cm28 | CYS 39 | - | VdWContact |
| VAL 13 | NTc.Cm28 | GLU 284 | - | Hydrophobic |
| LYS 14 | NTc.Cm27 | ASP 35 | - | Cationic |
| LYS 14 | NTc.Cm27 | ASP 35 | - | HBDonor |
| LYS 14 | NTc.Cm27 | ASP 35 | - | Hydrophobic |
| LYS 14 | NTc.Cm27 | ASP 35 | - | VdWContact |
| THR 16 | NTc.Cm25 | LEU 33 | - | Hydrophobic |
| THR 16 | NTc.Cm25 | LEU 33 | - | VdWContact |
| THR 16 | NTc.Cm25 | ALA 36 | - | Hydrophobic |
| SER 17 | NTc.Cm24 | TYR 23 | - | VdWContact |
| GLN 18 | NTc.Cm23 | TYR 25 | - | VdWContact |
| VAL 19 | NTc.Cm22 | TYR 25 | - | Hydrophobic |
| VAL 19 | NTc.Cm22 | TYR 25 | - | VdWContact |
| VAL 19 | NTc.Cm22 | LEU 33 | - | Hydrophobic |
| ARG 20 | NTc.Cm21 | TYR 23 | - | HBDonor |
| ARG 20 | NTc.Cm21 | TYR 23 | - | Hydrophobic |
| ARG 20 | NTc.Cm21 | TYR 23 | - | VdWContact |
| ARG 20 | NTc.Cm21 | SER 24 | - | VdWContact |
| ARG 20 | NTc.Cm21 | TYR 25 | - | Hydrophobic |
| ARG 20 | NTc.Cm21 | TYR 25 | - | VdWContact |
| PRO 21 | NTc.Cm20 | MET 6 | - | Hydrophobic |
| PRO 21 | NTc.Cm20 | TRP 15 | - | Hydrophobic |
| PRO 21 | NTc.Cm20 | LEU 20 | - | Hydrophobic |
| HIS 23 | NTc.Cm18 | TYR 25 | - | Hydrophobic |
| HIS 23 | NTc.Cm18 | TYR 25 | - | VdWContact |
| ILE 24 | NTc.Cm17 | MET 6 | - | Hydrophobic |
| THR 25 | NTc.Cm16 | MET 6 | - | HBAcceptor |
| THR 25 | NTc.Cm16 | MET 6 | - | VdWContact |
| THR 25 | NTc.Cm16 | GLU 7 | - | VdWContact |
| SER 26 | NTc.Cm15 | ASP 3 | - | HBDonor |
| SER 26 | NTc.Cm15 | ASP 3 | - | VdWContact |
| SER 26 | NTc.Cm15 | PHE 4 | - | VdWContact |
| LEU 27 | NTc.Cm14 | ASP 3 | - | VdWContact |
| LEU 27 | NTc.Cm14 | PHE 4 | - | HBAcceptor |
| LEU 27 | NTc.Cm14 | PHE 4 | - | HBDonor |
| LEU 27 | NTc.Cm14 | PHE 4 | - | Hydrophobic |
| LEU 27 | NTc.Cm14 | PHE 4 | - | VdWContact |
| LEU 27 | NTc.Cm14 | MET 6 | - | Hydrophobic |
| LEU 27 | NTc.Cm14 | MET 6 | - | VdWContact |
| GLU 28 | NTc.Cm13 | MET 1 | - | Hydrophobic |
| GLU 28 | NTc.Cm13 | MET 1 | - | VdWContact |
| GLU 28 | NTc.Cm13 | GLU 2 | - | VdWContact |
| VAL 29 | NTc.Cm12 | MET 1 | - | VdWContact |
| VAL 29 | NTc.Cm12 | GLU 2 | - | HBAcceptor |
| VAL 29 | NTc.Cm12 | GLU 2 | - | HBDonor |
| VAL 29 | NTc.Cm12 | GLU 2 | - | VdWContact |
| VAL 29 | NTc.Cm12 | PHE 4 | - | Hydrophobic |
| ILE 30 | NTc.Cm11 | MET 1 | - | Hydrophobic |
| ILE 30 | NTc.Cm11 | MET 1 | - | VdWContact |
| LYS 31 | NTc.Cm10 | GLU 2 | - | Cationic |
| LYS 31 | NTc.Cm10 | GLU 2 | - | VdWContact |
| PRO 34 | NTc.Cm7 | TYR 197 | 45.51x51 | Hydrophobic |
| PRO 34 | NTc.Cm7 | ASP 199 | - | Hydrophobic |
| PRO 34 | NTc.Cm7 | ASP 199 | - | VdWContact |
| PRO 34 | NTc.Cm7 | THR 204 | 5.31x32 | Hydrophobic |
| PRO 34 | NTc.Cm7 | THR 204 | 5.31x32 | VdWContact |
| PRO 37 | NTc.Cm4 | ASN 202 | - | VdWContact |
| ILE 42 | CX.4 | PRO 38 | - | Hydrophobic |
| LEU 45 | cxb1.2 | LEU 29 | - | Hydrophobic |
| LYS 46 | cxb1.5 | GLU 7 | - | Cationic |
| LYS 46 | cxb1.5 | GLU 7 | - | VdWContact |
| ASN 47 | cxb1.6 | LEU 29 | - | VdWContact |
| LYS 50 | cxb1.11 | PRO 38 | - | Hydrophobic |
| LYS 50 | cxb1.11 | PRO 38 | - | VdWContact |
| CYS 52 | cxb1.15 | ALA 36 | - | HBDonor |
| CYS 52 | cxb1.15 | ALA 36 | - | VdWContact |
| LEU 59 | B1.6 | TRP 15 | - | Hydrophobic |
| LEU 59 | B1.6 | TRP 15 | - | VdWContact |
| LEU 59 | B1.6 | GLU 18 | - | Hydrophobic |
| LEU 59 | B1.6 | GLU 18 | - | VdWContact |
| LEU 59 | B1.6 | LEU 20 | - | Hydrophobic |
| LEU 59 | B1.6 | TYR 23 | - | Hydrophobic |
| LEU 59 | B1.6 | TYR 23 | - | VdWContact |
| LYS 62 | b1b2.6 | PHE 14 | - | Hydrophobic |
| LYS 62 | b1b2.6 | TRP 15 | - | Hydrophobic |
| LYS 62 | b1b2.6 | GLU 18 | - | Cationic |
| LYS 62 | b1b2.6 | GLU 18 | - | HBDonor |
| LYS 62 | b1b2.6 | GLU 18 | - | VdWContact |
| ILE 63 | b1b2.7 | MET 6 | - | Hydrophobic |
| ILE 63 | b1b2.7 | PHE 11 | - | Hydrophobic |
| ILE 63 | b1b2.7 | TRP 15 | - | Hydrophobic |
| ILE 63 | b1b2.7 | TRP 15 | - | VdWContact |
| LYS 66 | b1b2.10 | SER 10 | - | VdWContact |
| LYS 66 | b1b2.10 | PHE 11 | - | Hydrophobic |
| LYS 66 | b1b2.10 | PHE 14 | - | Hydrophobic |
| LYS 66 | b1b2.10 | PHE 14 | - | VdWContact |
| LEU 67 | b1b2.12 | PHE 4 | - | Hydrophobic |
| LEU 67 | b1b2.12 | PHE 4 | - | VdWContact |
| LEU 67 | b1b2.12 | PHE 11 | - | Hydrophobic |
| LEU 67 | b1b2.12 | PHE 11 | - | VdWContact |
