Predicted complex interactions
CXCL8_HUMAN + CXCR2
SUMMARY
- Chemokine
- CXCL8_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR2 View partner entry
- Partner description
- UniProt: P25025; Gene: cxcr2_human; Family: Chemokine
- Interactions detected
- 135
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| VAL 4 | NTc.Cm30 | ASN 191 | - | Hydrophobic |
| VAL 4 | NTc.Cm30 | ASN 191 | - | VdWContact |
| VAL 4 | NTc.Cm30 | VAL 192 | - | VdWContact |
| LEU 5 | NTc.Cm29 | GLU 45 | 1.29x29 | VdWContact |
| LEU 5 | NTc.Cm29 | LYS 48 | 1.32x32 | VdWContact |
| PRO 6 | NTc.Cm28 | LYS 48 | 1.32x32 | HBAcceptor |
| PRO 6 | NTc.Cm28 | LYS 48 | 1.32x32 | VdWContact |
| PRO 6 | NTc.Cm28 | VAL 109 | 2.65x65 | VdWContact |
| PRO 6 | NTc.Cm28 | SER 193 | - | VdWContact |
| ARG 7 | NTc.Cm27 | PRO 41 | - | VdWContact |
| ARG 7 | NTc.Cm27 | SER 43 | - | VdWContact |
| ARG 7 | NTc.Cm27 | VAL 192 | - | Hydrophobic |
| SER 8 | NTc.Cm26 | LYS 108 | 2.64x64 | VdWContact |
| LYS 10 | NTc.Cm24 | TYR 197 | 45.51x51 | VdWContact |
| LYS 10 | NTc.Cm24 | TYR 267 | 6.51x51 | VdWContact |
| LYS 10 | NTc.Cm24 | LEU 296 | 7.35x34 | HBDonor |
| LYS 10 | NTc.Cm24 | LEU 296 | 7.35x34 | Hydrophobic |
| LYS 10 | NTc.Cm24 | LEU 296 | 7.35x34 | VdWContact |
| LYS 10 | NTc.Cm24 | GLU 300 | 7.39x38 | Cationic |
| LYS 10 | NTc.Cm24 | GLU 300 | 7.39x38 | HBDonor |
| LYS 10 | NTc.Cm24 | GLU 300 | 7.39x38 | VdWContact |
| GLU 11 | NTc.Cm23 | ARG 208 | 5.35x36 | Anionic |
| GLU 11 | NTc.Cm23 | ARG 208 | 5.35x36 | HBAcceptor |
| GLU 11 | NTc.Cm23 | ARG 208 | 5.35x36 | VdWContact |
| GLU 11 | NTc.Cm23 | ARG 212 | 5.39x40 | Anionic |
| GLU 11 | NTc.Cm23 | ARG 212 | 5.39x40 | HBAcceptor |
| GLU 11 | NTc.Cm23 | ARG 212 | 5.39x40 | VdWContact |
| GLU 11 | NTc.Cm23 | ARG 278 | 6.62x62 | Anionic |
| GLU 11 | NTc.Cm23 | ARG 278 | 6.62x62 | HBAcceptor |
| GLU 11 | NTc.Cm23 | ARG 278 | 6.62x62 | VdWContact |
| GLU 11 | NTc.Cm23 | LEU 296 | 7.35x34 | Hydrophobic |
| LEU 12 | NTc.Cm22 | VAL 187 | - | Hydrophobic |
| LEU 12 | NTc.Cm22 | TYR 197 | 45.51x51 | HBDonor |
| LEU 12 | NTc.Cm22 | TYR 197 | 45.51x51 | Hydrophobic |
| LEU 12 | NTc.Cm22 | TYR 197 | 45.51x51 | VdWContact |
| LEU 12 | NTc.Cm22 | ARG 278 | 6.62x62 | HBAcceptor |
| LEU 12 | NTc.Cm22 | ARG 278 | 6.62x62 | VdWContact |
| ARG 13 | NTc.Cm21 | ASP 274 | 6.58x58 | Cationic |
| ARG 13 | NTc.Cm21 | ASP 274 | 6.58x58 | HBDonor |
| ARG 13 | NTc.Cm21 | ASP 274 | 6.58x58 | VdWContact |
| ARG 13 | NTc.Cm21 | MET 277 | 6.61x61 | VdWContact |
| ARG 13 | NTc.Cm21 | GLU 284 | - | Cationic |
| ARG 13 | NTc.Cm21 | ASP 293 | 7.32x31 | Cationic |
| ARG 13 | NTc.Cm21 | ASP 293 | 7.32x31 | HBDonor |
| ARG 13 | NTc.Cm21 | ASP 293 | 7.32x31 | VdWContact |
| CYS 14 | NTc.Cm20 | ARG 289 | 7.28x27 | VdWContact |
| GLN 15 | NTc.Cm19 | PRO 38 | - | Hydrophobic |
| GLN 15 | NTc.Cm19 | CYS 39 | - | HBAcceptor |
| GLN 15 | NTc.Cm19 | CYS 39 | - | VdWContact |
| ILE 17 | NTc.Cm17 | CYS 39 | - | VdWContact |
| ILE 17 | NTc.Cm17 | GLU 284 | - | Hydrophobic |
| ILE 17 | NTc.Cm17 | ARG 289 | 7.28x27 | VdWContact |
| LYS 18 | NTc.Cm16 | ASP 35 | - | Cationic |
| LYS 18 | NTc.Cm16 | ASP 35 | - | HBDonor |
| LYS 18 | NTc.Cm16 | ASP 35 | - | Hydrophobic |
| LYS 18 | NTc.Cm16 | ASP 35 | - | VdWContact |
| LYS 18 | NTc.Cm16 | ALA 36 | - | VdWContact |
| TYR 20 | NTc.Cm14 | PRO 30 | - | Hydrophobic |
| TYR 20 | NTc.Cm14 | PRO 31 | - | Hydrophobic |
| TYR 20 | NTc.Cm14 | PRO 31 | - | VdWContact |
| TYR 20 | NTc.Cm14 | LEU 33 | - | Hydrophobic |
| TYR 20 | NTc.Cm14 | LEU 33 | - | VdWContact |
| PRO 23 | NTc.Cm11 | TYR 25 | - | Hydrophobic |
| PRO 23 | NTc.Cm11 | SER 26 | - | HBAcceptor |
| PRO 23 | NTc.Cm11 | SER 26 | - | VdWContact |
| PHE 24 | NTc.Cm10 | TYR 25 | - | VdWContact |
| PHE 24 | NTc.Cm10 | PRO 30 | - | Hydrophobic |
| HIS 25 | NTc.Cm9 | TRP 15 | - | Hydrophobic |
| HIS 25 | NTc.Cm9 | SER 26 | - | HBDonor |
| HIS 25 | NTc.Cm9 | SER 26 | - | VdWContact |
| PRO 26 | NTc.Cm8 | PHE 11 | - | Hydrophobic |
| PRO 26 | NTc.Cm8 | TRP 15 | - | Hydrophobic |
| PRO 26 | NTc.Cm8 | TRP 15 | - | VdWContact |
| LYS 27 | NTc.Cm7 | PHE 11 | - | VdWContact |
| LYS 27 | NTc.Cm7 | GLU 12 | - | Hydrophobic |
| PHE 28 | NTc.Cm6 | SER 27 | - | VdWContact |
| PHE 28 | NTc.Cm6 | LEU 29 | - | Hydrophobic |
| ILE 29 | NTc.Cm5 | PHE 11 | - | Hydrophobic |
| LYS 30 | NTc.Cm4 | MET 6 | - | VdWContact |
| ILE 35 | CX.4 | MET 1 | - | Hydrophobic |
| ILE 35 | CX.4 | MET 1 | - | VdWContact |
| ILE 35 | CX.4 | SER 190 | - | VdWContact |
| GLU 36 | CX.5 | MET 1 | - | Hydrophobic |
| GLU 36 | CX.5 | MET 1 | - | VdWContact |
| PRO 39 | cxb1.5 | VAL 187 | - | Hydrophobic |
| PRO 39 | cxb1.5 | ASP 199 | - | Hydrophobic |
| PRO 39 | cxb1.5 | ASP 199 | - | VdWContact |
| PRO 39 | cxb1.5 | THR 204 | 5.31x32 | Hydrophobic |
| HIS 40 | cxb1.6 | MET 1 | - | Hydrophobic |
| ALA 42 | cxb1.8 | ASN 202 | - | VdWContact |
| ILE 47 | cxb1.16 | PRO 38 | - | Hydrophobic |
| LEU 50 | B1.3 | LEU 29 | - | Hydrophobic |
| LEU 50 | B1.3 | PRO 30 | - | Hydrophobic |
| LEU 50 | B1.3 | PRO 30 | - | VdWContact |
| ASP 52 | B1.5 | LEU 29 | - | Hydrophobic |
| ASP 52 | B1.5 | LEU 29 | - | VdWContact |
| ARG 54 | B1.7 | LEU 29 | - | VdWContact |
| ARG 54 | B1.7 | PRO 30 | - | HBDonor |
| ARG 54 | B1.7 | PRO 30 | - | VdWContact |
| ARG 54 | B1.7 | PHE 32 | - | Hydrophobic |
| ARG 54 | B1.7 | PHE 32 | - | VdWContact |
| GLU 55 | b1b2.4 | PRO 38 | - | Hydrophobic |
| GLU 55 | b1b2.4 | PRO 38 | - | VdWContact |
| LEU 56 | b1b2.6 | PRO 30 | - | Hydrophobic |
| LEU 56 | b1b2.6 | ALA 36 | - | Hydrophobic |
| CYS 57 | b1b2.7 | ALA 36 | - | HBDonor |
| CYS 57 | b1b2.7 | ALA 36 | - | VdWContact |
| ASN 63 | b1b2.14 | TYR 23 | - | Hydrophobic |
| ASN 63 | b1b2.14 | TYR 23 | - | VdWContact |
| TRP 64 | b1b2.16 | TYR 23 | - | Hydrophobic |
| TRP 64 | b1b2.16 | TYR 25 | - | Hydrophobic |
| ARG 67 | B2.3 | TYR 23 | - | VdWContact |
| VAL 68 | B2.4 | TRP 15 | - | Hydrophobic |
| VAL 68 | B2.4 | TRP 15 | - | VdWContact |
| LYS 71 | b2b3.2 | PHE 14 | - | HBDonor |
| LYS 71 | b2b3.2 | PHE 14 | - | Hydrophobic |
| LYS 71 | b2b3.2 | PHE 14 | - | VdWContact |
| LYS 71 | b2b3.2 | TRP 15 | - | Hydrophobic |
| LYS 71 | b2b3.2 | TRP 15 | - | VdWContact |
| LYS 71 | b2b3.2 | GLU 18 | - | Cationic |
| LYS 71 | b2b3.2 | GLU 18 | - | VdWContact |
| PHE 72 | b2b3.4 | MET 6 | - | Hydrophobic |
| PHE 72 | b2b3.4 | MET 6 | - | VdWContact |
| PHE 72 | b2b3.4 | PHE 11 | - | Hydrophobic |
| PHE 72 | b2b3.4 | PHE 11 | - | VdWContact |
| LEU 73 | b2b3.11 | PHE 4 | - | Hydrophobic |
| LEU 73 | b2b3.11 | PHE 4 | - | VdWContact |
| ARG 75 | B3.1 | MET 6 | - | Hydrophobic |
| ARG 75 | B3.1 | MET 6 | - | VdWContact |
| ARG 75 | B3.1 | PHE 14 | - | Hydrophobic |
| ARG 75 | B3.1 | PHE 14 | - | VdWContact |
| ALA 76 | B3.2 | PHE 4 | - | Hydrophobic |
| ALA 76 | B3.2 | PHE 4 | - | VdWContact |
| ALA 76 | B3.2 | MET 6 | - | Hydrophobic |
| ALA 76 | B3.2 | MET 6 | - | VdWContact |
