Predicted complex interactions
CXCL12_HUMAN + CXCR3
SUMMARY
- Chemokine
- CXCL12_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR3 View partner entry
- Partner description
- UniProt: P49682; Gene: cxcr3_human; Family: Chemokine
- Interactions detected
- 125
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LYS 1 | NTc.Cm29 | TRP 109 | 2.60x60 | Hydrophobic |
| LYS 1 | NTc.Cm29 | TRP 109 | 2.60x60 | VdWContact |
| LYS 1 | NTc.Cm29 | GLY 128 | 3.29x29 | VdWContact |
| LYS 1 | NTc.Cm29 | ASP 186 | 4.60x61 | Cationic |
| LYS 1 | NTc.Cm29 | LEU 190 | 4.64x65 | Hydrophobic |
| LYS 1 | NTc.Cm29 | CYS 203 | 45.50x50 | HBDonor |
| LYS 1 | NTc.Cm29 | CYS 203 | 45.50x50 | VdWContact |
| LYS 1 | NTc.Cm29 | TYR 205 | 45.52x52 | HBDonor |
| LYS 1 | NTc.Cm29 | TYR 205 | 45.52x52 | Hydrophobic |
| LYS 1 | NTc.Cm29 | TYR 205 | 45.52x52 | VdWContact |
| PRO 2 | NTc.Cm28 | TRP 109 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TRP 109 | 2.60x60 | VdWContact |
| PRO 2 | NTc.Cm28 | TYR 308 | 7.43x42 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TYR 308 | 7.43x42 | VdWContact |
| VAL 3 | NTc.Cm27 | ARG 216 | 5.39x40 | VdWContact |
| VAL 3 | NTc.Cm27 | TYR 271 | 6.51x51 | Hydrophobic |
| VAL 3 | NTc.Cm27 | VAL 275 | 6.55x55 | Hydrophobic |
| VAL 3 | NTc.Cm27 | LYS 300 | 7.35x34 | Hydrophobic |
| VAL 3 | NTc.Cm27 | LYS 300 | 7.35x34 | VdWContact |
| SER 4 | NTc.Cm26 | SER 301 | 7.36x35 | VdWContact |
| LEU 5 | NTc.Cm25 | LEU 56 | 1.35x35 | Hydrophobic |
| LEU 5 | NTc.Cm25 | TRP 109 | 2.60x60 | Hydrophobic |
| LEU 5 | NTc.Cm25 | ASP 112 | 2.63x63 | VdWContact |
| LEU 5 | NTc.Cm25 | ALA 113 | 2.64x64 | Hydrophobic |
| TYR 7 | NTc.Cm23 | GLN 45 | 1.24x24 | VdWContact |
| TYR 7 | NTc.Cm23 | LEU 49 | 1.28x28 | Hydrophobic |
| TYR 7 | NTc.Cm23 | ARG 197 | - | HBAcceptor |
| TYR 7 | NTc.Cm23 | ARG 197 | - | VdWContact |
| TYR 7 | NTc.Cm23 | LEU 198 | - | Hydrophobic |
| TYR 7 | NTc.Cm23 | LEU 198 | - | VdWContact |
| TYR 7 | NTc.Cm23 | HIS 202 | - | Hydrophobic |
| ARG 8 | NTc.Cm22 | GLN 45 | 1.24x24 | HBAcceptor |
| ARG 8 | NTc.Cm22 | GLN 45 | 1.24x24 | VdWContact |
| ARG 8 | NTc.Cm22 | ARG 197 | - | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 278 | 6.58x58 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 278 | 6.58x58 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 278 | 6.58x58 | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 282 | 6.62x62 | Cationic |
| ARG 8 | NTc.Cm22 | GLU 293 | 7.28x27 | Cationic |
| ARG 8 | NTc.Cm22 | GLU 293 | 7.28x27 | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 297 | 7.32x31 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 297 | 7.32x31 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 297 | 7.32x31 | VdWContact |
| ARG 8 | NTc.Cm22 | LYS 300 | 7.35x34 | VdWContact |
| CYS 9 | NTc.Cm21 | ARG 197 | - | Anionic |
| CYS 9 | NTc.Cm21 | ARG 197 | - | VdWContact |
| PRO 10 | NTc.Cm20 | PRO 42 | - | Hydrophobic |
| PRO 10 | NTc.Cm20 | CYS 43 | - | HBAcceptor |
| PRO 10 | NTc.Cm20 | CYS 43 | - | VdWContact |
| PRO 10 | NTc.Cm20 | ARG 197 | - | Hydrophobic |
| PRO 10 | NTc.Cm20 | ARG 197 | - | VdWContact |
| ARG 12 | NTc.Cm18 | CYS 43 | - | Cationic |
| ARG 12 | NTc.Cm18 | CYS 43 | - | HBDonor |
| ARG 12 | NTc.Cm18 | CYS 43 | - | VdWContact |
| ARG 12 | NTc.Cm18 | GLU 293 | 7.28x27 | Cationic |
| ARG 12 | NTc.Cm18 | GLU 293 | 7.28x27 | HBDonor |
| ARG 12 | NTc.Cm18 | GLU 293 | 7.28x27 | VdWContact |
| PHE 13 | NTc.Cm17 | ARG 288 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | ARG 288 | - | VdWContact |
| GLU 15 | NTc.Cm15 | CYS 38 | - | HBAcceptor |
| GLU 15 | NTc.Cm15 | CYS 38 | - | Hydrophobic |
| GLU 15 | NTc.Cm15 | CYS 38 | - | VdWContact |
| GLU 15 | NTc.Cm15 | SER 40 | - | HBAcceptor |
| GLU 15 | NTc.Cm15 | SER 40 | - | VdWContact |
| VAL 18 | NTc.Cm12 | CYS 38 | - | VdWContact |
| ARG 20 | NTc.Cm10 | TYR 27 | - | CationPi |
| ARG 20 | NTc.Cm10 | TYR 27 | - | VdWContact |
| ARG 20 | NTc.Cm10 | TYR 29 | - | Hydrophobic |
| ARG 20 | NTc.Cm10 | TYR 29 | - | VdWContact |
| ALA 21 | NTc.Cm9 | TYR 29 | - | Hydrophobic |
| ALA 21 | NTc.Cm9 | TYR 29 | - | VdWContact |
| LYS 27 | NTc.Cm3 | GLU 196 | - | HBDonor |
| LYS 27 | NTc.Cm3 | GLU 196 | - | VdWContact |
| ILE 28 | NTc.Cm2 | LEU 20 | - | Hydrophobic |
| ILE 28 | NTc.Cm2 | LEU 20 | - | VdWContact |
| LEU 29 | NTc.Cm1 | ARG 197 | - | Hydrophobic |
| ASN 30 | CX.1 | ASP 13 | - | HBDonor |
| ASN 30 | CX.1 | ASP 13 | - | VdWContact |
| ASN 30 | CX.1 | ALA 17 | - | Hydrophobic |
| ASN 30 | CX.1 | GLU 196 | - | HBDonor |
| ASN 30 | CX.1 | GLU 196 | - | VdWContact |
| THR 31 | CX.4 | ASP 195 | - | VdWContact |
| THR 31 | CX.4 | ARG 197 | - | Hydrophobic |
| PRO 32 | CX.5 | ASN 206 | - | VdWContact |
| ASN 33 | cxb1.1 | GLN 204 | 45.51x51 | HBDonor |
| ASN 33 | cxb1.1 | GLN 204 | 45.51x51 | VdWContact |
| ASN 33 | cxb1.1 | ARG 212 | 5.35x36 | HBAcceptor |
| ASN 33 | cxb1.1 | ARG 212 | 5.35x36 | VdWContact |
| CYS 34 | cxb1.2 | ARG 197 | - | Anionic |
| CYS 34 | cxb1.2 | ARG 197 | - | VdWContact |
| VAL 39 | cxb1.11 | PRO 42 | - | Hydrophobic |
| LEU 42 | cxb1.16 | CYS 38 | - | Hydrophobic |
| LYS 43 | B1.1 | ASP 28 | - | Cationic |
| ASN 44 | B1.2 | GLU 33 | - | VdWContact |
| GLN 48 | B1.6 | PRO 41 | - | VdWContact |
| GLN 48 | B1.6 | PRO 42 | - | Hydrophobic |
| VAL 49 | B1.7 | CYS 38 | - | Hydrophobic |
| VAL 49 | B1.7 | CYS 38 | - | VdWContact |
| CYS 50 | b1b2.4 | SER 40 | - | HBDonor |
| CYS 50 | b1b2.4 | SER 40 | - | VdWContact |
| TYR 61 | B2.4 | LEU 20 | - | HBDonor |
| TYR 61 | B2.4 | LEU 20 | - | Hydrophobic |
| TYR 61 | B2.4 | LEU 20 | - | VdWContact |
| TYR 61 | B2.4 | PHE 23 | - | Hydrophobic |
| TYR 61 | B2.4 | PHE 23 | - | VdWContact |
| LEU 62 | B2.5 | LEU 20 | - | Hydrophobic |
| LYS 64 | b2b3.2 | TYR 27 | - | HBDonor |
| LYS 64 | b2b3.2 | TYR 27 | - | VdWContact |
| ALA 65 | b2b3.3 | LEU 20 | - | Hydrophobic |
| ALA 65 | b2b3.3 | LEU 20 | - | VdWContact |
| ALA 65 | b2b3.3 | PHE 23 | - | Hydrophobic |
| ALA 65 | b2b3.3 | PHE 23 | - | VdWContact |
| LEU 66 | b2b3.4 | LEU 11 | - | Hydrophobic |
| LEU 66 | b2b3.4 | LEU 11 | - | VdWContact |
| LEU 66 | b2b3.4 | VAL 16 | - | Hydrophobic |
| LEU 66 | b2b3.4 | VAL 16 | - | VdWContact |
| LYS 68 | b2b3.12 | PHE 23 | - | Hydrophobic |
| LYS 68 | b2b3.12 | PHE 23 | - | VdWContact |
| ARG 69 | B3.1 | GLU 15 | - | Cationic |
| ARG 69 | B3.1 | GLU 15 | - | HBDonor |
| ARG 69 | B3.1 | GLU 15 | - | VdWContact |
| ARG 69 | B3.1 | LEU 19 | - | Hydrophobic |
| ARG 69 | B3.1 | LEU 19 | - | VdWContact |
| PHE 70 | B3.2 | LEU 11 | - | Hydrophobic |
| PHE 70 | B3.2 | LEU 11 | - | VdWContact |
