Predicted complex interactions
CXCL8_HUMAN + CXCR3
SUMMARY
- Chemokine
- CXCL8_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR3 View partner entry
- Partner description
- UniProt: P49682; Gene: cxcr3_human; Family: Chemokine
- Interactions detected
- 138
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| ALA 3 | NTc.Cm31 | GLN 204 | 45.51x51 | Hydrophobic |
| ALA 3 | NTc.Cm31 | GLN 204 | 45.51x51 | VdWContact |
| ALA 3 | NTc.Cm31 | TYR 205 | 45.52x52 | VdWContact |
| ALA 3 | NTc.Cm31 | ASN 206 | - | VdWContact |
| VAL 4 | NTc.Cm30 | TYR 205 | 45.52x52 | HBAcceptor |
| VAL 4 | NTc.Cm30 | TYR 205 | 45.52x52 | HBDonor |
| VAL 4 | NTc.Cm30 | TYR 205 | 45.52x52 | VdWContact |
| VAL 4 | NTc.Cm30 | PHE 207 | - | VdWContact |
| VAL 4 | NTc.Cm30 | ARG 212 | 5.35x36 | Hydrophobic |
| VAL 4 | NTc.Cm30 | ARG 212 | 5.35x36 | VdWContact |
| LEU 5 | NTc.Cm29 | LEU 190 | 4.64x65 | Hydrophobic |
| LEU 5 | NTc.Cm29 | LEU 190 | 4.64x65 | VdWContact |
| LEU 5 | NTc.Cm29 | CYS 203 | 45.50x50 | Hydrophobic |
| LEU 5 | NTc.Cm29 | CYS 203 | 45.50x50 | VdWContact |
| LEU 5 | NTc.Cm29 | GLN 204 | 45.51x51 | VdWContact |
| LEU 5 | NTc.Cm29 | TYR 205 | 45.52x52 | HBAcceptor |
| LEU 5 | NTc.Cm29 | TYR 205 | 45.52x52 | Hydrophobic |
| LEU 5 | NTc.Cm29 | TYR 205 | 45.52x52 | VdWContact |
| PRO 6 | NTc.Cm28 | TYR 205 | 45.52x52 | Hydrophobic |
| PRO 6 | NTc.Cm28 | TYR 205 | 45.52x52 | VdWContact |
| PRO 6 | NTc.Cm28 | TYR 271 | 6.51x51 | HBAcceptor |
| PRO 6 | NTc.Cm28 | TYR 271 | 6.51x51 | VdWContact |
| ARG 7 | NTc.Cm27 | TRP 109 | 2.60x60 | VdWContact |
| ARG 7 | NTc.Cm27 | TRP 117 | 23.50x50 | VdWContact |
| ARG 7 | NTc.Cm27 | ALA 127 | 3.28x28 | VdWContact |
| SER 8 | NTc.Cm26 | LEU 56 | 1.35x35 | VdWContact |
| LYS 10 | NTc.Cm24 | LEU 49 | 1.28x28 | Hydrophobic |
| LYS 10 | NTc.Cm24 | LEU 49 | 1.28x28 | VdWContact |
| LYS 10 | NTc.Cm24 | LEU 198 | - | Hydrophobic |
| LYS 10 | NTc.Cm24 | LEU 198 | - | VdWContact |
| LYS 10 | NTc.Cm24 | HIS 202 | - | HBDonor |
| LYS 10 | NTc.Cm24 | HIS 202 | - | Hydrophobic |
| LYS 10 | NTc.Cm24 | HIS 202 | - | VdWContact |
| GLU 11 | NTc.Cm23 | ARG 197 | - | HBAcceptor |
| GLU 11 | NTc.Cm23 | ARG 197 | - | VdWContact |
| GLU 11 | NTc.Cm23 | ASP 297 | 7.32x31 | Hydrophobic |
| GLU 11 | NTc.Cm23 | ASP 297 | 7.32x31 | VdWContact |
| GLU 11 | NTc.Cm23 | LYS 300 | 7.35x34 | Anionic |
| GLU 11 | NTc.Cm23 | LYS 300 | 7.35x34 | HBAcceptor |
| GLU 11 | NTc.Cm23 | LYS 300 | 7.35x34 | VdWContact |
| LEU 12 | NTc.Cm22 | GLN 204 | 45.51x51 | VdWContact |
| ARG 13 | NTc.Cm21 | ASP 278 | 6.58x58 | Cationic |
| ARG 13 | NTc.Cm21 | ASP 278 | 6.58x58 | HBDonor |
| ARG 13 | NTc.Cm21 | ASP 278 | 6.58x58 | VdWContact |
| ARG 13 | NTc.Cm21 | ASP 282 | 6.62x62 | Cationic |
| ARG 13 | NTc.Cm21 | GLU 293 | 7.28x27 | Cationic |
| ARG 13 | NTc.Cm21 | GLU 293 | 7.28x27 | VdWContact |
| CYS 14 | NTc.Cm20 | ARG 288 | - | Anionic |
| CYS 14 | NTc.Cm20 | ARG 288 | - | HBAcceptor |
| CYS 14 | NTc.Cm20 | ARG 288 | - | VdWContact |
| GLN 15 | NTc.Cm19 | PRO 42 | - | Hydrophobic |
| GLN 15 | NTc.Cm19 | CYS 43 | - | HBAcceptor |
| GLN 15 | NTc.Cm19 | CYS 43 | - | VdWContact |
| CYS 16 | NTc.Cm18 | ARG 288 | - | HBAcceptor |
| CYS 16 | NTc.Cm18 | ARG 288 | - | VdWContact |
| ILE 17 | NTc.Cm17 | CYS 43 | - | VdWContact |
| ILE 17 | NTc.Cm17 | ARG 288 | - | Hydrophobic |
| ILE 17 | NTc.Cm17 | ARG 288 | - | VdWContact |
| ILE 17 | NTc.Cm17 | CYS 290 | 7.25x24 | VdWContact |
| LYS 18 | NTc.Cm16 | SER 40 | - | VdWContact |
| TYR 20 | NTc.Cm14 | CYS 37 | - | VdWContact |
| TYR 20 | NTc.Cm14 | CYS 38 | - | Hydrophobic |
| TYR 20 | NTc.Cm14 | CYS 38 | - | VdWContact |
| LYS 22 | NTc.Cm12 | GLU 33 | - | Cationic |
| PRO 23 | NTc.Cm11 | TYR 27 | - | Hydrophobic |
| PRO 23 | NTc.Cm11 | TYR 29 | - | Hydrophobic |
| PRO 23 | NTc.Cm11 | TYR 29 | - | VdWContact |
| PHE 24 | NTc.Cm10 | TYR 29 | - | VdWContact |
| HIS 25 | NTc.Cm9 | LEU 20 | - | Hydrophobic |
| HIS 25 | NTc.Cm9 | LEU 20 | - | VdWContact |
| HIS 25 | NTc.Cm9 | PHE 23 | - | Hydrophobic |
| HIS 25 | NTc.Cm9 | TYR 29 | - | Hydrophobic |
| HIS 25 | NTc.Cm9 | TYR 29 | - | PiStacking |
| PRO 26 | NTc.Cm8 | LEU 19 | - | Hydrophobic |
| PRO 26 | NTc.Cm8 | PHE 23 | - | Hydrophobic |
| PRO 26 | NTc.Cm8 | PHE 23 | - | VdWContact |
| LYS 27 | NTc.Cm7 | VAL 16 | - | Hydrophobic |
| LYS 27 | NTc.Cm7 | VAL 16 | - | VdWContact |
| LYS 27 | NTc.Cm7 | LEU 20 | - | Hydrophobic |
| LYS 27 | NTc.Cm7 | LEU 20 | - | VdWContact |
| PHE 28 | NTc.Cm6 | SER 34 | - | VdWContact |
| ILE 29 | NTc.Cm5 | LEU 11 | - | VdWContact |
| LYS 30 | NTc.Cm4 | VAL 10 | - | VdWContact |
| LYS 30 | NTc.Cm4 | LEU 11 | - | HBAcceptor |
| LYS 30 | NTc.Cm4 | LEU 11 | - | VdWContact |
| GLU 31 | NTc.Cm3 | HIS 8 | - | Hydrophobic |
| GLU 31 | NTc.Cm3 | HIS 8 | - | VdWContact |
| GLU 31 | NTc.Cm3 | GLN 9 | - | VdWContact |
| GLU 31 | NTc.Cm3 | VAL 10 | - | Hydrophobic |
| GLU 31 | NTc.Cm3 | VAL 10 | - | VdWContact |
| LEU 32 | NTc.Cm2 | GLN 9 | - | HBDonor |
| LEU 32 | NTc.Cm2 | GLN 9 | - | VdWContact |
| ARG 33 | NTc.Cm1 | GLU 196 | - | VdWContact |
| ARG 33 | NTc.Cm1 | ARG 197 | - | HBDonor |
| ARG 33 | NTc.Cm1 | ARG 197 | - | VdWContact |
| VAL 34 | CX.1 | VAL 5 | - | Hydrophobic |
| VAL 34 | CX.1 | VAL 5 | - | VdWContact |
| ILE 35 | CX.4 | ARG 197 | - | Hydrophobic |
| HIS 40 | cxb1.6 | ARG 197 | - | PiCation |
| HIS 40 | cxb1.6 | ARG 197 | - | VdWContact |
| ILE 47 | cxb1.16 | PRO 42 | - | Hydrophobic |
| ILE 47 | cxb1.16 | PRO 42 | - | VdWContact |
| ARG 54 | B1.7 | SER 34 | - | HBDonor |
| ARG 54 | B1.7 | SER 34 | - | VdWContact |
| ARG 54 | B1.7 | ASP 35 | - | HBDonor |
| ARG 54 | B1.7 | ASP 35 | - | VdWContact |
| GLU 55 | b1b2.4 | PRO 41 | - | VdWContact |
| GLU 55 | b1b2.4 | PRO 42 | - | Hydrophobic |
| LEU 56 | b1b2.6 | CYS 38 | - | Hydrophobic |
| LEU 56 | b1b2.6 | CYS 38 | - | VdWContact |
| CYS 57 | b1b2.7 | SER 40 | - | HBDonor |
| CYS 57 | b1b2.7 | SER 40 | - | VdWContact |
| TRP 64 | b1b2.16 | TYR 27 | - | Hydrophobic |
| ARG 67 | B2.3 | PHE 23 | - | Hydrophobic |
| VAL 68 | B2.4 | PHE 23 | - | Hydrophobic |
| VAL 69 | B2.5 | VAL 5 | - | Hydrophobic |
| LYS 71 | b2b3.2 | LEU 19 | - | Hydrophobic |
| LYS 71 | b2b3.2 | LEU 19 | - | VdWContact |
| LYS 71 | b2b3.2 | ASN 22 | - | HBDonor |
| LYS 71 | b2b3.2 | ASN 22 | - | VdWContact |
| LYS 71 | b2b3.2 | PHE 23 | - | Hydrophobic |
| LYS 71 | b2b3.2 | PHE 23 | - | VdWContact |
| PHE 72 | b2b3.4 | GLN 9 | - | HBAcceptor |
| PHE 72 | b2b3.4 | GLN 9 | - | Hydrophobic |
| PHE 72 | b2b3.4 | GLN 9 | - | VdWContact |
| PHE 72 | b2b3.4 | LEU 11 | - | Hydrophobic |
| PHE 72 | b2b3.4 | LEU 11 | - | VdWContact |
| PHE 72 | b2b3.4 | LEU 19 | - | Hydrophobic |
| LEU 73 | b2b3.11 | LEU 3 | - | Hydrophobic |
| LEU 73 | b2b3.11 | VAL 5 | - | Hydrophobic |
| LEU 73 | b2b3.11 | VAL 5 | - | VdWContact |
| ARG 75 | B3.1 | GLU 15 | - | Cationic |
| ARG 75 | B3.1 | GLU 15 | - | HBDonor |
| ARG 75 | B3.1 | GLU 15 | - | VdWContact |
| ALA 76 | B3.2 | GLN 9 | - | Hydrophobic |
| ALA 76 | B3.2 | GLN 9 | - | VdWContact |
| GLU 77 | B3.3 | LEU 3 | - | Hydrophobic |
| GLU 77 | B3.3 | LEU 3 | - | VdWContact |
