Predicted complex interactions
CCL1_HUMAN + CXCR4
SUMMARY
- Chemokine
- CCL1_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 102
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LYS 1 | NTc.Cm32 | ASN 37 | 1.31x31 | VdWContact |
| LYS 1 | NTc.Cm32 | ASP 97 | 2.63x63 | Cationic |
| LYS 1 | NTc.Cm32 | ASP 97 | 2.63x63 | HBDonor |
| LYS 1 | NTc.Cm32 | ASP 97 | 2.63x63 | VdWContact |
| LYS 1 | NTc.Cm32 | CYS 186 | 45.50x50 | HBDonor |
| LYS 1 | NTc.Cm32 | CYS 186 | 45.50x50 | VdWContact |
| SER 2 | NTc.Cm31 | GLU 288 | 7.39x38 | HBDonor |
| SER 2 | NTc.Cm31 | GLU 288 | 7.39x38 | VdWContact |
| MET 3 | NTc.Cm30 | TYR 45 | 1.39x39 | Hydrophobic |
| MET 3 | NTc.Cm30 | TYR 45 | 1.39x39 | VdWContact |
| MET 3 | NTc.Cm30 | PHE 87 | 2.53x53 | Hydrophobic |
| MET 3 | NTc.Cm30 | TRP 94 | 2.60x60 | Hydrophobic |
| MET 3 | NTc.Cm30 | TRP 94 | 2.60x60 | VdWContact |
| MET 3 | NTc.Cm30 | TYR 116 | 3.32x32 | Hydrophobic |
| MET 3 | NTc.Cm30 | ARG 188 | 45.52x52 | HBAcceptor |
| MET 3 | NTc.Cm30 | ARG 188 | 45.52x52 | VdWContact |
| MET 3 | NTc.Cm30 | GLU 288 | 7.39x38 | HBDonor |
| MET 3 | NTc.Cm30 | GLU 288 | 7.39x38 | VdWContact |
| MET 3 | NTc.Cm30 | PHE 292 | 7.43x42 | Hydrophobic |
| MET 3 | NTc.Cm30 | PHE 292 | 7.43x42 | VdWContact |
| GLN 4 | NTc.Cm29 | ARG 188 | 45.52x52 | HBAcceptor |
| GLN 4 | NTc.Cm29 | ARG 188 | 45.52x52 | VdWContact |
| GLN 4 | NTc.Cm29 | HIS 203 | 5.42x43 | Hydrophobic |
| GLN 4 | NTc.Cm29 | HIS 203 | 5.42x43 | VdWContact |
| GLN 4 | NTc.Cm29 | TYR 255 | 6.51x51 | Hydrophobic |
| GLN 4 | NTc.Cm29 | TYR 255 | 6.51x51 | VdWContact |
| GLN 4 | NTc.Cm29 | ILE 259 | 6.55x55 | Hydrophobic |
| GLN 4 | NTc.Cm29 | GLU 288 | 7.39x38 | HBDonor |
| GLN 4 | NTc.Cm29 | GLU 288 | 7.39x38 | VdWContact |
| VAL 5 | NTc.Cm28 | ARG 30 | 1.24x24 | VdWContact |
| VAL 5 | NTc.Cm28 | ILE 259 | 6.55x55 | Hydrophobic |
| VAL 5 | NTc.Cm28 | ASP 262 | 6.58x58 | VdWContact |
| VAL 5 | NTc.Cm28 | HIS 281 | 7.32x31 | Hydrophobic |
| VAL 5 | NTc.Cm28 | HIS 281 | 7.32x31 | VdWContact |
| VAL 5 | NTc.Cm28 | ILE 284 | 7.35x34 | Hydrophobic |
| PRO 6 | NTc.Cm27 | ARG 30 | 1.24x24 | HBAcceptor |
| PRO 6 | NTc.Cm27 | ARG 30 | 1.24x24 | VdWContact |
| PRO 6 | NTc.Cm27 | ASP 187 | 45.51x51 | VdWContact |
| PRO 6 | NTc.Cm27 | TYR 190 | - | Hydrophobic |
| PRO 6 | NTc.Cm27 | VAL 196 | 5.35x36 | Hydrophobic |
| PHE 7 | NTc.Cm26 | ASP 187 | 45.51x51 | HBDonor |
| PHE 7 | NTc.Cm26 | ASP 187 | 45.51x51 | VdWContact |
| SER 8 | NTc.Cm25 | PHE 189 | - | VdWContact |
| ARG 9 | NTc.Cm24 | CYS 28 | - | Cationic |
| ARG 9 | NTc.Cm24 | CYS 28 | - | VdWContact |
| ARG 9 | NTc.Cm24 | ARG 30 | 1.24x24 | VdWContact |
| ARG 9 | NTc.Cm24 | GLU 277 | 7.28x27 | Cationic |
| ARG 9 | NTc.Cm24 | GLU 277 | 7.28x27 | HBDonor |
| ARG 9 | NTc.Cm24 | GLU 277 | 7.28x27 | VdWContact |
| PHE 12 | NTc.Cm21 | ASN 192 | - | Hydrophobic |
| PHE 12 | NTc.Cm21 | ASN 192 | - | VdWContact |
| PHE 12 | NTc.Cm21 | ASP 193 | 5.32x33 | Hydrophobic |
| PHE 12 | NTc.Cm21 | ASP 193 | 5.32x33 | VdWContact |
| ALA 15 | NTc.Cm18 | MET 24 | - | Hydrophobic |
| ALA 15 | NTc.Cm18 | MET 24 | - | VdWContact |
| GLN 17 | NTc.Cm16 | TYR 21 | - | Hydrophobic |
| GLN 17 | NTc.Cm16 | MET 24 | - | Hydrophobic |
| GLN 17 | NTc.Cm16 | MET 24 | - | VdWContact |
| GLU 18 | NTc.Cm15 | TYR 21 | - | HBAcceptor |
| GLU 18 | NTc.Cm15 | TYR 21 | - | VdWContact |
| ILE 19 | NTc.Cm14 | TYR 21 | - | Hydrophobic |
| ILE 19 | NTc.Cm14 | TYR 21 | - | VdWContact |
| ILE 19 | NTc.Cm14 | MET 24 | - | Hydrophobic |
| PRO 20 | NTc.Cm13 | TYR 21 | - | Hydrophobic |
| PRO 20 | NTc.Cm13 | TYR 21 | - | VdWContact |
| ARG 28 | NTc.Cm5 | PHE 29 | - | Hydrophobic |
| ARG 28 | NTc.Cm5 | PHE 29 | - | VdWContact |
| ARG 28 | NTc.Cm5 | GLU 31 | 1.25x25 | Cationic |
| ARG 28 | NTc.Cm5 | GLU 31 | 1.25x25 | HBDonor |
| ARG 28 | NTc.Cm5 | GLU 31 | 1.25x25 | VdWContact |
| SER 31 | NTc.Cm2 | ALA 180 | - | VdWContact |
| ILE 33 | CX.1 | SER 178 | - | VdWContact |
| ILE 33 | CX.1 | ALA 180 | - | Hydrophobic |
| ILE 33 | CX.1 | ILE 185 | - | Hydrophobic |
| ILE 33 | CX.1 | ILE 185 | - | VdWContact |
| ILE 33 | CX.1 | PHE 189 | - | Hydrophobic |
| ILE 33 | CX.1 | PHE 189 | - | VdWContact |
| SER 35 | cxb1.1 | PRO 191 | - | HBDonor |
| SER 35 | cxb1.1 | PRO 191 | - | VdWContact |
| ILE 40 | cxb1.8 | PRO 27 | - | Hydrophobic |
| ILE 40 | cxb1.8 | PRO 27 | - | VdWContact |
| ILE 40 | cxb1.8 | PHE 29 | - | Hydrophobic |
| ILE 40 | cxb1.8 | PHE 29 | - | VdWContact |
| ARG 45 | cxb1.16 | ASP 22 | - | Cationic |
| LYS 47 | B1.2 | ASP 22 | - | Cationic |
| LYS 47 | B1.2 | ASP 22 | - | HBDonor |
| LYS 47 | B1.2 | ASP 22 | - | VdWContact |
| LYS 47 | B1.2 | GLU 26 | - | Cationic |
| LYS 47 | B1.2 | GLU 26 | - | Hydrophobic |
| LYS 47 | B1.2 | GLU 26 | - | VdWContact |
| GLU 48 | B1.3 | GLU 26 | - | VdWContact |
| GLU 48 | B1.3 | PRO 27 | - | Hydrophobic |
| GLU 48 | B1.3 | PRO 27 | - | VdWContact |
| GLU 48 | B1.3 | PHE 29 | - | HBAcceptor |
| GLU 48 | B1.3 | PHE 29 | - | VdWContact |
| ALA 49 | B1.4 | MET 24 | - | Hydrophobic |
| ALA 49 | B1.4 | PRO 27 | - | VdWContact |
| CYS 50 | B1.5 | PRO 27 | - | Hydrophobic |
| CYS 50 | B1.5 | PRO 27 | - | VdWContact |
| LYS 71 | B3.1 | GLU 31 | 1.25x25 | Cationic |
| LYS 71 | B3.1 | GLU 31 | 1.25x25 | Hydrophobic |
| LYS 71 | B3.1 | GLU 31 | 1.25x25 | VdWContact |
