Predicted complex interactions
CCL15_HUMAN + CXCR4
SUMMARY
- Chemokine
- CCL15_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 93
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LEU 17 | NTc.Cm36 | PRO 191 | - | Hydrophobic |
| PRO 20 | NTc.Cm33 | PHE 189 | - | Hydrophobic |
| PRO 20 | NTc.Cm33 | PHE 189 | - | VdWContact |
| PRO 20 | NTc.Cm33 | TYR 190 | - | VdWContact |
| VAL 21 | NTc.Cm32 | TYR 190 | - | HBAcceptor |
| VAL 21 | NTc.Cm32 | TYR 190 | - | HBDonor |
| VAL 21 | NTc.Cm32 | TYR 190 | - | VdWContact |
| VAL 21 | NTc.Cm32 | ASN 192 | - | VdWContact |
| VAL 21 | NTc.Cm32 | ASP 193 | 5.32x33 | VdWContact |
| VAL 21 | NTc.Cm32 | VAL 196 | 5.35x36 | Hydrophobic |
| VAL 22 | NTc.Cm31 | ASP 187 | 45.51x51 | Hydrophobic |
| VAL 22 | NTc.Cm31 | ASP 187 | 45.51x51 | VdWContact |
| VAL 22 | NTc.Cm31 | PHE 189 | - | Hydrophobic |
| VAL 22 | NTc.Cm31 | PHE 189 | - | VdWContact |
| LEU 23 | NTc.Cm30 | ASP 187 | 45.51x51 | VdWContact |
| LEU 23 | NTc.Cm30 | ARG 188 | 45.52x52 | HBDonor |
| LEU 23 | NTc.Cm30 | ARG 188 | 45.52x52 | VdWContact |
| LEU 23 | NTc.Cm30 | TYR 190 | - | Hydrophobic |
| LEU 23 | NTc.Cm30 | TYR 190 | - | VdWContact |
| LEU 23 | NTc.Cm30 | VAL 196 | 5.35x36 | Hydrophobic |
| LEU 23 | NTc.Cm30 | VAL 196 | 5.35x36 | VdWContact |
| LEU 23 | NTc.Cm30 | GLN 200 | 5.39x40 | Hydrophobic |
| ASN 24 | NTc.Cm29 | ASP 262 | 6.58x58 | HBDonor |
| ASN 24 | NTc.Cm29 | ASP 262 | 6.58x58 | VdWContact |
| ASN 24 | NTc.Cm29 | HIS 281 | 7.32x31 | Hydrophobic |
| ASN 24 | NTc.Cm29 | HIS 281 | 7.32x31 | VdWContact |
| SER 25 | NTc.Cm28 | ASP 187 | 45.51x51 | HBDonor |
| SER 25 | NTc.Cm28 | ASP 187 | 45.51x51 | VdWContact |
| PHE 26 | NTc.Cm27 | ASN 37 | 1.31x31 | HBAcceptor |
| PHE 26 | NTc.Cm27 | ASN 37 | 1.31x31 | VdWContact |
| PHE 26 | NTc.Cm27 | ILE 284 | 7.35x34 | Hydrophobic |
| PHE 26 | NTc.Cm27 | ILE 284 | 7.35x34 | VdWContact |
| PHE 26 | NTc.Cm27 | SER 285 | 7.36x35 | VdWContact |
| PHE 26 | NTc.Cm27 | GLU 288 | 7.39x38 | Hydrophobic |
| PHE 26 | NTc.Cm27 | GLU 288 | 7.39x38 | VdWContact |
| HIS 27 | NTc.Cm26 | LEU 41 | 1.35x35 | Hydrophobic |
| HIS 27 | NTc.Cm26 | LEU 41 | 1.35x35 | VdWContact |
| HIS 27 | NTc.Cm26 | ASP 97 | 2.63x63 | Hydrophobic |
| HIS 27 | NTc.Cm26 | ASP 97 | 2.63x63 | VdWContact |
| HIS 27 | NTc.Cm26 | ALA 98 | 2.64x64 | Hydrophobic |
| HIS 27 | NTc.Cm26 | ALA 98 | 2.64x64 | VdWContact |
| PHE 28 | NTc.Cm25 | ASP 181 | - | Hydrophobic |
| PHE 28 | NTc.Cm25 | ASP 181 | - | VdWContact |
| PHE 28 | NTc.Cm25 | ILE 185 | - | Hydrophobic |
| ALA 29 | NTc.Cm24 | ARG 30 | 1.24x24 | Hydrophobic |
| ALA 29 | NTc.Cm24 | ARG 30 | 1.24x24 | VdWContact |
| ASP 31 | NTc.Cm22 | CYS 28 | - | VdWContact |
| ASP 31 | NTc.Cm22 | PHE 29 | - | VdWContact |
| ASP 31 | NTc.Cm22 | ARG 30 | 1.24x24 | HBAcceptor |
| ASP 31 | NTc.Cm22 | ARG 30 | 1.24x24 | VdWContact |
| CYS 32 | NTc.Cm21 | CYS 28 | - | HBAcceptor |
| CYS 32 | NTc.Cm21 | CYS 28 | - | VdWContact |
| THR 34 | NTc.Cm19 | GLU 277 | 7.28x27 | HBDonor |
| THR 34 | NTc.Cm19 | GLU 277 | 7.28x27 | VdWContact |
| SER 35 | NTc.Cm18 | LYS 25 | - | VdWContact |
| TYR 36 | NTc.Cm17 | LYS 25 | - | HBAcceptor |
| TYR 36 | NTc.Cm17 | LYS 25 | - | VdWContact |
| ILE 37 | NTc.Cm16 | MET 24 | - | Hydrophobic |
| ILE 37 | NTc.Cm16 | MET 24 | - | VdWContact |
| GLN 39 | NTc.Cm14 | TYR 21 | - | Hydrophobic |
| GLN 39 | NTc.Cm14 | SER 23 | - | HBDonor |
| GLN 39 | NTc.Cm14 | SER 23 | - | VdWContact |
| PRO 42 | NTc.Cm11 | TYR 21 | - | Hydrophobic |
| PRO 42 | NTc.Cm11 | TYR 21 | - | VdWContact |
| PRO 42 | NTc.Cm11 | MET 24 | - | Hydrophobic |
| MET 46 | NTc.Cm7 | MET 24 | - | Hydrophobic |
| GLU 55 | cxb1.1 | SER 178 | - | HBAcceptor |
| GLU 55 | cxb1.1 | SER 178 | - | VdWContact |
| GLU 55 | cxb1.1 | ALA 180 | - | VdWContact |
| GLU 55 | cxb1.1 | PHE 189 | - | Hydrophobic |
| SER 57 | cxb1.5 | ASP 193 | 5.32x33 | HBDonor |
| SER 57 | cxb1.5 | ASP 193 | 5.32x33 | VdWContact |
| LYS 58 | cxb1.6 | GLU 268 | 6.64x64 | Cationic |
| LYS 58 | cxb1.6 | GLU 268 | 6.64x64 | HBDonor |
| LYS 58 | cxb1.6 | GLU 268 | 6.64x64 | VdWContact |
| ILE 62 | cxb1.11 | PRO 27 | - | Hydrophobic |
| ILE 62 | cxb1.11 | PRO 27 | - | VdWContact |
| THR 65 | cxb1.16 | MET 24 | - | Hydrophobic |
| ARG 69 | B1.4 | ASP 22 | - | Cationic |
| ARG 69 | B1.4 | ASP 22 | - | HBDonor |
| ARG 69 | B1.4 | ASP 22 | - | VdWContact |
| ARG 69 | B1.4 | GLU 26 | - | Cationic |
| ARG 69 | B1.4 | GLU 26 | - | VdWContact |
| GLN 70 | B1.5 | GLU 26 | - | VdWContact |
| GLN 70 | B1.5 | PRO 27 | - | Hydrophobic |
| GLN 70 | B1.5 | PRO 27 | - | VdWContact |
| GLN 70 | B1.5 | PHE 29 | - | Hydrophobic |
| GLN 70 | B1.5 | PHE 29 | - | VdWContact |
| VAL 71 | B1.6 | MET 24 | - | Hydrophobic |
| VAL 71 | B1.6 | MET 24 | - | VdWContact |
| CYS 72 | B1.7 | LYS 25 | - | HBDonor |
| CYS 72 | B1.7 | LYS 25 | - | VdWContact |
| CYS 72 | B1.7 | PRO 27 | - | VdWContact |
